JP2008029529A - Medical multi-chamber container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical multi-chamber container capable of attaching a cover member thereto despite of the shapes of a container body and a port and surely detaching the cover member from the port or a hanging hole simultaneously with the communication of the respective chambers. <P>SOLUTION: This medical multi-chamber container containing medicines includes a flexible container body liquid-tightly partitioned into an upper medicine chamber and a lower medicine chamber by a peelable weak seal part, the hanging hole provided in the upper part of the container body, the port provided in the lower part of the container body to communicate with the lower medicine chamber and having a penetration hole, and the bag-shaped cover member contracting and covering the port or the hanging hole across the outer circumference of its adjacent medicine chamber; and, when the medicine chamber non-covered with the cover member is pushed to peel off the weak seal part and communicate the respective medicine chambers, the cover member is broken and is removable from the container body. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a medical multi-chamber container. Specifically, the present invention relates to a medical multi-chamber container that cannot be used in an unconnected state.

  There are drugs and chemicals that have poor storability due to alteration when stored in a premixed state. These drugs and drug solutions are stored separately and mixed and used by aseptic mixing immediately before use. A medical multi-chamber container is used to store drugs and chemical solutions individually during storage and to aseptically mix these drugs and chemical solutions during use.

  This is because a plurality of medicines and chemical solutions are stored separately in a plurality of chambers partitioned by weak seal parts that can be easily peeled off, and the weak seal parts are removed by pressing the container by hand immediately before drug administration. The contents are exfoliated and the contents are mixed or dissolved under aseptic conditions by communicating with a plurality of chambers.

  However, the conventional medical multi-chamber container does not have a method of distinguishing whether or not a plurality of chambers communicate with each other, and is generally distinguished visually. For this reason, it has been reported that a drug enclosed in a medical multi-chamber container is administered to a patient without communication.

  In order to avoid the administration of the drug from the multi-chamber container to the patient in such a disconnected state, a mechanism that does not administer the drug in the disconnected state has been proposed. For example, when a drug is sealed in a drug chamber adjacent to a port or suspension hole and the drug chamber filled with the liquid is coated, the adjacent port or suspension hole is covered with a bag-shaped member. Has proposed a structure in which a bag-like member can be removed from a drug chamber filled with a liquid agent present in a bag-like member by moving the liquid agent to the other drug chamber (patent) Reference 1).

In addition, the port portion of the multi-chamber container is attached by engaging a hard covering member, and the drug chamber on the side where the port is not communicated is pressed and communicated, and the drug chamber on the side where the port is communicated A structure that destroys a covering member by expanding is proposed (Patent Document 2).

JP-A-2005-212558 JP-A-2005-305136

  However, in the case of a configuration in which a bag-like member formed of a heat-shrink film, such as Patent Document 1, is covered, contracted, and pulled out, it is contracted more than necessary, resulting in a multi-chamber container. Even after the communication of each drug room, it cannot be detached from the multi-chamber container, or the bag is shrunk so that it is wrapped in close contact with the shape of the port and opened. Problems such as being unable to do so occur. In addition, when a hard material is used for the covering member as in Patent Document 2, when the hard covering member is attached to the drug chamber in which the liquid agent is sealed, pressure is applied and communication occurs. In addition, since it depends on the shape of the port, the container main body, etc. when mounting, it cannot be used for different shapes. Therefore, there is no need for a special structure for fixing the non-communication use prevention member to the multi-chamber container, and it is possible to avoid drug administration to the patient without communication, having a structure that can be surely removed simultaneously with communication. A structure is needed.

  It is an object of the present invention to attach a covering member regardless of the shape of a container main body, a port or the like, and a medical multiple chamber in which each chamber communicates with each other and the covering member can be reliably detached from a port or a suspension hole. To provide a container.

Therefore, the present inventors
(1) A medical multi-chamber container containing a medicine, which is liquid-tightly divided into an upper medicine chamber and a lower medicine chamber by a peelable weak seal portion, and at least the upper medicine chamber is filled with a medicine solution A flexible container body, a suspension hole provided in an upper part of the container body, a port having a piercing port provided in a lower part of the container body so as to communicate with the lower drug chamber, A bag-shaped covering member that shrinks and covers the entire port so as to relate to the outer periphery of the lower drug chamber, the cover member pressing the upper drug chamber to peel off the weak seal portion, and communicating each drug chamber A medical multi-chamber container which is destroyed when removed and can be removed from the container body.
(2) The medical multi-chamber container according to (1), which has a grip portion in a region below the covering member and not related to the container main body and the port.
(3) The medical multi-chamber container according to (1) or (2), wherein the covering member has a broken line-like notch from the upper end of the covering member so as to be easily broken.
(4) A medical multi-chamber container containing a medicine, which is liquid-tightly divided into an upper medicine chamber and a lower medicine chamber by a peelable weak seal portion, and at least the lower medicine chamber is filled with a medicine solution A flexible container body, a suspension hole provided in the upper part of the container body, a port having a piercing port provided in the lower part of the container body so as to communicate with the lower drug chamber, and an upper part A covering member that shrinks and coats the entire suspension hole so as to relate to the outer periphery of the drug chamber, and the cover member presses the lower drug chamber to peel off the weak seal portion, thereby communicating each drug chamber. A medical multi-chamber container that is broken and can be removed from the container body.
(5) The medical multi-chamber container according to (4), which has a grip portion in an area which is an upper part of the covering member and is not related to the container body.
(6) The medical multi-chamber container according to (4) or (5), wherein the covering member has a broken line-like cut from the lower end of the covering member so as to be easily broken.
(7) The medical multi-chamber container according to any one of (1) to (6), wherein at least a part of the covering member is formed of a shrink film.
(8) The medical multi-chamber container according to any one of (1) to (7), wherein a hard member is attached to the piercing opening.
By using this, the covering member is attached by being contracted, so that it is possible to attach it without depending on the shape of the container body or the port. In addition, since the covering member is destroyed by pressing and communicating with the uncoated medicine chamber, the covering member is used in the container even if the covering member contracts too much when the container member is attached to the container body. Separation from the main body is never impossible. As described above, each chamber of the multi-chamber container is provided so as to cover the port or the hanging hole in a non-communication state, and is sealed in the drug chamber on the side not covered by the covering member by the communication of each chamber. The structure is such that the communication member and the covering member can be detached because the covering member can be detached because the medicine is moved and destroyed by increasing the thickness of the medicine chamber on the coated side. Because it is linked, the risk of administering an unprepared drug to a patient is avoided, and when each drug chamber of a multi-chamber container communicates, it has been found that it can be used quickly, and the present invention has been achieved. .

  The medical multi-chamber container of the present invention is provided with a shrinkable and wearable covering member that is attached to the outer periphery of the drug container, and can be easily attached to the medical multi-chamber container without depending on the shape of the drug container, Since the covering members are destroyed at the same time as the respective drug chambers communicate with each other, there is no possibility that they will not come off. In addition, since the port piercing port is covered in a non-communication state, an unadjusted medicine that remains uncommitted is not erroneously administered to a patient, and thus can be suitably used for medical treatment.

  Hereinafter, the medical multi-chamber container of the present invention will be described with reference to the drawings. However, the present invention is not limited to the exemplary embodiments described in these drawings.

  FIG. 1 is a view of an embodiment of a type in which a port of a medical multi-chamber container of the present invention is covered. FIG. 2 is a diagram of an embodiment of the type in which the suspension hole of the medical multi-chamber container of the present invention is covered. FIG. 3 is a diagram of an embodiment of a type in which a grip portion is provided on the covering member of the medical multi-chamber container of the present invention. FIG. 4 is a view in which a hard member is provided at the port piercing port of the medical multi-chamber container of the present invention. 5 is a diagram of the use state of the medical multi-chamber container of the present invention.

  FIG. 1 is a medical multi-chamber container including a multi-chamber container body A composed of a lower drug chamber 1 and an upper drug chamber 2, a port 3 and a non-communication use preventing member 4. The container body A is composed of a bag-like lower drug chamber 1 and an upper drug chamber 2 formed from a cylindrical film, and the lower drug chamber 1 and the upper drug chamber 2 are partitioned liquid-tightly by a weak seal portion 5. It is a flexible multi-chamber container. The lower drug chamber 1 and the upper drug chamber 2 are filled with a liquid agent. A suspending hole 6 as a container suspending means is provided in the upper part of the container main body A, and the lower end of the container main body A located symmetrically with the suspending hole 6 is pierced at the lower end that communicates with the lower drug chamber 1. A port 3 is provided that is closed by a rubber plug 31 that is a passage. As the covering member 4, a bag-like member whose lower side is closed is covered by being contracted and tightened from the port 3 so as to be related to the lower drug chamber 1 of the container body A, and directed downward from the upper end of the covering member 4. A broken line-shaped cut 41 is formed.

  When the upper drug chamber 2 is pressed, the weak seal portion 5 is peeled off, the lower drug chamber 1 and the upper drug chamber 2 communicate with each other, and the liquid drug sealed in the upper drug chamber 2 in the initial state is the lower drug chamber. Flow into 1. The volume of the lower drug chamber 1 to which the liquid agent has moved expands. By increasing the thickness of the lower drug chamber 1 in this way, the broken line-shaped cut 41 formed in the cover member 4 contracted and attached to the lower drug chamber 1 is cut into pieces and divided, thereby covering the member 4. Therefore, the covering member 4 can be detached from the container body A. Thus, the non-communication use preventing member 4 communicates with the lower drug chamber 1 and the upper drug chamber 2, and the liquid drug sealed in the upper drug chamber 2 flows into the lower drug chamber 1, whereby the lower drug chamber 1. Since the swell expands, the covering member 4 is destroyed and can be separated. Further, even if the covering member 4 is contracted excessively when being attached to the container main body A, the covering member 4 is destroyed, so that the container main body A cannot be separated. That is, the non-communication use preventing member 4 does not come off without the lower drug chamber 1 expanding, and the container main body A can be used because the lower drug chamber 1 and the upper drug chamber 2 communicate with each other and can be detached. . Therefore, since the rubber plug 31 of the port 3 does not appear when the non-communication use preventing member 4 is covered in the non-communication state, it can be prevented from communicating with the infusion device in the non-communication state. Even when the lower drug chamber 1 is pressed and communicated, if the upper drug chamber 2 is pressed thereafter, the drug solution moves to the lower drug chamber 1, so that the covering member 4 is broken and detached from the container body A. It is possible.

  FIG. 2 blocks use when not in communication by closing the suspension hole. A suspending hole 6 as a container suspending means is provided in the upper part of the container main body A, and the lower end of the container main body A located symmetrically with the suspending hole 6 is pierced at the lower end that communicates with the lower drug chamber 1. A port 3 is provided that is closed by a rubber plug 31 that is a passage. As the covering member 4, a bag-like or band-like member whose upper side is closed closes the suspension hole 6, contracts and covers the upper drug chamber 1 of the container body A, and starts from the lower end of the covering member 4. A broken line-shaped cut is formed upward.

  When the suspension hole is covered with a covering member, the weak seal 5 is peeled off by pressing the lower drug chamber 1, and the lower drug chamber 1 and the upper drug chamber 2 communicate with each other. The liquid agent sealed in the chamber 1 flows into the lower drug chamber 1. The volume of the upper drug chamber 2 to which the liquid agent has moved expands. By increasing the thickness of the upper drug chamber 2 in this way, the broken line-shaped cut 41 formed in the cover member 4 contracted and attached to the upper drug chamber 2 is cut off and divided, thereby covering the member 4. Therefore, the covering member 4 can be detached from the container body A.

  The material of the drug chamber is not particularly limited as long as the drug can be stably stored, and is usually formed of a synthetic resin film used for a drug bag. When the drug is a powder, it is preferable that the drug can be stably stored, has gas / moisture barrier properties, and has excellent bag strength, and has an innermost layer that comes into contact with the drug when the film is formed into a bag shape. Polyethylene and cyclic polyolefin that can stably store chemicals, vapor-deposited polyethylene terephthalate with an intermediate layer that blocks moisture and gas, and excellent printing strength, and the outermost layer on the outside is polyethylene or polyethylene terephthalate with excellent bag-making properties. It is particularly preferable to use a laminated film to be formed. By laminating films in this way, it is possible to block moisture and gas that are going to permeate the synthetic resin. When the drug is a liquid, it is preferable to use polyethylene that is resistant to low temperature impact and excellent in flexibility.

  The container body A illustrated in FIG. 1 and FIG. 2 is divided and formed into multiple chambers from a cylindrical film, but when it is necessary to change the laminated material of the film between the upper drug chamber and the lower drug chamber The first drug chamber and the second drug chamber may be manufactured separately and connected by a weak seal part to form a container body. If necessary, the container body is divided into a front seat and a rear seat. You may form the chemical | medical chamber by bonding together the film which carried out. Here, the drug sealed in the multi-chamber container may be a liquid or powdered form for the drug sealed in the drug chamber on the side not covered by the liquid drug in the drug chamber on the side not covered by the covering member. The material state is not particularly limited.

  When using chemicals and chemicals that deteriorate or deteriorate when exposed to light, a film having a light shielding property is laminated on the film forming the chemical chamber. Normally, one side of the drug room is formed with a laminated film with an aluminum foil layer added, and the other side is formed with a laminated film without an aluminum foil layer, and the laminated film with no aluminum foil layer added. On the side, a cover sheet made of peelable aluminum and polyethylene terephthalate is coated. This is in order to avoid using the double-sided aluminum foil layer without observing the sealed drug state and not knowing the alteration.

  The structure of the weak seal 5 is not particularly limited as long as each drug chamber can be partitioned in a liquid-tight manner, and each drug chamber can be communicated quickly when the container is pressed. For example, when a weak seal portion is formed by biting a weak seal portion forming sheet into the weak seal portion, the innermost layer material and a resin having low welding strength are usually used for the sheet. For example, when the innermost layer is polyethylene, a polymer blend in which polyethylene and polypropylene are mixed at 3: 7 to 7: 3 is suitably employed. By using the resin of the innermost layer and the resin having a weak welding strength, weak seals are possible because the portions not welded to the innermost layer are scattered in the weak seal portion. When the innermost layer is a polymer blend of polyethylene and polypropylene, the container body is welded at 200 to 250 ° C., and the weak seal portion forming sheet is welded at around 120 ° C. to form a weak seal portion. Thus, it is possible to achieve a structure in which only the weak seal portion can be peeled without peeling off the peripheral edge of the container due to pressing during communication.

  The port 3 is a cylindrical body, and a stopper is attached to the piercing opening at the bottom of the port. Usually, isoprene rubber, butadiene rubber or the like is used as the rubber of the plug.

  The covering member 4 is provided by contracting the upper or lower drug chamber so that each chamber cannot be detached when the chamber is not in communication, and is formed of, for example, a shrink film made of polyethylene or PET. When the covering member 4 is attached to the container main body A, it is contracted by heat treatment and tightened and attached. At this time, depending on the processing conditions, a member that can be partially contracted may be used so as not to contract too much. More preferred. For example, a polypropylene sheet that is a non-shrinkable portion and a PET shrink film that is a shrinkable portion are joined together. Since only the shrink film made of PET is shrunk by heat treatment, it can be designed appropriately so that tightening of the band after shrinkage is preferable by forming it so as to shrink partially. It does not shrink too much and is not easily detached. Also, since the heat shrinkage is applied after attaching to the multi-chamber container, it can be easily fixed.

  As a means to be destroyed when the medicine chamber which the covering member 4 is covering expands, a broken line-shaped cut 41 is provided as shown in FIGS. At this time, the broken line-shaped cut 41 may be formed from the upper end or the lower end to the vicinity of the center as shown in FIGS. 1 and 2, or may be formed from the upper end or the lower end to the other end. The shape of the broken line is a simple dotted line or the like, and the end point position and shape of the cut are not particularly limited.

  Furthermore, a grip portion 42 may be provided on the covering member 4 so that the covering member 4 is easily detached when the covering member 4 is detached from the container body A.

  The hard member 43 may be provided in the piercing opening so that the infusion device cannot be communicated by mistake from above the covering member. The material and shape of the puncture blocking member is not particularly limited as long as it can block the puncture of the rubber plug 31 with the puncture needle of the infusion line. Examples of the material include PET, PP, PC, and the like. The shape may also be a disc shape or a hemisphere with a curved surface on the lower side. Alternatively, a piercing port is provided so as to form a recess with respect to the lowermost surface of the port so that the hard member does not deviate from the piercing port, and the hard member is engaged with the recess. Such a hard member 43 is attached with, for example, a tamper seal 44 so as not to expose the port piercing opening, and then the covering member is attached to the container body. In particular, as shown in FIG. 4, in the case where the covering member covers the port, by providing a hard member 43, the tamper seal is peeled off from the port when the covering member is covered by the port. Since it is impossible to detach the hard member from the piercing opening, it is impossible to puncture the infusion line, so that it can be reliably prevented from being used when not connected. When the covering member is detached, the hard member can be removed and used quickly.

  A method of using the medical multi-chamber container shown in FIG. 1 will be described with reference to FIG. First, the upper drug chamber 1 is pressed from the outside, the weak seal portion 5 is peeled off, and the lower drug chamber 1 and the upper drug chamber 2 are communicated. By communicating, the medicine in the upper medicine chamber 2 moves to the lower medicine chamber 1, the lower medicine chamber 1 expands, and its thickness increases. By increasing the thickness, the broken line-shaped cuts 41 formed in the covering member 4 are broken, and the substantial tightening of the covering member 4 to the drug container A is released. Therefore, the covering member 4 can be detached from the container body A, and when the covering member 4 is pulled out by grasping the grip portion 42, the communication port 31 covered by the covering member 4 is exposed. In this way, the upper drug chamber containing the non-chemical solution is pressed to communicate with each drug chamber, and the chemical solution flows into the lower drug chamber to increase the thickness. Has a linked structure. By adopting the above structure, since the covering member covers the communication port until the multiple chambers communicate with each other, the infusion line can be prevented from being punctured, and there is no possibility of administering the drug solution to the patient in an unconnected state.

  Since the medical multi-chamber container of the present invention is provided with the flexible covering member that can be attached to the outer periphery of the drug container as described above, the medical multi-chamber container can be easily used without depending on the shape of the drug container. Since the covering member is destroyed at the same time as the respective drug chambers communicate with each other, there is no possibility that they will not come off. In addition, since the port piercing port is covered in a non-communication state, an unadjusted medicine that remains uncommitted is not erroneously administered to a patient, and thus can be suitably used for medical treatment.

The figure of one embodiment of the type which coat | covered the port of the medical multiple chamber container of this invention. The figure of one embodiment example of the type which coat | covered the suspension hole of the medical multiple-chamber container of this invention. The figure of one embodiment of the type which provided the holding part in the coating | coated member of the medical multiple-chamber container of this invention. The figure which provided the hard member in the port penetration port of the medical multiple-chamber container of this invention. The figure of the use condition of the medical multiple-chamber container of this invention.

Explanation of symbols

A Container body 1 Lower drug chamber 2 Upper drug chamber 3 Port 31 Plug body 4 Cover member 41 Broken line-shaped cut 42 Gripping part 43 Hard member 44 Tamper seal 5 Weak seal part 6 Hanging hole

Claims (8)

A medical multi-chamber container containing a medicine,
A flexible container body that is liquid-tightly divided into an upper drug chamber and a lower drug chamber by a peelable weak seal, and at least the upper drug chamber is filled with a drug solution;
A suspension hole provided in the upper part of the container body;
A port having a piercing opening provided in the lower part of the container body so as to communicate with the lower drug chamber;
A bag-shaped covering member that shrinks and covers the entire port so as to relate to the outer periphery of the lower drug chamber,
The covering member presses the upper drug chamber, peels off the weak seal portion, is broken when each drug chamber is communicated, and can be removed from the container body,
Medical multi-chamber container.   The medical multi-chamber container according to claim 1, further comprising a grip portion in a region below the covering member and not related to the container body and the port. The medical multi-chamber container according to claim 1 or 2, wherein the covering member has a broken line-like cut from the upper end of the covering member downward so as to be easily broken. A medical multi-chamber container containing a medicine,
A flexible container body that is liquid-tightly divided into an upper drug chamber and a lower drug chamber by a peelable weak seal portion, and at least the lower drug chamber is sealed with a drug solution;
A suspension hole provided in the upper part of the container body;
A port having a piercing opening provided in the lower part of the container body so as to communicate with the lower drug chamber;
A covering member that shrinks and covers the entire suspension hole so as to relate to the outer periphery of the upper drug chamber,
The covering member presses the lower drug chamber, peels off the weak seal portion, is broken when each drug chamber is communicated, and can be removed from the container body,
Medical multi-chamber container.   The medical multi-chamber container according to claim 4, wherein the medical multi-chamber container has a grip portion in an area which is an upper part of the covering member and is not related to the container main body.   The medical multi-chamber container according to claim 4 or 5, wherein the covering member has a broken line-like cut from the lower end of the covering member so as to be easily broken.   The medical multi-chamber container according to any one of claims 1 to 6, wherein at least a part of the covering member is formed of a shrink film.   The medical multi-chamber container according to any one of claims 1 to 7, wherein a hard member is attached to the piercing opening.

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