JP2007523093A - 非ＣｐＧ核酸を使用した全身性免疫活性化法 - Google Patents

非ＣｐＧ核酸を使用した全身性免疫活性化法 Download PDF

Info

Publication number
JP2007523093A
JP2007523093A JP2006553373A JP2006553373A JP2007523093A JP 2007523093 A JP2007523093 A JP 2007523093A JP 2006553373 A JP2006553373 A JP 2006553373A JP 2006553373 A JP2006553373 A JP 2006553373A JP 2007523093 A JP2007523093 A JP 2007523093A
Authority
JP
Japan
Prior art keywords
nucleic acid
tumor
cells
cldc
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006553373A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007523093A5 (enExample
Inventor
ダブリュ． ダウ，スティーブン
フェアマン，ジェフェリー
Original Assignee
ジュバリス バイオセラピューティクス，インコーポレイティド
コロラド ステイト ユニバーシティ リサーチ ファウンデイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジュバリス バイオセラピューティクス，インコーポレイティド, コロラド ステイト ユニバーシティ リサーチ ファウンデイション filed Critical ジュバリス バイオセラピューティクス，インコーポレイティド
Publication of JP2007523093A publication Critical patent/JP2007523093A/ja
Publication of JP2007523093A5 publication Critical patent/JP2007523093A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2006553373A 2004-02-17 2005-02-17 非ＣｐＧ核酸を使用した全身性免疫活性化法 Pending JP2007523093A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/780,294 US20050181035A1 (en) 2004-02-17 2004-02-17 Systemic immune activation method using non CpG nucleic acids
PCT/US2005/005336 WO2005079511A2 (en) 2004-02-17 2005-02-17 SYSTEM IMMUNE ACTIVATION METHOD USING NON CpG NUCLEIC ACIDS

Publications (2)

Publication Number Publication Date
JP2007523093A true JP2007523093A (ja) 2007-08-16
JP2007523093A5 JP2007523093A5 (enExample) 2008-04-03

Family

ID=34838562

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006553373A Pending JP2007523093A (ja) 2004-02-17 2005-02-17 非ＣｐＧ核酸を使用した全身性免疫活性化法

Country Status (6)

Country Link
US (1) US20050181035A1 (enExample)
EP (1) EP1718149A4 (enExample)
JP (1) JP2007523093A (enExample)
AU (1) AU2005215020A1 (enExample)
CA (1) CA2556229A1 (enExample)
WO (1) WO2005079511A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011515490A (ja) * 2008-03-25 2011-05-19 ジュバリス・バイオセラピューティクス・インコーポレイテッド カチオン性脂質−ｄｎａ複合体（ｃｌｄｃ）の投与による免疫応答の増強
JP2012526734A (ja) * 2009-05-14 2012-11-01 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 鳥類において増強された免疫応答
JP2020509039A (ja) * 2017-03-02 2020-03-26 ダンディ バイオサイエンス インコーポレイテッドＤａｎｄｉ Ｂｉｏｓｃｉｅｎｃｅ Ｉｎｃ 免疫抑制因子制御物質を含む多重ドメインカプセル、その製造方法、及びこれを含む免疫調節組成物

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
EP0855184A1 (en) * 1997-01-23 1998-07-29 Grayson B. Dr. Lipford Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
WO2000048630A1 (en) 1999-02-17 2000-08-24 Csl Limited Immunogenic complexes and methods relating thereto
DK1221955T3 (da) * 1999-09-25 2006-01-30 Univ Iowa Res Found Immunstimulerende nukleinsyre
US11576958B2 (en) 2013-02-07 2023-02-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
WO2015128461A1 (en) 2014-02-28 2015-09-03 Bayer Animal Health Gmbh Immunostimulatory plasmids
TWI739740B (zh) 2015-04-22 2021-09-21 德商奎爾法克股份有限公司 用於治療腫瘤疾病之含有ｒｎａ的組成物
MX2018001251A (es) 2015-07-31 2018-03-26 Bayer Animal Health Gmbh Respuesta inmunitaria potenciada de las especies porcinas.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066879A2 (en) * 1998-06-25 1999-12-29 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
WO2003101375A2 (en) * 2002-05-30 2003-12-11 Immunotech S.A. Immunostimulatory oligonucleotides and uses thereof

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957735A (en) * 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US5043164A (en) * 1989-01-17 1991-08-27 The University Of Tennessee Research Corporation Blood-stable, cholesterol-free liposomes
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5693622A (en) * 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5399346A (en) * 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5676954A (en) * 1989-11-03 1997-10-14 Vanderbilt University Method of in vivo delivery of functioning foreign genes
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5858784A (en) * 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5643578A (en) * 1992-03-23 1997-07-01 University Of Massachusetts Medical Center Immunization by inoculation of DNA transcription unit
WO1994022468A1 (en) * 1993-04-02 1994-10-13 Anticancer, Inc. Method for delivering beneficial compositions to hair follicles
WO1993025673A1 (en) * 1992-06-04 1993-12-23 The Regents Of The University Of California In vivo gene therapy with intron-free sequence of interest
JP3351476B2 (ja) * 1993-01-22 2002-11-25 三菱化学株式会社 リン脂質誘導体及びそれを含有するリポソーム
US5593972A (en) * 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5679647A (en) * 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
WO1995026204A1 (en) * 1994-03-25 1995-10-05 Isis Pharmaceuticals, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) * 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
ES2366201T3 (es) * 1994-07-15 2011-10-18 University Of Iowa Research Foundation Oligonucleótidos inmunmoduladores.
US5820873A (en) * 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US5703057A (en) * 1995-04-07 1997-12-30 Board Of Regents The University Of Texas System Expression library immunization
US5830878A (en) * 1995-06-07 1998-11-03 Megabios Corporation Cationic lipid: DNA complexes for gene targeting
US5981501A (en) * 1995-06-07 1999-11-09 Inex Pharmaceuticals Corp. Methods for encapsulating plasmids in lipid bilayers
ES2231819T3 (es) * 1995-06-07 2005-05-16 Inex Pharmaceuticals Corp Particulas de lipido-acido nucleico preparadas a traves de un intermedio complejo de lipido-acido nucleico hidrofobo y uso para transferir genes.
US5705385A (en) * 1995-06-07 1998-01-06 Inex Pharmaceuticals Corporation Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US5817856A (en) * 1995-12-11 1998-10-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Radiation-protective phospholipid and method
US6121247A (en) * 1996-03-29 2000-09-19 The Johns Hopkins University Therapy for allergic diseases
US5853719A (en) * 1996-04-30 1998-12-29 Duke University Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
US6406705B1 (en) * 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
DE69841002D1 (de) * 1997-05-14 2009-09-03 Univ British Columbia Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln
CA2301575C (en) * 1997-05-20 2003-12-23 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
US6977245B2 (en) * 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
US20020156033A1 (en) * 2000-03-03 2002-10-24 Bratzler Robert L. Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer
ES2253398T3 (es) * 2000-06-30 2006-06-01 Inex Pharmaceuticals Corp. Camptotecinas liposomales mejoradas y sus usos.
WO2002089772A1 (en) * 2001-05-09 2002-11-14 Inex Pharmaceuticals Corporation Anti-angiogenic therapy using liposome-encapsulated chemotherapeutic agents
US20040009944A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Methylated immunostimulatory oligonucleotides and methods of using the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066879A2 (en) * 1998-06-25 1999-12-29 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
WO2003101375A2 (en) * 2002-05-30 2003-12-11 Immunotech S.A. Immunostimulatory oligonucleotides and uses thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011515490A (ja) * 2008-03-25 2011-05-19 ジュバリス・バイオセラピューティクス・インコーポレイテッド カチオン性脂質−ｄｎａ複合体（ｃｌｄｃ）の投与による免疫応答の増強
JP2012526734A (ja) * 2009-05-14 2012-11-01 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 鳥類において増強された免疫応答
JP2020509039A (ja) * 2017-03-02 2020-03-26 ダンディ バイオサイエンス インコーポレイテッドＤａｎｄｉ Ｂｉｏｓｃｉｅｎｃｅ Ｉｎｃ 免疫抑制因子制御物質を含む多重ドメインカプセル、その製造方法、及びこれを含む免疫調節組成物
JP2020510663A (ja) * 2017-03-02 2020-04-09 ダンディ バイオサイエンス インコーポレイテッドＤａｎｄｉ Ｂｉｏｓｃｉｅｎｃｅ Ｉｎｃ 免疫活性物質を含む多重ドメインカプセル、その製造方法、及びこれを含む免疫調節組成物

Also Published As

Publication number Publication date
AU2005215020A1 (en) 2005-09-01
EP1718149A4 (en) 2010-06-09
WO2005079511A3 (en) 2006-01-19
EP1718149A2 (en) 2006-11-08
US20050181035A1 (en) 2005-08-18
CA2556229A1 (en) 2005-09-01
WO2005079511A2 (en) 2005-09-01

Similar Documents

Publication Publication Date Title
US6693086B1 (en) Systemic immune activation method using nucleic acid-lipid complexes
US20040247662A1 (en) Systemic immune activation method using nucleic acid-lipid complexes
US7741300B2 (en) Methods of using nucleic acid vector-lipid complexes
CN1805758B (zh) 核酸和细胞疫苗的组分
US5705151A (en) Gene therapy for T cell regulation
AU704012B2 (en) Gene therapy for effector cell regulation
JP2000503853A (ja) 抗原特異的免疫応答を生起させる遺伝子発現ベクターおよびその使用方法
WO1996036366A9 (en) Gene therapy for effector cell regulation
US20090010948A1 (en) Anti-tumor vaccines delivered by dendritic cells devoid of interleukin-10
JP2005247709A (ja) 制御性ｔ細胞の活性を制御する方法および組成物
JP2011036251A (ja) ウイルスベクターおよびその遺伝子治療のための使用
JP2007523093A (ja) 非ＣｐＧ核酸を使用した全身性免疫活性化法
WO2021259206A1 (zh) 针对sars-cov-2病毒的dna疫苗及其用途
JPH10505339A (ja) 腫瘍疾患の治療のための生ワクチン
Lopez et al. IL-12 and IL-10 expression synergize to induce the immune-mediated eradication of established colon and mammary tumors and lung metastasis
JP2008526763A (ja) 予防又は治療目的のｍｈｃクラスｉ拘束性エピトープに対する免疫応答の誘導、増強及び保持方法
Yurina DNA Vaccine: Mechanism of Action and factors which increase its efficacy
WO2006099574A2 (en) Cockroach allergen gene expression and delivery systems and uses
KR20250089555A (ko) 면역요법 조성물 및 사용 방법
CN118119399A (zh) 包含IL-4和/或IL-13 RNA的mRNA疫苗及其用途
JP2003026599A (ja) Ｉｌ−１５遺伝子を応用したワクチンアジュバント
Egilmez Cytokines as vaccine adjuvants
US20030202962A1 (en) Gene therapy for effector cell regulation
MXPA05010222A (es) Metodos y composiciones para tratar y prevenir condiciones inflamatorias.
HK1081869A (en) Method and composition for regulating the activity of regulatory t cells

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080213

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080213

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110621

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120124