JP2008514665A - 新規置換チオフェンカルボン酸アミド、それらの製造方法及び薬剤としてのそれらの使用 - Google Patents
新規置換チオフェンカルボン酸アミド、それらの製造方法及び薬剤としてのそれらの使用 Download PDFInfo
- Publication number
- JP2008514665A JP2008514665A JP2007533923A JP2007533923A JP2008514665A JP 2008514665 A JP2008514665 A JP 2008514665A JP 2007533923 A JP2007533923 A JP 2007533923A JP 2007533923 A JP2007533923 A JP 2007533923A JP 2008514665 A JP2008514665 A JP 2008514665A
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- atom
- methyl
- thiophene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(C)(CC*)CN(C)C Chemical compound CC(C)(CC*)CN(C)C 0.000 description 16
- VIPSDMFAVHWRQW-UHFFFAOYSA-N CC(C)(CC1)CN(C)C1=O Chemical compound CC(C)(CC1)CN(C)C1=O VIPSDMFAVHWRQW-UHFFFAOYSA-N 0.000 description 1
- MQIIUKRKXLRGAK-UHFFFAOYSA-N CC(C)(CN1)CN(C)S1(=O)=O Chemical compound CC(C)(CN1)CN(C)S1(=O)=O MQIIUKRKXLRGAK-UHFFFAOYSA-N 0.000 description 1
- UPTCMYMLOZCVPI-UHFFFAOYSA-M COC[NH+](O)[Al](C)(N)I Chemical compound COC[NH+](O)[Al](C)(N)I UPTCMYMLOZCVPI-UHFFFAOYSA-M 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004047840A DE102004047840A1 (de) | 2004-09-29 | 2004-09-29 | Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
| PCT/EP2005/010307 WO2006034822A1 (de) | 2004-09-29 | 2005-09-23 | Neue substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514665A true JP2008514665A (ja) | 2008-05-08 |
| JP2008514665A5 JP2008514665A5 (enExample) | 2008-11-06 |
Family
ID=35385703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533923A Pending JP2008514665A (ja) | 2004-09-29 | 2005-09-23 | 新規置換チオフェンカルボン酸アミド、それらの製造方法及び薬剤としてのそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7563786B2 (enExample) |
| EP (1) | EP1797080A1 (enExample) |
| JP (1) | JP2008514665A (enExample) |
| CA (1) | CA2581580A1 (enExample) |
| DE (1) | DE102004047840A1 (enExample) |
| WO (1) | WO2006034822A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008546741A (ja) * | 2005-06-30 | 2008-12-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規な置換グリシンアミド、その製造方法及びその薬物としての使用 |
| JP2011528016A (ja) * | 2008-07-15 | 2011-11-10 | ノバルティス アーゲー | Dgat1阻害剤としてのヘテロアリール誘導体 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007537179A (ja) * | 2004-05-13 | 2007-12-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換チオフェン−2−カルボン酸アミド、その製法及び薬物としての使用 |
| PE20081834A1 (es) * | 2006-12-31 | 2009-01-16 | Boehringer Ingelheim Int | Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos |
| EP2220079A2 (en) | 2007-11-15 | 2010-08-25 | Boehringer Ingelheim International GmbH | Substituted amides, manufacturing and use thereof as medicaments |
| EP2480531B1 (en) | 2009-09-21 | 2014-11-05 | ChemoCentryx, Inc. | Pyrrolidinone carboxamide derivatives as chemerin-r (chemr23) modulators |
| US8912221B2 (en) * | 2010-12-27 | 2014-12-16 | Hoffmann-La Roche Inc. | Biaryl amide derivatives |
| CN105294669B (zh) * | 2014-10-24 | 2019-01-22 | 山东凯森制药有限公司 | 一种第十因子抑制剂及其制备方法和应用 |
| EP3078378B1 (en) | 2015-04-08 | 2020-06-24 | Vaiomer | Use of factor xa inhibitors for regulating glycemia |
| US11691960B2 (en) | 2020-11-06 | 2023-07-04 | Boehringer Ingelheim International Gmbh | 2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001096303A1 (en) * | 2000-06-13 | 2001-12-20 | Eli Lilly And Company | Serine protease inhibitors |
| JP2003519141A (ja) * | 1999-12-24 | 2003-06-17 | バイエル アクチェンゲゼルシャフト | 置換オキサゾリジノン及び血液凝固の分野におけるそれらの使用 |
| JP2003183286A (ja) * | 2001-10-09 | 2003-07-03 | Dai Ichi Seiyaku Co Ltd | ジアミン誘導体 |
| WO2004031145A2 (en) * | 2002-10-02 | 2004-04-15 | Bristol-Myers Squibb Company | Lactam-containing diaminoalkyl, beta-aminoacids, alpha-aminoacids and derivatives thereof as factor xa inhibitors |
| WO2004046138A1 (de) * | 2002-11-21 | 2004-06-03 | Merck Patent Gmbh | Carbonsäureamide |
-
2004
- 2004-09-29 DE DE102004047840A patent/DE102004047840A1/de not_active Withdrawn
-
2005
- 2005-09-23 WO PCT/EP2005/010307 patent/WO2006034822A1/de not_active Ceased
- 2005-09-23 JP JP2007533923A patent/JP2008514665A/ja active Pending
- 2005-09-23 EP EP05788511A patent/EP1797080A1/de not_active Withdrawn
- 2005-09-23 CA CA002581580A patent/CA2581580A1/en not_active Abandoned
- 2005-09-29 US US11/238,599 patent/US7563786B2/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003519141A (ja) * | 1999-12-24 | 2003-06-17 | バイエル アクチェンゲゼルシャフト | 置換オキサゾリジノン及び血液凝固の分野におけるそれらの使用 |
| WO2001096303A1 (en) * | 2000-06-13 | 2001-12-20 | Eli Lilly And Company | Serine protease inhibitors |
| JP2003183286A (ja) * | 2001-10-09 | 2003-07-03 | Dai Ichi Seiyaku Co Ltd | ジアミン誘導体 |
| WO2004031145A2 (en) * | 2002-10-02 | 2004-04-15 | Bristol-Myers Squibb Company | Lactam-containing diaminoalkyl, beta-aminoacids, alpha-aminoacids and derivatives thereof as factor xa inhibitors |
| WO2004046138A1 (de) * | 2002-11-21 | 2004-06-03 | Merck Patent Gmbh | Carbonsäureamide |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008546741A (ja) * | 2005-06-30 | 2008-12-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規な置換グリシンアミド、その製造方法及びその薬物としての使用 |
| JP4768016B2 (ja) * | 2005-06-30 | 2011-09-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規な置換グリシンアミド、その製造方法及びその薬物としての使用 |
| JP2011528016A (ja) * | 2008-07-15 | 2011-11-10 | ノバルティス アーゲー | Dgat1阻害剤としてのヘテロアリール誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2581580A1 (en) | 2006-04-06 |
| EP1797080A1 (de) | 2007-06-20 |
| DE102004047840A1 (de) | 2006-03-30 |
| US20060069082A1 (en) | 2006-03-30 |
| WO2006034822A8 (de) | 2006-06-15 |
| WO2006034822A1 (de) | 2006-04-06 |
| US7563786B2 (en) | 2009-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080919 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080919 |
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| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110719 |
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| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20110720 |
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| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120123 |