JP2007535658A5 - - Google Patents
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- Publication number
- JP2007535658A5 JP2007535658A5 JP2006546922A JP2006546922A JP2007535658A5 JP 2007535658 A5 JP2007535658 A5 JP 2007535658A5 JP 2006546922 A JP2006546922 A JP 2006546922A JP 2006546922 A JP2006546922 A JP 2006546922A JP 2007535658 A5 JP2007535658 A5 JP 2007535658A5
- Authority
- JP
- Japan
- Prior art keywords
- matrix
- sulfonamide
- ligand
- porous support
- carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011159 matrix material Substances 0.000 claims 9
- 230000027455 binding Effects 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 5
- 229960001663 sulfanilamide Drugs 0.000 claims 5
- 238000000926 separation method Methods 0.000 claims 4
- FDDDEECHVMSUSB-UHFFFAOYSA-N Sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 claims 3
- 239000000969 carrier Substances 0.000 claims 3
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 102000004965 antibodies Human genes 0.000 claims 2
- 108090001123 antibodies Proteins 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000000565 sulfonamide group Chemical group 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 229940093912 Gynecological Sulfonamides Drugs 0.000 claims 1
- 230000003213 activating Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 150000007824 aliphatic compounds Chemical class 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 230000003100 immobilizing Effects 0.000 claims 1
- 229940079867 intestinal antiinfectives Sulfonamides Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229940005938 ophthalmologic antiinfectives Sulfonamides Drugs 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 229940026752 topical Sulfonamides Drugs 0.000 claims 1
Claims (10)
- 適宜スペーサーアームを介してリガンドが固定化された多孔質担体からなる分離マトリックスであって、前記リガンドが、スルホニルのＲ基が脂肪族化合物である１以上のスルホンアミドを含む分離マトリックス。
- 前記スルホンアミドがその窒素を介して前記多孔質担体に結合している、請求項１記載のマトリックス。
- 前記スルホンアミドがその硫黄を介して前記多孔質担体に結合している、請求項１記載のマトリックス。
- 前記Ｒ基がメチル基である、請求項１乃至請求項３のいずれか１項記載のマトリックス。
- 前記リガンドが、前記担体に固定化されたポリマーの繰返し単位として存在する、請求項１乃至請求項４のいずれか１項記載のマトリックス。
- 前記担体が架橋多糖である、請求項１乃至請求項５のいずれか１項記載のマトリックス。
- 請求項１乃至請求項６のいずれか１項記載の分離マトリックスを充填したクロマトグラフィーカラム。
- 実質的に無菌である、請求項７記載のクロマトグラフィーカラム。
- アミン及び／又はポリアミンを多孔質担体に固定化する第１の段階と、前記アミンをスルホニル化して脂肪族スルホンアミドリガンドを形成する後続の段階とを含む抗体分離用マトリックスの調製方法。
- 多孔質担体を活性化する第１の段階と、スルホンアミドを、その硫黄を介して前記活性化部位に付着させて脂肪族スルホンアミドリガンドを形成する後続の段階とを含む抗体分離用マトリックスの調製方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0303532-6 | 2003-12-23 | ||
| SE0303532A SE0303532D0 (sv) | 2003-12-23 | 2003-12-23 | Purification of immunoglobulins |
| PCT/SE2004/002007 WO2005061543A1 (en) | 2003-12-23 | 2004-12-21 | Purification of immunoglobulins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007535658A JP2007535658A (ja) | 2007-12-06 |
| JP2007535658A5 true JP2007535658A5 (ja) | 2008-02-14 |
| JP4739233B2 JP4739233B2 (ja) | 2011-08-03 |
Family
ID=30768847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546922A Active JP4739233B2 (ja) | 2003-12-23 | 2004-12-21 | 免疫グロブリンの精製 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20070151928A1 (ja) |
| EP (1) | EP1697416B1 (ja) |
| JP (1) | JP4739233B2 (ja) |
| CN (1) | CN100516086C (ja) |
| AT (1) | ATE391729T1 (ja) |
| AU (1) | AU2004303746B2 (ja) |
| CA (1) | CA2549923A1 (ja) |
| DE (1) | DE602004013040T2 (ja) |
| ES (1) | ES2304638T3 (ja) |
| SE (1) | SE0303532D0 (ja) |
| WO (1) | WO2005061543A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0401665D0 (sv) | 2004-06-24 | 2004-06-24 | Amersham Biosciences Ab | Purification of immunoglobulins |
| JP4677623B2 (ja) * | 2005-05-16 | 2011-04-27 | 独立行政法人産業技術総合研究所 | 液体クロマトグラフィー用担体、該担体を充填したクロマトグラフィー用カラム、及び該カラムを用いた有機物の分離方法 |
| SE529259C2 (sv) * | 2005-08-31 | 2007-06-12 | Ge Healthcare Bio Sciences Ab | Tillverkning av kromarografimatriser, en kromarografimatris, en vätskekromatografikolonn, prcess för att isolera målföreningar och användning av en kromarografimatris för vätskekromatografi |
| WO2007064281A1 (en) * | 2005-12-02 | 2007-06-07 | Ge Healthcare Bio-Sciences Ab | Hydrophobic interaction chromatography |
| WO2008121042A1 (en) * | 2007-03-30 | 2008-10-09 | Ge Healthcare Bio-Sciences Ab | Purification of immunoglobulins |
| JP2014507649A (ja) * | 2011-01-18 | 2014-03-27 | バクスター・インターナショナル・インコーポレイテッド | ヒト血液中の抗βアミロイド抗体の測定 |
| CN102276840B (zh) * | 2011-05-06 | 2012-08-01 | 中国药科大学 | 一种樟脑磺酰胺掺杂乙烷桥键球形介孔硅胶 |
| EP2570183A1 (en) * | 2011-09-15 | 2013-03-20 | InstrAction GmbH | Sorbent comprising on its surface an aliphatic unit for the purification of organic molecules |
| WO2014078729A1 (en) * | 2012-11-15 | 2014-05-22 | Genentech, Inc. | IONIC STRENGTH-MEDIATED pH GRADIENT ION EXCHANGE CHROMATOGRAPHY |
| WO2015138928A2 (en) * | 2014-03-14 | 2015-09-17 | Bio-Rad Laboratories, Inc. | Mixed mode ligands |
| WO2015137860A1 (en) * | 2014-03-14 | 2015-09-17 | Ge Healthcare Bio-Sciences Ab | Separation matrices for purification of biological particles |
| WO2015168383A1 (en) * | 2014-05-02 | 2015-11-05 | W. R. Grace & Co.-Conn. | Functionalized support material and methods of making and using functionalized support material |
| WO2020109162A1 (en) * | 2018-11-28 | 2020-06-04 | Cube Biotech Gmbh | Solid-phase chelator material, method for producing thereof and use thereof for the purification of proteins |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4212905A (en) * | 1976-06-30 | 1980-07-15 | Board of Reagents, for and on behalf of the University of Florida | Method of coating supports using addition copolymers of aminimides |
| JPS6145773A (ja) * | 1984-08-07 | 1986-03-05 | テルモ株式会社 | 体液浄化材 |
| DE3664729D1 (en) * | 1985-04-09 | 1989-09-07 | Terumo Corp | Immunoglobulin adsorbent and adsorption apparatus |
| US4752398A (en) * | 1985-08-05 | 1988-06-21 | Holbein Bruce E | Method for removing mercury and other related metals from a liquid medium |
| JPS6253669A (ja) * | 1985-08-31 | 1987-03-09 | テルモ株式会社 | 免疫グロブリン物質の吸着材および吸着装置 |
| JPS639450A (ja) * | 1986-06-28 | 1988-01-16 | テルモ株式会社 | 体液成分分離材およびこれを備えた体液成分分離装置 |
| US5240602A (en) * | 1987-06-08 | 1993-08-31 | Chromatochem, Inc. | Chromatographic material |
| DE3811042A1 (de) * | 1988-03-31 | 1989-10-19 | Merck Patent Gmbh | Ionenaustauscher |
| US5043062A (en) * | 1989-02-21 | 1991-08-27 | Eastman Kodak Company | High performance affinity chromatography column comprising non-porous, nondisperse polymeric packing material |
| JP2558007B2 (ja) * | 1990-10-31 | 1996-11-27 | 株式会社資生堂 | 液体クロマトグラフィー用充填剤およびその製造方法 |
| US5410648A (en) * | 1991-08-30 | 1995-04-25 | International Business Machines Corporation | Debugging system wherein multiple code views are simultaneously managed |
| US6117996A (en) * | 1995-09-20 | 2000-09-12 | Novo Nordisk A/S | Triazine based ligands and use thereof |
| SE9600590D0 (sv) * | 1996-02-19 | 1996-02-19 | Pharmacia Biotech Ab | Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris |
| AU729039C (en) * | 1996-08-30 | 2001-08-02 | Upfront Chromatography A/S | Isolation of immunoglobulins |
| US5953526A (en) * | 1997-11-10 | 1999-09-14 | Internatinal Business Machines Corp. | Object oriented programming system with displayable natural language documentation through dual translation of program source code |
| WO2003046063A1 (en) * | 2001-11-26 | 2003-06-05 | Amersham Biosciences Ab | Post-modification of a porous support |
| WO2007064281A1 (en) * | 2005-12-02 | 2007-06-07 | Ge Healthcare Bio-Sciences Ab | Hydrophobic interaction chromatography |
-
2003
- 2003-12-23 SE SE0303532A patent/SE0303532D0/xx unknown
-
2004
- 2004-12-21 DE DE200460013040 patent/DE602004013040T2/de active Active
- 2004-12-21 US US10/584,714 patent/US20070151928A1/en not_active Abandoned
- 2004-12-21 ES ES04809180T patent/ES2304638T3/es active Active
- 2004-12-21 AU AU2004303746A patent/AU2004303746B2/en not_active Ceased
- 2004-12-21 WO PCT/SE2004/002007 patent/WO2005061543A1/en active Application Filing
- 2004-12-21 CA CA 2549923 patent/CA2549923A1/en not_active Abandoned
- 2004-12-21 EP EP04809180A patent/EP1697416B1/en active Active
- 2004-12-21 JP JP2006546922A patent/JP4739233B2/ja active Active
- 2004-12-21 CN CNB2004800382829A patent/CN100516086C/zh active Active
- 2004-12-21 AT AT04809180T patent/ATE391729T1/de not_active IP Right Cessation
-
2010
- 2010-02-22 US US12/709,556 patent/US8685248B2/en active Active
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