JP2008509147A

JP2008509147A - ヒト神経精神病を治療するためのｎ−デスメチルクロザピンの使用

ヒト神経精神病を治療するためのｎ−デスメチルクロザピンの使用 Download PDF

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Publication number: JP2008509147A
Authority: JP; Japan
Prior art keywords: clozapine; desmethylclozapine; ndmc; subject; symptoms
Prior art date: 2004-08-05
Legal status : Pending

Application number

JP2007524968A

Other languages

English (en)

Japanese (ja)

Other versions

JP2008509147A5 (enExample

Inventor

ワイナー、デイビッド、エム．

ブラン、マーク、アール．

Original Assignee

アカディアファーマシューティカルズ，インコーポレーテッド

Priority date

2004-08-05

Filing date

2005-08-04

Publication date

2008-03-27

2004-08-05 Priority claimed from US10/913,117 external-priority patent/US20050085463A1/en

2005-04-04 Priority claimed from US11/098,892 external-priority patent/US20050250767A1/en

2005-08-04 Application filed by アカディアファーマシューティカルズ，インコーポレーテッド filed Critical アカディアファーマシューティカルズ，インコーポレーテッド

2008-03-27 Publication of JP2008509147A publication Critical patent/JP2008509147A/ja

2008-10-02 Publication of JP2008509147A5 publication Critical patent/JP2008509147A5/ja

Status Pending legal-status Critical Current

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JNNOSTQEZICQQP-UHFFFAOYSA-N N-desmethylclozapine Chemical compound N=1C2=CC(Cl)=CC=C2NC2=CC=CC=C2C=1N1CCNCC1 JNNOSTQEZICQQP-UHFFFAOYSA-N 0.000 title claims abstract description 463
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QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 claims description 280
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QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 82
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KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 claims description 16
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