JP2008518974A5 - - Google Patents
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- Publication number
- JP2008518974A5 JP2008518974A5 JP2007539372A JP2007539372A JP2008518974A5 JP 2008518974 A5 JP2008518974 A5 JP 2008518974A5 JP 2007539372 A JP2007539372 A JP 2007539372A JP 2007539372 A JP2007539372 A JP 2007539372A JP 2008518974 A5 JP2008518974 A5 JP 2008518974A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- long chain
- nkt cell
- composition according
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000581 natural killer T-cell Anatomy 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 229930195729 fatty acid Natural products 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- 150000004665 fatty acids Chemical class 0.000 claims 4
- 150000002632 lipids Chemical class 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 230000020411 cell activation Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical class O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 2
- 150000001414 amino alcohols Chemical class 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 229930182830 galactose Natural products 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 150000003333 secondary alcohols Chemical class 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 1
- 206010013710 Drug interaction Diseases 0.000 claims 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 238000010171 animal model Methods 0.000 claims 1
- POQRWMRXUOPCLD-HIIAJUEOSA-N beta-D-galactosyl-N-(tetracosanoyl)sphingosine Chemical group CCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O POQRWMRXUOPCLD-HIIAJUEOSA-N 0.000 claims 1
- 229940106189 ceramide Drugs 0.000 claims 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000036737 immune function Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62456804P | 2004-11-02 | 2004-11-02 | |
| US60/624,568 | 2004-11-02 | ||
| US70654805P | 2005-08-08 | 2005-08-08 | |
| US60/706,548 | 2005-08-08 | ||
| PCT/US2005/040182 WO2006060117A2 (en) | 2004-11-02 | 2005-11-02 | Methods for inhibition of nkt cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008518974A JP2008518974A (ja) | 2008-06-05 |
| JP2008518974A5 true JP2008518974A5 (enExample) | 2008-11-27 |
| JP4948418B2 JP4948418B2 (ja) | 2012-06-06 |
Family
ID=36565493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007539372A Expired - Fee Related JP4948418B2 (ja) | 2004-11-02 | 2005-11-02 | Nkt細胞を抑制するための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7682614B2 (enExample) |
| EP (1) | EP1812015B1 (enExample) |
| JP (1) | JP4948418B2 (enExample) |
| CN (1) | CN101031307B (enExample) |
| AT (1) | ATE539757T1 (enExample) |
| AU (1) | AU2005310247A1 (enExample) |
| CA (1) | CA2584971C (enExample) |
| DK (1) | DK1812015T3 (enExample) |
| ES (1) | ES2378076T3 (enExample) |
| PT (1) | PT1812015E (enExample) |
| WO (1) | WO2006060117A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002254396A1 (en) | 2001-03-26 | 2002-10-08 | Dana-Farber Cancer Institute, Inc. | Method of attenuating reactions to skin irritants |
| EP2575824A4 (en) * | 2010-05-24 | 2014-02-19 | Childrens Medical Center | METHOD FOR THE TREATMENT AND PREVENTION OF INFLAMMATORY DISEASES |
| DK2643346T3 (en) * | 2010-11-25 | 2018-10-29 | Imnate Sarl | MODULATION OF ANTIGEN IMMUNOGENICITY BY ADDITION OF EPITOPES RECOGNIZED BY NKT CELLS |
| EP2731617A4 (en) | 2011-07-12 | 2015-07-01 | Brigham & Womens Hospital | LIPID-BASED PSA COMPOSITIONS, METHOD FOR THEIR INSULATION AND USE METHOD THEREFOR |
| CN103945867B (zh) * | 2011-10-27 | 2018-01-02 | Nkt治疗公司 | 针对iNKT的人类化抗体 |
| EP2906576B1 (en) | 2012-10-12 | 2019-09-11 | The Brigham and Women's Hospital, Inc. | Glycosphingolipids and methods of use thereof |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| CA2910766C (en) | 2013-04-30 | 2020-12-15 | Otitopic Inc. | Dry powder formulations and methods of use |
| JP6743051B2 (ja) | 2015-01-27 | 2020-08-19 | ラヴァ・セラピューティクス・ベー・フェー | Cd1dを標的とする単一ドメイン抗体 |
| CN108135167B (zh) | 2015-08-19 | 2021-07-09 | 哈佛学院院长及董事 | 脂化psa组合物和方法 |
| EP3484441A4 (en) | 2016-07-15 | 2020-03-18 | President and Fellows of Harvard College | GLYCOLIPID COMPOSITIONS AND METHOD FOR USE |
| WO2019059953A2 (en) | 2017-09-22 | 2019-03-28 | Otitopic Inc. | DRY POWDER COMPOSITIONS CONTAINING MAGNESIUM STEARATE |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| EP3853255A1 (en) | 2018-09-19 | 2021-07-28 | Lava Therapeutics B.V. | Novel bispecific antibodies for use in the treatment of hematological malignancies |
| IL305579A (en) | 2021-03-01 | 2023-10-01 | Deciduous Therapeutics Inc | Compounds for activating invariant natural killer T cells and methods for use in eliminating inflammatory senescent cells |
| EP4480486A1 (en) * | 2022-02-14 | 2024-12-25 | Riken | Nkt cell ligand-containing liposome composition |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6800738B1 (en) * | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
| US7063844B2 (en) * | 1992-12-10 | 2006-06-20 | The Brigham And Women's Hospital, Inc. | Presentation of hydrophobic antigens to T-cells by CD1 molecules |
| US5679347A (en) * | 1992-12-10 | 1997-10-21 | Brigham And Women's Hospital | Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods |
| DE69433115T2 (de) | 1993-06-21 | 2004-04-01 | Brigham And Women's Hospital, Boston | Verfahren zur isolierung von cda-präsentierten antigenen, cd1-präsentierte antigeneenthaltende impfstoffe und in besagten verfahren verwendbare zelllinien |
| US6632976B1 (en) * | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
| ATE421881T1 (de) * | 1997-04-10 | 2009-02-15 | Kyowa Hakko Kirin Co Ltd | Nkt-zellenaktivatoren, die alpha-glycosylceramide enthalten |
| EP1011719A1 (en) * | 1997-09-12 | 2000-06-28 | Brigham & Women's Hospital | Synthetic antigens for cd1-restricted immune responses |
| TW575420B (en) * | 1997-09-22 | 2004-02-11 | Kirin Brewery | Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides |
| US6197582B1 (en) * | 1998-03-18 | 2001-03-06 | The Trustees Of Columbia University In The City Of New York | Development of human monoclonal antibodies and uses thereof |
| AU4837499A (en) | 1998-07-09 | 2000-02-01 | Brian J. Nickoloff | Method of treating disorders by modulating the interaction of natural killer receptors on t cells with their respective ligands |
| US20010051156A1 (en) * | 2000-04-28 | 2001-12-13 | Defu Zeng | Methods for inhibition of polyclonal B cell activation and immunoglobulin class switching to pathogenic autoantibodies by blocking CD1-mediated interactions |
| WO2001094949A2 (en) | 2000-06-05 | 2001-12-13 | The Brigham And Women's Hospital, Inc. | Soluble cd1 compositions and uses thereof |
| CN1444648A (zh) * | 2000-06-06 | 2003-09-24 | 麒麟麦酒株式会社 | 扩增自然杀伤t细胞的方法 |
| PT1297017E (pt) * | 2000-06-19 | 2012-09-04 | Gen Hospital Corp | Composições e métodos de anticorpos monoclonais e policlonais específicos para subpopulações de célula t |
| US20020115624A1 (en) * | 2000-06-22 | 2002-08-22 | Behar Samuel M. | Alpha gylcosylceramides for treating bacterial and fungal infections |
| WO2002016825A1 (fr) * | 2000-08-18 | 2002-02-28 | Mitsubishi Denki Kabushiki Kaisha | Douille et transformateur pour lampe et procede de fabrication d'un transformateur pour lampe |
| DE10046658A1 (de) | 2000-09-20 | 2002-04-04 | Bosch Gmbh Robert | Induktiver Übertrager und ein Verfahren zu dessen Herstellung |
| DE60131456T2 (de) * | 2000-11-30 | 2008-07-10 | Medarex, Inc., Milpitas | Transchromosomale transgen-nagetiere zur herstellung von humanen antikörpern |
| IL140537A0 (en) * | 2000-12-25 | 2002-02-10 | Hadasit Med Res Service | Educated nk t cells and their uses in the treatment of immune-related disorders |
| AU2002254396A1 (en) * | 2001-03-26 | 2002-10-08 | Dana-Farber Cancer Institute, Inc. | Method of attenuating reactions to skin irritants |
| US6662434B2 (en) * | 2001-04-03 | 2003-12-16 | General Electric Company | Method and apparatus for magnetizing a permanent magnet |
| US8178098B2 (en) * | 2001-04-03 | 2012-05-15 | National Jewish Health | Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies |
| CA2444429A1 (en) * | 2001-04-11 | 2002-11-07 | Atherogenics, Inc. | Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality |
| US20020171538A1 (en) * | 2001-05-15 | 2002-11-21 | Kuo-Hsin Su | Vehicle motion detector and control device arrangement |
| US20020171557A1 (en) * | 2001-05-18 | 2002-11-21 | Wegener William E. | Security electronic system |
| JP2005500336A (ja) * | 2001-07-25 | 2005-01-06 | ニューヨーク・ユニバーシティ | 感染および癌に対するワクチンのためのアジュバントとしてのグリコシルセラミドの使用 |
| AU2003234443A1 (en) | 2002-05-01 | 2003-11-17 | Beth Israel Deaconess Medical Center | Use of anti-cd1 antibodies for the modulation of immune responses |
| US7273852B2 (en) * | 2002-06-13 | 2007-09-25 | The Research Foundation Of The City University Of New York | Synthetic C-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases |
| DE60239566D1 (de) | 2002-06-14 | 2011-05-05 | Brigham And Women S Hospital Boston | Verfahren zur behandlung und prävention von kolitis, an der il-13 und nk-t zellen beteiligt sind |
| US7368142B2 (en) * | 2002-08-01 | 2008-05-06 | Renew Life Formulas, Inc. | Natural sweetener |
| JP2006511462A (ja) | 2002-08-27 | 2006-04-06 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 上皮組織損傷又は脱毛症の予防又は治療 |
| AU2003277021A1 (en) | 2002-09-27 | 2004-04-19 | Biomira, Inc. | Glycosylceramide analogues |
| US9717754B2 (en) * | 2003-02-27 | 2017-08-01 | Enzo Therapeutics, Inc. | Glucocerebroside treatment of disease |
| US20040171522A1 (en) * | 2003-02-27 | 2004-09-02 | Yaron Ilan | Regulation of immune responses by manipulation of intermediary metabolite levels |
| WO2005032462A2 (en) | 2003-02-27 | 2005-04-14 | Enzo Therapeutics, Inc. | Glucocerebroside treatment of disease |
| US20040235162A1 (en) * | 2003-03-18 | 2004-11-25 | Kirin Beer Kabushiki Kaisha | Method of preparing immunoregulatory dendritic cells and the use thereof |
| US20050032210A1 (en) * | 2003-03-18 | 2005-02-10 | Kirin Beer Kabushiki Kaisha | Method of preparing immuno-regulatory dendritic cells and the use thereof |
| AU2003225891A1 (en) | 2003-03-20 | 2004-11-19 | Brigham Young University | 6"-amino-6"-deoxygalactosylceramides |
| WO2004084874A2 (en) | 2003-03-24 | 2004-10-07 | Brigham And Women's Hospital, Inc. | Mtp inhibitors for inhibiting inflammation |
| EP1653977A2 (en) | 2003-07-17 | 2006-05-10 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Treatment of disorders associated with natural killer t cells |
| AU2005251589B2 (en) * | 2004-06-11 | 2011-01-06 | Riken | Drug having regulatory cell ligand contained in liposome |
-
2005
- 2005-11-02 CN CN2005800330994A patent/CN101031307B/zh not_active Expired - Fee Related
- 2005-11-02 PT PT05851383T patent/PT1812015E/pt unknown
- 2005-11-02 AU AU2005310247A patent/AU2005310247A1/en not_active Abandoned
- 2005-11-02 AT AT05851383T patent/ATE539757T1/de active
- 2005-11-02 WO PCT/US2005/040182 patent/WO2006060117A2/en not_active Ceased
- 2005-11-02 DK DK05851383.9T patent/DK1812015T3/da active
- 2005-11-02 JP JP2007539372A patent/JP4948418B2/ja not_active Expired - Fee Related
- 2005-11-02 US US11/266,033 patent/US7682614B2/en not_active Expired - Fee Related
- 2005-11-02 ES ES05851383T patent/ES2378076T3/es not_active Expired - Lifetime
- 2005-11-02 CA CA2584971A patent/CA2584971C/en not_active Expired - Fee Related
- 2005-11-02 EP EP05851383A patent/EP1812015B1/en not_active Expired - Lifetime
-
2010
- 2010-02-01 US US12/697,882 patent/US8679499B2/en not_active Expired - Fee Related
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