JP2007537243A - ２０位にてインテグリンアンタゴニストと接合した７−ｔ−ブトキシイミノメチルカンプトテシン - Google Patents

２０位にてインテグリンアンタゴニストと接合した７−ｔ−ブトキシイミノメチルカンプトテシン Download PDF

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Publication number
JP2007537243A
JP2007537243A JP2007512729A JP2007512729A JP2007537243A JP 2007537243 A JP2007537243 A JP 2007537243A JP 2007512729 A JP2007512729 A JP 2007512729A JP 2007512729 A JP2007512729 A JP 2007512729A JP 2007537243 A JP2007537243 A JP 2007537243A
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JP
Japan
Prior art keywords
cancer
branched
group
phe
linear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007512729A
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English (en)
Japanese (ja)
Other versions
JP2007537243A5 (cg-RX-API-DMAC7.html
Inventor
アルマ・ダル・ポッツォ
セルジョ・ペンコ
ルーチョ・メルリーニ
ジュゼッペ・ジャンニーニ
マリア・オルネッラ・ティンティ
クラウディオ・ピサーノ
フランコ・ツニーノ
ドメニコ・アッロアッティ
ロレダナ・ヴェシ
サブリナ・ダッラヴァッレ
ミン・ホン・ニ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori, Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Publication of JP2007537243A publication Critical patent/JP2007537243A/ja
Publication of JP2007537243A5 publication Critical patent/JP2007537243A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2007512729A 2004-05-13 2005-04-28 ２０位にてインテグリンアンタゴニストと接合した７−ｔ−ブトキシイミノメチルカンプトテシン Withdrawn JP2007537243A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000242A ITRM20040242A1 (it) 2004-05-13 2004-05-13 "7-t-butossiimminometilcamptotecina coniugata in posizione 20 con antagonisti delle integrine.
PCT/IT2005/000245 WO2005110486A2 (en) 2004-05-13 2005-04-28 7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists

Publications (2)

Publication Number Publication Date
JP2007537243A true JP2007537243A (ja) 2007-12-20
JP2007537243A5 JP2007537243A5 (cg-RX-API-DMAC7.html) 2008-06-26

Family

ID=35124315

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007512729A Withdrawn JP2007537243A (ja) 2004-05-13 2005-04-28 ２０位にてインテグリンアンタゴニストと接合した７−ｔ−ブトキシイミノメチルカンプトテシン

Country Status (12)

Country Link
US (1) US7589099B2 (cg-RX-API-DMAC7.html)
EP (1) EP1747020A2 (cg-RX-API-DMAC7.html)
JP (1) JP2007537243A (cg-RX-API-DMAC7.html)
CN (1) CN101065150A (cg-RX-API-DMAC7.html)
AR (1) AR049337A1 (cg-RX-API-DMAC7.html)
AU (1) AU2005243883A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0511077A (cg-RX-API-DMAC7.html)
CA (1) CA2562569A1 (cg-RX-API-DMAC7.html)
IT (1) ITRM20040242A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA06012885A (cg-RX-API-DMAC7.html)
TW (1) TW200538123A (cg-RX-API-DMAC7.html)
WO (1) WO2005110486A2 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20040239A1 (it) * 2004-05-13 2004-08-13 Sigma Tau Ind Farmaceuti Derivati ciclopeptidici ad attivita' antintegrine.
WO2011086553A1 (en) * 2010-01-13 2011-07-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Cyclic peptides, compositions comprising them and uses thereof as nucleases of nucleotidic macromolecules
CN103275094B (zh) * 2013-05-08 2015-07-08 中国农业科学院植物保护研究所 (20s)-喜树碱的衍生物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19815812A1 (de) * 1998-04-08 1999-10-14 Bayer Ag Modifizierte Cytostatika
ES2175919T3 (es) * 1999-03-09 2002-11-16 Sigma Tau Ind Farmaceuti Derivados del camptothecin con actividad antitumoral.
ITRM20020306A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Esteri in posizione 20 di camptotecine.

Also Published As

Publication number Publication date
TW200538123A (en) 2005-12-01
BRPI0511077A (pt) 2007-12-26
AU2005243883A1 (en) 2005-11-24
WO2005110486A3 (en) 2007-03-08
CN101065150A (zh) 2007-10-31
EP1747020A2 (en) 2007-01-31
AR049337A1 (es) 2006-07-19
MXPA06012885A (es) 2007-08-14
US20070225311A1 (en) 2007-09-27
WO2005110486A2 (en) 2005-11-24
CA2562569A1 (en) 2005-11-24
ITRM20040242A1 (it) 2004-08-13
US7589099B2 (en) 2009-09-15

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