JP2008500391A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008500391A5 JP2008500391A5 JP2007527494A JP2007527494A JP2008500391A5 JP 2008500391 A5 JP2008500391 A5 JP 2008500391A5 JP 2007527494 A JP2007527494 A JP 2007527494A JP 2007527494 A JP2007527494 A JP 2007527494A JP 2008500391 A5 JP2008500391 A5 JP 2008500391A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- moiety
- branched
- unbranched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *[C@]([C@](*)(C(*)(*)[C@]([C@](*)(C(*)(CCCC1)C1(*)C1=O)I)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound *[C@]([C@](*)(C(*)(*)[C@]([C@](*)(C(*)(CCCC1)C1(*)C1=O)I)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O 0.000 description 62
- CVQUWLDCFXOXEN-UHFFFAOYSA-N O=C1C=COC=C1 Chemical compound O=C1C=COC=C1 CVQUWLDCFXOXEN-UHFFFAOYSA-N 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 5
- GCNTZFIIOFTKIY-UHFFFAOYSA-N Oc1ccncc1 Chemical compound Oc1ccncc1 GCNTZFIIOFTKIY-UHFFFAOYSA-N 0.000 description 4
- FVDHISZJWKGJBG-UHFFFAOYSA-N C1=CN=[I]C=N1 Chemical compound C1=CN=[I]C=N1 FVDHISZJWKGJBG-UHFFFAOYSA-N 0.000 description 3
- GSQFIZQPEKLFBK-UHFFFAOYSA-N NC(C(C(C(C(CC1Cc2cccc(O)c22)C3)C(O)=C1C2=O)=O)=C3O)=O Chemical compound NC(C(C(C(C(CC1Cc2cccc(O)c22)C3)C(O)=C1C2=O)=O)=C3O)=O GSQFIZQPEKLFBK-UHFFFAOYSA-N 0.000 description 2
- ZXFCRFYULUUSDW-OWXODZSWSA-N NC(C(C([C@]([C@@H](C[C@@H]1Cc2cccc(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O Chemical compound NC(C(C([C@]([C@@H](C[C@@H]1Cc2cccc(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O ZXFCRFYULUUSDW-OWXODZSWSA-N 0.000 description 2
- CADMLLAWKHABIJ-UXSWERMXSA-N N[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O Chemical compound N[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O CADMLLAWKHABIJ-UXSWERMXSA-N 0.000 description 2
- UBQKCCHYAOITMY-UHFFFAOYSA-N O=C1NC=CC=C1 Chemical compound O=C1NC=CC=C1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 2
- QGEQTBNMGHWHBJ-UHFFFAOYSA-N O=C1NCC=CC=C1 Chemical compound O=C1NCC=CC=C1 QGEQTBNMGHWHBJ-UHFFFAOYSA-N 0.000 description 2
- QTJMEGVCSPTQDY-HZDAAVBUSA-N C/C=C/S/C=C\N Chemical compound C/C=C/S/C=C\N QTJMEGVCSPTQDY-HZDAAVBUSA-N 0.000 description 1
- ZWVVGYSAWRURPJ-DNVGVPOPSA-N C=C/C=C\C=C(/N)\O Chemical compound C=C/C=C\C=C(/N)\O ZWVVGYSAWRURPJ-DNVGVPOPSA-N 0.000 description 1
- HLPIHRDZBHXTFJ-UHFFFAOYSA-N CCc1ccc[o]1 Chemical compound CCc1ccc[o]1 HLPIHRDZBHXTFJ-UHFFFAOYSA-N 0.000 description 1
- LNPCVMAMMOWWNA-JCWFFFCVSA-N CN(C)[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O Chemical compound CN(C)[C@@H]([C@H](CC=C(C1=O)Sc2ccccc2)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O LNPCVMAMMOWWNA-JCWFFFCVSA-N 0.000 description 1
- AGICWGYTRZOXTK-RISOHXOYSA-N CN(C)[C@@H]([C@H](CC=CC1=O)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O Chemical compound CN(C)[C@@H]([C@H](CC=CC1=O)[C@]11O)c([o]nc2OCc3ccccc3)c2C1=O AGICWGYTRZOXTK-RISOHXOYSA-N 0.000 description 1
- VAJQQYNAZZDPSF-ILBVQXBRSA-N CN(C)[C@@H]([C@H](C[C@@H](C1=C2O)Nc3cccc(O)c3C1=O)[C@]21O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@@H](C1=C2O)Nc3cccc(O)c3C1=O)[C@]21O)C(O)=C(C(N)=O)C1=O VAJQQYNAZZDPSF-ILBVQXBRSA-N 0.000 description 1
- PNEIPZRZIYUCAJ-PHQPAESFSA-N CN(C)[C@@H]([C@H](C[C@H](Cc(cc(cc1O)N(C)C)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H](Cc(cc(cc1O)N(C)C)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O PNEIPZRZIYUCAJ-PHQPAESFSA-N 0.000 description 1
- YLDDJDHRUCEIPV-WZDYVRJHSA-N CN(C)[C@@H]([C@H](C[C@H](Cc1cc(cccc2)c2c(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(Nc(cc2)cc3c2cc(C[C@@H]([C@@H]([C@@H]([C@@H](C(O)=C(C(N)=O)C2=O)N(C)C)[C@@]22O)O)C(C4=O)=C2O)c4c3O)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H](Cc1cc(cccc2)c2c(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(Nc(cc2)cc3c2cc(C[C@@H]([C@@H]([C@@H]([C@@H](C(O)=C(C(N)=O)C2=O)N(C)C)[C@@]22O)O)C(C4=O)=C2O)c4c3O)=O)C1=O YLDDJDHRUCEIPV-WZDYVRJHSA-N 0.000 description 1
- UGDVSQPADGAASW-YLJJCILVSA-N CN(C)[C@@H]([C@H](C[C@H]([C@@H](C=C)c1cccc(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H]([C@@H](C=C)c1cccc(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O UGDVSQPADGAASW-YLJJCILVSA-N 0.000 description 1
- HMNIESCBNPRAGK-KREUMBAPSA-N CN(C)[C@@H]([C@H](C[C@H]([C@@H](Cc1ccccc1)c(cccc1O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H]([C@@H](Cc1ccccc1)c(cccc1O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O HMNIESCBNPRAGK-KREUMBAPSA-N 0.000 description 1
- VPSYZTXEIWRROQ-IZULZFRASA-N CN(C)[C@@H]([C@H](C[C@H]([C@H](c1cccc(O)c1C1=O)N)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H](C[C@H]([C@H](c1cccc(O)c1C1=O)N)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O VPSYZTXEIWRROQ-IZULZFRASA-N 0.000 description 1
- HXEHTAQRKPBRKA-PYCKEEFSSA-N CN(C)[C@@H]([C@H]([C@H]([C@@H](C1=C2O)Nc3cccc(O)c3C1=O)O)[C@]21O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H]([C@H]([C@@H](C1=C2O)Nc3cccc(O)c3C1=O)O)[C@]21O)C(O)=C(C(N)=O)C1=O HXEHTAQRKPBRKA-PYCKEEFSSA-N 0.000 description 1
- HFANKLFGBAEFCU-LNRRCFIDSA-N CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(c(N(C)C)ccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(c(N(C)C)ccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O HFANKLFGBAEFCU-LNRRCFIDSA-N 0.000 description 1
- WTEHJBKCQZLJQY-KHKNGSCWSA-N CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(cccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O Chemical compound CN(C)[C@@H]([C@H]([C@H]([C@H](Cc(cccc1O)c1C1=O)C1=C1O)O)[C@]11O)C(O)=C(C(N)=O)C1=O WTEHJBKCQZLJQY-KHKNGSCWSA-N 0.000 description 1
- AMAIXBQOAQTXQV-WNBBPZJKSA-N C[C@@](C1)([C@@]1(C[C@@H]([C@@H](C(O)=C(C(N)=O)C1=O)N(C)C)[C@@]11O)C2=C1O)c1cccc(O)c1C2=O Chemical compound C[C@@](C1)([C@@]1(C[C@@H]([C@@H](C(O)=C(C(N)=O)C1=O)N(C)C)[C@@]11O)C2=C1O)c1cccc(O)c1C2=O AMAIXBQOAQTXQV-WNBBPZJKSA-N 0.000 description 1
- KWMSNSRQDXXQIO-REDYYMJGSA-N N/C(/O)=C\C=C/C=[IH] Chemical compound N/C(/O)=C\C=C/C=[IH] KWMSNSRQDXXQIO-REDYYMJGSA-N 0.000 description 1
- BVUCSUXMIMMGLO-UHFFFAOYSA-N NC(C(C(C(C(CC1Cc2c3[nH]cc2)C2)C(O)=C1C3=O)=O)=C2O)=O Chemical compound NC(C(C(C(C(CC1Cc2c3[nH]cc2)C2)C(O)=C1C3=O)=O)=C2O)=O BVUCSUXMIMMGLO-UHFFFAOYSA-N 0.000 description 1
- BYSOXTSLPHTBAL-UHFFFAOYSA-N NC(C(C(C(C(CC1Cc2c3[nH]cn2)C2)C(O)=C1C3=O)=O)=C2O)=O Chemical compound NC(C(C(C(C(CC1Cc2c3[nH]cn2)C2)C(O)=C1C3=O)=O)=C2O)=O BYSOXTSLPHTBAL-UHFFFAOYSA-N 0.000 description 1
- QMXZMGVLLYUITI-GANBNBROSA-N NC(C(C([C@]([C@@H](C[C@@H]1Cc2c3c(O)c4ncccc4c2)C2)(C(O)=C1C3=O)O)=O)=C2O)=O Chemical compound NC(C(C([C@]([C@@H](C[C@@H]1Cc2c3c(O)c4ncccc4c2)C2)(C(O)=C1C3=O)O)=O)=C2O)=O QMXZMGVLLYUITI-GANBNBROSA-N 0.000 description 1
- FSFVYRPQKBDXJN-LYSPQLLHSA-N NC(C(C([C@]([C@@H](C[C@@H]1Cc2cc3cccc(O)c3c(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O Chemical compound NC(C(C([C@]([C@@H](C[C@@H]1Cc2cc3cccc(O)c3c(O)c22)C3)(C(O)=C1C2=O)O)=O)=C3O)=O FSFVYRPQKBDXJN-LYSPQLLHSA-N 0.000 description 1
- ZPSJGADGUYYRKE-UHFFFAOYSA-N O=C1OC=CC=C1 Chemical compound O=C1OC=CC=C1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 description 1
- IOJUPLGTWVMSFF-UHFFFAOYSA-N c1nc(cccc2)c2[s]1 Chemical compound c1nc(cccc2)c2[s]1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57362304P | 2004-05-21 | 2004-05-21 | |
| US60/573,623 | 2004-05-21 | ||
| US66094705P | 2005-03-11 | 2005-03-11 | |
| US60/660,947 | 2005-03-11 | ||
| PCT/US2005/017831 WO2005112945A2 (en) | 2004-05-21 | 2005-05-20 | Synthesis of tetracyclines and analogues thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011119770A Division JP5971900B2 (ja) | 2004-05-21 | 2011-05-27 | テトラサイクリンおよびそれらの類似物の合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008500391A JP2008500391A (ja) | 2008-01-10 |
| JP2008500391A5 true JP2008500391A5 (https=) | 2008-07-10 |
| JP5242161B2 JP5242161B2 (ja) | 2013-07-24 |
Family
ID=35428840
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527494A Expired - Lifetime JP5242161B2 (ja) | 2004-05-21 | 2005-05-20 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2011119770A Expired - Lifetime JP5971900B2 (ja) | 2004-05-21 | 2011-05-27 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2013164980A Withdrawn JP2013227346A (ja) | 2004-05-21 | 2013-08-08 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2015168496A Expired - Lifetime JP6185966B2 (ja) | 2004-05-21 | 2015-08-28 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2016243003A Pending JP2017052797A (ja) | 2004-05-21 | 2016-12-15 | テトラサイクリンおよびそれらの類似物の合成 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011119770A Expired - Lifetime JP5971900B2 (ja) | 2004-05-21 | 2011-05-27 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2013164980A Withdrawn JP2013227346A (ja) | 2004-05-21 | 2013-08-08 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2015168496A Expired - Lifetime JP6185966B2 (ja) | 2004-05-21 | 2015-08-28 | テトラサイクリンおよびそれらの類似物の合成 |
| JP2016243003A Pending JP2017052797A (ja) | 2004-05-21 | 2016-12-15 | テトラサイクリンおよびそれらの類似物の合成 |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US7807842B2 (https=) |
| EP (2) | EP1753713B1 (https=) |
| JP (5) | JP5242161B2 (https=) |
| KR (2) | KR101171408B1 (https=) |
| CN (3) | CN101027279B (https=) |
| AU (1) | AU2005244988C1 (https=) |
| BR (2) | BR122018069604B1 (https=) |
| CA (3) | CA2892332C (https=) |
| CY (1) | CY1118519T1 (https=) |
| DK (1) | DK1753713T3 (https=) |
| ES (1) | ES2607453T3 (https=) |
| HU (1) | HUE030212T2 (https=) |
| IL (5) | IL179467A (https=) |
| LT (1) | LT1753713T (https=) |
| PL (1) | PL1753713T3 (https=) |
| PT (1) | PT1753713T (https=) |
| SG (1) | SG10201810312UA (https=) |
| SI (1) | SI1753713T1 (https=) |
| WO (1) | WO2005112945A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| EP1381372A2 (en) | 2001-03-14 | 2004-01-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| AU2002365120A1 (en) * | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
| EP2311451A1 (en) * | 2002-03-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | Amino-methyl substituted tetracycline compounds |
| AU2003261161B2 (en) * | 2002-07-12 | 2009-09-10 | Paratek Pharmaceuticals, Inc | 3, 10, and 12a substituted tetracycline compounds |
| US20050143352A1 (en) | 2003-07-09 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| SI1753713T1 (sl) | 2004-05-21 | 2017-01-31 | President And Fellows Of Harvard College | Sinteza tetraciklinov in njihovih analogov |
| EP2033950A1 (en) | 2004-10-25 | 2009-03-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP1805134B1 (en) * | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| CA2597212A1 (en) | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| US20070093455A1 (en) * | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
| WO2007117639A2 (en) | 2006-04-07 | 2007-10-18 | The President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| US8440646B1 (en) * | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
| EP2487160B1 (en) | 2006-10-11 | 2016-02-03 | President and Fellows of Harvard College | Synthesis of Enone Intermediate |
| WO2008079339A2 (en) | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections |
| US20080305186A1 (en) * | 2007-06-11 | 2008-12-11 | Board Of Regents, The University Of Texas System | Method and Composition for the Treatment of Cardiac Hypertrophy |
| DE102008028334B4 (de) * | 2008-06-13 | 2014-02-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Probenkammer-Adapter für die Kryokonservierung biologischer Proben |
| JP2011527708A (ja) | 2008-07-11 | 2011-11-04 | ニュメディックス | 減少した抗菌活性および神経保護作用の利点を有するテトラサイクリン誘導体 |
| KR101746795B1 (ko) | 2008-08-08 | 2017-06-13 | 테트라페이즈 파마슈티컬스, 인코포레이티드 | Ｃ７-플루오로 치환된 테트라시클린 화합물 |
| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| WO2010129057A2 (en) * | 2009-05-08 | 2010-11-11 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| ES2440000T3 (es) * | 2009-05-08 | 2014-01-27 | Tetraphase Pharmaceuticals, Inc. | Compuestos de 8-aza-tetraciclina |
| US20120115819A1 (en) * | 2009-05-13 | 2012-05-10 | Clark Roger B | Pentacycline Compounds |
| NO2470500T3 (https=) | 2009-08-28 | 2018-03-03 | ||
| DK2552890T3 (en) * | 2010-03-31 | 2017-04-03 | Tetraphase Pharmaceuticals Inc | POLYCYCLIC TETRACYCLINE COMPOUNDS |
| WO2012047907A1 (en) | 2010-10-04 | 2012-04-12 | President And Fellows Of Harvard College | Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto |
| CN102675145B (zh) * | 2012-04-27 | 2013-10-16 | 山东恩康药业有限公司 | 一种愈创木酚磺酸多西环素的制备方法 |
| CN103387511B (zh) * | 2012-05-08 | 2016-12-28 | 成都睿智化学研究有限公司 | 一种山环素的制备方法 |
| CA2883238C (en) * | 2012-08-31 | 2021-11-23 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| CN103044281A (zh) * | 2013-01-02 | 2013-04-17 | 湖南赛隆药业有限公司 | 高纯度替加环素的制法 |
| WO2016062279A1 (zh) * | 2014-10-24 | 2016-04-28 | 朗齐生物医学股份有限公司 | 苹果酸丙氯陪拉辛锭用于制备治疗癌症药物的用途 |
| DK3268480T3 (da) * | 2015-03-09 | 2021-07-26 | Sinai Health Sys | Værktøjer og fremgangsmåder til anvendelse af celledelingsloci til at styre celleproliferation |
| MX2017012062A (es) | 2015-03-23 | 2018-06-18 | Biopharmx Inc | Composicion farmaceutica de tetraciclina para uso dermatologico. |
| CN107188875B (zh) * | 2016-03-15 | 2020-11-10 | 联化科技股份有限公司 | 一种取代苯酞类化合物的制备方法及其中间体 |
| HUE066360T2 (hu) | 2016-10-19 | 2024-07-28 | Tetraphase Pharmaceuticals Inc | Eravaciklin kristályformái |
| CA3103614C (en) | 2018-06-13 | 2024-05-28 | Texas Tech University System | Modified tetracycline for treatment of alcohol use disorder, pain and other disorders involving potential inflammatory processes |
| GB201914847D0 (en) * | 2019-10-14 | 2019-11-27 | Helperby Therapeutics Ltd | Combination |
| CN112979666A (zh) * | 2019-12-18 | 2021-06-18 | 中国科学院生态环境研究中心 | 土霉素衍生物、制备方法及其检测方法 |
| CN115340446B (zh) * | 2021-05-12 | 2024-04-19 | 复旦大学 | 一种手性苯并环丁烯醇、其合成方法及用途 |
| CN113388556B (zh) * | 2021-08-02 | 2022-12-02 | 金河生物科技股份有限公司 | 利用金色链霉菌生产金霉素的方法 |
| CN113929593B (zh) * | 2021-09-02 | 2024-05-31 | 河北圣雪大成唐山制药有限责任公司 | 一种土霉素-2,5-二羟基苯甲酸共晶及其制备方法 |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2482055A (en) | 1948-02-11 | 1949-09-13 | American Cyanamid Co | Aureomycin and preparation of same |
| GB935384A (en) * | 1959-03-30 | 1963-08-28 | Pfizer & Co C | Tetracycline derivatives and preparation thereof |
| US3019260A (en) * | 1959-05-13 | 1962-01-30 | American Cyanamid Co | Process for the catalytic reduction of 6-hydroxy hydronaphthacenes |
| US3338963A (en) | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
| US3219671A (en) * | 1961-04-14 | 1965-11-23 | American Cyanamid Co | Substituted 6-deoxytetracyclines and 6-demethyl-6-deoxytetracyclines |
| US3697552A (en) | 1961-08-18 | 1972-10-10 | Pfizer | Anthracyclidine-acetic acid derivatives |
| US3509184A (en) | 1961-08-18 | 1970-04-28 | Pfizer & Co C | Anthracyclidine-acetic acid derivatives |
| US3862225A (en) | 1961-08-18 | 1975-01-21 | Pfizer | D-ring substituted tetracyclines |
| US3829453A (en) | 1961-08-18 | 1974-08-13 | Pfizer | Octahydroanthracene-2-aminoacetic acids and esters and mixed anhydrides thereof |
| GB1019562A (en) | 1961-08-18 | 1966-02-09 | Pfizer & Co C | Octahydroanthracenes and preparation thereof |
| US3772363A (en) | 1961-08-18 | 1973-11-13 | Pfizer | 3,4,10-trioxo octahydroanthracene-2-aminoacetic acids and derivatives thereof |
| FR1365279A (fr) | 1961-08-18 | 1964-07-03 | Pfizer & Co C | Dérivés d'octahydroanthracènes, et procédé pour leur préparation |
| US3109007A (en) * | 1962-10-02 | 1963-10-29 | Pfizer & Co C | Derivatives of tetracycline and its analogs |
| USRE26253E (en) | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
| GB1100885A (en) | 1965-03-15 | 1968-01-24 | Pfizer & Co C | Oxytetracycline esters and preparation thereof |
| GB1077598A (en) * | 1965-05-12 | 1967-08-02 | Pfizer & Co C | Preparation of n-demethyl tetracyclines |
| US3849493A (en) * | 1966-08-01 | 1974-11-19 | Pfizer | D-ring substituted 6-deoxytetracyclines |
| US3502660A (en) | 1967-01-12 | 1970-03-24 | Pfizer & Co C | 2-((5'-(3' and/or 4'-substituted)isoxazoyl) methylidene)-3,4,10-trioxo-1,2,3,4,4a,9,9a,10-octahydroanthracenes |
| US4066694A (en) | 1971-02-09 | 1978-01-03 | Pfizer Inc. | 4-hydroxy-4-dedimethylamino-tetracyclines |
| US4052467A (en) | 1967-11-08 | 1977-10-04 | Phillips Petroleum Company | Catalytic reduction of aldehydes to alcohols |
| US3947517A (en) | 1969-06-12 | 1976-03-30 | Research Corporation | Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines |
| US3914299A (en) * | 1969-06-12 | 1975-10-21 | Research Corp | Tetracyclines |
| US3699117A (en) | 1969-07-29 | 1972-10-17 | Pfizer | 2-((5'-(3'-and/or 4'-substituted) isoxazolyl) aminoethyl) - 3,4,10 - trioxo-1,2,3,4,4,9,9,10-octahydroanthracenes and related compounds |
| BE788479A (fr) | 1971-09-06 | 1973-01-02 | Medimpex Gyogyszerkulkereskede | Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques |
| DK501474A (https=) | 1973-09-28 | 1975-05-26 | Ankerfarm Spa | |
| US4060605A (en) | 1973-09-28 | 1977-11-29 | Ankerfarm, S.P.A. | Water-soluble derivative of 6-deoxy-tetracyclines |
| DE2355118A1 (de) | 1973-11-03 | 1975-05-28 | Hoechst Ag | 2-carboxamido-substituierte tetracycline und verfahren zu ihrer herstellung |
| GB1469384A (en) * | 1974-06-25 | 1977-04-06 | Farmaceutici Italia | Tetracyclines |
| US5589470A (en) | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| DK386784A (da) | 1983-08-17 | 1985-02-18 | Hovione Int Ltd | Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner |
| SG52361A1 (en) | 1991-10-04 | 1998-09-28 | American Cyanamid Co | Novel 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| US6756365B2 (en) | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US5420272A (en) | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| SG47520A1 (en) | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| US5688516A (en) | 1992-11-12 | 1997-11-18 | Board Of Regents, The University Of Texas System | Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices |
| US5362754A (en) | 1992-11-12 | 1994-11-08 | Univ. Of Tx Md Anderson Cancer Center | M-EDTA pharmaceutical preparations and uses thereof |
| US5538954A (en) | 1994-06-24 | 1996-07-23 | A/S Dumex (Dumex Ltd.) | Salts of tetracyclines |
| WO1995022529A1 (en) * | 1994-02-17 | 1995-08-24 | Pfizer Inc. | 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
| US5574026A (en) | 1994-12-13 | 1996-11-12 | American Cyanamid Company | Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth |
| CA2219277A1 (en) | 1995-05-03 | 1996-11-07 | Pfizer Limited | Novel tetracycline derivatives |
| WO1996036229A1 (en) | 1995-05-17 | 1996-11-21 | E.I. Du Pont De Nemours And Company | Fungicidal cyclic amides |
| US6165484A (en) | 1997-08-26 | 2000-12-26 | Wake Forest University | EDTA and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections |
| PT102160B (pt) | 1998-05-26 | 2001-04-30 | Hovione Sociedade Quimica S A | Processo para a preparacao de 4-(des-dimetilamino)-tetraciclinas |
| US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
| US6581606B2 (en) * | 1999-07-06 | 2003-06-24 | The Rx Files Corporation | Method, apparatus and system for use in treating patient with a drug having an antineoplastic effect to optimize therapy and prevent an adverse drug response |
| EA016099B1 (ru) | 1999-09-14 | 2012-02-28 | Трастис Оф Тафтс Коллидж | Замещенный аналог тетрациклина (варианты) и способ получения замещенного аналога тетрациклина |
| US6849615B2 (en) | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| US6730320B2 (en) | 2000-02-24 | 2004-05-04 | Advancis Pharmaceutical Corp. | Tetracycline antibiotic product, use and formulation thereof |
| US6638532B2 (en) | 2000-02-24 | 2003-10-28 | Advancis Pharmaceutical Corp. | Tetracycline—doxycycline antibiotic composition |
| EA200201046A1 (ru) | 2000-03-31 | 2003-04-24 | Трастис Оф Тафтс Коллидж | 7- или 9-замещенные соединения тетрациклина, способ их получения (варианты), фармацевтическая композиция, способ лечения состояния, чувствительного к действию тетрациклина, у млекопитающего и реакционноспособное промежуточное производное |
| CA2409063A1 (en) | 2000-05-15 | 2001-11-22 | Mark L. Nelson | 7-substituted fused ring tetracycline compounds |
| AU2001268475A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| AU2000254942A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| AU2000257445A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-n-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US20020128237A1 (en) | 2000-06-16 | 2002-09-12 | Nelson Mark L. | 7-N-substituted phenyl tetracycline compounds |
| WO2002004404A2 (en) * | 2000-07-07 | 2002-01-17 | Trustees Of Tufts College | 7,8 and 9-substituted tetracycline compounds |
| WO2002012170A1 (en) | 2000-08-04 | 2002-02-14 | Trustees Of Tufts College | 8-substituted tetracycline compounds |
| IL153672A0 (en) | 2000-07-07 | 2003-07-06 | Tufts College | 7-substituted tetracycline compounds |
| EA009175B1 (ru) | 2000-07-07 | 2007-12-28 | Трастис Оф Тафтс Коллидж | Замещенные соединения миноциклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего |
| WO2002072506A2 (en) | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| EA013835B1 (ru) | 2001-03-13 | 2010-08-30 | Пэрэтек Фамэсьютикэлс, Инк. | Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта |
| EP1241160A1 (en) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
| US6841546B2 (en) | 2001-03-14 | 2005-01-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
| EP1381372A2 (en) | 2001-03-14 | 2004-01-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| ES2338994T3 (es) * | 2001-04-24 | 2010-05-14 | Paratek Pharmaceuticals, Inc. | Compuestos de tetraciclina sustituida para el tratamiento de la malaria. |
| EP2327409A1 (en) | 2001-07-13 | 2011-06-01 | Paratek Pharmaceuticals, Inc. | Tetracycline compound having target therapeutic activities |
| RU2300380C2 (ru) | 2001-10-05 | 2007-06-10 | Тетрадженекс Фармасьютикалс, Инк. | Производные тетрациклина и способы их применения |
| ES2551708T3 (es) * | 2002-01-08 | 2015-11-23 | Paratek Pharmaceuticals, Inc. | Compuestos de 4-desdimetilamino tetraciclina |
| AU2003224672B2 (en) | 2002-03-08 | 2010-02-04 | Eisai R&D Management Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
| EP1556007A4 (en) * | 2002-10-24 | 2008-12-17 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF MALARIA |
| WO2004064728A2 (en) * | 2003-01-16 | 2004-08-05 | Paratek Pharmaceuticals, Inc. | Use of specific tetracycline compounds in therapy |
| WO2005030149A2 (en) * | 2003-09-26 | 2005-04-07 | The Johns Hopkins University | Suppression of hiv replication for prevention and treatment of hiv |
| UA83266C2 (en) | 2003-12-08 | 2008-06-25 | Уайет | Oxazole derivatives of tetracyclines |
| DE102004024674A1 (de) | 2004-05-18 | 2005-12-15 | Wolfgang Lorenz | Mittel und Verfahren zur Diagnose, Prophylaxe und Therapie von Bindegewebserkrankungen |
| SI1753713T1 (sl) | 2004-05-21 | 2017-01-31 | President And Fellows Of Harvard College | Sinteza tetraciklinov in njihovih analogov |
| WO2005123729A1 (en) | 2004-06-08 | 2005-12-29 | Metabasis Therapeutics, Inc. | Lewis acid mediated synthesis of cyclic esters |
| US7327803B2 (en) | 2004-10-22 | 2008-02-05 | Parkervision, Inc. | Systems and methods for vector power amplification |
| JP4857634B2 (ja) * | 2005-07-22 | 2012-01-18 | 三菱瓦斯化学株式会社 | ポリアミド樹脂 |
| CA2632568A1 (en) | 2005-12-07 | 2007-06-14 | Alacrity Biosciences, Inc. | Tetracyclines for treating ocular diseases and disorders |
| AU2007230844A1 (en) | 2006-03-27 | 2007-10-04 | Government Of The United States Of America, As Represented By The Secretary | Tetracycline compounds and methods of treatment |
| WO2007117639A2 (en) | 2006-04-07 | 2007-10-18 | The President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| US20100316918A1 (en) | 2006-04-07 | 2010-12-16 | President And Fellows Of Harvard College | Nano-scale gas separation device utilizing thin film structures for hydrogen production |
| EP2487160B1 (en) * | 2006-10-11 | 2016-02-03 | President and Fellows of Harvard College | Synthesis of Enone Intermediate |
| CN101684101B (zh) | 2008-09-16 | 2011-11-09 | 山东轩竹医药科技有限公司 | 哌嗪酮取代的四环素衍生物 |
| WO2010126607A2 (en) | 2009-04-30 | 2010-11-04 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| WO2012047907A1 (en) | 2010-10-04 | 2012-04-12 | President And Fellows Of Harvard College | Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto |
-
2005
- 2005-05-20 SI SI200532106A patent/SI1753713T1/sl unknown
- 2005-05-20 BR BR122018069604-4A patent/BR122018069604B1/pt active IP Right Grant
- 2005-05-20 DK DK05779988.4T patent/DK1753713T3/en active
- 2005-05-20 US US11/133,789 patent/US7807842B2/en active Active
- 2005-05-20 BR BRPI0510113-1A patent/BRPI0510113B1/pt not_active IP Right Cessation
- 2005-05-20 CN CN2005800234944A patent/CN101027279B/zh not_active Expired - Lifetime
- 2005-05-20 AU AU2005244988A patent/AU2005244988C1/en not_active Expired
- 2005-05-20 EP EP05779988.4A patent/EP1753713B1/en not_active Expired - Lifetime
- 2005-05-20 SG SG10201810312UA patent/SG10201810312UA/en unknown
- 2005-05-20 ES ES05779988.4T patent/ES2607453T3/es not_active Expired - Lifetime
- 2005-05-20 HU HUE05779988A patent/HUE030212T2/en unknown
- 2005-05-20 KR KR1020067026944A patent/KR101171408B1/ko not_active Expired - Lifetime
- 2005-05-20 EP EP16180780.5A patent/EP3138831B1/en not_active Expired - Lifetime
- 2005-05-20 PL PL05779988T patent/PL1753713T3/pl unknown
- 2005-05-20 CA CA2892332A patent/CA2892332C/en not_active Expired - Lifetime
- 2005-05-20 CN CN201310052791.8A patent/CN103224474B/zh not_active Expired - Lifetime
- 2005-05-20 KR KR1020117009068A patent/KR101336462B1/ko not_active Expired - Lifetime
- 2005-05-20 CA CA2767912A patent/CA2767912C/en not_active Expired - Lifetime
- 2005-05-20 CA CA2566464A patent/CA2566464C/en not_active Expired - Lifetime
- 2005-05-20 WO PCT/US2005/017831 patent/WO2005112945A2/en not_active Ceased
- 2005-05-20 PT PT57799884T patent/PT1753713T/pt unknown
- 2005-05-20 JP JP2007527494A patent/JP5242161B2/ja not_active Expired - Lifetime
- 2005-05-20 CN CN201310052794.1A patent/CN103214409B/zh not_active Expired - Lifetime
- 2005-05-20 LT LTEP05779988.4T patent/LT1753713T/lt unknown
-
2006
- 2006-11-21 IL IL179467A patent/IL179467A/en active IP Right Grant
-
2010
- 2010-05-12 US US12/778,797 patent/US8598148B2/en not_active Expired - Lifetime
-
2011
- 2011-05-27 JP JP2011119770A patent/JP5971900B2/ja not_active Expired - Lifetime
- 2011-06-20 IL IL213664A patent/IL213664A0/en unknown
-
2012
- 2012-01-01 IL IL217315A patent/IL217315A/en active IP Right Grant
- 2012-01-01 IL IL217314A patent/IL217314A/en active IP Right Grant
- 2012-01-01 IL IL217316A patent/IL217316A/en active IP Right Grant
-
2013
- 2013-08-08 JP JP2013164980A patent/JP2013227346A/ja not_active Withdrawn
- 2013-10-25 US US14/063,868 patent/US9365493B2/en not_active Expired - Lifetime
-
2015
- 2015-08-28 JP JP2015168496A patent/JP6185966B2/ja not_active Expired - Lifetime
-
2016
- 2016-05-20 US US15/161,165 patent/US9884830B2/en not_active Expired - Fee Related
- 2016-10-26 CY CY20161101083T patent/CY1118519T1/el unknown
- 2016-12-15 JP JP2016243003A patent/JP2017052797A/ja active Pending
-
2018
- 2018-02-02 US US15/887,956 patent/US10669244B2/en not_active Expired - Lifetime
-
2019
- 2019-05-20 US US16/417,458 patent/US11192866B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008500391A5 (https=) | ||
| CA2566464A1 (en) | Synthesis of tetracyclines and analogues thereof | |
| JP2009533346A5 (https=) | ||
| AU2005204259B2 (en) | Methods of preparing substituted tetracyclines with transition metal-based chemistries | |
| JP4925549B2 (ja) | ９−置換ミノサイクリン化合物 | |
| AU2008207359C1 (en) | 7,9-substituted tetracycline compounds | |
| US6833365B2 (en) | Tetracycline compounds for treatment of Cryptosporidium parvum related disorders | |
| EP1303479B1 (en) | 7-, 8- and 9-substituted tetracycline compounds | |
| US7871993B2 (en) | Tigecycline crystalline forms and processes for preparation thereof | |
| CA2183565A1 (en) | 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics | |
| EP1474380A2 (en) | 4-dedimethylamino tetracycline compounds | |
| JP2009526864A5 (https=) | ||
| AU2010200845A1 (en) | Methods for synthesizing substituted tetracycline compounds | |
| JP2008530106A5 (https=) | ||
| JP2004529172A5 (https=) | ||
| US6770644B1 (en) | Hydroxamic acid derivatives, process for the production thereof and drug containing the same as the active ingredient | |
| JP5261374B2 (ja) | 抗ウイルス性ピリミジンヌクレオシド誘導体 | |
| CZ196494A3 (en) | N,n'-substituted imidocarbonimidediamides derived from hydroxylamines | |
| JP2009505974A5 (https=) | ||
| JP2022501350A5 (https=) | ||
| JP2021529203A5 (https=) | ||
| EP2064173A1 (en) | Crystalline form of cinacalcet | |
| JP2008503582A5 (https=) | ||
| FI94346B (fi) | Menetelmä tyydyttymättömien aminodikarboksyylihappojohdannaisten valmistamiseksi | |
| CN100357284C (zh) | 抗流感病毒化合物及其制备方法和用途 |