JP2008513472A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008513472A5 JP2008513472A5 JP2007532479A JP2007532479A JP2008513472A5 JP 2008513472 A5 JP2008513472 A5 JP 2008513472A5 JP 2007532479 A JP2007532479 A JP 2007532479A JP 2007532479 A JP2007532479 A JP 2007532479A JP 2008513472 A5 JP2008513472 A5 JP 2008513472A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- haloalkyl
- alkyl
- haloalkoxy
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- -1 cyano, carboxy Chemical group 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 150000003573 thiols Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61080604P | 2004-09-17 | 2004-09-17 | |
| PCT/US2005/033051 WO2006034004A2 (en) | 2004-09-17 | 2005-09-16 | Processes and intermediates for preparing cysteine protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008513472A JP2008513472A (ja) | 2008-05-01 |
| JP2008513472A5 true JP2008513472A5 (https=) | 2008-07-03 |
Family
ID=35899659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007532479A Pending JP2008513472A (ja) | 2004-09-17 | 2005-09-16 | システインプロテアーゼインヒビターの調製のための方法及び中間体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7737300B2 (https=) |
| EP (1) | EP1799645A2 (https=) |
| JP (1) | JP2008513472A (https=) |
| KR (1) | KR20070061877A (https=) |
| CN (1) | CN101068783A (https=) |
| AU (1) | AU2005287046A1 (https=) |
| BR (1) | BRPI0515470A (https=) |
| CA (1) | CA2580065A1 (https=) |
| CR (1) | CR8993A (https=) |
| EC (1) | ECSP077321A (https=) |
| IL (1) | IL181792A0 (https=) |
| MX (1) | MX2007003118A (https=) |
| NO (1) | NO20071937L (https=) |
| WO (1) | WO2006034004A2 (https=) |
| ZA (1) | ZA200703102B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1663958E (pt) | 2003-09-18 | 2015-06-01 | Virobay Inc | Compostos contendo haloalquilo como inibidores de protease de cisteína |
| EP1819667B1 (en) | 2004-12-02 | 2012-10-17 | ViroBay, Inc. | Sulfonamide compounds as cysteine protease inhibitors |
| US7488848B2 (en) | 2005-03-21 | 2009-02-10 | Virobay, Inc. | Alpha ketoamide compounds as cysteine protease inhibitors |
| US7893093B2 (en) | 2005-03-22 | 2011-02-22 | Virobay, Inc. | Sulfonyl containing compounds as cysteine protease inhibitors |
| WO2008028301A1 (en) * | 2006-09-08 | 2008-03-13 | Merck Frosst Canada Ltd. | Prodrugs of inhibitors of cathepsin s |
| US20100048717A1 (en) * | 2006-09-25 | 2010-02-25 | MERCK FROSST CANADA LTD, Merk & Co., Inc. | Cathepsin b inhibitors |
| US7893112B2 (en) | 2006-10-04 | 2011-02-22 | Virobay, Inc. | Di-fluoro containing compounds as cysteine protease inhibitors |
| EP2079683B1 (en) | 2006-10-04 | 2015-01-21 | Virobay, Inc. | Di-fluoro containing compounds as cysteine protease inhibitors |
| CA2672494A1 (en) | 2006-12-14 | 2008-06-19 | Nps Pharmaceuticals, Inc. | Use of d-serine derivatives for the treatment of anxiety disorders |
| US8273913B2 (en) | 2007-04-02 | 2012-09-25 | Merck Canada Inc. | Amidation process for the preparation of cathepsin K inhibitors |
| JO3032B1 (ar) | 2008-10-17 | 2016-09-05 | Xenon Pharmaceuticals Inc | مركبات سبيرو – اوكسندول وإستعمالاتها كعوامل علاجية. |
| US20120101053A1 (en) * | 2009-06-22 | 2012-04-26 | Cameron Black | Cathepsin cysteine protease inhibitors for the treatment of various diseases |
| US8324417B2 (en) | 2009-08-19 | 2012-12-04 | Virobay, Inc. | Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof |
| WO2012119941A1 (en) | 2011-03-04 | 2012-09-13 | Prozymex A/S | Peptidyl nitrilcompounds as peptidase inhibitors |
| WO2012174552A2 (en) * | 2011-06-17 | 2012-12-20 | Virobay, Inc. | Cathepsin inhibitors for treating microglia-mediated neuron loss in the central nervous system |
| EP3342765B1 (en) * | 2015-08-29 | 2021-09-15 | Sunshine Lake Pharma Co., Ltd. | Cathepsin k inhibitor and application thereof |
| CN106478564B (zh) * | 2015-08-29 | 2021-11-12 | 广东东阳光药业有限公司 | 组织蛋白酶k抑制剂及其用途 |
| WO2020201572A1 (en) | 2019-04-05 | 2020-10-08 | Université De Bretagne Occidentale | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9723407D0 (en) * | 1997-11-05 | 1998-01-07 | Ciba Geigy Ag | Organic compounds |
| SK6572000A3 (en) * | 1997-11-05 | 2000-10-09 | Novartis Ag | Dipeptide nitriles, process for the preparation thereof, their use as medicaments and pharmaceutical composition comprising them |
| JP2002537293A (ja) * | 1999-02-20 | 2002-11-05 | アストラゼネカ アクチボラグ | カテプシンｌおよび／またはカテプシンｓの阻害剤としてのアセタミドアセトニトリル誘導体 |
| CA2459825A1 (en) * | 2001-10-02 | 2003-04-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cysteine proteases |
| CN100430052C (zh) * | 2002-03-05 | 2008-11-05 | 默克弗罗斯特加拿大有限公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
| JP4076955B2 (ja) * | 2002-03-11 | 2008-04-16 | 花王株式会社 | 化粧料 |
-
2005
- 2005-09-16 WO PCT/US2005/033051 patent/WO2006034004A2/en not_active Ceased
- 2005-09-16 CA CA002580065A patent/CA2580065A1/en not_active Abandoned
- 2005-09-16 AU AU2005287046A patent/AU2005287046A1/en not_active Abandoned
- 2005-09-16 JP JP2007532479A patent/JP2008513472A/ja active Pending
- 2005-09-16 MX MX2007003118A patent/MX2007003118A/es not_active Application Discontinuation
- 2005-09-16 BR BRPI0515470-7A patent/BRPI0515470A/pt not_active Application Discontinuation
- 2005-09-16 EP EP05796693A patent/EP1799645A2/en not_active Withdrawn
- 2005-09-16 KR KR1020077008584A patent/KR20070061877A/ko not_active Withdrawn
- 2005-09-16 US US11/662,933 patent/US7737300B2/en active Active
- 2005-09-16 CN CNA2005800389964A patent/CN101068783A/zh active Pending
-
2007
- 2007-03-08 IL IL181792A patent/IL181792A0/en unknown
- 2007-03-15 EC EC2007007321A patent/ECSP077321A/es unknown
- 2007-03-15 CR CR8993A patent/CR8993A/es unknown
- 2007-04-16 ZA ZA200703102A patent/ZA200703102B/xx unknown
- 2007-04-16 NO NO20071937A patent/NO20071937L/no not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008513472A5 (https=) | ||
| CY2020012I2 (el) | Προφαρμακα των ενωσεων 2,4-πυριμιδινδιαμινης και οι χρησεις αυτων | |
| EP1939199A4 (en) | NEW ADENINE CONNECTION | |
| JP2008506632A5 (https=) | ||
| JP2009524695A5 (https=) | ||
| EP2103619A4 (en) | IMIDAZOTHIAZOLDERIVATE | |
| ATE481383T1 (de) | 3-aza-bicycloä3.1.0ühexanderivate | |
| BRPI0810646A2 (pt) | " compostos farmacêuticos ". | |
| DE602005015215D1 (de) | Orthosubstituierte aryl- oder heteroarylamidverbindungen | |
| BRPI0818958A2 (pt) | "processos para a fabricação dos hidrofluoroalquenos, para a fabricação dos hidrofluoroalcanóis, para a fabricação dos hidrofluoroésteres e composto" | |
| WO2007048064A3 (en) | Amino-pyrimidines as casein kinase ii (ck2) modulators | |
| WO2006058700A8 (en) | Acetamide compounds as fungicides | |
| EP1938155A4 (en) | BUSINESS PROCESS EXECUTE ENGINE | |
| EP1794167A4 (en) | SUBSTITUTED ISOXAZOLE AS FUNGICIDES | |
| WO2009064374A3 (en) | Oral formulations of bis(thiohydrazide amides) | |
| JP2007520565A5 (https=) | ||
| ATE531717T1 (de) | Neue kristalline form eines pyridazinoä4,5- büindolderivats | |
| IT1366567B (it) | Granulati espandibili a basemdi polimeri vinilaromatici dotati di migliorata espansibilita'e procedimento per la loro preparazione | |
| EP1945731A4 (en) | ADHESIVE AGENTS | |
| NO20054767D0 (no) | Sammensetninger omfattende apomorfin for inhalering i lunge | |
| ZA200707933B (en) | Substituted aryl 1.4-pyrazine derivatives | |
| PL377747A1 (pl) | Synteza amidu kwasu 3-(4-hydroksyfenylo) propanowego | |
| JP2005298393A5 (https=) | ||
| JP2005298653A5 (https=) | ||
| JP2010504415A5 (https=) |