JP2008510775A5 - - Google Patents
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- Publication number
- JP2008510775A5 JP2008510775A5 JP2007528850A JP2007528850A JP2008510775A5 JP 2008510775 A5 JP2008510775 A5 JP 2008510775A5 JP 2007528850 A JP2007528850 A JP 2007528850A JP 2007528850 A JP2007528850 A JP 2007528850A JP 2008510775 A5 JP2008510775 A5 JP 2008510775A5
- Authority
- JP
- Japan
- Prior art keywords
- disorder
- pain
- methylamine
- syndrome
- enyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000002193 Pain Diseases 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 208000011580 syndromic disease Diseases 0.000 claims 5
- 206010012289 Dementia Diseases 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 4
- -1 2,5-disubstituted phenyl Chemical group 0.000 claims 3
- 208000020925 Bipolar disease Diseases 0.000 claims 3
- 208000019906 panic disease Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000007848 Alcoholism Diseases 0.000 claims 2
- 206010013654 Drug abuse Diseases 0.000 claims 2
- 208000030814 Eating disease Diseases 0.000 claims 2
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 2
- 208000026139 Memory disease Diseases 0.000 claims 2
- 208000019022 Mood disease Diseases 0.000 claims 2
- 206010043269 Tension headache Diseases 0.000 claims 2
- 208000008548 Tension-Type Headache Diseases 0.000 claims 2
- 206010043903 Tobacco abuse Diseases 0.000 claims 2
- 206010046543 Urinary incontinence Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 235000014632 disordered eating Nutrition 0.000 claims 2
- 201000001881 impotence Diseases 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 208000011117 substance-related disease Diseases 0.000 claims 2
- OVRDFQQTKQJVBU-HWKANZROSA-N (e)-2-(2,3-dichlorophenoxy)-n-methylpent-3-en-1-amine Chemical compound CNCC(\C=C\C)OC1=CC=CC(Cl)=C1Cl OVRDFQQTKQJVBU-HWKANZROSA-N 0.000 claims 1
- MFVWHUAYMMIZAV-HWKANZROSA-N (e)-3-(2,3-dichlorophenoxy)-n-methylhex-4-en-1-amine Chemical compound CNCCC(\C=C\C)OC1=CC=CC(Cl)=C1Cl MFVWHUAYMMIZAV-HWKANZROSA-N 0.000 claims 1
- VJWFAWYJUNMSBE-HWKANZROSA-N (e)-3-(2,3-difluorophenoxy)-n-methylhex-4-en-1-amine Chemical compound CNCCC(\C=C\C)OC1=CC=CC(F)=C1F VJWFAWYJUNMSBE-HWKANZROSA-N 0.000 claims 1
- YZEIVERTMJAREP-ONNFQVAWSA-N (e)-3-(3,4-dichlorophenoxy)-n,4-dimethylhex-4-en-1-amine Chemical compound CNCCC(C(\C)=C\C)OC1=CC=C(Cl)C(Cl)=C1 YZEIVERTMJAREP-ONNFQVAWSA-N 0.000 claims 1
- OHYQJNOWVMVSPC-ONEGZZNKSA-N (e)-3-(3,4-dichlorophenoxy)-n-methylhex-4-en-1-amine Chemical compound CNCCC(\C=C\C)OC1=CC=C(Cl)C(Cl)=C1 OHYQJNOWVMVSPC-ONEGZZNKSA-N 0.000 claims 1
- SBYOQXAUYVLYAE-ONEGZZNKSA-N (e)-3-(4-bromo-3-chlorophenoxy)-n-methylhex-4-en-1-amine Chemical compound CNCCC(\C=C\C)OC1=CC=C(Br)C(Cl)=C1 SBYOQXAUYVLYAE-ONEGZZNKSA-N 0.000 claims 1
- HILVBDZZCPEAFP-XVNBXDOJSA-N (e)-n-methyl-3-naphthalen-1-yloxyhex-4-en-1-amine Chemical compound C1=CC=C2C(OC(CCNC)\C=C\C)=CC=CC2=C1 HILVBDZZCPEAFP-XVNBXDOJSA-N 0.000 claims 1
- LRICJXFIUBRUPW-UHFFFAOYSA-N 3-(2,3-dichlorophenoxy)-n,5-dimethylhex-4-en-1-amine Chemical compound CNCCC(C=C(C)C)OC1=CC=CC(Cl)=C1Cl LRICJXFIUBRUPW-UHFFFAOYSA-N 0.000 claims 1
- PVUNNFFSHMUPDE-UHFFFAOYSA-N 3-(3,4-dichlorophenoxy)-n,5-dimethylhex-4-en-1-amine Chemical compound CNCCC(C=C(C)C)OC1=CC=C(Cl)C(Cl)=C1 PVUNNFFSHMUPDE-UHFFFAOYSA-N 0.000 claims 1
- QHHDETPFMGUEAK-UHFFFAOYSA-N 3-(4-bromo-3-chlorophenoxy)-n,5-dimethylhex-4-en-1-amine Chemical compound CNCCC(C=C(C)C)OC1=CC=C(Br)C(Cl)=C1 QHHDETPFMGUEAK-UHFFFAOYSA-N 0.000 claims 1
- WJECMYQUJAQSDY-UHFFFAOYSA-N 3-cyclopropyl-3-(2,3-dichlorophenoxy)-n-methylpropan-1-amine Chemical compound C1CC1C(CCNC)OC1=CC=CC(Cl)=C1Cl WJECMYQUJAQSDY-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000008811 Agoraphobia Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- 208000008035 Back Pain Diseases 0.000 claims 1
- 208000032841 Bulimia Diseases 0.000 claims 1
- 206010006550 Bulimia nervosa Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000022497 Cocaine-Related disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 208000026097 Factitious disease Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000011688 Generalised anxiety disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 208000028389 Nerve injury Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 206010033664 Panic attack Diseases 0.000 claims 1
- 206010052794 Panic disorder with agoraphobia Diseases 0.000 claims 1
- 206010033668 Panic disorder without agoraphobia Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010034010 Parkinsonism Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
- 206010052276 Pseudodementia Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 201000001880 Sexual dysfunction Diseases 0.000 claims 1
- 206010041250 Social phobia Diseases 0.000 claims 1
- 206010066218 Stress Urinary Incontinence Diseases 0.000 claims 1
- 208000011962 Substance-induced mood disease Diseases 0.000 claims 1
- 231100000395 Substance-induced mood disorder Toxicity 0.000 claims 1
- 208000031674 Traumatic Acute Stress disease Diseases 0.000 claims 1
- 208000026345 acute stress disease Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 208000025748 atypical depressive disease Diseases 0.000 claims 1
- 230000006931 brain damage Effects 0.000 claims 1
- 231100000874 brain damage Toxicity 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000001272 cocaine abuse Diseases 0.000 claims 1
- 210000004246 corpus luteum Anatomy 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 208000024732 dysthymic disease Diseases 0.000 claims 1
- 210000001097 facial muscle Anatomy 0.000 claims 1
- 208000029364 generalized anxiety disease Diseases 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000024714 major depressive disease Diseases 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 230000007074 memory dysfunction Effects 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 208000013465 muscle pain Diseases 0.000 claims 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 230000008764 nerve damage Effects 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 230000001561 neurotransmitter reuptake Effects 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 206010029446 nocturia Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002831 pharmacologic agent Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 206010036596 premature ejaculation Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 231100000872 sexual dysfunction Toxicity 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000002889 sympathetic effect Effects 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
- 208000002271 trichotillomania Diseases 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200401290 | 2004-08-26 | ||
| US60517504P | 2004-08-30 | 2004-08-30 | |
| PCT/EP2005/054151 WO2006021564A1 (en) | 2004-08-26 | 2005-08-24 | Novel substituted aryloxy alkylamines and their use as monoamine neurotransmitter re-uptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008510775A JP2008510775A (ja) | 2008-04-10 |
| JP2008510775A5 true JP2008510775A5 (enExample) | 2008-09-11 |
Family
ID=35134278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007528850A Abandoned JP2008510775A (ja) | 2004-08-26 | 2005-08-24 | モノアミン神経伝達物質再取込み阻害剤としての新規な置換アリールオキシアルキルアミン及びそれらの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7973082B2 (enExample) |
| EP (1) | EP1784381A1 (enExample) |
| JP (1) | JP2008510775A (enExample) |
| WO (1) | WO2006021564A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108586204A (zh) * | 2018-05-28 | 2018-09-28 | 朱晓萍 | 一种2,3-二氟苯酚的合成工艺 |
| CN108558618A (zh) * | 2018-05-28 | 2018-09-21 | 朱晓萍 | 一种制备2,3-二氟苯酚的方法 |
| US11691790B2 (en) | 2019-01-18 | 2023-07-04 | S.C. Johnson & Son, Inc. | Storage bag with improved gripping features |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1094985A (en) * | 1964-07-07 | 1967-12-13 | Wellcome Found | Amidine derivatives, processes for their preparation, and compositions incorporating them |
| GB1079747A (en) * | 1965-07-07 | 1967-08-16 | Ici Ltd | Alkene derivatives |
| DE3017812A1 (de) * | 1980-05-09 | 1981-11-12 | Merck Patent Gmbh, 6100 Darmstadt | Cyclopropanderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
| US4956388A (en) | 1986-12-22 | 1990-09-11 | Eli Lilly And Company | 3-aryloxy-3-substituted propanamines |
| KR880007433A (ko) | 1986-12-22 | 1988-08-27 | 메리 앤 터커 | 3-아릴옥시-3-치환된 프로판아민 |
| JP2584807B2 (ja) * | 1987-12-25 | 1997-02-26 | サントリー株式会社 | マレイミド誘導体、その製造法およびそれを有効成分として含有する農園芸用殺菌剤 |
| CA2071474A1 (en) | 1991-06-19 | 1992-12-20 | Hisato Itoh | Phthalocyanine compounds and usage thereof |
| US6861053B1 (en) * | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US6140033A (en) * | 1998-12-22 | 2000-10-31 | Eastman Kodak Company | Photographic element |
| GB0004152D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| GB0112122D0 (en) | 2001-05-18 | 2001-07-11 | Lilly Co Eli | Heteroaryloxy 3-substituted propanamines |
| US7417064B2 (en) | 2002-11-05 | 2008-08-26 | Eli Lilly And Company | 3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norepinephrine reuptake |
-
2005
- 2005-08-24 JP JP2007528850A patent/JP2008510775A/ja not_active Abandoned
- 2005-08-24 US US11/658,902 patent/US7973082B2/en not_active Expired - Fee Related
- 2005-08-24 WO PCT/EP2005/054151 patent/WO2006021564A1/en not_active Ceased
- 2005-08-24 EP EP05774064A patent/EP1784381A1/en not_active Withdrawn
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