JP2007530068A5 - - Google Patents

Info

Publication number

JP2007530068A5

JP2007530068A5 JP2007505621A JP2007505621A JP2007530068A5 JP 2007530068 A5 JP2007530068 A5 JP 2007530068A5 JP 2007505621 A JP2007505621 A JP 2007505621A JP 2007505621 A JP2007505621 A JP 2007505621A JP 2007530068 A5 JP2007530068 A5 JP 2007530068A5

Authority

JP

Japan

Prior art keywords

antibody

seq

hosm

interaction

polynucleotide

Prior art date

2005-03-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 102000040430 polynucleotide Human genes 0.000 claims 25
• 108091033319 polynucleotide Proteins 0.000 claims 25
• 239000002157 polynucleotide Substances 0.000 claims 25
• 230000001225 therapeutic effect Effects 0.000 claims 23
• 230000003993 interaction Effects 0.000 claims 17
• 210000004027 cell Anatomy 0.000 claims 16
• 241000282414 Homo sapiens Species 0.000 claims 11
• 238000000034 method Methods 0.000 claims 10
• 239000012634 fragment Substances 0.000 claims 9
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 239000000427 antigen Substances 0.000 claims 7
• 102000036639 antigens Human genes 0.000 claims 7
• 108091007433 antigens Proteins 0.000 claims 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
• 201000010099 disease Diseases 0.000 claims 6
• 101001042362 Homo sapiens Leukemia inhibitory factor receptor Proteins 0.000 claims 5
• 101000586302 Homo sapiens Oncostatin-M-specific receptor subunit beta Proteins 0.000 claims 5
• 102100021747 Leukemia inhibitory factor receptor Human genes 0.000 claims 5
• 102100030098 Oncostatin-M-specific receptor subunit beta Human genes 0.000 claims 5
• 238000002965 ELISA Methods 0.000 claims 3
• 239000005557 antagonist Substances 0.000 claims 3
• 238000003556 assay Methods 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 201000004681 Psoriasis Diseases 0.000 claims 2
• 230000002917 arthritic effect Effects 0.000 claims 2
• 208000006673 asthma Diseases 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
• 238000012216 screening Methods 0.000 claims 2
• 210000001179 synovial fluid Anatomy 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 206010012289 Dementia Diseases 0.000 claims 1
• 206010065390 Inflammatory pain Diseases 0.000 claims 1
• 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
• 208000019693 Lung disease Diseases 0.000 claims 1
• 241000699666 Mus <mouse, genus> Species 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
• 208000002193 Pain Diseases 0.000 claims 1
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 241000288906 Primates Species 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
• 241000700159 Rattus Species 0.000 claims 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
• 239000012472 biological sample Substances 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 201000000050 myeloid neoplasm Diseases 0.000 claims 1
• 208000004296 neuralgia Diseases 0.000 claims 1
• 208000021722 neuropathic pain Diseases 0.000 claims 1
• 201000008482 osteoarthritis Diseases 0.000 claims 1
• 239000013612 plasmid Substances 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 230000022983 regulation of cell cycle Effects 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 230000001131 transforming effect Effects 0.000 claims 1