JP2008500391A5 - - Google Patents
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- JP2008500391A5 JP2008500391A5 JP2007527494A JP2007527494A JP2008500391A5 JP 2008500391 A5 JP2008500391 A5 JP 2008500391A5 JP 2007527494 A JP2007527494 A JP 2007527494A JP 2007527494 A JP2007527494 A JP 2007527494A JP 2008500391 A5 JP2008500391 A5 JP 2008500391A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- moiety
- branched
- unbranched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *[C@]([C@](*)(C(*)(*)[C@]([C@](*)(C(*)(CCCC1)C1(*)C1=O)I)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound *[C@]([C@](*)(C(*)(*)[C@]([C@](*)(C(*)(CCCC1)C1(*)C1=O)I)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O 0.000 description 62
- CVQUWLDCFXOXEN-UHFFFAOYSA-N O=C1C=COC=C1 Chemical compound O=C1C=COC=C1 CVQUWLDCFXOXEN-UHFFFAOYSA-N 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 5
- GCNTZFIIOFTKIY-UHFFFAOYSA-N Oc1ccncc1 Chemical compound Oc1ccncc1 GCNTZFIIOFTKIY-UHFFFAOYSA-N 0.000 description 4
- FVDHISZJWKGJBG-UHFFFAOYSA-N C1=CN=[I]C=N1 Chemical compound C1=CN=[I]C=N1 FVDHISZJWKGJBG-UHFFFAOYSA-N 0.000 description 3
- GSQFIZQPEKLFBK-UHFFFAOYSA-N NC(C(C(C(C(CC1Cc2cccc(O)c22)C3)C(O)=C1C2=O)=O)=C3O)=O Chemical compound NC(C(C(C(C(CC1Cc2cccc(O)c22)C3)C(O)=C1C2=O)=O)=C3O)=O GSQFIZQPEKLFBK-UHFFFAOYSA-N 0.000 description 2
- ZXFCRFYULUUSDW-OWXODZSWSA-N NC(C(C([C@]([C@@H](C[C@@H]1Cc2cccc(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O Chemical compound NC(C(C([C@]([C@@H](C[C@@H]1Cc2cccc(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O ZXFCRFYULUUSDW-OWXODZSWSA-N 0.000 description 2
- CADMLLAWKHABIJ-UXSWERMXSA-N N[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O Chemical compound N[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O CADMLLAWKHABIJ-UXSWERMXSA-N 0.000 description 2
- UBQKCCHYAOITMY-UHFFFAOYSA-N O=C1NC=CC=C1 Chemical compound O=C1NC=CC=C1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 2
- QGEQTBNMGHWHBJ-UHFFFAOYSA-N O=C1NCC=CC=C1 Chemical compound O=C1NCC=CC=C1 QGEQTBNMGHWHBJ-UHFFFAOYSA-N 0.000 description 2
- QTJMEGVCSPTQDY-HZDAAVBUSA-N C/C=C/S/C=C\N Chemical compound C/C=C/S/C=C\N QTJMEGVCSPTQDY-HZDAAVBUSA-N 0.000 description 1
- ZWVVGYSAWRURPJ-DNVGVPOPSA-N C=C/C=C\C=C(/N)\O Chemical compound C=C/C=C\C=C(/N)\O ZWVVGYSAWRURPJ-DNVGVPOPSA-N 0.000 description 1
- HLPIHRDZBHXTFJ-UHFFFAOYSA-N CCc1ccc[o]1 Chemical compound CCc1ccc[o]1 HLPIHRDZBHXTFJ-UHFFFAOYSA-N 0.000 description 1
- LNPCVMAMMOWWNA-JCWFFFCVSA-N CN(C)[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O Chemical compound CN(C)[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O LNPCVMAMMOWWNA-JCWFFFCVSA-N 0.000 description 1
- AGICWGYTRZOXTK-RISOHXOYSA-N CN(C)[C@@H]([C@H](CC=CC1=O)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O Chemical compound CN(C)[C@@H]([C@H](CC=CC1=O)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O AGICWGYTRZOXTK-RISOHXOYSA-N 0.000 description 1
- VAJQQYNAZZDPSF-ILBVQXBRSA-N CN(C)[C@@H]([C@H](C[C@@H](C1=C2O)Nc3cccc(O)c3C1=O)[C@]21O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@@H](C1=C2O)Nc3cccc(O)c3C1=O)[C@]21O)C(O)=C(C(N)=O)C1=O VAJQQYNAZZDPSF-ILBVQXBRSA-N 0.000 description 1
- PNEIPZRZIYUCAJ-PHQPAESFSA-N CN(C)[C@@H]([C@H](C[C@H](Cc(cc(cc1O)N(C)C)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H](Cc(cc(cc1O)N(C)C)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O PNEIPZRZIYUCAJ-PHQPAESFSA-N 0.000 description 1
- YLDDJDHRUCEIPV-WZDYVRJHSA-N CN(C)[C@@H]([C@H](C[C@H](Cc1cc(cccc2)c2c(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(Nc(cc2)cc3c2cc(C[C@@H]([C@@H]([C@@H]([C@@H](C(O)=C(C(N)=O)C2=O)N(C)C)[C@@]22O)O)C(C4=O)=C2O)c4c3O)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H](Cc1cc(cccc2)c2c(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(Nc(cc2)cc3c2cc(C[C@@H]([C@@H]([C@@H]([C@@H](C(O)=C(C(N)=O)C2=O)N(C)C)[C@@]22O)O)C(C4=O)=C2O)c4c3O)=O)C1=O YLDDJDHRUCEIPV-WZDYVRJHSA-N 0.000 description 1
- UGDVSQPADGAASW-YLJJCILVSA-N CN(C)[C@@H]([C@H](C[C@H]([C@@H](C=C)c1cccc(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H]([C@@H](C=C)c1cccc(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O UGDVSQPADGAASW-YLJJCILVSA-N 0.000 description 1
- HMNIESCBNPRAGK-KREUMBAPSA-N CN(C)[C@@H]([C@H](C[C@H]([C@@H](Cc1ccccc1)c(cccc1O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H]([C@@H](Cc1ccccc1)c(cccc1O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O HMNIESCBNPRAGK-KREUMBAPSA-N 0.000 description 1
- VPSYZTXEIWRROQ-IZULZFRASA-N CN(C)[C@@H]([C@H](C[C@H]([C@H](c1cccc(O)c1C1=O)N)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H]([C@H](c1cccc(O)c1C1=O)N)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O VPSYZTXEIWRROQ-IZULZFRASA-N 0.000 description 1
- HXEHTAQRKPBRKA-PYCKEEFSSA-N CN(C)[C@@H]([C@H]([C@H]([C@@H](C1=C2O)Nc3cccc(O)c3C1=O)O)[C@]21O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H]([C@H]([C@@H](C1=C2O)Nc3cccc(O)c3C1=O)O)[C@]21O)C(O)=C(C(N)=O)C1=O HXEHTAQRKPBRKA-PYCKEEFSSA-N 0.000 description 1
- HFANKLFGBAEFCU-LNRRCFIDSA-N CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(c(N(C)C)ccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(c(N(C)C)ccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O HFANKLFGBAEFCU-LNRRCFIDSA-N 0.000 description 1
- WTEHJBKCQZLJQY-KHKNGSCWSA-N CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(cccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(cccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O WTEHJBKCQZLJQY-KHKNGSCWSA-N 0.000 description 1
- AMAIXBQOAQTXQV-WNBBPZJKSA-N C[C@@](C1)([C@@]1(C[C@@H]([C@@H](C(O)=C(C(N)=O)C1=O)N(C)C)[C@@]11O)C2=C1O)c1cccc(O)c1C2=O Chemical compound C[C@@](C1)([C@@]1(C[C@@H]([C@@H](C(O)=C(C(N)=O)C1=O)N(C)C)[C@@]11O)C2=C1O)c1cccc(O)c1C2=O AMAIXBQOAQTXQV-WNBBPZJKSA-N 0.000 description 1
- KWMSNSRQDXXQIO-REDYYMJGSA-N N/C(/O)=C\C=C/C=[IH] Chemical compound N/C(/O)=C\C=C/C=[IH] KWMSNSRQDXXQIO-REDYYMJGSA-N 0.000 description 1
- BVUCSUXMIMMGLO-UHFFFAOYSA-N NC(C(C(C(C(CC1Cc2c3[nH]cc2)C2)C(O)=C1C3=O)=O)=C2O)=O Chemical compound NC(C(C(C(C(CC1Cc2c3[nH]cc2)C2)C(O)=C1C3=O)=O)=C2O)=O BVUCSUXMIMMGLO-UHFFFAOYSA-N 0.000 description 1
- BYSOXTSLPHTBAL-UHFFFAOYSA-N NC(C(C(C(C(CC1Cc2c3[nH]cn2)C2)C(O)=C1C3=O)=O)=C2O)=O Chemical compound NC(C(C(C(C(CC1Cc2c3[nH]cn2)C2)C(O)=C1C3=O)=O)=C2O)=O BYSOXTSLPHTBAL-UHFFFAOYSA-N 0.000 description 1
- QMXZMGVLLYUITI-GANBNBROSA-N NC(C(C([C@]([C@@H](C[C@@H]1Cc2c3c(O)c4ncccc4c2)C2)(C(O)=C1C3=O)O)=O)=C2O)=O Chemical compound NC(C(C([C@]([C@@H](C[C@@H]1Cc2c3c(O)c4ncccc4c2)C2)(C(O)=C1C3=O)O)=O)=C2O)=O QMXZMGVLLYUITI-GANBNBROSA-N 0.000 description 1
- FSFVYRPQKBDXJN-LYSPQLLHSA-N NC(C(C([C@]([C@@H](C[C@@H]1Cc2cc3cccc(O)c3c(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O Chemical compound NC(C(C([C@]([C@@H](C[C@@H]1Cc2cc3cccc(O)c3c(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O FSFVYRPQKBDXJN-LYSPQLLHSA-N 0.000 description 1
- ZPSJGADGUYYRKE-UHFFFAOYSA-N O=C1OC=CC=C1 Chemical compound O=C1OC=CC=C1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 description 1
- IOJUPLGTWVMSFF-UHFFFAOYSA-N c1nc(cccc2)c2[s]1 Chemical compound c1nc(cccc2)c2[s]1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57362304P | 2004-05-21 | 2004-05-21 | |
| US60/573,623 | 2004-05-21 | ||
| US66094705P | 2005-03-11 | 2005-03-11 | |
| US60/660,947 | 2005-03-11 | ||
| PCT/US2005/017831 WO2005112945A2 (en) | 2004-05-21 | 2005-05-20 | Synthesis of tetracyclines and analogues thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011119770A Division JP5971900B2 (ja) | 2004-05-21 | 2011-05-27 | テトラサイクリンおよびそれらの類似物の合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008500391A JP2008500391A (ja) | 2008-01-10 |
| JP2008500391A5 true JP2008500391A5 (https=) | 2008-07-10 |
| JP5242161B2 JP5242161B2 (ja) | 2013-07-24 |
Family
ID=35428840
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527494A Expired - Lifetime JP5242161B2 (ja) | 2004-05-21 | 2005-05-20 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2011119770A Expired - Lifetime JP5971900B2 (ja) | 2004-05-21 | 2011-05-27 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2013164980A Withdrawn JP2013227346A (ja) | 2004-05-21 | 2013-08-08 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2015168496A Expired - Lifetime JP6185966B2 (ja) | 2004-05-21 | 2015-08-28 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2016243003A Pending JP2017052797A (ja) | 2004-05-21 | 2016-12-15 | テトラサイクリンおよびそれらの類似物の合成 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011119770A Expired - Lifetime JP5971900B2 (ja) | 2004-05-21 | 2011-05-27 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2013164980A Withdrawn JP2013227346A (ja) | 2004-05-21 | 2013-08-08 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2015168496A Expired - Lifetime JP6185966B2 (ja) | 2004-05-21 | 2015-08-28 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2016243003A Pending JP2017052797A (ja) | 2004-05-21 | 2016-12-15 | テトラサイクリンおよびそれらの類似物の合成 |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US7807842B2 (https=) |
| EP (2) | EP1753713B1 (https=) |
| JP (5) | JP5242161B2 (https=) |
| KR (2) | KR101171408B1 (https=) |
| CN (3) | CN103214409B (https=) |
| AU (1) | AU2005244988C1 (https=) |
| BR (2) | BRPI0510113B1 (https=) |
| CA (3) | CA2892332C (https=) |
| CY (1) | CY1118519T1 (https=) |
| DK (1) | DK1753713T3 (https=) |
| ES (1) | ES2607453T3 (https=) |
| HU (1) | HUE030212T2 (https=) |
| IL (5) | IL179467A (https=) |
| LT (1) | LT1753713T (https=) |
| PL (1) | PL1753713T3 (https=) |
| PT (1) | PT1753713T (https=) |
| SG (1) | SG10201810312UA (https=) |
| SI (1) | SI1753713T1 (https=) |
| WO (1) | WO2005112945A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| WO2002072031A2 (en) | 2001-03-14 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| AU2002365120A1 (en) | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
| JP2005526754A (ja) * | 2002-03-08 | 2005-09-08 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノメチル置換されたテトラサイクリン化合物 |
| CA2492273C (en) * | 2002-07-12 | 2013-02-05 | Paratek Pharmaceuticals, Inc. | 3, 10, and 12a substituted tetracycline compounds |
| CA2531728A1 (en) | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| CA2892332C (en) * | 2004-05-21 | 2017-03-21 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| AU2005299294B2 (en) * | 2004-10-25 | 2012-06-07 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| EP2269985A3 (en) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| WO2006084265A1 (en) | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS |
| JP2009502809A (ja) * | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | １０−置換テトラサイクリンおよびその使用方法 |
| JP5335664B2 (ja) * | 2006-04-07 | 2013-11-06 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | テトラサイクリンおよびその類似体の合成 |
| WO2008127361A2 (en) | 2006-10-11 | 2008-10-23 | President And Fellows Of Harvard College | Synthesis of enone intermediate |
| WO2008045507A2 (en) * | 2006-10-11 | 2008-04-17 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of bacillus anthracis infections |
| PL2109602T3 (pl) * | 2006-12-21 | 2014-09-30 | Paratek Pharm Innc | Pochodne tetracyliny do leczenia zakażeń bakteryjnych, wirusowych i pasożytniczych |
| US20080305186A1 (en) * | 2007-06-11 | 2008-12-11 | Board Of Regents, The University Of Texas System | Method and Composition for the Treatment of Cardiac Hypertrophy |
| DE102008028334B4 (de) * | 2008-06-13 | 2014-02-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Probenkammer-Adapter für die Kryokonservierung biologischer Proben |
| CA2730377C (en) | 2008-07-11 | 2017-09-19 | Neumedics | Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits |
| PT2323972E (pt) | 2008-08-08 | 2013-10-09 | Tetraphase Pharmaceuticals Inc | Compostos de tetraciclina substituídos com c7-flúor |
| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| EP2427425B1 (en) * | 2009-05-08 | 2017-03-08 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| ES2440000T3 (es) | 2009-05-08 | 2014-01-27 | Tetraphase Pharmaceuticals, Inc. | Compuestos de 8-aza-tetraciclina |
| WO2010132670A2 (en) * | 2009-05-13 | 2010-11-18 | Tetraphase Pharmaceuticals, Inc. | Pentacycline compounds |
| IN2012DN02502A (https=) | 2009-08-28 | 2015-08-28 | Tetraphase Pharmaceuticals Inc | |
| TWI592390B (zh) * | 2010-03-31 | 2017-07-21 | 四相製藥公司 | 聚環狀四環素化合物 |
| WO2012047907A1 (en) | 2010-10-04 | 2012-04-12 | President And Fellows Of Harvard College | Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto |
| CN102675145B (zh) * | 2012-04-27 | 2013-10-16 | 山东恩康药业有限公司 | 一种愈创木酚磺酸多西环素的制备方法 |
| CN103387511B (zh) * | 2012-05-08 | 2016-12-28 | 成都睿智化学研究有限公司 | 一种山环素的制备方法 |
| BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
| CN103044281A (zh) * | 2013-01-02 | 2013-04-17 | 湖南赛隆药业有限公司 | 高纯度替加环素的制法 |
| US20170304286A1 (en) * | 2014-10-24 | 2017-10-26 | Launx Biomedical Co., Ltd. | New indication of paroxetine pharmaceutical composition for treating cancer |
| HUE055500T2 (hu) * | 2015-03-09 | 2021-11-29 | Sinai Health Sys | Eszközök és módszerek a sejtdivíciós loci használatára a sejtek szaporodásának szabályozására |
| KR20170134514A (ko) | 2015-03-23 | 2017-12-06 | 바이오팜엑스 인코포레이티드 | 피부과 사용을 위한 약학 테트라사이클린 조성물 |
| CN107188875B (zh) * | 2016-03-15 | 2020-11-10 | 联化科技股份有限公司 | 一种取代苯酞类化合物的制备方法及其中间体 |
| CN110582486B (zh) | 2016-10-19 | 2024-01-12 | 四相制药公司 | 艾若威四环素的结晶形式 |
| WO2019241490A1 (en) * | 2018-06-13 | 2019-12-19 | Texas Tech University System | Novel modified tetracyclines for treatment of alcohol use disorder, pain and other disorder involving potential inflammatory processes |
| GB201914847D0 (en) * | 2019-10-14 | 2019-11-27 | Helperby Therapeutics Ltd | Combination |
| CN112979666A (zh) * | 2019-12-18 | 2021-06-18 | 中国科学院生态环境研究中心 | 土霉素衍生物、制备方法及其检测方法 |
| CN115340446B (zh) * | 2021-05-12 | 2024-04-19 | 复旦大学 | 一种手性苯并环丁烯醇、其合成方法及用途 |
| CN113388556B (zh) * | 2021-08-02 | 2022-12-02 | 金河生物科技股份有限公司 | 利用金色链霉菌生产金霉素的方法 |
| CN113929593B (zh) * | 2021-09-02 | 2024-05-31 | 河北圣雪大成唐山制药有限责任公司 | 一种土霉素-2,5-二羟基苯甲酸共晶及其制备方法 |
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