JP2008512399A - 医薬組成物およびアルギナーゼを用いる肝炎の処置方法 - Google Patents

医薬組成物およびアルギナーゼを用いる肝炎の処置方法 Download PDF

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JP2008512399A
JP2008512399A JP2007530572A JP2007530572A JP2008512399A JP 2008512399 A JP2008512399 A JP 2008512399A JP 2007530572 A JP2007530572 A JP 2007530572A JP 2007530572 A JP2007530572 A JP 2007530572A JP 2008512399 A JP2008512399 A JP 2008512399A
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Prior art keywords
arginase
pharmaceutical composition
enzyme
composition according
use according
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Pending
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JP2007530572A
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Japanese (ja)
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JP2008512399A5 (enExample
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寧 民 鄭
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康達医藥科技有限公司
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Publication of JP2008512399A5 publication Critical patent/JP2008512399A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/50Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2007530572A 2004-09-08 2005-09-06 医薬組成物およびアルギナーゼを用いる肝炎の処置方法 Pending JP2008512399A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNA2004100768544A CN1745847A (zh) 2004-09-08 2004-09-08 用精氨酸酶治疗肝炎的药物组合物和方法
PCT/CN2005/001411 WO2006026915A1 (fr) 2004-09-08 2005-09-06 Composition pharmaceutique et methode de traitement de l'hepatite avec des arginases

Publications (2)

Publication Number Publication Date
JP2008512399A true JP2008512399A (ja) 2008-04-24
JP2008512399A5 JP2008512399A5 (enExample) 2008-10-02

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ID=36036072

Family Applications (1)

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JP2007530572A Pending JP2008512399A (ja) 2004-09-08 2005-09-06 医薬組成物およびアルギナーゼを用いる肝炎の処置方法

Country Status (6)

Country Link
US (1) US20080299638A1 (enExample)
EP (1) EP1803465A4 (enExample)
JP (1) JP2008512399A (enExample)
KR (1) KR20070100875A (enExample)
CN (1) CN1745847A (enExample)
WO (1) WO2006026915A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2350273B1 (en) 2008-10-31 2016-04-06 AERase, Inc. Compositions of engineered human arginases and methods for treating cancer
AU2010242422B2 (en) * 2009-03-26 2014-12-04 The Hong Kong Polytechnic University Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents
CN103184208B (zh) 2011-12-27 2015-09-16 拜奥生物科技(上海)有限公司 人精氨酸酶和定点聚乙二醇化人精氨酸酶及其应用
ES2897635T3 (es) 2014-04-29 2022-03-02 Bio Cancer Treat International Ltd Métodos y composiciones para modular el sistema inmunológico con la arginasa I
SMT202200157T1 (it) 2016-08-08 2022-05-12 Aerase Inc Composizioni e procedimenti per trattare il cancro con deplezione di arginina e agenti immuno-oncologici
MX2020005933A (es) 2017-12-05 2021-01-15 Aerase Inc Metodo y composicion para tratar la deficiencia de arginasa 1.
EP3866837A1 (en) 2018-10-19 2021-08-25 AERase, Inc. Arginine depletion therapy for treatment of gamt deficiency
JP2022545738A (ja) 2019-08-30 2022-10-28 アエグリア バイオセラピューティクス, インク. ヒト組換えアルギナーゼ1の製造方法およびその使用
CA3180529A1 (en) * 2020-04-17 2021-10-21 Bio-Cancer Treatment International Limited Methods of treating viral infections using arginase

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004001048A1 (en) * 2002-06-20 2003-12-31 Bio-Cancer Treatment International Limited Pharmaceutical composition and method of treatment of human malignancies with arginine deprivation
WO2004000349A1 (en) * 2002-06-20 2003-12-31 Bio-Cancer Treatment International Limited Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1059127C (zh) * 1995-07-19 2000-12-06 郝文学 治疗肝病的药物“疏肝酶”的制法
US5780286A (en) * 1996-03-14 1998-07-14 Smithkline Beecham Corporation Arginase II
US5851985A (en) * 1996-08-16 1998-12-22 Tepic; Slobodan Treatment of tumors by arginine deprivation
US6183738B1 (en) * 1997-05-12 2001-02-06 Phoenix Pharamacologics, Inc. Modified arginine deiminase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004001048A1 (en) * 2002-06-20 2003-12-31 Bio-Cancer Treatment International Limited Pharmaceutical composition and method of treatment of human malignancies with arginine deprivation
WO2004000349A1 (en) * 2002-06-20 2003-12-31 Bio-Cancer Treatment International Limited Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation

Also Published As

Publication number Publication date
EP1803465A1 (en) 2007-07-04
KR20070100875A (ko) 2007-10-12
CN1745847A (zh) 2006-03-15
EP1803465A4 (en) 2009-08-12
WO2006026915A1 (fr) 2006-03-16
US20080299638A1 (en) 2008-12-04

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