JP2008513012A5 - - Google Patents
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- JP2008513012A5 JP2008513012A5 JP2007532436A JP2007532436A JP2008513012A5 JP 2008513012 A5 JP2008513012 A5 JP 2008513012A5 JP 2007532436 A JP2007532436 A JP 2007532436A JP 2007532436 A JP2007532436 A JP 2007532436A JP 2008513012 A5 JP2008513012 A5 JP 2008513012A5
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- JP
- Japan
- Prior art keywords
- compound
- oligonucleotide
- seq
- virus
- targeting sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 51
- 108091034117 Oligonucleotide Proteins 0.000 claims description 35
- 230000008685 targeting Effects 0.000 claims description 18
- 241000700605 Viruses Species 0.000 claims description 14
- 241000710781 Flaviviridae Species 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 239000001257 hydrogen Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000004475 Arginine Substances 0.000 claims description 8
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 8
- 230000000295 complement effect Effects 0.000 claims description 8
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 7
- MHCMWGPPLOSCJY-UHFFFAOYSA-N 4-$l^{1}-azanylmorpholine Chemical compound [N]N1CCOCC1 MHCMWGPPLOSCJY-UHFFFAOYSA-N 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 241001493065 dsRNA viruses Species 0.000 claims description 6
- 229910052698 phosphorus Inorganic materials 0.000 claims description 6
- 239000011574 phosphorus Substances 0.000 claims description 6
- 229920001184 polypeptide Polymers 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 5
- 241000711573 Coronaviridae Species 0.000 claims description 5
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims description 5
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 125000003282 alkyl amino group Chemical group 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- ANCLJVISBRWUTR-UHFFFAOYSA-N diaminophosphinic acid Chemical compound NP(N)(O)=O ANCLJVISBRWUTR-UHFFFAOYSA-N 0.000 claims description 5
- 108091033319 polynucleotide Proteins 0.000 claims description 5
- 102000040430 polynucleotide Human genes 0.000 claims description 5
- 239000002157 polynucleotide Substances 0.000 claims description 5
- IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 claims description 5
- 125000005309 thioalkoxy group Chemical group 0.000 claims description 5
- 108091027305 Heteroduplex Proteins 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 238000010494 dissociation reaction Methods 0.000 claims description 3
- 230000005593 dissociations Effects 0.000 claims description 3
- 239000002773 nucleotide Substances 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 5
- -1 nucleotide compound Chemical class 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 230000010076 replication Effects 0.000 claims 4
- 230000003612 virological effect Effects 0.000 claims 3
- 101710163270 Nuclease Proteins 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 241000725619 Dengue virus Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000710771 Tick-borne encephalitis virus Species 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 241000710772 Yellow fever virus Species 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 238000004590 computer program Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000010532 solid phase synthesis reaction Methods 0.000 claims 1
- 229940051021 yellow-fever virus Drugs 0.000 claims 1
- 241001292006 Arteriviridae Species 0.000 description 1
- 241001533362 Astroviridae Species 0.000 description 1
- 241000714198 Caliciviridae Species 0.000 description 1
- 241001122120 Hepeviridae Species 0.000 description 1
- 241000710924 Togaviridae Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000000074 antisense oligonucleotide Substances 0.000 description 1
- 238000012230 antisense oligonucleotides Methods 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61106304P | 2004-09-16 | 2004-09-16 | |
| US60/611,063 | 2004-09-16 | ||
| US11/226,995 | 2005-09-14 | ||
| US11/226,995 US8129352B2 (en) | 2004-09-16 | 2005-09-14 | Antisense antiviral compound and method for treating ssRNA viral infection |
| PCT/US2005/032815 WO2006033933A2 (en) | 2004-09-16 | 2005-09-15 | Antisense antiviral compound and method for treating ssrna viral infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008513012A JP2008513012A (ja) | 2008-05-01 |
| JP2008513012A5 true JP2008513012A5 (cg-RX-API-DMAC7.html) | 2011-12-22 |
| JP5425396B2 JP5425396B2 (ja) | 2014-02-26 |
Family
ID=36074482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007532436A Expired - Fee Related JP5425396B2 (ja) | 2004-09-16 | 2005-09-15 | アンチセンス抗ウイルス化合物及びｓｓＲＮＡウイルス感染を治療する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US8129352B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1802777B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5425396B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005287160C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2579815C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006033933A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2351976T3 (es) * | 2003-04-29 | 2011-02-14 | Avi Biopharma, Inc. | Composiciones para mejorar el transporte y la eficacia antisentido de análogos de ácidos nucleicos en células. |
| EP1668145A4 (en) * | 2003-08-07 | 2010-03-10 | Avi Biopharma Inc | SENSE ANTIVIRUS COMPOUND AND METHOD FOR TREATING SSRNA VIRUS INFECTION |
| US20050222068A1 (en) * | 2003-10-23 | 2005-10-06 | Mourich Dan V | Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells |
| US20050171044A1 (en) * | 2003-12-24 | 2005-08-04 | Stein David A. | Oligonucleotide compound and method for treating nidovirus infections |
| US20050288246A1 (en) | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
| EP2206781B1 (en) | 2004-06-28 | 2015-12-02 | The University Of Western Australia | Antisense oligonucleotides for inducing exon skipping and methods of use thereof |
| US8129352B2 (en) * | 2004-09-16 | 2012-03-06 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating ssRNA viral infection |
| US8357664B2 (en) | 2004-10-26 | 2013-01-22 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating influenza viral infection |
| US7524829B2 (en) * | 2004-11-01 | 2009-04-28 | Avi Biopharma, Inc. | Antisense antiviral compounds and methods for treating a filovirus infection |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| US8524676B2 (en) * | 2005-09-08 | 2013-09-03 | Sarepta Therapeutics, Inc. | Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds |
| EP1937278B1 (en) * | 2005-09-08 | 2012-07-25 | AVI BioPharma, Inc. | Antisense antiviral compound and method for treating picornavirus infection |
| US8501704B2 (en) | 2005-11-08 | 2013-08-06 | Sarepta Therapeutics, Inc. | Immunosuppression compound and treatment method |
| CA2651881A1 (en) * | 2006-05-10 | 2008-03-27 | Avi Biopharma, Inc. | Oligonucleotide analogs having cationic intersubunit linkages |
| US8785407B2 (en) * | 2006-05-10 | 2014-07-22 | Sarepta Therapeutics, Inc. | Antisense antiviral agent and method for treating ssRNA viral infection |
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| WO2009005793A2 (en) * | 2007-06-29 | 2009-01-08 | Avi Biopharma, Inc. | Tissue specific peptide conjugates and methods |
| CA2740328A1 (en) | 2008-10-24 | 2010-04-29 | Avi Biopharma, Inc. | Multiple exon skipping compositions for dmd |
| CA2746508A1 (en) * | 2008-12-17 | 2010-07-15 | Avi Biopharma, Inc. | Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis |
| US20110269665A1 (en) | 2009-06-26 | 2011-11-03 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| LT2499249T (lt) | 2009-11-12 | 2018-12-27 | The University Of Western Australia | Priešprasmės molekulės ir patologijų gydymo būdai |
| CA2779830C (en) | 2009-11-13 | 2020-07-21 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating influenza viral infection |
| KR102182663B1 (ko) | 2010-05-28 | 2020-11-25 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체 |
| US8198429B2 (en) | 2010-08-09 | 2012-06-12 | Avi Biopharma, Inc. | Antisense antiviral compounds and methods for treating a filovirus infection |
| US10017763B2 (en) | 2010-09-03 | 2018-07-10 | Sarepta Therapeutics, Inc. | dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups |
| US9161948B2 (en) | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| CA2834128A1 (en) | 2011-05-05 | 2012-11-08 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| MX354940B (es) | 2011-11-18 | 2018-03-27 | Sarepta Therapeutics Inc | Oligonucleotidos funcionalmente modificados y subunidades de los mismos. |
| KR102079284B1 (ko) * | 2012-03-20 | 2020-02-19 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 올리고뉴클레오티드 유사체의 보론산 접합체 |
| BR112015023001B8 (pt) | 2013-03-14 | 2022-08-09 | Sarepta Therapeutics Inc | Oligonucleotídeo antisenso, composição farmacêutica compreendendo o mesmo e uso da dita composição para o tratamento de distrofia muscular de duchenne (dmd) |
| AU2014233456B2 (en) | 2013-03-15 | 2019-02-21 | Sarepta Therapeutics, Inc. | Improved compositions for treating muscular dystrophy |
| CN103235902B (zh) * | 2013-04-18 | 2016-03-09 | 山东建筑大学 | 包含假结的rna结构预测方法 |
| EP3268473B1 (en) * | 2015-03-11 | 2020-05-13 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for the treatment of filovirus infections |
| WO2016196897A1 (en) | 2015-06-04 | 2016-12-08 | Sarepta Therapeutics, Inc. | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
| WO2018089306A1 (en) | 2016-11-10 | 2018-05-17 | Oyagen, Inc. | Methods of treating and inhibiting ebola virus infection |
| LT3554553T (lt) | 2016-12-19 | 2022-08-25 | Sarepta Therapeutics, Inc. | Egzoną šalinantys oligomero konjugatai nuo raumenų distrofojos |
| US12370261B2 (en) | 2018-03-16 | 2025-07-29 | Sarepta Therapeutics, Inc. | Chimeric peptides for antisense delivery |
| US12215382B2 (en) | 2019-03-01 | 2025-02-04 | The General Hospital Corporation | Liver protective MARC variants and uses thereof |
| CN115175991A (zh) | 2019-10-16 | 2022-10-11 | 博德研究所 | 工程化肌肉靶向组合物 |
| WO2021158248A1 (en) | 2020-02-04 | 2021-08-12 | Oyagen, Inc. | Method for treating coronavirus infections |
| WO2021211572A1 (en) * | 2020-04-14 | 2021-10-21 | Oregon State University | Antisense therapeutics for the treatment of coronavirus |
| JP2025524656A (ja) | 2022-07-14 | 2025-07-30 | ザ・ブロード・インスティテュート・インコーポレイテッド | トランスフェリン受容体との相互作用を通じてｃｎｓ全体への遺伝子送達を可能にするａａｖキャプシド |
| WO2025155923A1 (en) | 2024-01-17 | 2025-07-24 | The Broad Institute, Inc. | Aav capsid modifications that enable improved cns-wide gene delivery through interactions with the transferrin receptor |
| WO2025217163A2 (en) | 2024-04-08 | 2025-10-16 | The Broad Institute, Inc. | Novel aav capsids binding to human cd59 |
| WO2025217174A1 (en) | 2024-04-08 | 2025-10-16 | The Broad Institute, Inc. | Aav capsid modifications that enable improved cns-wide gene delivery through interactions with carbonic anhydrase iv |
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| US8129352B2 (en) | 2004-09-16 | 2012-03-06 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating ssRNA viral infection |
| US8357664B2 (en) | 2004-10-26 | 2013-01-22 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating influenza viral infection |
| US7524829B2 (en) | 2004-11-01 | 2009-04-28 | Avi Biopharma, Inc. | Antisense antiviral compounds and methods for treating a filovirus infection |
| US8067571B2 (en) * | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| US8524676B2 (en) | 2005-09-08 | 2013-09-03 | Sarepta Therapeutics, Inc. | Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds |
| EP1937278B1 (en) | 2005-09-08 | 2012-07-25 | AVI BioPharma, Inc. | Antisense antiviral compound and method for treating picornavirus infection |
| WO2007103529A2 (en) | 2006-03-07 | 2007-09-13 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating arenavirus infection |
| US8785407B2 (en) | 2006-05-10 | 2014-07-22 | Sarepta Therapeutics, Inc. | Antisense antiviral agent and method for treating ssRNA viral infection |
| CA2651881A1 (en) | 2006-05-10 | 2008-03-27 | Avi Biopharma, Inc. | Oligonucleotide analogs having cationic intersubunit linkages |
| WO2009005793A2 (en) | 2007-06-29 | 2009-01-08 | Avi Biopharma, Inc. | Tissue specific peptide conjugates and methods |
-
2005
- 2005-09-14 US US11/226,995 patent/US8129352B2/en not_active Expired - Fee Related
- 2005-09-15 JP JP2007532436A patent/JP5425396B2/ja not_active Expired - Fee Related
- 2005-09-15 CA CA2579815A patent/CA2579815C/en not_active Expired - Fee Related
- 2005-09-15 EP EP05796604A patent/EP1802777B1/en not_active Expired - Lifetime
- 2005-09-15 WO PCT/US2005/032815 patent/WO2006033933A2/en not_active Ceased
- 2005-09-15 AU AU2005287160A patent/AU2005287160C1/en not_active Ceased
-
2006
- 2006-05-10 US US11/432,031 patent/US8084433B2/en not_active Expired - Fee Related
-
2011
- 2011-12-22 US US13/335,450 patent/US8906872B2/en not_active Expired - Fee Related
-
2014
- 2014-11-06 US US14/535,092 patent/US10479996B2/en not_active Expired - Lifetime
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