CA2576153A1

CA2576153A1 - Use of n-desmethylclozapine to treat human neuropsychiatric disease

Use of n-desmethylclozapine to treat human neuropsychiatric disease Download PDF

Info

Publication number: CA2576153A1
Authority: CA; Canada
Prior art keywords: clozapine; desmethylclozapine; ndmc; symptoms; subject
Prior art date: 2004-08-05
Legal status : Abandoned

Application number

CA002576153A

Other languages

English (en)

French (fr)

Inventor

David M. Weiner

Mark R. Brann

Current Assignee

Acadia Pharmaceuticals Inc

Original Assignee

Individual

Priority date

2004-08-05

Filing date

2005-08-04

Publication date

2006-02-16

2004-08-05 Priority claimed from US10/913,117 external-priority patent/US20050085463A1/en

2005-04-04 Priority claimed from US11/098,892 external-priority patent/US20050250767A1/en

2005-08-04 Application filed by Individual filed Critical Individual

2006-02-16 Publication of CA2576153A1 publication Critical patent/CA2576153A1/en

Status Abandoned legal-status Critical Current

Links

JNNOSTQEZICQQP-UHFFFAOYSA-N N-desmethylclozapine Chemical compound N=1C2=CC(Cl)=CC=C2NC2=CC=CC=C2C=1N1CCNCC1 JNNOSTQEZICQQP-UHFFFAOYSA-N 0.000 title claims abstract description 505
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QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 claims description 329
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KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 claims description 28
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LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims description 22
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