JP2008514655A5 - - Google Patents
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- Publication number
- JP2008514655A5 JP2008514655A5 JP2007533891A JP2007533891A JP2008514655A5 JP 2008514655 A5 JP2008514655 A5 JP 2008514655A5 JP 2007533891 A JP2007533891 A JP 2007533891A JP 2007533891 A JP2007533891 A JP 2007533891A JP 2008514655 A5 JP2008514655 A5 JP 2008514655A5
- Authority
- JP
- Japan
- Prior art keywords
- diyl
- atoms
- hal
- ocoor
- ocon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 pyrrolidine-1,2-diyl Chemical group 0.000 description 2
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical group O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004047254A DE102004047254A1 (de) | 2004-09-29 | 2004-09-29 | Carbonylverbindungen |
| PCT/EP2005/009418 WO2006034769A1 (de) | 2004-09-29 | 2005-09-01 | Carbonylverbindungen verwendbar als inhibitoren des koagulationsfaktors xa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514655A JP2008514655A (ja) | 2008-05-08 |
| JP2008514655A5 true JP2008514655A5 (enExample) | 2008-10-16 |
Family
ID=35395743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533891A Pending JP2008514655A (ja) | 2004-09-29 | 2005-09-01 | 凝固因子Ｘａの阻害剤として用いられるカルボニル化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080081814A1 (enExample) |
| EP (1) | EP1797071A1 (enExample) |
| JP (1) | JP2008514655A (enExample) |
| KR (1) | KR20070057878A (enExample) |
| CN (1) | CN101031561A (enExample) |
| AU (1) | AU2005289164A1 (enExample) |
| BR (1) | BRPI0515577A (enExample) |
| CA (1) | CA2581732A1 (enExample) |
| DE (1) | DE102004047254A1 (enExample) |
| MX (1) | MX2007003470A (enExample) |
| RU (1) | RU2007116036A (enExample) |
| WO (1) | WO2006034769A1 (enExample) |
| ZA (1) | ZA200703443B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| JP5420395B2 (ja) | 2006-04-07 | 2014-02-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセット輸送体の調節剤 |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| EP2632465B1 (en) | 2010-10-27 | 2015-12-30 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2012058134A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| ES2605164T3 (es) | 2011-08-19 | 2017-03-13 | Merck Sharp & Dohme Corp. | Inhibidores del canal de potasio de la médula renal externa |
| WO2013039802A1 (en) | 2011-09-16 | 2013-03-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2771005B1 (en) | 2011-10-25 | 2016-05-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2771004B1 (en) | 2011-10-25 | 2016-05-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US9493474B2 (en) | 2011-10-31 | 2016-11-15 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US9108947B2 (en) | 2011-10-31 | 2015-08-18 | Merck Sharp & Dohme Corp. | Inhibitors of the Renal Outer Medullary Potassium channel |
| EP2773199B1 (en) | 2011-10-31 | 2019-04-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US9206199B2 (en) | 2011-12-16 | 2015-12-08 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| IN2014CN04174A (enExample) | 2011-12-22 | 2015-09-04 | Novartis Ag | |
| AU2013290444B2 (en) | 2012-07-16 | 2018-04-26 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof |
| AR092031A1 (es) | 2012-07-26 | 2015-03-18 | Merck Sharp & Dohme | Inhibidores del canal de potasio medular externo renal |
| WO2014085210A1 (en) | 2012-11-29 | 2014-06-05 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2014099633A2 (en) | 2012-12-19 | 2014-06-26 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2956142B1 (en) | 2013-02-18 | 2017-09-20 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US9765074B2 (en) | 2013-03-15 | 2017-09-19 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US9751881B2 (en) | 2013-07-31 | 2017-09-05 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| PL3925607T5 (pl) | 2014-04-15 | 2026-06-01 | Vertex Pharmaceuticals Incorporated | Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa |
| WO2016127358A1 (en) | 2015-02-12 | 2016-08-18 | Merck Sharp & Dohme Corp. | Inhibitors of renal outer medullary potassium channel |
| JP6980534B2 (ja) | 2015-06-25 | 2021-12-15 | ザ チルドレンズ メディカル センター コーポレーション | 造血幹細胞の増大、富化、および維持に関する方法および組成物 |
| WO2017161001A1 (en) | 2016-03-15 | 2017-09-21 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
| CN106674200B (zh) * | 2016-12-21 | 2019-04-12 | 西安交通大学 | 一种含有l-脯氨酰胺片段的化合物及其制备方法和应用 |
| CN108997200A (zh) * | 2018-07-17 | 2018-12-14 | 成都睿智化学研究有限公司 | 一种5-氨甲基-哌啶-2-酮的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| PL377633A1 (pl) * | 2003-04-03 | 2006-02-06 | Merck Patent Gmbh | Związki karbonylowe |
| DE10329457A1 (de) * | 2003-04-03 | 2005-01-20 | Merck Patent Gmbh | Ethinylprolinderivate |
| DE102004045796A1 (de) * | 2004-09-22 | 2006-03-23 | Merck Patent Gmbh | Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung |
-
2004
- 2004-09-29 DE DE102004047254A patent/DE102004047254A1/de not_active Withdrawn
-
2005
- 2005-09-01 WO PCT/EP2005/009418 patent/WO2006034769A1/de not_active Ceased
- 2005-09-01 CA CA002581732A patent/CA2581732A1/en not_active Abandoned
- 2005-09-01 KR KR1020077007053A patent/KR20070057878A/ko not_active Withdrawn
- 2005-09-01 RU RU2007116036/04A patent/RU2007116036A/ru unknown
- 2005-09-01 CN CNA2005800327898A patent/CN101031561A/zh active Pending
- 2005-09-01 US US11/576,207 patent/US20080081814A1/en not_active Abandoned
- 2005-09-01 JP JP2007533891A patent/JP2008514655A/ja active Pending
- 2005-09-01 MX MX2007003470A patent/MX2007003470A/es not_active Application Discontinuation
- 2005-09-01 AU AU2005289164A patent/AU2005289164A1/en not_active Abandoned
- 2005-09-01 EP EP05790356A patent/EP1797071A1/de not_active Withdrawn
- 2005-09-01 BR BRPI0515577-0A patent/BRPI0515577A/pt not_active Application Discontinuation
-
2007
- 2007-04-26 ZA ZA200703443A patent/ZA200703443B/xx unknown