JP2008504551A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008504551A5 JP2008504551A5 JP2007518700A JP2007518700A JP2008504551A5 JP 2008504551 A5 JP2008504551 A5 JP 2008504551A5 JP 2007518700 A JP2007518700 A JP 2007518700A JP 2007518700 A JP2007518700 A JP 2007518700A JP 2008504551 A5 JP2008504551 A5 JP 2008504551A5
- Authority
- JP
- Japan
- Prior art keywords
- gsk
- level
- disease
- alzheimer
- inactive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 claims 13
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 claims 13
- 208000024827 Alzheimer disease Diseases 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Claims (10)
- 被検者から採取された血液サンプルにおけるＧＳＫ−３のレベルを測定することを含む、アルツハイマー病を予測又は診断する方法。
- ＧＳＫ−３アイソタイプの総量が測定され、対照と比較されることを特徴とする、請求項１に記載の方法。
- 活性型ＧＳＫ−３及び不活性型ＧＳＫ−３の両方のレベルが測定され、不活性型ＧＳＫ−３のレベルに対する活性型ＧＳＫ−３のレベルの増加がアルツハイマー病を示す、請求項１に記載の方法。
- 不活性型ＧＳＫ−３のレベルが変化しないときの活性型ＧＳＫ−３のレベルの増加がアルツハイマー病を示す、請求項３に記載の方法。
- ＧＳＫ−３タンパク質又はＧＳＫ−３活性の２０％の増大を検出することにより、アルツハイマー病が陽性と判定される、請求項１〜４のいずれか一項に記載の方法。
- 被検者が軽度の認識機能障害であると診断されていることを特徴とする、請求項１〜５のいずれか一項に記載の方法。
- 検査されるサンプルが血清、血漿、白血球又はリンパ球である、請求項１〜６のいずれか一項に記載の方法。
- アルツハイマー病の予測又は診断用の検査において使用するためのキットであって、
活性型ＧＳＫ−３に対する抗体と不活性型ＧＳＫ−３に対する抗体とを含むことを特徴とする、キット。 - 活性型ＧＳＫ−３に対する抗体が抗ＧＳＫ−３ α／β Ｔｙｒ２１６／２１９である、請求項８に記載のキット。
- 不活性型ＧＳＫ−３に対する抗体が抗ＧＳＫ−３ α／β Ｓｅｒ２１／９である、請求項８又は９に記載のキット。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0414894.6A GB0414894D0 (en) | 2004-07-02 | 2004-07-02 | Biomarkers of alzheimer's disease |
| PCT/GB2005/002592 WO2006003414A2 (en) | 2004-07-02 | 2005-07-01 | Biomarkers of alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008504551A JP2008504551A (ja) | 2008-02-14 |
| JP2008504551A5 true JP2008504551A5 (ja) | 2008-08-21 |
Family
ID=32843494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007518700A Withdrawn JP2008504551A (ja) | 2004-07-02 | 2005-07-01 | アルツハイマー病のバイオマーカー |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080076140A1 (ja) |
| EP (1) | EP1763674A2 (ja) |
| JP (1) | JP2008504551A (ja) |
| CN (1) | CN101010589A (ja) |
| AU (1) | AU2005258926A1 (ja) |
| BR (1) | BRPI0512948A (ja) |
| CA (1) | CA2571692A1 (ja) |
| GB (1) | GB0414894D0 (ja) |
| WO (1) | WO2006003414A2 (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2029503B1 (en) | 2006-05-25 | 2013-01-02 | GE Healthcare Limited | 11c-labeled inhibitors of glycogen synthase kinase-3 |
| WO2009074331A2 (en) * | 2007-12-11 | 2009-06-18 | Julius-Maximilians-Universität Würzburg | Early and differential diagnosis test for alzheimer's disease |
| EP2279420B1 (en) | 2008-03-21 | 2014-01-29 | Manuela G. Neuman | METHODS FOR THE DIFFERENTIAL DIAGNOSIS OF ALZHEIMER'S DISEASE VERSUS FRONTOTEMPORAL DEMENTIA, COMPRISING FAS-L, TNF-alpha AND ccCK-18 AS BIOMARKERS |
| US20100151457A1 (en) * | 2008-12-17 | 2010-06-17 | National Tsing Hua University | Detection of Unhealthy Cell and Uses Thereof |
| US20120040361A1 (en) * | 2010-07-22 | 2012-02-16 | National Tsing Hua University | Methods and compositions for detection of lethal system and uses thereof |
| CN104237526B (zh) * | 2013-06-18 | 2016-08-17 | 磁量生技股份有限公司 | 一种检测阿兹海默症罹患风险的系统 |
| US20170102398A1 (en) * | 2014-03-05 | 2017-04-13 | Humanetics Corporation | Predicting and reducing cognitive decline based on gsk-3 levels |
| CN104698188A (zh) * | 2015-03-04 | 2015-06-10 | 华中科技大学 | 检测人血小板GSK-3β蛋白活性的斑点印迹方法 |
| CN111323597A (zh) * | 2018-12-14 | 2020-06-23 | 陈志成 | 用于检测受试者中mci和/或ad的方法、试剂盒及筛选化合物的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2569083A1 (en) * | 2004-05-07 | 2005-11-17 | Garvan Institute Of Medical Research | Detecting disease association with aberrant glycogen synthase kinase 3.beta. expression |
-
2004
- 2004-07-02 GB GBGB0414894.6A patent/GB0414894D0/en not_active Ceased
-
2005
- 2005-07-01 BR BRPI0512948-6A patent/BRPI0512948A/pt not_active Application Discontinuation
- 2005-07-01 EP EP05756942A patent/EP1763674A2/en not_active Withdrawn
- 2005-07-01 JP JP2007518700A patent/JP2008504551A/ja not_active Withdrawn
- 2005-07-01 AU AU2005258926A patent/AU2005258926A1/en not_active Abandoned
- 2005-07-01 WO PCT/GB2005/002592 patent/WO2006003414A2/en active Application Filing
- 2005-07-01 CA CA002571692A patent/CA2571692A1/en not_active Abandoned
- 2005-07-01 US US11/630,769 patent/US20080076140A1/en not_active Abandoned
- 2005-07-01 CN CNA2005800225150A patent/CN101010589A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008504551A5 (ja) | ||
| Dharnidharka et al. | Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis | |
| Dong et al. | Sputum and salivary protein biomarkers and point-of-care biosensors for the management of COPD | |
| JP2009501333A5 (ja) | ||
| Däbritz et al. | Improving relapse prediction in inflammatory bowel disease by neutrophil-derived S100A12 | |
| Palone et al. | Fecal HMGB1 reveals microscopic inflammation in adult and pediatric patients with inflammatory bowel disease in clinical and endoscopic remission | |
| WO2009132058A3 (en) | Levels of bcma protein expression on b cells and use in diagnostic methods | |
| Harrison et al. | Screening tests of platelet function: update on their appropriate uses for diagnostic testing | |
| WO2006026020A3 (en) | Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin | |
| NO20083820L (no) | Deteksjon av kreft ved forhoyede nivaer av BCL-2 | |
| JP2012509477A5 (ja) | ||
| Kumaresan et al. | A comparison of serum cystatin C and creatinine with glomerular filtration rate in Indian patients with chronic kidney disease | |
| JP2008537474A5 (ja) | ||
| RU2008103988A (ru) | Способ диагностики рассеяного склероза | |
| WO2009001545A1 (ja) | 移植片対宿主疾患の検査および治療方法 | |
| JP2008538812A5 (ja) | ||
| Tian et al. | Serum levels of procalcitonin as a biomarker for differentiating between sepsis and systemic inflammatory response syndrome in the neurological intensive care unit | |
| JP2013504766A5 (ja) | ||
| JP2018536170A5 (ja) | ||
| WO2005118403A3 (en) | Methods for detecting gene expression in peripheral blood cells and uses thereof | |
| Finn et al. | Urinary biomarkers and nephrotoxicity | |
| JP2011523037A5 (ja) | ||
| JP2012533066A5 (ja) | ||
| CN107589260A (zh) | 尿液中mmp-7作为肾脏纤维化和慢性肾脏病的生物标志物的用途 | |
| CN204359796U (zh) | 一种检测ecp和mpo的试纸条 |