JP2008504335A - Hmgb1に関連する病変の治療のための核酸 - Google Patents

Hmgb1に関連する病変の治療のための核酸 Download PDF

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JP2008504335A
JP2008504335A JP2007518555A JP2007518555A JP2008504335A JP 2008504335 A JP2008504335 A JP 2008504335A JP 2007518555 A JP2007518555 A JP 2007518555A JP 2007518555 A JP2007518555 A JP 2007518555A JP 2008504335 A JP2008504335 A JP 2008504335A
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nucleic acid
hmgb1
molecule
double
use according
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JP2008504335A5 (enExample
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ドメニコ・ジ・バロン
マルコ・エ・ビアンキ
エンリコ・エンメ・ブッチ
シルヴァノ・フメロ
マルゲリータ・ヴァレンテ
ロベルト・サピオ
ドメニカ・ムスメチ
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クレアビリス・セラピューティクス・エスピーエー
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    • AHUMAN NECESSITIES
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/318Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181Peptide nucleic acid, PNA
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/52Physical structure branched

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  • General Engineering & Computer Science (AREA)
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  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2007518555A 2004-07-02 2005-07-04 Hmgb1に関連する病変の治療のための核酸 Pending JP2008504335A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58467804P 2004-07-02 2004-07-02
US64658605P 2005-01-26 2005-01-26
PCT/EP2005/007198 WO2006002971A2 (en) 2004-07-02 2005-07-04 Nucleic acids for the treatment of hmgb1-related pathologies

Publications (2)

Publication Number Publication Date
JP2008504335A true JP2008504335A (ja) 2008-02-14
JP2008504335A5 JP2008504335A5 (enExample) 2008-08-21

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JP2007518555A Pending JP2008504335A (ja) 2004-07-02 2005-07-04 Hmgb1に関連する病変の治療のための核酸

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US (1) US20080305073A1 (enExample)
EP (1) EP1768677B1 (enExample)
JP (1) JP2008504335A (enExample)
AT (1) ATE399014T1 (enExample)
AU (1) AU2005259381A1 (enExample)
BR (1) BRPI0512944A (enExample)
CA (1) CA2572519A1 (enExample)
DE (1) DE602005007746D1 (enExample)
DK (1) DK1768677T3 (enExample)
ES (1) ES2306195T3 (enExample)
IL (1) IL179828A0 (enExample)
PL (1) PL1768677T3 (enExample)
PT (1) PT1768677E (enExample)
WO (1) WO2006002971A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012036215A1 (ja) 2010-09-17 2012-03-22 Taniguchi Tadatsugu Hmgbタンパクによって仲介される免疫応答の活性化の抑制剤及びスクリーニング方法
JP2012532310A (ja) * 2009-07-03 2012-12-13 ザ・ユニヴァーシティ・オヴ・リヴァプール 器官または組織の損傷を検出する方法
JP2016141678A (ja) * 2015-02-05 2016-08-08 国立大学法人広島大学 ヒトhmgb1結合剤、ヒトhmgb1除去装置および新規ポリペプチド

Families Citing this family (26)

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GEP20105110B (en) 2004-08-03 2010-11-10 Transtech Pharma Inc Rage fusion proteins and their use
US20100172909A1 (en) * 2005-10-24 2010-07-08 Masahiro Nishibori Cerebral edema suppressant
EP1989227A2 (en) * 2006-02-09 2008-11-12 Transtech Pharma, Inc. Rage fusion proteins and methods of use
JP3882090B1 (ja) * 2006-05-19 2007-02-14 国立大学法人 岡山大学 脳血管攣縮抑制剤
KR20090087483A (ko) * 2006-11-17 2009-08-17 클리니컬 진 네트웍스 아베 유전자 gypc, agpat3, agl, pvrl2, hmgb3, hsdl2 및/또는 ldb2를 포함하는 스크리닝 및 치료방법
CN101589309A (zh) * 2006-11-17 2009-11-25 临床基因网络公司 涉及基因gypc、agpat3、agl、pvrl2、hmgb3、hsdl2和/或ldb2的筛选和治疗方法
US8927510B2 (en) 2008-05-16 2015-01-06 Children's Medical Center Corporation Compositions and methods for inhibition of retroviruses
WO2009149921A2 (en) * 2008-06-11 2009-12-17 Bionucleon S.R.L. Inhibition of hrp-3 using modified oligonucleotides
PT2329266E (pt) 2008-09-11 2016-06-07 Pasteur Institut Monitorização e inibição da infecção pelo vírus da imunodeficiência humana mediante modulação do desencadeamento dependente de hmgb1 da replicação e persistência do vih-1
US20120165244A1 (en) * 2008-10-30 2012-06-28 Hua-Lin Wu Methods for binding lewis y antigen
NZ593438A (en) 2008-12-22 2012-12-21 Creabilis S A Synthesis of polymer conjugates of indolocarbazole compounds
AU2010240569A1 (en) 2009-04-20 2011-10-20 Pfizer Inc. Control of protein glycosylation and compositions and methods relating thereto
JP5467313B2 (ja) * 2009-09-28 2014-04-09 国立大学法人 岡山大学 アテローム動脈硬化抑制剤
US8975019B2 (en) * 2009-10-19 2015-03-10 University Of Massachusetts Deducing exon connectivity by RNA-templated DNA ligation/sequencing
US20140378531A1 (en) * 2012-02-01 2014-12-25 New York University Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors
WO2018175340A1 (en) 2017-03-20 2018-09-27 Sienna Biopharmaceuticals, Inc. Reduced exposure conjugates modulating therapeutic targets
WO2018175315A1 (en) 2017-03-20 2018-09-27 Sienna Biopharmaceuticals, Inc. Polymer conjugates of staurosporine derivatives having reduced exposure
WO2018175302A1 (en) 2017-03-20 2018-09-27 Sienna Biopharmaceuticals, Inc. Polymer conjugates targeting c-src with reduced exposure
WO2018175301A1 (en) 2017-03-20 2018-09-27 Sienna Biopharmaceuticals, Inc. Polymer conjugate of montesanib with reduced exposure
WO2018208369A1 (en) 2017-05-10 2018-11-15 Sienna Biopharmaceuticals, Inc. Uses of polymer conjugates of indolocarbazole compounds with reduced exposure
CN111304202B (zh) * 2020-02-26 2023-03-28 西安交通大学 一种用于识别且增强hmgb1生物学活性的核酸适配子及其应用
CN114957440A (zh) * 2022-05-26 2022-08-30 江苏大学 一种重组HMGB1 A Box蛋白及其获取方法与应用
CN119630405A (zh) * 2022-06-23 2025-03-14 J·大卫格莱斯顿研究所-根据J·大卫格莱斯顿遗嘱的遗嘱信托 用于治疗包括阿尔茨海默病的APOE4相关Tau蛋白病的HMGB1抑制剂
CN114807150B (zh) * 2022-06-28 2022-10-14 中国科学院基础医学与肿瘤研究所(筹) 靶向和拮抗hmgb1分子的核酸适体
CA3262218A1 (en) 2022-07-19 2024-01-25 Rampart Bioscience, Inc. CIRCULAR NON-IMMUNOGENEOUS NON-VIRAL DNA VECTORS
CN115774004B (zh) * 2022-08-19 2024-07-05 四川大学华西医院 二氧化锆@量子点复合微球在制备检测hmgb1的荧光探针中的用途

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WO2002074337A1 (en) * 2001-03-16 2002-09-26 Bio3 Research S.R.L. Hmgb1 protein inhibitors and/or antagonists for the treatment of vascular diseases

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AU5442194A (en) * 1992-10-14 1994-05-09 University Research Corporation Method for selecting nucleic acids on the basis of structure
JP2006510619A (ja) * 2002-11-20 2006-03-30 クリティカル セラピューティクス,インコーポレイテッド 抗炎症剤としてのhmgb断片の使用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074337A1 (en) * 2001-03-16 2002-09-26 Bio3 Research S.R.L. Hmgb1 protein inhibitors and/or antagonists for the treatment of vascular diseases

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012532310A (ja) * 2009-07-03 2012-12-13 ザ・ユニヴァーシティ・オヴ・リヴァプール 器官または組織の損傷を検出する方法
WO2012036215A1 (ja) 2010-09-17 2012-03-22 Taniguchi Tadatsugu Hmgbタンパクによって仲介される免疫応答の活性化の抑制剤及びスクリーニング方法
US9186371B2 (en) 2010-09-17 2015-11-17 Japan Science And Technology Agency Inhibitor of HMGB protein-mediated immune response activation, and screening method
JP2016141678A (ja) * 2015-02-05 2016-08-08 国立大学法人広島大学 ヒトhmgb1結合剤、ヒトhmgb1除去装置および新規ポリペプチド

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Publication number Publication date
WO2006002971A3 (en) 2006-04-20
IL179828A0 (en) 2008-03-20
ATE399014T1 (de) 2008-07-15
PT1768677E (pt) 2008-10-06
ES2306195T3 (es) 2008-11-01
EP1768677A2 (en) 2007-04-04
BRPI0512944A (pt) 2008-04-15
CA2572519A1 (en) 2006-01-12
EP1768677B1 (en) 2008-06-25
DK1768677T3 (da) 2008-10-20
DE602005007746D1 (de) 2008-08-07
AU2005259381A1 (en) 2006-01-12
PL1768677T3 (pl) 2009-01-30
WO2006002971A2 (en) 2006-01-12
US20080305073A1 (en) 2008-12-11

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