JP2008513472A5 - - Google Patents
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- Publication number
- JP2008513472A5 JP2008513472A5 JP2007532479A JP2007532479A JP2008513472A5 JP 2008513472 A5 JP2008513472 A5 JP 2008513472A5 JP 2007532479 A JP2007532479 A JP 2007532479A JP 2007532479 A JP2007532479 A JP 2007532479A JP 2008513472 A5 JP2008513472 A5 JP 2008513472A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- haloalkyl
- alkyl
- haloalkoxy
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- -1 cyano, carboxy Chemical group 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 150000003573 thiols Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61080604P | 2004-09-17 | 2004-09-17 | |
| PCT/US2005/033051 WO2006034004A2 (en) | 2004-09-17 | 2005-09-16 | Processes and intermediates for preparing cysteine protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008513472A JP2008513472A (ja) | 2008-05-01 |
| JP2008513472A5 true JP2008513472A5 (enExample) | 2008-07-03 |
Family
ID=35899659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007532479A Pending JP2008513472A (ja) | 2004-09-17 | 2005-09-16 | システインプロテアーゼインヒビターの調製のための方法及び中間体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7737300B2 (enExample) |
| EP (1) | EP1799645A2 (enExample) |
| JP (1) | JP2008513472A (enExample) |
| KR (1) | KR20070061877A (enExample) |
| CN (1) | CN101068783A (enExample) |
| AU (1) | AU2005287046A1 (enExample) |
| BR (1) | BRPI0515470A (enExample) |
| CA (1) | CA2580065A1 (enExample) |
| CR (1) | CR8993A (enExample) |
| EC (1) | ECSP077321A (enExample) |
| IL (1) | IL181792A0 (enExample) |
| MX (1) | MX2007003118A (enExample) |
| NO (1) | NO20071937L (enExample) |
| WO (1) | WO2006034004A2 (enExample) |
| ZA (1) | ZA200703102B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005028429A2 (en) | 2003-09-18 | 2005-03-31 | Axys Pharmaceuticals, Inc. | Haloalkyl containing compounds as cysteine protease inhibitors |
| EP1819667B1 (en) | 2004-12-02 | 2012-10-17 | ViroBay, Inc. | Sulfonamide compounds as cysteine protease inhibitors |
| HRP20130419T1 (en) | 2005-03-21 | 2013-06-30 | Virobay, Inc. | Alpha ketoamide compounds as cysteine protease inhibitors |
| MX2007011739A (es) | 2005-03-22 | 2008-03-14 | Celera Genomics | Compuestos que contienen sulfonilo como inhibidores de cisteina proteasa. |
| EP2064178A4 (en) * | 2006-09-08 | 2011-10-05 | Merck Canada Inc | PRODRUGS OF INHIBITORS OF CATHEPSIN S |
| WO2008037072A1 (en) | 2006-09-25 | 2008-04-03 | Merck Frosst Canada Ltd. | Cathepsin b inhibitors |
| DK2079683T3 (en) | 2006-10-04 | 2015-04-27 | Virobay Inc | Difluoro-containing compounds as cysteine protease inhibitors |
| US7893112B2 (en) | 2006-10-04 | 2011-02-22 | Virobay, Inc. | Di-fluoro containing compounds as cysteine protease inhibitors |
| WO2008070994A1 (en) | 2006-12-14 | 2008-06-19 | Nps Pharmaceuticals, Inc. | Use of d-serine derivatives for the treatment of anxiety disorders |
| CN101668736B (zh) | 2007-04-02 | 2013-06-12 | 默克弗罗斯特加拿大有限公司 | 用于制备组织蛋白酶k抑制剂的酰胺化反应 |
| PT2350090E (pt) | 2008-10-17 | 2015-11-13 | Xenon Pharmaceuticals Inc | Composto espiro-oxindol e suas utilizações como agentes terapêuticos |
| WO2010148488A1 (en) * | 2009-06-22 | 2010-12-29 | Merck Frosst Canada Ltd. | Cathepsin cysteine protease inhibitors for the treatment of various diseases |
| US8324417B2 (en) | 2009-08-19 | 2012-12-04 | Virobay, Inc. | Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof |
| WO2012119941A1 (en) | 2011-03-04 | 2012-09-13 | Prozymex A/S | Peptidyl nitrilcompounds as peptidase inhibitors |
| CN104039151A (zh) * | 2011-06-17 | 2014-09-10 | 维罗贝股份有限公司 | 治疗中枢神经系统中小神经胶质细胞介导的神经元缺失的组织蛋白酶抑制剂 |
| EP3342765B1 (en) * | 2015-08-29 | 2021-09-15 | Sunshine Lake Pharma Co., Ltd. | Cathepsin k inhibitor and application thereof |
| CN106478564B (zh) * | 2015-08-29 | 2021-11-12 | 广东东阳光药业有限公司 | 组织蛋白酶k抑制剂及其用途 |
| AU2020250933A1 (en) | 2019-04-05 | 2021-10-28 | Centre Hospitalier Régional Et Universitaire De Brest | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4450988B2 (ja) * | 1997-11-05 | 2010-04-14 | ノバルティス アーゲー | ジペプチドニトリル |
| GB9723407D0 (en) * | 1997-11-05 | 1998-01-07 | Ciba Geigy Ag | Organic compounds |
| AU2560300A (en) * | 1999-02-20 | 2000-09-04 | Astrazeneca Ab | Acetamido acetonitrile derivatives as inhibitors of cathepsin l and/or cathepsins |
| EP1434769A2 (en) * | 2001-10-02 | 2004-07-07 | Boehringer Ingelheim Pharmaceuticals Inc. | Compounds useful as reversible inhibitors of cysteine proteases |
| CN100430052C (zh) * | 2002-03-05 | 2008-11-05 | 默克弗罗斯特加拿大有限公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
| WO2003075863A1 (en) * | 2002-03-11 | 2003-09-18 | Kanebo Cosmetics Inc. | Cosmetics |
-
2005
- 2005-09-16 AU AU2005287046A patent/AU2005287046A1/en not_active Abandoned
- 2005-09-16 JP JP2007532479A patent/JP2008513472A/ja active Pending
- 2005-09-16 CN CNA2005800389964A patent/CN101068783A/zh active Pending
- 2005-09-16 BR BRPI0515470-7A patent/BRPI0515470A/pt not_active Application Discontinuation
- 2005-09-16 CA CA002580065A patent/CA2580065A1/en not_active Abandoned
- 2005-09-16 KR KR1020077008584A patent/KR20070061877A/ko not_active Withdrawn
- 2005-09-16 US US11/662,933 patent/US7737300B2/en active Active
- 2005-09-16 EP EP05796693A patent/EP1799645A2/en not_active Withdrawn
- 2005-09-16 WO PCT/US2005/033051 patent/WO2006034004A2/en not_active Ceased
- 2005-09-16 MX MX2007003118A patent/MX2007003118A/es not_active Application Discontinuation
-
2007
- 2007-03-08 IL IL181792A patent/IL181792A0/en unknown
- 2007-03-15 EC EC2007007321A patent/ECSP077321A/es unknown
- 2007-03-15 CR CR8993A patent/CR8993A/es unknown
- 2007-04-16 ZA ZA200703102A patent/ZA200703102B/xx unknown
- 2007-04-16 NO NO20071937A patent/NO20071937L/no not_active Application Discontinuation
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