JP2007530694A - ナトリウムチャネル遮断薬としてのビアリール置換ピラジノン - Google Patents
ナトリウムチャネル遮断薬としてのビアリール置換ピラジノン Download PDFInfo
- Publication number
- JP2007530694A JP2007530694A JP2007506398A JP2007506398A JP2007530694A JP 2007530694 A JP2007530694 A JP 2007530694A JP 2007506398 A JP2007506398 A JP 2007506398A JP 2007506398 A JP2007506398 A JP 2007506398A JP 2007530694 A JP2007530694 A JP 2007530694A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- effective amount
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC=CC=CC(c1cccc(C2=NC(*)=C(*)NC2=O)c1)=*C Chemical compound CC=CC=CC(c1cccc(C2=NC(*)=C(*)NC2=O)c1)=*C 0.000 description 4
- VLYFSYWPYKMYIO-UHFFFAOYSA-N CC(c1cc(-c(c(F)ccc2)c2OC(F)(F)F)ccc1)=O Chemical compound CC(c1cc(-c(c(F)ccc2)c2OC(F)(F)F)ccc1)=O VLYFSYWPYKMYIO-UHFFFAOYSA-N 0.000 description 1
- BBSDMELJSOYPSO-UHFFFAOYSA-N CN(C=C(C(N)=O)N=C1c2cc(-c3c(C(F)(F)F)cccc3)ccc2)C1=O Chemical compound CN(C=C(C(N)=O)N=C1c2cc(-c3c(C(F)(F)F)cccc3)ccc2)C1=O BBSDMELJSOYPSO-UHFFFAOYSA-N 0.000 description 1
- JUACNALZYSWQIG-UHFFFAOYSA-N OC(C(N=C1c2cc(-c(cccc3)c3OC(F)(F)F)ccc2)=CNC1=O)=O Chemical compound OC(C(N=C1c2cc(-c(cccc3)c3OC(F)(F)F)ccc2)=CNC1=O)=O JUACNALZYSWQIG-UHFFFAOYSA-N 0.000 description 1
- DLZRFSGLPAKRKB-UHFFFAOYSA-N OC(C(c1cc(-c(c(F)ccc2)c2OC(F)(F)F)ccc1)=O)=O Chemical compound OC(C(c1cc(-c(c(F)ccc2)c2OC(F)(F)F)ccc1)=O)=O DLZRFSGLPAKRKB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/14—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with multiple outlet openings; with strainers in or outside the outlet opening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/16—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant characterised by the actuating means
- B65D83/20—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant characterised by the actuating means operated by manual action, e.g. button-type actuator or actuator caps
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/02—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to produce a jet, spray, or other discharge of particular shape or nature, e.g. in single drops, or having an outlet of particular shape
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55735504P | 2004-03-29 | 2004-03-29 | |
PCT/US2005/010153 WO2005097136A1 (en) | 2004-03-29 | 2005-03-25 | Biaryl substituted pyrazinones as sodium channel blockers |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007530694A true JP2007530694A (ja) | 2007-11-01 |
JP2007530694A5 JP2007530694A5 (US07794700-20100914-C00152.png) | 2008-02-21 |
Family
ID=35124829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007506398A Withdrawn JP2007530694A (ja) | 2004-03-29 | 2005-03-25 | ナトリウムチャネル遮断薬としてのビアリール置換ピラジノン |
Country Status (7)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021513561A (ja) * | 2018-02-13 | 2021-05-27 | ギリアード サイエンシーズ, インコーポレイテッド | Pd−1/pd−l1阻害剤 |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
EP2129225B1 (en) * | 2007-04-03 | 2012-12-05 | E. I. Du Pont de Nemours and Company | Substituted benzene fungicides |
US8815859B2 (en) * | 2008-04-29 | 2014-08-26 | Merck Patent Gmbh | Substituted pyrazin-2-ones and substituted 5,6,7,8-tetrahydroquinoxalin-2-ones and methods of use thereof |
RU2011119626A (ru) | 2008-10-17 | 2012-11-27 | Ксенон Фармасьютикалз Инк. | Спирооксиндольные соединения и их применение в качестве терапевтичеких средств |
US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
EP2488531B1 (en) | 2009-10-14 | 2014-03-26 | Xenon Pharmaceuticals Inc. | Synthetic methods for spiro-oxindole compounds |
WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | CRF−1受容体アンタゴニストとしてのピラゾロ[5,1b]オキサゾール誘導体 |
ES2527849T3 (es) | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
WO2011106729A2 (en) | 2010-02-26 | 2011-09-01 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
AR086554A1 (es) | 2011-05-27 | 2014-01-08 | Novartis Ag | Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina |
FR2985202A1 (fr) * | 2012-01-03 | 2013-07-05 | Oreal | Tete de distribution |
DE102012201178B3 (de) * | 2012-01-27 | 2013-02-14 | Aptar Radolfzell Gmbh | Düseneinheit und Spender mit einer solchen |
EP2852591A1 (en) | 2012-05-03 | 2015-04-01 | Novartis AG | L-malate salt of 2, 7 - diaza - spiro [4.5]dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists |
FR3004901B1 (fr) * | 2013-04-30 | 2016-02-12 | Oreal | Dispositif aerosol a diffusion a multi-orifices pour le lavage a sec des cheveux |
FR3004902A1 (fr) | 2013-04-30 | 2014-10-31 | Oreal | Dispositif aerosol a diffusion a multi-orifices pour la mise en forme des cheveux et/ou le maintien de la coiffure |
FR3022770B1 (fr) | 2014-06-30 | 2016-07-29 | Oreal | Dispositif aerosol a base de sel de calcium, de polymere fixant, de tensioactif et d'eau |
EP3177405B1 (en) | 2014-08-06 | 2020-05-06 | S.C. Johnson & Son, Inc. | Spray inserts |
WO2016127068A1 (en) | 2015-02-05 | 2016-08-11 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
US10174884B2 (en) * | 2015-06-25 | 2019-01-08 | The Gillette Company Llc | Valve stem for a compressible valve |
US10493471B2 (en) * | 2015-09-04 | 2019-12-03 | L'oreal | Spraying device for a product |
US11033531B2 (en) | 2016-12-14 | 2021-06-15 | Sk Biopharmaceuticals Co., Ltd. | Use of carbamate compound for preventing, alleviating, or treating tremors or tremor syndrome |
CN106674264A (zh) * | 2016-12-20 | 2017-05-17 | 苏州汉德创宏生化科技有限公司 | (2,2,2‑三氟乙氧基)苯硼酸类化合物的合成方法 |
FR3063606B1 (fr) | 2017-03-09 | 2021-07-23 | Oreal | Dispositif aerosol pour la mise en forme des cheveux et/ou le maintien de la coiffure |
FR3063605B1 (fr) * | 2017-03-09 | 2021-07-23 | Oreal | Dispositif aerosol pour la mise en forme des cheveux et/ou le maintien de la coiffure |
FR3063607B1 (fr) | 2017-03-09 | 2021-07-23 | Oreal | Dispositif aerosol pour le lavage a sec et le traitement des cheveux |
EP3513880B1 (en) | 2018-01-23 | 2021-08-25 | The Procter & Gamble Company | Dispensing device suitable for a foamable product |
US11267644B2 (en) * | 2018-11-08 | 2022-03-08 | The Procter And Gamble Company | Aerosol foam dispenser and methods for delivering a textured foam product |
CN114230552B (zh) * | 2021-12-29 | 2023-11-03 | 江苏广域化学有限公司 | 三氟甲氧基二苯并噻吩、其制备方法及相关中间体的制备方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3342382A (en) | 1965-10-22 | 1967-09-19 | Clayton Corp Of Delaware | Pressured dispenser spout having plurality of decorator orifices |
US3401888A (en) | 1965-10-22 | 1968-09-17 | Sutter Arthur | Snow nozzle |
US3415426A (en) * | 1966-05-16 | 1968-12-10 | Eaton Yale & Towne | Dispensing valve |
US3406913A (en) * | 1966-09-01 | 1968-10-22 | Revlon | Mechanical break-up actuator for fluid dispensers |
US3504862A (en) | 1968-01-05 | 1970-04-07 | Gillette Co | Dispensing device |
US3628733A (en) * | 1969-05-01 | 1971-12-21 | Associated Products Inc | Two-hole aerosol button |
US3767125A (en) * | 1971-05-28 | 1973-10-23 | Union Carbide Corp | Multiple orifice aerosol actuator |
FR2367681A1 (fr) * | 1976-08-06 | 1978-05-12 | Oreal | Recipient pressurise du type " bombe aerosol " a debit de distribution sensiblement constant |
US4239407A (en) | 1979-02-22 | 1980-12-16 | Knight Hester L | Hard to reach places spray can |
DE2925435A1 (de) | 1979-06-23 | 1981-01-22 | Hans Ing Grad Grothoff | Spruehkopf |
IT8112656A0 (it) | 1981-10-21 | 1981-10-21 | Orlando Morchio | Pettine irroratore avente lo scopo di irrorare qualsiasi sostanza |
US4690312A (en) | 1986-05-15 | 1987-09-01 | S. C. Johnson & Son, Inc. | Dual function cap |
US5249747A (en) * | 1990-07-12 | 1993-10-05 | Par-Way Group | Sprayable dispensing system for viscous vegetable oils and apparatus therefor |
FR2691383B1 (fr) | 1992-05-21 | 1994-08-19 | Oreal | Bouton-poussoir destiné à être monté sur une valve ou une pompe équipant un distributeur, et distributeur comportant un tel bouton-poussoir. |
DE9390268U1 (de) * | 1993-05-24 | 1995-01-12 | Praezisions Ventil Gmbh | Betätigungsteil für einen Aerosol-Behälter |
FR2737198B1 (fr) * | 1995-07-24 | 1997-09-26 | Oreal | Tete de distribution d'un produit liquide sous forme d'aerosol et distributeur muni d'une telle tete |
FR2744104B1 (fr) | 1996-01-29 | 1998-03-20 | Oreal | Dispositif de conditionnement, de distribution et d'application d'un gel ou mousse |
US5890661A (en) * | 1996-11-27 | 1999-04-06 | Par-Way Group | Colliding stream spray dispensing system with a moldable nozzle |
US6158674A (en) * | 1999-04-28 | 2000-12-12 | Humphreys; Ronald O. | Liquid dispenser with multiple nozzles |
US6820823B2 (en) | 2003-02-25 | 2004-11-23 | S. C. Johnson & Son, Inc. | Aerosol dispensing nozzle |
US6971557B2 (en) * | 2003-06-19 | 2005-12-06 | S. C. Johnson & Son, Inc. | Actuator for a pressurized material dispenser |
US6817493B1 (en) * | 2003-08-22 | 2004-11-16 | S. C. Johnson & Son, Inc. | Spray nozzle |
-
2005
- 2005-03-25 EP EP05730103A patent/EP1732564A1/en not_active Withdrawn
- 2005-03-25 JP JP2007506398A patent/JP2007530694A/ja not_active Withdrawn
- 2005-03-25 WO PCT/US2005/010153 patent/WO2005097136A1/en not_active Application Discontinuation
- 2005-03-25 US US10/594,367 patent/US20080280873A1/en not_active Abandoned
- 2005-03-25 CA CA002560796A patent/CA2560796A1/en not_active Abandoned
- 2005-03-25 AU AU2005231332A patent/AU2005231332A1/en not_active Abandoned
- 2005-03-25 CN CNA2005800101317A patent/CN1938031A/zh active Pending
- 2005-03-29 US US11/092,088 patent/US8191802B2/en active Active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021513561A (ja) * | 2018-02-13 | 2021-05-27 | ギリアード サイエンシーズ, インコーポレイテッド | Pd−1/pd−l1阻害剤 |
JP7062792B2 (ja) | 2018-02-13 | 2022-05-06 | ギリアード サイエンシーズ, インコーポレイテッド | Pd-1/pd-l1阻害剤 |
Also Published As
Publication number | Publication date |
---|---|
CA2560796A1 (en) | 2005-10-20 |
CN1938031A (zh) | 2007-03-28 |
AU2005231332A1 (en) | 2005-10-20 |
WO2005097136A1 (en) | 2005-10-20 |
EP1732564A1 (en) | 2006-12-20 |
US20080280873A1 (en) | 2008-11-13 |
US20050224524A1 (en) | 2005-10-13 |
US8191802B2 (en) | 2012-06-05 |
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