JP2008506695A5 - - Google Patents
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- Publication number
- JP2008506695A5 JP2008506695A5 JP2007521595A JP2007521595A JP2008506695A5 JP 2008506695 A5 JP2008506695 A5 JP 2008506695A5 JP 2007521595 A JP2007521595 A JP 2007521595A JP 2007521595 A JP2007521595 A JP 2007521595A JP 2008506695 A5 JP2008506695 A5 JP 2008506695A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- amino
- methyloxy
- pyrrolidinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 9
- -1 hydroxy, amino, piperidyl Chemical group 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 7
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000004414 alkyl thio group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000005035 acylthio group Chemical group 0.000 claims 2
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 2
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical group C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims 2
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
- ATCNPKSZRNXFKY-UHFFFAOYSA-N 6-[[2-[1-(6-methoxy-1,5-naphthyridin-4-yl)pyrrolidin-3-yl]sulfanylethylamino]methyl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound O1CC(=O)NC2=NC(CNCCSC3CCN(C3)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 ATCNPKSZRNXFKY-UHFFFAOYSA-N 0.000 claims 1
- IUVOTHWPMIKARN-UHFFFAOYSA-N 6-[[2-[1-(6-methoxy-1,5-naphthyridin-4-yl)pyrrolidin-3-yl]sulfanylethylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNCCSC3CCN(C3)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 IUVOTHWPMIKARN-UHFFFAOYSA-N 0.000 claims 1
- PKSTXACHNLNDBB-UHFFFAOYSA-N 6-[[2-[[1-(6-methoxy-1,5-naphthyridin-4-yl)pyrrolidin-3-yl]amino]ethylamino]methyl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound O1CC(=O)NC2=NC(CNCCNC3CCN(C3)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 PKSTXACHNLNDBB-UHFFFAOYSA-N 0.000 claims 1
- OOOOIBUVJIMLGI-UHFFFAOYSA-N 6-[[2-[[1-(6-methoxy-1,5-naphthyridin-4-yl)pyrrolidin-3-yl]amino]ethylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNCCNC3CCN(C3)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 OOOOIBUVJIMLGI-UHFFFAOYSA-N 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- LJOBTIKWVFKMAI-UHFFFAOYSA-N [1,4]dioxino[2,3-c]pyridine Chemical compound N1=CC=C2OC=COC2=C1 LJOBTIKWVFKMAI-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000005090 alkenylcarbonyl group Chemical group 0.000 claims 1
- 125000005137 alkenylsulfonyl group Chemical group 0.000 claims 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 1
- 125000005360 alkyl sulfoxide group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
- 125000005361 aryl sulfoxide group Chemical group 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000004468 heterocyclylthio group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- RNYXCUVREHDUPX-UHFFFAOYSA-N n-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-n'-[1-(6-methoxy-1,5-naphthyridin-4-yl)pyrrolidin-3-yl]ethane-1,2-diamine Chemical compound O1CCOC(C=N2)=C1C=C2CNCCNC(C1)CCN1C1=CC=NC2=CC=C(OC)N=C21 RNYXCUVREHDUPX-UHFFFAOYSA-N 0.000 claims 1
- ZYYMGKURHMWNRV-UHFFFAOYSA-N n-[1-(6-methoxy-1,5-naphthyridin-4-yl)pyrrolidin-3-yl]-n-methyl-2-[(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]acetamide Chemical compound O1CC(=O)NC2=NC(CNCC(=O)N(C)C3CCN(C3)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 ZYYMGKURHMWNRV-UHFFFAOYSA-N 0.000 claims 1
- HBAPNOXUKRXVBB-UHFFFAOYSA-N n-[2-[1-(6-methoxy-1,5-naphthyridin-4-yl)pyrrolidin-3-yl]sulfanylethyl]-2,3-dihydro-1,4-benzodioxine-6-sulfonamide Chemical compound O1CCOC2=CC(S(=O)(=O)NCCSC3CCN(C3)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 HBAPNOXUKRXVBB-UHFFFAOYSA-N 0.000 claims 1
- JDUNOTDHYCPVRT-UHFFFAOYSA-N n-[2-[1-(6-methoxy-1,5-naphthyridin-4-yl)pyrrolidin-3-yl]sulfanylethyl]-3-oxo-4h-1,4-benzothiazine-6-sulfonamide Chemical compound S1CC(=O)NC2=CC(S(=O)(=O)NCCSC3CCN(C3)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 JDUNOTDHYCPVRT-UHFFFAOYSA-N 0.000 claims 1
- MUATWPDXODGBIQ-UHFFFAOYSA-N n-[2-[1-(6-methoxy-1,5-naphthyridin-4-yl)pyrrolidin-3-yl]sulfonylethyl]-3-oxo-4h-1,4-benzothiazine-6-sulfonamide Chemical compound S1CC(=O)NC2=CC(S(=O)(=O)NCCS(=O)(=O)C3CCN(C3)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 MUATWPDXODGBIQ-UHFFFAOYSA-N 0.000 claims 1
- XOVJCLSPGLLARQ-UHFFFAOYSA-N n-[2-[[1-(6-methoxy-1,5-naphthyridin-4-yl)pyrrolidin-3-yl]amino]ethyl]-3-oxo-4h-pyrido[3,2-b][1,4]thiazine-6-carboxamide Chemical compound S1CC(=O)NC2=NC(C(=O)NCCNC3CCN(C3)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 XOVJCLSPGLLARQ-UHFFFAOYSA-N 0.000 claims 1
- SPSCGHBFCVLWFI-UHFFFAOYSA-N n-[2-[[1-(6-methoxy-1,5-naphthyridin-4-yl)pyrrolidin-3-yl]amino]ethyl]-3-oxo-4h-pyrido[3,2-b][1,4]thiazine-6-sulfonamide Chemical compound S1CC(=O)NC2=NC(S(=O)(=O)NCCNC3CCN(C3)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 SPSCGHBFCVLWFI-UHFFFAOYSA-N 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58743904P | 2004-07-13 | 2004-07-13 | |
| PCT/US2005/024801 WO2006017326A1 (en) | 2004-07-13 | 2005-07-13 | Antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008506695A JP2008506695A (ja) | 2008-03-06 |
| JP2008506695A5 true JP2008506695A5 (https=) | 2008-09-04 |
Family
ID=35839598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007521595A Pending JP2008506695A (ja) | 2004-07-13 | 2005-07-13 | 抗細菌剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7648984B2 (https=) |
| EP (1) | EP1773343A4 (https=) |
| JP (1) | JP2008506695A (https=) |
| WO (1) | WO2006017326A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070202127A1 (en) * | 1993-06-07 | 2007-08-30 | Duke University | Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids |
| WO2006017468A2 (en) * | 2004-08-02 | 2006-02-16 | Glaxo Group Limited | Antibacterial agents |
| EP1845995A4 (en) * | 2005-01-25 | 2010-03-03 | Glaxo Group Ltd | ANTIBACTERIAL AGENTS |
| EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| WO2007118130A2 (en) | 2006-04-06 | 2007-10-18 | Glaxo Group Limited | Antibacterial agents |
| EP2001887B1 (en) | 2006-04-06 | 2010-09-15 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| AU2008240764C1 (en) * | 2007-04-20 | 2011-10-20 | Glaxo Group Limited | Tricyclic nitrogen containing compounds as antibacterial agents |
| EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
| EP2352734A1 (en) | 2008-10-17 | 2011-08-10 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
| US8318940B2 (en) | 2009-01-15 | 2012-11-27 | Glaxo Group Limited | Naphthyridin-2 (1 H)-one compounds useful as antibacterials |
| JP6112724B2 (ja) * | 2013-10-31 | 2017-04-12 | 日本化薬株式会社 | １，５−ナフチリジン誘導体およびそれを有効成分として含んでなる殺虫剤 |
| US10702521B2 (en) | 2014-08-22 | 2020-07-07 | Glaxosmithkline Intellectual Property Development Limited | Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones |
| TW201722965A (zh) | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
| IL264178B2 (en) * | 2016-07-14 | 2024-05-01 | Crinetics Pharmaceuticals Inc | Somatostatin modulators and uses thereof |
| EP3658560A4 (en) | 2017-07-25 | 2021-01-06 | Crinetics Pharmaceuticals, Inc. | SOMATOSTAT IN MODULATORS AND USES THEREOF |
| PT3740475T (pt) | 2018-01-17 | 2022-07-18 | Crinetics Pharmaceuticals Inc | Processo de produção de moduladores da somatostatina |
| US12590298B2 (en) | 2019-10-18 | 2026-03-31 | The Regents Of The University Of California | Ex vivo tumor angiogenesis model |
| KR20220087497A (ko) | 2019-10-18 | 2022-06-24 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 병원성 혈관을 표적화하기 위한 화합물 및 방법 |
| CA3191084A1 (en) | 2020-09-09 | 2022-03-17 | Gerald Burke | Formulations of a somatostatin modulator |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6440995B1 (en) * | 1999-10-01 | 2002-08-27 | Hoffman-La Roche Inc. | Quinolin-4-yl derivatives |
| GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| BR0312204A (pt) * | 2002-06-27 | 2005-04-26 | Schering Ag | Antagonista de receptor ccr5 de quinolina substituìda |
| AU2003270199A1 (en) * | 2002-09-13 | 2004-04-30 | Glaxo Group Limited | Urea compounds active as vanilloid receptor antagonists for the treatment of pain |
| EP1560488B1 (en) | 2002-11-05 | 2010-09-01 | Glaxo Group Limited | Antibacterial agents |
| WO2004050036A2 (en) | 2002-12-04 | 2004-06-17 | Glaxo Group Limited | Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents |
-
2005
- 2005-07-13 JP JP2007521595A patent/JP2008506695A/ja active Pending
- 2005-07-13 WO PCT/US2005/024801 patent/WO2006017326A1/en not_active Ceased
- 2005-07-13 EP EP05769569A patent/EP1773343A4/en not_active Withdrawn
- 2005-07-13 US US11/570,600 patent/US7648984B2/en not_active Expired - Fee Related
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