JP2008504837A5 - - Google Patents
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- Publication number
- JP2008504837A5 JP2008504837A5 JP2007519914A JP2007519914A JP2008504837A5 JP 2008504837 A5 JP2008504837 A5 JP 2008504837A5 JP 2007519914 A JP2007519914 A JP 2007519914A JP 2007519914 A JP2007519914 A JP 2007519914A JP 2008504837 A5 JP2008504837 A5 JP 2008504837A5
- Authority
- JP
- Japan
- Prior art keywords
- autism
- pitx1
- subject
- spectrum disorder
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 19
- 206010003805 Autism Diseases 0.000 claims 13
- 208000020706 Autistic disease Diseases 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 101000583156 Homo sapiens Pituitary homeobox 1 Proteins 0.000 claims 11
- 102100030345 Pituitary homeobox 1 Human genes 0.000 claims 11
- 208000029560 autism spectrum disease Diseases 0.000 claims 9
- 102000054766 genetic haplotypes Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 5
- 101150103310 pitx1 gene Proteins 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 4
- 108700028369 Alleles Proteins 0.000 claims 3
- 230000004075 alteration Effects 0.000 claims 3
- 108700008625 Reporter Genes Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108091030071 RNAI Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58413004P | 2004-07-01 | 2004-07-01 | |
| US60/584,130 | 2004-07-01 | ||
| PCT/IB2005/002319 WO2006003520A2 (en) | 2004-07-01 | 2005-06-30 | Human autism predisposition gene encoding a transcription factor and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008504837A JP2008504837A (ja) | 2008-02-21 |
| JP2008504837A5 true JP2008504837A5 (https=) | 2008-07-24 |
| JP4949240B2 JP4949240B2 (ja) | 2012-06-06 |
Family
ID=35432082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519914A Expired - Fee Related JP4949240B2 (ja) | 2004-07-01 | 2005-06-30 | 転写因子をコードするヒト自閉症素因遺伝子及びその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20070218068A1 (https=) |
| EP (1) | EP1761649B1 (https=) |
| JP (1) | JP4949240B2 (https=) |
| AT (1) | ATE382101T1 (https=) |
| AU (1) | AU2005258838B2 (https=) |
| CA (1) | CA2571365A1 (https=) |
| DE (1) | DE602005004026T2 (https=) |
| ES (1) | ES2299059T3 (https=) |
| IL (1) | IL179751A (https=) |
| WO (1) | WO2006003520A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110118135A1 (en) * | 2008-01-09 | 2011-05-19 | State Matthew W | Mutations in Contaction Associated Protein 2 (CNTNAP2) are Associated with Increased Risk for Ideopathic Autism |
| WO2009150221A1 (en) * | 2008-06-12 | 2009-12-17 | Integragen | A method for autism prediction |
| EP2963129A3 (en) * | 2008-11-12 | 2016-05-11 | University of Utah Research Foundation | Autism associated genetic markers |
| WO2011067296A1 (en) | 2009-12-01 | 2011-06-09 | Integragen | A combination of eight risk alleles associated with autism |
| KR101167942B1 (ko) | 2010-02-12 | 2012-07-23 | 차의과학대학교 산학협력단 | Ａｌｇ12 유전자로부터 유래된 단일염기다형을 포함하는 폴리뉴클레오티드, 이를 포함하는 마이크로어레이 및 진단키트, 및 이를 이용한 자폐 스펙트럼 장애 분석방법 |
| CA2797319A1 (en) | 2010-05-04 | 2011-11-10 | Integragen | A new combination of eight risk alleles associated with autism |
| EP2860265B1 (en) | 2011-02-24 | 2016-10-26 | The Chinese University of Hong Kong | Determining fetal DNA percentage for twins |
| CN111808943B (zh) * | 2020-06-18 | 2021-07-20 | 重庆浦洛通基因医学研究院有限公司 | 一种精神类个体化用药基因检测方法 |
-
2005
- 2005-06-30 AT AT05764390T patent/ATE382101T1/de active
- 2005-06-30 CA CA002571365A patent/CA2571365A1/en not_active Abandoned
- 2005-06-30 AU AU2005258838A patent/AU2005258838B2/en not_active Ceased
- 2005-06-30 DE DE602005004026T patent/DE602005004026T2/de not_active Expired - Lifetime
- 2005-06-30 ES ES05764390T patent/ES2299059T3/es not_active Expired - Lifetime
- 2005-06-30 JP JP2007519914A patent/JP4949240B2/ja not_active Expired - Fee Related
- 2005-06-30 US US11/570,543 patent/US20070218068A1/en not_active Abandoned
- 2005-06-30 EP EP05764390A patent/EP1761649B1/en not_active Expired - Lifetime
- 2005-06-30 WO PCT/IB2005/002319 patent/WO2006003520A2/en not_active Ceased
-
2006
- 2006-11-30 IL IL179751A patent/IL179751A/en not_active IP Right Cessation
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