CA2554353A1 - Treatment of neurodegenerative diseases by the use of gpr49 - Google Patents
Treatment of neurodegenerative diseases by the use of gpr49 Download PDFInfo
- Publication number
- CA2554353A1 CA2554353A1 CA002554353A CA2554353A CA2554353A1 CA 2554353 A1 CA2554353 A1 CA 2554353A1 CA 002554353 A CA002554353 A CA 002554353A CA 2554353 A CA2554353 A CA 2554353A CA 2554353 A1 CA2554353 A1 CA 2554353A1
- Authority
- CA
- Canada
- Prior art keywords
- gpr49
- secretase
- protein
- beta
- gamma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
- C07K2317/82—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies functional in the cytoplasm, the inner aspect of the cell membrane, the nucleus or the mitochondria
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04001895 | 2004-01-29 | ||
| EP04001895.4 | 2004-01-29 | ||
| EP04001894.7 | 2004-01-29 | ||
| EP04001894 | 2004-01-29 | ||
| EP04007447 | 2004-03-26 | ||
| EP04007447.8 | 2004-03-26 | ||
| EPPCT/EP2004/004889 | 2004-05-07 | ||
| EP2004004889 | 2004-05-07 | ||
| EP2004004891 | 2004-05-07 | ||
| EPPCT/EP2004/004891 | 2004-05-07 | ||
| PCT/EP2004/013539 WO2005074980A1 (en) | 2004-01-29 | 2004-11-29 | Treatment of neurodegenerative diseases by the use of gpr49 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2554353A1 true CA2554353A1 (en) | 2005-08-18 |
Family
ID=38556372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002554353A Abandoned CA2554353A1 (en) | 2004-01-29 | 2004-11-29 | Treatment of neurodegenerative diseases by the use of gpr49 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080025969A1 (enExample) |
| EP (1) | EP1713501B1 (enExample) |
| JP (1) | JP2007525491A (enExample) |
| AT (1) | ATE383870T1 (enExample) |
| AU (1) | AU2004315111B2 (enExample) |
| CA (1) | CA2554353A1 (enExample) |
| DE (1) | DE602004011400T2 (enExample) |
| DK (1) | DK1713501T3 (enExample) |
| ES (1) | ES2300852T3 (enExample) |
| PT (1) | PT1713501E (enExample) |
| WO (2) | WO2005074980A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| JP2009516514A (ja) * | 2005-11-21 | 2009-04-23 | ジェネンテック・インコーポレーテッド | 新規遺伝子破壊、それらに関する組成物および方法 |
| EP2022848A1 (en) | 2007-08-10 | 2009-02-11 | Hubrecht Institut | A method for identifying, expanding, and removing adult stem cells and cancer stem cells |
| WO2010016766A2 (en) * | 2008-08-08 | 2010-02-11 | Koninklijke Nederlandse Akademie Van Wetenschappen | Antibodies recognizing endogenous human lgr5 and/or lgr6 |
| US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
| US8604074B2 (en) | 2009-01-09 | 2013-12-10 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| CA2804161A1 (en) | 2010-07-07 | 2012-01-12 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| CA2882826A1 (en) | 2012-08-24 | 2014-02-27 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| WO2014108168A1 (en) | 2013-01-10 | 2014-07-17 | Merck Patent Gmbh | Piperidinylcarbazole as antimalarial |
| WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
| US9902713B2 (en) | 2013-11-11 | 2018-02-27 | Board Of Regents Of The University Of Texas System | Neuroprotective compounds and use thereof |
| US9994577B2 (en) | 2014-07-04 | 2018-06-12 | Merck Patent Gmbh | Azepanyl-derivatives and pharmaceutical compositions comprising the same with antiparasitic activity |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4980286A (en) * | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5096815A (en) * | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| US5198346A (en) * | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5498538A (en) * | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| JP2938569B2 (ja) * | 1990-08-29 | 1999-08-23 | ジェンファーム インターナショナル，インコーポレイティド | 異種免疫グロブリンを作る方法及びトランスジェニックマウス |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5582981A (en) * | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| AU4589297A (en) * | 1996-10-07 | 1998-05-05 | Scios Inc. | Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase |
| US6555339B1 (en) * | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| CA2361124A1 (en) * | 1999-01-22 | 2000-07-27 | Matthew John During | Vaccine-mediated treatment of neurological disorders |
| DE19941039A1 (de) * | 1999-08-28 | 2001-03-01 | Boehringer Ingelheim Pharma | gamma-Sekretase in vitro Testsystem |
| GB0005894D0 (en) * | 2000-03-10 | 2000-05-03 | Glaxo Group Ltd | Assay |
| WO2002061087A2 (en) * | 2000-12-19 | 2002-08-08 | Lifespan Biosciences, Inc. | Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides |
| EP1354950A4 (en) * | 2000-12-28 | 2005-01-12 | Asahi Kasei Pharma Corp | ACTIVATION GENE OF NF-KB |
| WO2002060867A2 (en) * | 2001-01-29 | 2002-08-08 | Insight Strategy And Marketing Ltd | Carbazole derivatives and their uses as heparanase inhibitors |
| CA2490278A1 (en) * | 2002-06-26 | 2004-01-22 | Cellzome Ag | Components of the presenilin-complex |
| EP1380644A1 (en) * | 2002-07-08 | 2004-01-14 | Kylix B.V. | The use of specified TCF target genes to identify drugs for the treatment of cancer, in particular colorectal cancer, in which TCF/beta-catenin/WNT signalling plays a central role |
| US7056685B1 (en) * | 2002-11-05 | 2006-06-06 | Amgen Inc. | Receptor ligands and methods of modulating receptors |
| US7189539B2 (en) * | 2003-11-25 | 2007-03-13 | Bristol-Myers Squibb Company | Polynucleotide encoding a human relaxin receptor, HGPRBMY5v1 |
-
2004
- 2004-11-29 JP JP2006549895A patent/JP2007525491A/ja not_active Withdrawn
- 2004-11-29 PT PT04803345T patent/PT1713501E/pt unknown
- 2004-11-29 EP EP04803345A patent/EP1713501B1/en not_active Expired - Lifetime
- 2004-11-29 US US10/587,159 patent/US20080025969A1/en not_active Abandoned
- 2004-11-29 AT AT04803345T patent/ATE383870T1/de not_active IP Right Cessation
- 2004-11-29 CA CA002554353A patent/CA2554353A1/en not_active Abandoned
- 2004-11-29 AU AU2004315111A patent/AU2004315111B2/en not_active Expired - Fee Related
- 2004-11-29 WO PCT/EP2004/013539 patent/WO2005074980A1/en not_active Ceased
- 2004-11-29 DE DE602004011400T patent/DE602004011400T2/de not_active Expired - Lifetime
- 2004-11-29 ES ES04803345T patent/ES2300852T3/es not_active Expired - Lifetime
- 2004-11-29 DK DK04803345T patent/DK1713501T3/da active
- 2004-12-01 WO PCT/EP2004/013620 patent/WO2005074971A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004315111A1 (en) | 2005-08-18 |
| AU2004315111B2 (en) | 2010-03-04 |
| PT1713501E (pt) | 2008-04-30 |
| EP1713501A1 (en) | 2006-10-25 |
| WO2005074980A1 (en) | 2005-08-18 |
| DE602004011400D1 (de) | 2008-03-06 |
| DK1713501T3 (da) | 2008-05-26 |
| US20080025969A1 (en) | 2008-01-31 |
| WO2005074971A1 (en) | 2005-08-18 |
| EP1713501B1 (en) | 2008-01-16 |
| DE602004011400T2 (de) | 2009-01-22 |
| ATE383870T1 (de) | 2008-02-15 |
| ES2300852T3 (es) | 2008-06-16 |
| JP2007525491A (ja) | 2007-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |