JP2008510799A5 - 薬学的組成物 - Google Patents
薬学的組成物 Download PDFInfo
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- JP2008510799A5 JP2008510799A5 JP2007529682A JP2007529682A JP2008510799A5 JP 2008510799 A5 JP2008510799 A5 JP 2008510799A5 JP 2007529682 A JP2007529682 A JP 2007529682A JP 2007529682 A JP2007529682 A JP 2007529682A JP 2008510799 A5 JP2008510799 A5 JP 2008510799A5
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- 239000008194 pharmaceutical composition Substances 0.000 title claims 12
- 150000001875 compounds Chemical class 0.000 claims 16
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 5
- 241000196324 Embryophyta Species 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 229920001301 Hexahydroxydiphenic acid Polymers 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 241000001522 Terminalia chebula Species 0.000 claims 2
- 235000011517 Terminalia chebula Nutrition 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims 1
- 241000694401 Acer maximowiczianum Species 0.000 claims 1
- HGJXAVROWQLCTP-YABCKIEDSA-N Chebulagic acid Chemical compound O([C@H]1[C@H]2[C@H]3OC(=O)C4=CC(O)=C(O)C(O)=C4C4=C(O)C(O)=C(O)C=C4C(=O)OC[C@@H](O1)[C@H]3OC(=O)[C@@H](CC(O)=O)[C@@H]1[C@@H](C(OC=3C(O)=C(O)C=C(C1=3)C(=O)O2)=O)O)C(=O)C1=CC(O)=C(O)C(O)=C1 HGJXAVROWQLCTP-YABCKIEDSA-N 0.000 claims 1
- 229920002052 Chebulagic acid Polymers 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 229920002786 Corilagin Polymers 0.000 claims 1
- 235000015489 Emblica officinalis Nutrition 0.000 claims 1
- 241000387101 Erodium stephanianum Species 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 1
- 208000000185 Localized scleroderma Diseases 0.000 claims 1
- IYMHVUYNBVWXKH-ZITZVVOASA-N Pedunculagin Chemical compound C([C@H]1OC2O)OC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)O[C@H]1[C@H]1[C@H]2OC(=O)C2=CC(O)=C(O)C(O)=C2C2=C(O)C(O)=C(O)C=C2C(=O)O1 IYMHVUYNBVWXKH-ZITZVVOASA-N 0.000 claims 1
- 229920000158 Pedunculagin Polymers 0.000 claims 1
- HVXQPVRDPFKKHP-UHFFFAOYSA-N Pedunculagin Natural products OC1C2COC(=O)c3cc(O)c(O)c(O)c3c4c(O)c(O)c(O)cc4C(=O)OC(O2)C5OC(=O)c6cc(O)c(O)c(O)c6c7c(O)c(O)c(O)cc7C(=O)OC15 HVXQPVRDPFKKHP-UHFFFAOYSA-N 0.000 claims 1
- 244000294611 Punica granatum Species 0.000 claims 1
- 235000014360 Punica granatum Nutrition 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 1
- UGIVASYMZSZAMP-UHFFFAOYSA-N chebulagic acid Natural products OC1C2c3c(OC1=O)c(O)c(O)cc3C(=O)OC4C(OC(=O)c5cc(O)c(O)c(O)c5)OC6COC(=O)c7cc(O)c(O)c(O)c7c8c(O)c(O)c(O)cc8C(=O)OC4C6OC(=O)C2(O)C(=O)O UGIVASYMZSZAMP-UHFFFAOYSA-N 0.000 claims 1
- TUSDEZXZIZRFGC-XIGLUPEJSA-N corilagin Chemical compound O([C@H]1[C@H](O)[C@H]2OC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC[C@@H](O1)[C@H]2O)C(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-XIGLUPEJSA-N 0.000 claims 1
- CPWYQGWOJMNXGJ-UHFFFAOYSA-N corilagin Natural products OC1C2COC(=O)c3c(O)c(O)c(O)c(O)c3c4c(O)c(O)c(O)c(O)c4C(=O)OC1C(O)C(OC(=O)c5cc(O)c(O)c(O)c5)O2 CPWYQGWOJMNXGJ-UHFFFAOYSA-N 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- -1 panicaragin Chemical compound 0.000 claims 1
- IYMHVUYNBVWXKH-UHFFFAOYSA-N pedunculagin I isomer Natural products OC1OC2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C2C1OC(=O)C1=CC(O)=C(O)C(O)=C1C1=C(O)C(O)=C(O)C=C1C(=O)O2 IYMHVUYNBVWXKH-UHFFFAOYSA-N 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Claims (10)
- 下記化学式２のヘキサヒドロキシジフェノイル（hexahydroxydiphenoyl）構造を含む化合物を有効成分として含有する、臓器移植拒否反応、及び、移植片−対−宿主疾患を予防または治療するための薬学的組成物：
- 下記化学式２のヘキサヒドロキシジフェノイル（hexahydroxydiphenoyl）構造を含む化合物を有効成分として含有する、自己免疫疾患を予防または治療するための薬学的組成物：
- 下記化学式２のヘキサヒドロキシジフェノイル（hexahydroxydiphenoyl）構造を含む化合物を有効成分として含有する、喘息を予防または治療するための薬学的組成物：
- 自己免疫疾患は、リューマチ性関節炎（rheumatoid arthritis）、乾癬（psoriasis）、炎症性臓疾患（inflammatory bowel disease）、第１型糖尿病（Type I diabetes mellitus）、潰瘍性大膓炎（ulcerative colitis）、多発性硬化症（multiple sclerosis）、強皮症（dermatosclerosis）、重症筋無力症（Myastheniagravis）、多発性筋肉炎（Polymyositis）、皮膚筋炎（dermatomyositis）、自己免疫血球減少症（autoimmune hemolytic anemia）、脈管炎症候群（vasculitis syndrome）、全身性エリテマトーデス（systemic erythematosus lupus）からなる群より選ばれたものであることを特徴とする請求項２に記載の薬学的組成物。
- 化学式２の化合物は、ケブラジン酸（Chebulagic acid）、パニカラギン（Punicalagin）、コリラジン（Corilagin）及びペドゥンクラジン（Pedunculagin）からなる群より選ばれたものであることを特徴とする請求項１〜４のうち何れか１項に記載の薬学的組成物。
- 化学式２の化合物は、ケブラジン酸であることを特徴とする請求項１〜４のうち何れか１項に記載の薬学的組成物。
- 化学式２の化合物は、植物から分離された抽出物であることを特徴とする請求項１〜４のうち何れか１項に記載の薬学的組成物。
- 化学式２の化合物がケブラジン酸であり、植物がミロバラン（Terminalia chebula）またはキクバフウロ（Erodium stephanianum Willd）である請求項７に記載の薬学的組成物。
- 化学式２の化合物がパニカラギンであり、植物が石榴（Punica granatum）である請求項７に記載の薬学的組成物。
- 化学式２の化合物がコリラジンであり、植物が目薬の木（Acer nikoense）である請求項７に記載の薬学的組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20040066463 | 2004-08-23 | ||
| PCT/KR2005/002764 WO2006022502A1 (en) | 2004-08-23 | 2005-08-22 | Compounds with diphenoyl -structure for the treatment of immune diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008510799A JP2008510799A (ja) | 2008-04-10 |
| JP2008510799A5 true JP2008510799A5 (ja) | 2008-09-18 |
Family
ID=35967680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007529682A Abandoned JP2008510799A (ja) | 2004-08-23 | 2005-08-22 | 免疫疾患の治療用ジフェノイル構造化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20080214656A1 (ja) |
| EP (1) | EP1789034A4 (ja) |
| JP (1) | JP2008510799A (ja) |
| KR (1) | KR20060050555A (ja) |
| WO (1) | WO2006022502A1 (ja) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2094085A4 (en) * | 2006-12-22 | 2011-09-28 | Univ Johns Hopkins | ANTI-CHOLESTEROLMIC COMPOUNDS AND METHODS OF USE |
| WO2009078495A1 (ja) * | 2007-12-19 | 2009-06-25 | Kirin Holdings Kabushiki Kaisha | 穀類植物種子由来の不溶性食物繊維含有物質 |
| EP2303252A1 (en) | 2008-05-15 | 2011-04-06 | Alois Jungbauer | Compounds for the treatment of metabolic syndrome and insulin resistance |
| US20100004334A1 (en) * | 2008-07-01 | 2010-01-07 | Mead Johnson Nutrition Company | Nutritional Compositions Containing Punicalagins |
| WO2010141883A1 (en) * | 2009-06-04 | 2010-12-09 | The Regents Of The University Of Colorado | Compounds that modulate autoimmunity and methods of using the same |
| US8933217B2 (en) * | 2009-07-24 | 2015-01-13 | Amazentis Sa | Compounds, compositions, and methods for protecting brain health in neurodegenerative disorders |
| JP2011057596A (ja) * | 2009-09-09 | 2011-03-24 | Ichimaru Pharcos Co Ltd | トリプターゼ活性阻害剤およびその利用 |
| AU2011348068B2 (en) * | 2010-12-23 | 2016-05-05 | Amazentis Sa | Compositions and methods for improving mitochondrial function and treating neurodegenerative diseases and cognitive disorders |
| WO2012162697A1 (en) | 2011-05-26 | 2012-11-29 | The Regents Of The University Of Colorado, A Body Corporate | Compounds that modulate autoimmunity and methods of using the same |
| US20130266676A1 (en) * | 2012-04-10 | 2013-10-10 | Natreon, Inc. | Terminalia chebula compositions and method of extracting same |
| WO2016115253A1 (en) | 2015-01-14 | 2016-07-21 | The Regents Of The University Ofcolordo, A Body Corporate | Insulin mimotopes and methods of using the same |
| EP3432877B1 (en) | 2016-03-24 | 2023-01-11 | ImmunoMolecular Therapeutics, Inc. | D-alpha-methyldopa for treating autoimmune disease |
| US11052060B2 (en) | 2018-02-12 | 2021-07-06 | The Regents Of The University Of Colorado, A Body Corporate | Compounds and methods for treating autoimmunity |
| US11013707B2 (en) | 2018-03-23 | 2021-05-25 | The Regents Of The University Of Colorado, A Body Corporate | Administration of oral methyldopa |
| KR20200025244A (ko) * | 2018-08-29 | 2020-03-10 | 연세대학교 산학협력단 | 푸니칼라진을 포함하는 소양증 예방, 개선 또는 치료용 조성물 |
| CN109674804B (zh) * | 2019-02-02 | 2021-04-16 | 武汉大学 | 柯里拉京在制备抗心肌纤维化药物中的用途 |
| KR102316961B1 (ko) * | 2020-01-29 | 2021-10-26 | 프라비바이오 주식회사 | 면역억제제로서의 벤젠 유도체의 면역억제용 약학적 조성물 |
| CN114344318A (zh) * | 2022-01-06 | 2022-04-15 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 一种安石榴苷在制备用于治疗银屑病药物中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2557797B1 (fr) * | 1984-01-09 | 1986-05-30 | Cheikho Zahira | Composition therapeutique a base de terminalia chebula pour le traitement du psoriasis par voie orale. |
| IL151334A0 (en) * | 2000-02-28 | 2003-04-10 | Natural Remedies Private Ltd | An improved herbal composition having antiallergic properties and a process for the preparation thereof |
-
2005
- 2005-08-22 EP EP05776183A patent/EP1789034A4/en not_active Withdrawn
- 2005-08-22 JP JP2007529682A patent/JP2008510799A/ja not_active Abandoned
- 2005-08-22 US US11/661,153 patent/US20080214656A1/en not_active Abandoned
- 2005-08-22 WO PCT/KR2005/002764 patent/WO2006022502A1/en active Application Filing
- 2005-08-23 KR KR1020050077125A patent/KR20060050555A/ko not_active Application Discontinuation
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