JP2007536260A - 虚血性および腎毒性障害の軽減および改善用ngal - Google Patents
虚血性および腎毒性障害の軽減および改善用ngal Download PDFInfo
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- JP2007536260A JP2007536260A JP2007511623A JP2007511623A JP2007536260A JP 2007536260 A JP2007536260 A JP 2007536260A JP 2007511623 A JP2007511623 A JP 2007511623A JP 2007511623 A JP2007511623 A JP 2007511623A JP 2007536260 A JP2007536260 A JP 2007536260A
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- ngal
- kidney
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
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- Oncology (AREA)
- Environmental Sciences (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56864504P | 2004-05-06 | 2004-05-06 | |
| US61556604P | 2004-10-01 | 2004-10-01 | |
| PCT/US2005/015799 WO2005107793A2 (en) | 2004-05-06 | 2005-05-06 | Ngal for reduction and amelioration of ischemic and nephrotoxic injuries |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007536260A true JP2007536260A (ja) | 2007-12-13 |
| JP2007536260A5 JP2007536260A5 (https=) | 2008-03-06 |
Family
ID=35320735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007511623A Withdrawn JP2007536260A (ja) | 2004-05-06 | 2005-05-06 | 虚血性および腎毒性障害の軽減および改善用ngal |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US7776824B2 (https=) |
| EP (2) | EP1750500B1 (https=) |
| JP (1) | JP2007536260A (https=) |
| AU (1) | AU2005240190C1 (https=) |
| CA (1) | CA2565701A1 (https=) |
| WO (1) | WO2005107793A2 (https=) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010126055A1 (ja) * | 2009-04-27 | 2010-11-04 | 国立大学法人新潟大学 | 腎障害の検出用マーカーとしての尿中メガリンの使用 |
| JP2012509477A (ja) * | 2008-11-21 | 2012-04-19 | ファディア・アクチボラグ | 急性腎臓損傷を検出またはモニターするための方法、装置およびキット |
| US8663931B2 (en) | 2009-04-27 | 2014-03-04 | Niigata University | Method for detecting renal disease comprising measuring human megalin in urine |
| US8703430B2 (en) | 2006-03-28 | 2014-04-22 | Niigata University | Method for measuring human megalin |
| JP2017160182A (ja) * | 2015-12-23 | 2017-09-14 | 國立台湾師範大学 | 好中球ゼラチナーゼ結合性リポカリンを含む多発性嚢胞腎の予防または治療用の医薬組成物 |
| CN110996985A (zh) * | 2017-06-23 | 2020-04-10 | Aki医疗有限公司 | 用于预防和治疗急性肾损伤的组合物 |
| CN112057470A (zh) * | 2014-09-29 | 2020-12-11 | 弗莱德哈钦森癌症研究中心 | 使用应激蛋白质诱导剂诱导获得性细胞抗性的组合物、试剂盒及方法 |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| AU2005288522B2 (en) * | 2004-09-28 | 2012-06-28 | Quark Pharmaceuticals, Inc. | Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases |
| PL1831699T3 (pl) * | 2004-12-20 | 2010-04-30 | Antibodyshop As | Oznaczanie lipokaliny neutrofilowej związanej z żelatynazą (NGAL) jako markera diagnostycznego dla zaburzeń nerek |
| WO2006078717A2 (en) * | 2005-01-19 | 2006-07-27 | Beth Israel Deaconess Medical Center | Lipocalin 2 for the treatment, prevention, and management of cancer metastasis, angiogenesis, and fibrosis |
| US20070037232A1 (en) * | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
| US20080090304A1 (en) * | 2006-10-13 | 2008-04-17 | Barasch Jonathan Matthew | Diagnosis and monitoring of chronic renal disease using ngal |
| US7825099B2 (en) * | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
| US7662578B2 (en) | 2006-04-21 | 2010-02-16 | Children's Hospital Medical Center | Method and kit for the early detection of impaired renal status |
| US20080090765A1 (en) * | 2006-05-25 | 2008-04-17 | The Trustees Of Columbia University In The City Of New York | Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage |
| WO2007137584A1 (en) | 2006-05-30 | 2007-12-06 | Antibodyshop A/S | Methods and devices for rapid assessment of severity of injury |
| WO2008017306A1 (en) * | 2006-08-07 | 2008-02-14 | Antibodyshop A/S | Diagnostic test to exclude significant renal injury |
| WO2008060607A2 (en) | 2006-11-14 | 2008-05-22 | Biosite Incorporated | Methods and compositions for monitoring and risk prediction in cardiorenal syndrome |
| EP2095106B1 (en) * | 2006-11-14 | 2013-03-20 | Alere San Diego, Inc. | Methods and compositions for diagnosis and prognosis of renal artery stenosis |
| JP5128828B2 (ja) * | 2007-02-16 | 2013-01-23 | 月桂冠株式会社 | 抗炎症剤及び抗酸化剤 |
| EP2137538B1 (en) | 2007-03-21 | 2014-04-09 | Bioporto Diagnostics A/s | Diagnostic test for renal injury |
| WO2009001359A2 (en) * | 2007-06-27 | 2008-12-31 | Quark Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of pro-apoptotic genes |
| US8846036B2 (en) | 2007-10-19 | 2014-09-30 | Abbott Laboratories | Antibodies that bind to mammalian NGAL and uses thereof |
| EP2257813A4 (en) * | 2008-03-12 | 2011-11-02 | Univ Columbia | NGAL WITH HIGH MOLECULAR WEIGHT AS BIOMARKER FOR CHRONIC KIDNEY DISEASE |
| US8030097B2 (en) * | 2008-04-30 | 2011-10-04 | Versitech Limited and R & C Biogenius Limited | Lipocalin-2 as a prognostic and diagnostic marker for heart and stroke risks |
| US8227439B2 (en) | 2008-05-15 | 2012-07-24 | Morphotek, Inc. | Treatment of metastatic tumors |
| US20100122355A1 (en) * | 2008-07-16 | 2010-05-13 | Neal Paragas | Transgenic Reporter Mouse and Method for Use |
| EP2330897A4 (en) * | 2008-09-18 | 2013-11-27 | Univ Columbia | NGAL-BINDING SIDEROPHORES AND THEIR USE FOR THE TREATMENT OF IRON DEFICIENCY AND IRON SURPLUS |
| US20110212104A1 (en) * | 2008-11-03 | 2011-09-01 | Schering Corporation | Inflammatory bowel disease biomarkers and related methods of treatment |
| US20100233739A1 (en) * | 2009-02-12 | 2010-09-16 | Jonathan Barasch | Use of urinary ngal to diagnose unilateral and bilateral urinary obstruction |
| US20100233740A1 (en) * | 2009-02-12 | 2010-09-16 | Jonathan Barasch | Use of urinary ngal to distinguish kidney disease and predict mortality in subjects with cirrhosis |
| EP2292284B1 (en) * | 2009-09-04 | 2014-02-26 | B. Braun Avitum AG | Kidney substitution treatment machine |
| JP5858932B2 (ja) | 2010-02-04 | 2016-02-10 | モルフォテック, インコーポレイテッド | クロロトキシンポリペプチドおよびコンジュゲートならびにその使用 |
| WO2011140554A1 (en) * | 2010-05-07 | 2011-11-10 | The Trustees Of Columbia University In The City Of New York | Ngal and urinary tract infection |
| JP2013532126A (ja) | 2010-05-11 | 2013-08-15 | フレッド ハッチンソン キャンサー リサーチ センター | クロロトキシン変異体、コンジュゲート、およびそれらを使用する方法 |
| ES2667066T3 (es) | 2010-05-24 | 2018-05-09 | The Trustees Of Columbia University In The City Of New York | Proteínas NGAL mutantes y usos de las mismas |
| ES2606140T3 (es) * | 2010-10-01 | 2017-03-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Métodos para predecir la progresión y tratar una enfermedad renal crónica en un paciente |
| EP2697389A4 (en) * | 2011-04-11 | 2014-09-10 | Univ Columbia | ABOUT OSTEOBLASTEN EXPRESSED LIPOCALIN 2 FOR THE ADJUSTMENT OF GLUCOSE COMPOUND CHANGES |
| WO2012167092A2 (en) * | 2011-06-03 | 2012-12-06 | The Regents Of The University Of Colorado, A Body Corporate | Uses of and methods of treatment with cystathionine |
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| CN105008393A (zh) | 2012-12-10 | 2015-10-28 | 弗莱德哈钦森癌症研究中心 | 用于筛选的方法 |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
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| WO2017027858A1 (en) | 2015-08-12 | 2017-02-16 | The Trustees Of Columbia University In The City Of New York | Methods of treating volume depletion and kidney injury |
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| AU698350B2 (en) * | 1995-04-12 | 1998-10-29 | Oy Medix Biochemica Ab | Methods and test kits for diagnosis of periodontal diseases and for predicting the risk of progression thereof |
| WO1997044460A1 (en) | 1996-05-24 | 1997-11-27 | Biogen, Inc. | Modulators of tissue regeneration |
| AUPP784398A0 (en) * | 1998-12-21 | 1999-01-21 | Monash University | Kidney disease detection and treatment |
| US6114123A (en) * | 1999-06-14 | 2000-09-05 | Incyte Pharmaceuticals, Inc. | Lipocalin family protein |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| GB0215509D0 (en) * | 2002-07-04 | 2002-08-14 | Novartis Ag | Marker genes |
| AU2003247303A1 (en) * | 2002-07-17 | 2004-02-02 | Index Pharmaceuticals Ab | Antisense compounds, methods and compositions for treating ngal-related inflammatory disorders |
| MXPA05010385A (es) * | 2003-03-27 | 2006-03-08 | Childrens Hosp Medical Center | Metodo y estuche para detectar el inicio temprano de lesion celular tubular renal. |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
-
2005
- 2005-05-06 CA CA002565701A patent/CA2565701A1/en not_active Abandoned
- 2005-05-06 EP EP05749675.4A patent/EP1750500B1/en not_active Expired - Lifetime
- 2005-05-06 EP EP13178086.8A patent/EP2661963B1/en not_active Expired - Lifetime
- 2005-05-06 WO PCT/US2005/015799 patent/WO2005107793A2/en not_active Ceased
- 2005-05-06 JP JP2007511623A patent/JP2007536260A/ja not_active Withdrawn
- 2005-05-06 US US11/123,364 patent/US7776824B2/en not_active Expired - Fee Related
- 2005-05-06 AU AU2005240190A patent/AU2005240190C1/en not_active Ceased
-
2010
- 2010-06-17 US US12/817,566 patent/US8247376B2/en not_active Expired - Fee Related
-
2012
- 2012-01-27 US US13/359,772 patent/US20120219956A1/en not_active Abandoned
-
2013
- 2013-03-14 US US13/804,169 patent/US20130295589A1/en not_active Abandoned
-
2016
- 2016-02-26 US US15/054,551 patent/US20170003298A1/en not_active Abandoned
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8703430B2 (en) | 2006-03-28 | 2014-04-22 | Niigata University | Method for measuring human megalin |
| JP2012509477A (ja) * | 2008-11-21 | 2012-04-19 | ファディア・アクチボラグ | 急性腎臓損傷を検出またはモニターするための方法、装置およびキット |
| WO2010126055A1 (ja) * | 2009-04-27 | 2010-11-04 | 国立大学法人新潟大学 | 腎障害の検出用マーカーとしての尿中メガリンの使用 |
| US8628930B2 (en) | 2009-04-27 | 2014-01-14 | Niigata University | Use of megalin in urine as marker for detecting renal disorder |
| US8663931B2 (en) | 2009-04-27 | 2014-03-04 | Niigata University | Method for detecting renal disease comprising measuring human megalin in urine |
| CN112057470A (zh) * | 2014-09-29 | 2020-12-11 | 弗莱德哈钦森癌症研究中心 | 使用应激蛋白质诱导剂诱导获得性细胞抗性的组合物、试剂盒及方法 |
| CN112057470B (zh) * | 2014-09-29 | 2022-11-15 | 弗莱德哈钦森癌症研究中心 | 使用应激蛋白质诱导剂诱导获得性细胞抗性的组合物、试剂盒及方法 |
| US11878029B2 (en) | 2014-09-29 | 2024-01-23 | Fred Hutchinson Cancer Center | Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers |
| US12083145B2 (en) | 2014-09-29 | 2024-09-10 | Fred Hutchinson Cancer Research Center | Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers |
| US10307461B2 (en) | 2015-12-23 | 2019-06-04 | National Taiwan Normal University | Method of preventing polycystic kidney disease and PKD animal model with exogenous neutrophil gelatinase-associated lipocalin |
| JP2017160182A (ja) * | 2015-12-23 | 2017-09-14 | 國立台湾師範大学 | 好中球ゼラチナーゼ結合性リポカリンを含む多発性嚢胞腎の予防または治療用の医薬組成物 |
| CN110996985A (zh) * | 2017-06-23 | 2020-04-10 | Aki医疗有限公司 | 用于预防和治疗急性肾损伤的组合物 |
| JP2020524714A (ja) * | 2017-06-23 | 2020-08-20 | エーケーアイ・セラピューティクス・エーぺーエス | 急性腎障害の予防及び治療のための組成物 |
| US11471445B2 (en) | 2017-06-23 | 2022-10-18 | Aki Therapeutics Aps | Compositions for the prevention and treatment of acute renal injury |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1750500B1 (en) | 2015-07-08 |
| AU2005240190C1 (en) | 2012-01-19 |
| EP1750500A2 (en) | 2007-02-14 |
| AU2005240190B2 (en) | 2011-08-25 |
| US7776824B2 (en) | 2010-08-17 |
| US20170003298A1 (en) | 2017-01-05 |
| EP2661963A1 (en) | 2013-11-13 |
| US20100254970A1 (en) | 2010-10-07 |
| US20120219956A1 (en) | 2012-08-30 |
| US8247376B2 (en) | 2012-08-21 |
| AU2005240190A1 (en) | 2005-11-17 |
| US20130295589A1 (en) | 2013-11-07 |
| WO2005107793A3 (en) | 2005-12-29 |
| CA2565701A1 (en) | 2005-11-17 |
| WO2005107793A2 (en) | 2005-11-17 |
| EP2661963B1 (en) | 2015-09-16 |
| EP1750500A4 (en) | 2009-09-09 |
| US20050261191A1 (en) | 2005-11-24 |
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