JP2007521273A5 - - Google Patents
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- Publication number
- JP2007521273A5 JP2007521273A5 JP2006517409A JP2006517409A JP2007521273A5 JP 2007521273 A5 JP2007521273 A5 JP 2007521273A5 JP 2006517409 A JP2006517409 A JP 2006517409A JP 2006517409 A JP2006517409 A JP 2006517409A JP 2007521273 A5 JP2007521273 A5 JP 2007521273A5
- Authority
- JP
- Japan
- Prior art keywords
- dioxo
- octahydro
- benzamide
- ethenocycloprop
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 carboxy, cyano, amino Chemical group 0.000 claims description 30
- 150000001875 compounds Chemical class 0.000 claims description 21
- RGTBYNJLXMRUQN-UHFFFAOYSA-N ac1meupd Chemical compound O=C1C(C2C=CC3C4CC42)C3C(=O)N1NC(=O)C1=CC=NC=C1 RGTBYNJLXMRUQN-UHFFFAOYSA-N 0.000 claims description 6
- QRWZSMGXNJSJBA-UHFFFAOYSA-N stk023504 Chemical compound C1=CC(Br)=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3C=C2)C3C1=O QRWZSMGXNJSJBA-UHFFFAOYSA-N 0.000 claims description 6
- IYWDNVOMIGEONH-UHFFFAOYSA-N ac1md7zq Chemical compound BrC1=CC=CC(C(=O)NN2C(C3C(C4C=CC3C3CC34)C2=O)=O)=C1 IYWDNVOMIGEONH-UHFFFAOYSA-N 0.000 claims description 4
- MQUPWTBHHPUUMC-UHFFFAOYSA-N isoindole Chemical compound C1=CC=C[C]2C=NC=C21 MQUPWTBHHPUUMC-UHFFFAOYSA-N 0.000 claims description 4
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 4
- ZPZCRHNAIUYXKE-UHFFFAOYSA-N st000007 Chemical compound C1=CC(OC)=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3C=C2)C3C1=O ZPZCRHNAIUYXKE-UHFFFAOYSA-N 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims 30
- 150000003254 radicals Chemical class 0.000 claims 27
- 239000003814 drug Substances 0.000 claims 20
- 229940124597 therapeutic agent Drugs 0.000 claims 20
- 238000000034 method Methods 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- SANSPEXFDMFMEB-UHFFFAOYSA-N 2-amino-2-iminoacetamide Chemical compound NC(=N)C(N)=O SANSPEXFDMFMEB-UHFFFAOYSA-N 0.000 claims 10
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 10
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 10
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 10
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 10
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 10
- 125000004414 alkyl thio group Chemical group 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 239000002904 solvent Substances 0.000 claims 10
- 229940124530 sulfonamide Drugs 0.000 claims 10
- 150000003456 sulfonamides Chemical class 0.000 claims 10
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 10
- 229940125904 compound 1 Drugs 0.000 claims 8
- 125000000168 pyrrolyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 208000015181 infectious disease Diseases 0.000 claims 7
- 241000700629 Orthopoxvirus Species 0.000 claims 6
- 125000004502 1,2,3-oxadiazolyl group Chemical group 0.000 claims 5
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 5
- ZIHQUWYJSTVYAT-UHFFFAOYSA-N [NH-][N+]([O-])=O Chemical compound [NH-][N+]([O-])=O ZIHQUWYJSTVYAT-UHFFFAOYSA-N 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 125000004103 aminoalkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- CISNNLXXANUBPI-UHFFFAOYSA-N cyano(nitro)azanide Chemical compound [O-][N+](=O)[N-]C#N CISNNLXXANUBPI-UHFFFAOYSA-N 0.000 claims 5
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 5
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000004663 dialkyl amino group Chemical group 0.000 claims 5
- 125000002541 furyl group Chemical group 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000002883 imidazolyl group Chemical group 0.000 claims 5
- 125000001786 isothiazolyl group Chemical group 0.000 claims 5
- 125000000842 isoxazolyl group Chemical group 0.000 claims 5
- 125000002971 oxazolyl group Chemical group 0.000 claims 5
- 125000003226 pyrazolyl group Chemical group 0.000 claims 5
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- CSKDFZIMJXRJGH-UHFFFAOYSA-N tecovirimat Chemical compound C1=CC(C(F)(F)F)=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3C=C2)C3C1=O CSKDFZIMJXRJGH-UHFFFAOYSA-N 0.000 claims 5
- 125000003831 tetrazolyl group Chemical group 0.000 claims 5
- 125000000335 thiazolyl group Chemical group 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- 229930192474 thiophene Natural products 0.000 claims 5
- GKBDXTNCBPZMFX-UHFFFAOYSA-N 4-(trifluoromethyl)benzohydrazide Chemical compound NNC(=O)C1=CC=C(C(F)(F)F)C=C1 GKBDXTNCBPZMFX-UHFFFAOYSA-N 0.000 claims 4
- NHMSINHXUXEFJT-UHFFFAOYSA-N 4-bromo-N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodecan-4-yl)benzamide Chemical compound C1=CC(Br)=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3CC2)C3C1=O NHMSINHXUXEFJT-UHFFFAOYSA-N 0.000 claims 4
- KJDNIXCMYMBSNO-UHFFFAOYSA-N 4-bromo-n-(1,3-dioxo-3a,4,5,6,7,7a-hexahydroisoindol-2-yl)benzamide Chemical compound C1=CC(Br)=CC=C1C(=O)NN1C(=O)C2CCCCC2C1=O KJDNIXCMYMBSNO-UHFFFAOYSA-N 0.000 claims 4
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- IVYPVGFVVJXQCM-UHFFFAOYSA-N N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)-3-fluorobenzamide Chemical compound FC1=CC=CC(C(=O)NN2C(C3C(C4C=CC3C3CC34)C2=O)=O)=C1 IVYPVGFVVJXQCM-UHFFFAOYSA-N 0.000 claims 4
- YIRDWOBUQUNSNY-UHFFFAOYSA-N N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)-4-fluorobenzamide Chemical compound C1=CC(F)=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3C=C2)C3C1=O YIRDWOBUQUNSNY-UHFFFAOYSA-N 0.000 claims 4
- OLFJAAPWKAVFKS-UHFFFAOYSA-N 2-bromo-N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)benzamide Chemical compound BrC1=CC=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3C=C2)C3C1=O OLFJAAPWKAVFKS-UHFFFAOYSA-N 0.000 claims 3
- XIDCFAYBJPWRRW-UHFFFAOYSA-N 4-cyano-N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)benzamide Chemical compound O=C1C(C2C=CC3C4CC42)C3C(=O)N1NC(=O)C1=CC=C(C#N)C=C1 XIDCFAYBJPWRRW-UHFFFAOYSA-N 0.000 claims 3
- XOHZZDFJOIMTMY-UHFFFAOYSA-N C1=CC(C(F)(F)F)=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3CC2)C3C1=O Chemical compound C1=CC(C(F)(F)F)=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3CC2)C3C1=O XOHZZDFJOIMTMY-UHFFFAOYSA-N 0.000 claims 3
- AGTXHHZRNMTLHL-UHFFFAOYSA-N N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)-4-nitrobenzamide Chemical compound C1=CC([N+](=O)[O-])=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3C=C2)C3C1=O AGTXHHZRNMTLHL-UHFFFAOYSA-N 0.000 claims 3
- UOHVZYYJHRCWBD-UHFFFAOYSA-N N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)pyridine-2-carboxamide Chemical compound O=C1C(C2C=CC3C4CC42)C3C(=O)N1NC(=O)C1=CC=CC=N1 UOHVZYYJHRCWBD-UHFFFAOYSA-N 0.000 claims 3
- 241000700618 Vaccinia virus Species 0.000 claims 3
- 241000700647 Variola virus Species 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- KVTCHDSYFPESLK-UHFFFAOYSA-N ac1metpm Chemical compound ClC1=CC=CC(C(=O)NN2C(C3C(C4C=CC3C3CC34)C2=O)=O)=C1 KVTCHDSYFPESLK-UHFFFAOYSA-N 0.000 claims 3
- USPKYYZDABFFSZ-UHFFFAOYSA-N ac1meuqj Chemical compound C1=CC(Cl)=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3C=C2)C3C1=O USPKYYZDABFFSZ-UHFFFAOYSA-N 0.000 claims 3
- PGAGSPWHPNHQCY-UHFFFAOYSA-N ac1mfhx1 Chemical compound O=C1C(C2C=CC3C4CC42)C3C(=O)N1NC(=O)C1=CC=CN=C1 PGAGSPWHPNHQCY-UHFFFAOYSA-N 0.000 claims 3
- HSZNSVLYPJLCRF-UHFFFAOYSA-N ac1mr9p8 Chemical compound ClC1=CC(Cl)=CC=C1C(=O)NN1C(=O)C2C(C=C3)CC3C2C1=O HSZNSVLYPJLCRF-UHFFFAOYSA-N 0.000 claims 3
- 239000003443 antiviral agent Substances 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- CHVJITGCYZJHLR-UHFFFAOYSA-N cyclohepta-1,3,5-triene Chemical compound C1C=CC=CC=C1 CHVJITGCYZJHLR-UHFFFAOYSA-N 0.000 claims 3
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 3
- RIMPTBZGDBXUFE-UHFFFAOYSA-N stk364697 Chemical compound C1=CC(Br)=CC=C1C(=O)NN1C(=O)C2C(C=C3)CC3C2C1=O RIMPTBZGDBXUFE-UHFFFAOYSA-N 0.000 claims 3
- 241001137864 Camelpox virus Species 0.000 claims 2
- 241000700627 Monkeypox virus Species 0.000 claims 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims 2
- MSJDEALLCYFPIJ-UHFFFAOYSA-N ac1mevsz Chemical compound O=C1C(C2C=CC3C4CC42)C3C(=O)N1NC(=O)CC1=CC=CC=C1 MSJDEALLCYFPIJ-UHFFFAOYSA-N 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 229910052786 argon Inorganic materials 0.000 claims 2
- 230000002238 attenuated effect Effects 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- LHPDNQMEZBYLEE-UHFFFAOYSA-N molport-007-558-141 Chemical compound C1C(C2)CC(C3)CC2CC13C(=O)NN1C(=O)C(C2C3CC3C3C=C2)C3C1=O LHPDNQMEZBYLEE-UHFFFAOYSA-N 0.000 claims 2
- ATWGPAAGZWQRJW-UHFFFAOYSA-N molport-007-561-796 Chemical compound ClC1=CC=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3C=C2)C3C1=O ATWGPAAGZWQRJW-UHFFFAOYSA-N 0.000 claims 2
- WRNZHKUBWSDTRF-UHFFFAOYSA-N n-(1,3-dioxooctahydro-4,6-ethenocyclopropa[f]isoindol-2(1h)-yl)-4-methylbenzamide Chemical compound C1=CC(C)=CC=C1C(=O)NN1C(=O)C(C2C3CC3C3C=C2)C3C1=O WRNZHKUBWSDTRF-UHFFFAOYSA-N 0.000 claims 2
- 239000008096 xylene Substances 0.000 claims 2
- 241000957224 BeAn 58058 virus Species 0.000 claims 1
- 241001455646 Buffalopox virus Species 0.000 claims 1
- WGMPKSCITMJWSS-UHFFFAOYSA-N CC1=C(C)C2C3CC3C1C(C1=O)C2C(=O)N1NC(=O)CC=1C=CSC=1 Chemical compound CC1=C(C)C2C3CC3C1C(C1=O)C2C(=O)N1NC(=O)CC=1C=CSC=1 WGMPKSCITMJWSS-UHFFFAOYSA-N 0.000 claims 1
- 241000562578 Cantagalo virus Species 0.000 claims 1
- 241000700626 Cowpox virus Species 0.000 claims 1
- 241000725630 Ectromelia virus Species 0.000 claims 1
- 241000321599 Elephantpox virus Species 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- IUUHNLBNSSSLDJ-UHFFFAOYSA-N N-(11,12-dimethyl-3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)-2-pyridin-4-ylacetamide Chemical compound CC1=C(C)C2C3CC3C1C(C1=O)C2C(=O)N1NC(=O)CC1=CC=NC=C1 IUUHNLBNSSSLDJ-UHFFFAOYSA-N 0.000 claims 1
- WKUMMKBQIGXLPV-UHFFFAOYSA-N N-(11,12-dimethyl-3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)acetamide Chemical compound CC1=C(C)C2C3CC3C1C1C(=O)N(NC(=O)C)C(=O)C21 WKUMMKBQIGXLPV-UHFFFAOYSA-N 0.000 claims 1
- MCYYZVFTMRDPKR-UHFFFAOYSA-N N-(11,12-dimethyl-3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)but-3-enamide Chemical compound CC1=C(C)C2C(C(=O)N(NC(=O)CC=C)C3=O)C3C1C1CC12 MCYYZVFTMRDPKR-UHFFFAOYSA-N 0.000 claims 1
- KHIWSAHWTVUIBO-UHFFFAOYSA-N N-(11,12-dimethyl-3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)cyclohexanecarboxamide Chemical compound CC1=C(C)C2C3CC3C1C(C1=O)C2C(=O)N1NC(=O)C1CCCCC1 KHIWSAHWTVUIBO-UHFFFAOYSA-N 0.000 claims 1
- CPRMSEKYJFJGII-UHFFFAOYSA-N N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)-2,4-dimethyl-1,3-thiazole-5-carboxamide Chemical compound S1C(C)=NC(C)=C1C(=O)NN1C(=O)C(C2C3CC3C3C=C2)C3C1=O CPRMSEKYJFJGII-UHFFFAOYSA-N 0.000 claims 1
- PDTWJALCALXIIH-UHFFFAOYSA-N N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)-N-ethyl-4-(trifluoromethyl)benzamide Chemical compound O=C1C(C2C=CC3C4CC42)C3C(=O)N1N(CC)C(=O)C1=CC=C(C(F)(F)F)C=C1 PDTWJALCALXIIH-UHFFFAOYSA-N 0.000 claims 1
- AZNCJZUWAHJCLB-UHFFFAOYSA-N N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)-N-methyl-4-(trifluoromethyl)benzamide Chemical compound O=C1C(C2C=CC3C4CC42)C3C(=O)N1N(C)C(=O)C1=CC=C(C(F)(F)F)C=C1 AZNCJZUWAHJCLB-UHFFFAOYSA-N 0.000 claims 1
- CSKDFZIMJXRJGH-FYYZZUKCSA-N N-[(1S,2R,6S,7R,8R,10S)-3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl]-4-(trifluoromethyl)benzamide Chemical compound C1=CC(C(F)(F)F)=CC=C1C(=O)NN1C(=O)[C@@H]([C@H]2[C@@H]3C[C@@H]3[C@@H]3C=C2)[C@@H]3C1=O CSKDFZIMJXRJGH-FYYZZUKCSA-N 0.000 claims 1
- 206010069586 Orthopox virus infection Diseases 0.000 claims 1
- 241001455645 Rabbitpox virus Species 0.000 claims 1
- 241000700638 Raccoonpox virus Species 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- 241000321597 Skunkpox virus Species 0.000 claims 1
- 241001137863 Taterapox virus Species 0.000 claims 1
- 241001137865 Volepox virus Species 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 229960005475 antiinfective agent Drugs 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 2
- FKVMWDZRDMCIAJ-UHFFFAOYSA-N undecanamide Chemical compound CCCCCCCCCCC(N)=O FKVMWDZRDMCIAJ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48018203P | 2003-06-20 | 2003-06-20 | |
| US60/480,182 | 2003-06-20 | ||
| PCT/US2004/019552 WO2004112718A2 (en) | 2003-06-20 | 2004-06-18 | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011179109A Division JP5657489B2 (ja) | 2003-06-20 | 2011-08-18 | オルトポックスウイルス感染及び関連疾患を治療及び予防するための化合物、組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007521273A JP2007521273A (ja) | 2007-08-02 |
| JP2007521273A5 true JP2007521273A5 (https=) | 2009-10-22 |
| JP4884216B2 JP4884216B2 (ja) | 2012-02-29 |
Family
ID=33539267
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006517409A Expired - Lifetime JP4884216B2 (ja) | 2003-06-20 | 2004-06-18 | オルトポックスウイルス感染及び関連疾患を治療及び予防するための化合物、組成物及び方法 |
| JP2011179109A Expired - Lifetime JP5657489B2 (ja) | 2003-06-20 | 2011-08-18 | オルトポックスウイルス感染及び関連疾患を治療及び予防するための化合物、組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011179109A Expired - Lifetime JP5657489B2 (ja) | 2003-06-20 | 2011-08-18 | オルトポックスウイルス感染及び関連疾患を治療及び予防するための化合物、組成物及び方法 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1638938B1 (https=) |
| JP (2) | JP4884216B2 (https=) |
| AU (1) | AU2004249250C1 (https=) |
| BE (1) | BE2022C521I2 (https=) |
| CA (1) | CA2529761C (https=) |
| DK (1) | DK1638938T3 (https=) |
| ES (1) | ES2632313T3 (https=) |
| FR (1) | FR22C1022I1 (https=) |
| NL (1) | NL301177I2 (https=) |
| PL (1) | PL1638938T3 (https=) |
| WO (1) | WO2004112718A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| AU2012268859B2 (en) * | 2003-06-20 | 2016-05-05 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
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| EP1638938B1 (en) * | 2003-06-20 | 2017-04-12 | Siga Technologies Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| MY141198A (en) * | 2004-08-30 | 2010-03-31 | Janssen Pharmaceutica Nv | Tricyclic adamantylamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
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| JP2008535862A (ja) * | 2005-04-08 | 2008-09-04 | キメリクス，インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
| JP2008538354A (ja) * | 2005-04-08 | 2008-10-23 | キメリクス，インコーポレイテッド | ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法 |
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| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| RU2412168C1 (ru) * | 2009-12-02 | 2011-02-20 | Федеральное государственное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФГУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Гидрат n-{3,5-диоксо-4-азатетрацикло[5.3.2.02,6.08,10]додец-11-ен-4-ил}-2-гидроксибензамида, обладающий противовирусной активностью в отношении ортопоксвирусов |
| RU2412167C1 (ru) * | 2009-12-02 | 2011-02-20 | Федеральное государственное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФГУН ГНЦ ВБ "Вектор" Роспотребнадзора) | {3,5-диоксо-4-азатетрацикло[5.3.2.02,6.08,10]додец-11-ен-4-ил}тиомочевина, обладающая противовирусной активностью в отношении ортопоксвирусов |
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| CN101906064A (zh) * | 2010-08-09 | 2010-12-08 | 中国人民解放军军事医学科学院微生物流行病研究所 | St-246的立体异构体的制备方法 |
| RU2440983C1 (ru) * | 2010-09-28 | 2012-01-27 | Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | Метил, хлор и нитропроизводные n-{3, 5-диоксо-4-азатетрацикло[5.3.2.02,6.08,10]додец-11-ен-4-ил}-2-гидроксибензамида-противовирусные препараты, ингибирующие репликацию различных видов ортопоксвирусов |
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| EP1638938B1 (en) * | 2003-06-20 | 2017-04-12 | Siga Technologies Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
-
2004
- 2004-06-18 EP EP04776765.2A patent/EP1638938B1/en not_active Expired - Lifetime
- 2004-06-18 DK DK04776765.2T patent/DK1638938T3/en active
- 2004-06-18 CA CA2529761A patent/CA2529761C/en not_active Expired - Lifetime
- 2004-06-18 ES ES04776765.2T patent/ES2632313T3/es not_active Expired - Lifetime
- 2004-06-18 JP JP2006517409A patent/JP4884216B2/ja not_active Expired - Lifetime
- 2004-06-18 AU AU2004249250A patent/AU2004249250C1/en not_active Expired
- 2004-06-18 PL PL04776765T patent/PL1638938T3/pl unknown
- 2004-06-18 WO PCT/US2004/019552 patent/WO2004112718A2/en not_active Ceased
-
2011
- 2011-08-18 JP JP2011179109A patent/JP5657489B2/ja not_active Expired - Lifetime
-
2022
- 2022-05-30 BE BE2022C521C patent/BE2022C521I2/nl unknown
- 2022-06-02 FR FR22C1022C patent/FR22C1022I1/fr active Active
- 2022-06-02 NL NL301177C patent/NL301177I2/nl unknown
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