JP2007525491A5 - - Google Patents

Info

Publication number

JP2007525491A5

JP2007525491A5 JP2006549895A JP2006549895A JP2007525491A5 JP 2007525491 A5 JP2007525491 A5 JP 2007525491A5 JP 2006549895 A JP2006549895 A JP 2006549895A JP 2006549895 A JP2006549895 A JP 2006549895A JP 2007525491 A5 JP2007525491 A5 JP 2007525491A5

Authority

JP

Japan

Prior art keywords

gpr49

secretase

gamma

beta

inhibitor

Prior art date

2004-11-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
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• 101001063456 Homo sapiens Leucine-rich repeat-containing G-protein coupled receptor 5 Proteins 0.000 claims 14
• 102100031036 Leucine-rich repeat-containing G-protein coupled receptor 5 Human genes 0.000 claims 14
• 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 12
• 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 12
• 238000000034 method Methods 0.000 claims 11
• 239000003112 inhibitor Substances 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 150000001875 compounds Chemical class 0.000 claims 4
• 230000004770 neurodegeneration Effects 0.000 claims 4
• 208000015122 neurodegenerative disease Diseases 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 3
• 208000024827 Alzheimer disease Diseases 0.000 claims 2
• 230000003993 interaction Effects 0.000 claims 2
• 102400000574 Amyloid-beta protein 42 Human genes 0.000 claims 1
• 108091023037 Aptamer Proteins 0.000 claims 1
• 102000053642 Catalytic RNA Human genes 0.000 claims 1
• 108090000994 Catalytic RNA Proteins 0.000 claims 1
• 108091034117 Oligonucleotide Proteins 0.000 claims 1
• 108020004459 Small interfering RNA Proteins 0.000 claims 1
• 108010064539 amyloid beta-protein (1-42) Proteins 0.000 claims 1
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 1
• 239000000074 antisense oligonucleotide Substances 0.000 claims 1
• 238000012230 antisense oligonucleotides Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 230000003834 intracellular effect Effects 0.000 claims 1
• 239000000816 peptidomimetic Substances 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 108091092562 ribozyme Proteins 0.000 claims 1