JP2008500556A - 低流量動作を可能にするためのhplc定流量ポンプの閉ループ流量制御 - Google Patents
低流量動作を可能にするためのhplc定流量ポンプの閉ループ流量制御 Download PDFInfo
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Abstract
Description
Claims (19)
- 第1のポンプであって、第1のポンプからの液体の第1の部分を第1の熱ベースの流量センサに搬送する第1の流路に流体連通しており、前記第1の熱ベースの流量センサが流体T字部に流体連通しており、前記第1の熱ベースの流量センサが動作可能に前記第1の流路に配設され、第1の信号を生成するように構成されている、第1のポンプと、
第2のポンプであって、第2のポンプからの液体の第2の部分を第2の熱ベースの流量センサに搬送する第2の流路に流体連通しており、前記第2の熱ベースの流量センサが前記流体T字部に流体連通しており、前記第2の熱ベースの流量センサが動作可能に前記第2の流路に配設され、第2の信号を生成するように構成されている、第2のポンプと、
前記第1および第2の信号で各流路内の流速を制御するための手段とを備える、
細管システムにおいて液体を送出するための装置。 - 第1のポンプが第1の流量源を備え、第2のポンプが第2の流量源を備える、請求項1に記載の装置。
- 第1の流量源がピストンを備える、請求項2に記載の装置。
- 第1の流量源が、ピストンの速度およびピストンの表面積に応じて特定の流速を提供するように構成されている、請求項3に記載の装置。
- 第1のポンプであって、前記第1のポンプからの液体の第1の部分を第1のセンサへ搬送する第1の流路に流体連通しており、前記第1のセンサが流体T字部に流体連通しており、前記第1のセンサが動作可能に前記第1の流路に配設され、第1の信号を生成するように構成されている、第1のポンプと、
前記第1の流路に動作可能に配設されている第1の流量制限要素と、
第2のポンプであって、前記第2のポンプからの液体の第2の部分を第2のセンサへ搬送する第2の流路に流体連通しており、前記第2のセンサが前記流体T字部に流体連通しており、前記第2のセンサが動作可能に前記第2の流路に配設され、第2の信号を生成するように構成されている、第2のポンプと、
前記第2の流路に動作可能に配設されている第2の流量制限要素と、
前記流体T字部と流体連結している第3のセンサと、
第1の流速を生み出す、前記第1のセンサと前記第3のセンサの間の圧力降下を測定するための減算器手段と、
第2の流速を生み出す、前記第2のセンサと前記第3のセンサの間の圧力降下を測定するための減算器手段であって、前記第1の流速および前記第2の流速が前記第1のポンプおよび第2のポンプそれぞれによって送出される流量に比例する減算器手段と、
前記第1および第2の信号で各流路内の流速を制御するための手段とを備える、
細管システムにおいて液体の流速を測定するための装置。 - 前記細管システムが、ほぼ1nL/minからほぼ100μL/minの範囲の流れ流速を有する高速液体クロマトグラフィ(HPLC)システムを備える、請求項1または5に記載の装置。
- 前記流量センサが圧力タイプの流量センサを備える、請求項5に記載の装置。
- 前記流量センサが熱ベースの流量センサを備える、請求項5に記載の装置。
- 前記減算器手段が電子減算回路を備える、請求項5に記載の装置。
- 流量を制御するための前記手段が前記減速器手段に反応する、請求項5に記載の装置。
- 制御するための手段が、前記減算器手段より差信号を受け、前記差信号に応じて前記流路における液体流速を調整するように構成されているコントローラを備える、請求項5に記載の装置。
- 前記センサおよび前記制限要素がさらに恒温ブロック内に収容されている、請求項5に記載の装置。
- 第1の流路において第1のHPLCポンプと第1のセンサの間の第1の圧力を測定するステップと、
第2の流路において第2のHPLCポンプと第2のセンサの間の第2の圧力を測定するステップと、
前記第1の圧力および前記第2の圧力を含む流体交差部において第3の圧力を測定するステップと、
前記第1の圧力と前記第3の圧力の間の第1の圧力降下を計算するステップと、
前記第2の圧力と前記第3の圧力の間の第2の圧力降下を計算するステップと、
前記第1の圧力降下と第2の圧力降下の間の差を決定することによって第1および第2のHPLCポンプのポンプ流速を調整するステップとを備える、
高速液体クロマトグラフィ(HPLC)システムにおいて液体のナノ規模の流速を測定するための方法。 - 前記調整のステップが、前記HPLCポンプの出力流速を変更することによって前記流路における液体流量を調整するステップを含む、請求項13に記載の方法。
- 前記細管システムが、ほぼ50nL/minからほぼ100μL/minの範囲の流路流速を有する高速液体クロマトグラフィ(HPLC)システムを備える、請求項13に記載の方法。
- 前記測定結果が、デルタPタイプの圧力トランスデューサによるものである、請求項13に記載の方法。
- 第1の流路において第1のHPLC流量源ポンプと第1の熱ベースのセンサの間の第1の流速を測定して第1の流量信号を生成するステップと、
第2の流路において第2のHPLC流量源ポンプと第2の熱ベースのセンサの間の第2の流速を測定し第2の流速信号を生成するステップと、
第1および第2の流速信号の少なくとも1つに応じて第1および第2のHPLC流量源ポンプの少なくとも1つのポンプ出力を調整するステップとを備える、
高速液体クロマトグラフィ(HPLC)システムにおいて液体のナノ規模の流速を送出するための方法。 - 前記調整のステップが、前記HPLCポンプの出力流速を変更することによって前記流路において液体流量を調整するステップを含む、請求項17に記載の方法。
- 前記細管システムが、ほぼ50nL/minからほぼ100μL/minの範囲の流路流速を有する高速液体クロマトグラフィ(HPLC)システムを備える、請求項17に記載の方法。
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US57352804P | 2004-05-21 | 2004-05-21 | |
US60/573,528 | 2004-05-21 | ||
PCT/US2005/017923 WO2005113457A2 (en) | 2004-05-21 | 2005-05-20 | Closed loop flow control of a hplc constant flow pump to enable low-flow operation |
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JP2020527456A (ja) * | 2017-07-21 | 2020-09-10 | カーライル フルイド テクノロジーズ,インコーポレイティド | 衝突混合の制御を改善するためのシステム及び方法 |
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US20100116745A1 (en) | 2010-05-13 |
GB2429785B (en) | 2009-11-18 |
GB2429785A (en) | 2007-03-07 |
GB0624464D0 (en) | 2007-01-24 |
US7674375B2 (en) | 2010-03-09 |
US8679333B2 (en) | 2014-03-25 |
DE112005001172T5 (de) | 2008-07-17 |
US20140131277A1 (en) | 2014-05-15 |
WO2005113457A2 (en) | 2005-12-01 |
US20080245136A1 (en) | 2008-10-09 |
JP4959565B2 (ja) | 2012-06-27 |
GB0624707D0 (en) | 2007-01-17 |
US9393504B2 (en) | 2016-07-19 |
WO2005113457A3 (en) | 2005-12-29 |
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