AU2005258838B2 - Human autism predisposition gene encoding a transcription factor and uses thereof - Google Patents

Human autism predisposition gene encoding a transcription factor and uses thereof Download PDF

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Publication number
AU2005258838B2
AU2005258838B2 AU2005258838A AU2005258838A AU2005258838B2 AU 2005258838 B2 AU2005258838 B2 AU 2005258838B2 AU 2005258838 A AU2005258838 A AU 2005258838A AU 2005258838 A AU2005258838 A AU 2005258838A AU 2005258838 B2 AU2005258838 B2 AU 2005258838B2
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AU
Australia
Prior art keywords
autism
gene
pitx1
alteration
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005258838A
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English (en)
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AU2005258838A1 (en
Inventor
Peter Brooks
Jorg Hager
Anne Philippi
Francis Rousseau
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IntegraGen SA
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IntegraGen SA
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Publication date
Application filed by IntegraGen SA filed Critical IntegraGen SA
Publication of AU2005258838A1 publication Critical patent/AU2005258838A1/en
Application granted granted Critical
Publication of AU2005258838B2 publication Critical patent/AU2005258838B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AU2005258838A 2004-07-01 2005-06-30 Human autism predisposition gene encoding a transcription factor and uses thereof Ceased AU2005258838B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58413004P 2004-07-01 2004-07-01
US60/584,130 2004-07-01
PCT/IB2005/002319 WO2006003520A2 (en) 2004-07-01 2005-06-30 Human autism predisposition gene encoding a transcription factor and uses thereof

Publications (2)

Publication Number Publication Date
AU2005258838A1 AU2005258838A1 (en) 2006-01-12
AU2005258838B2 true AU2005258838B2 (en) 2009-05-14

Family

ID=35432082

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005258838A Ceased AU2005258838B2 (en) 2004-07-01 2005-06-30 Human autism predisposition gene encoding a transcription factor and uses thereof

Country Status (10)

Country Link
US (1) US20070218068A1 (https=)
EP (1) EP1761649B1 (https=)
JP (1) JP4949240B2 (https=)
AT (1) ATE382101T1 (https=)
AU (1) AU2005258838B2 (https=)
CA (1) CA2571365A1 (https=)
DE (1) DE602005004026T2 (https=)
ES (1) ES2299059T3 (https=)
IL (1) IL179751A (https=)
WO (1) WO2006003520A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110118135A1 (en) * 2008-01-09 2011-05-19 State Matthew W Mutations in Contaction Associated Protein 2 (CNTNAP2) are Associated with Increased Risk for Ideopathic Autism
WO2009150221A1 (en) * 2008-06-12 2009-12-17 Integragen A method for autism prediction
EP2963129A3 (en) * 2008-11-12 2016-05-11 University of Utah Research Foundation Autism associated genetic markers
WO2011067296A1 (en) 2009-12-01 2011-06-09 Integragen A combination of eight risk alleles associated with autism
KR101167942B1 (ko) 2010-02-12 2012-07-23 차의과학대학교 산학협력단 Ａｌｇ12 유전자로부터 유래된 단일염기다형을 포함하는 폴리뉴클레오티드, 이를 포함하는 마이크로어레이 및 진단키트, 및 이를 이용한 자폐 스펙트럼 장애 분석방법
CA2797319A1 (en) 2010-05-04 2011-11-10 Integragen A new combination of eight risk alleles associated with autism
EP2860265B1 (en) 2011-02-24 2016-10-26 The Chinese University of Hong Kong Determining fetal DNA percentage for twins
CN111808943B (zh) * 2020-06-18 2021-07-20 重庆浦洛通基因医学研究院有限公司 一种精神类个体化用药基因检测方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHASTRY B S: "Molecular genetics of autism disorders" Journal of Human genetics, vol. 48, no. 10, 2003, pages 495-501. *

Also Published As

Publication number Publication date
DE602005004026T2 (de) 2008-12-24
EP1761649A2 (en) 2007-03-14
ES2299059T3 (es) 2008-05-16
EP1761649B1 (en) 2007-12-26
WO2006003520A2 (en) 2006-01-12
CA2571365A1 (en) 2006-01-12
IL179751A0 (en) 2007-05-15
US20070218068A1 (en) 2007-09-20
JP4949240B2 (ja) 2012-06-06
WO2006003520A3 (en) 2006-03-02
JP2008504837A (ja) 2008-02-21
DE602005004026D1 (de) 2008-02-07
IL179751A (en) 2011-01-31
ATE382101T1 (de) 2008-01-15
AU2005258838A1 (en) 2006-01-12

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired