JP2007520444A - 置換二環式キナゾリン−４−イルアミン誘導体 - Google Patents
置換二環式キナゾリン−４−イルアミン誘導体 Download PDFInfo
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- JP2007520444A JP2007520444A JP2006526316A JP2006526316A JP2007520444A JP 2007520444 A JP2007520444 A JP 2007520444A JP 2006526316 A JP2006526316 A JP 2006526316A JP 2006526316 A JP2006526316 A JP 2006526316A JP 2007520444 A JP2007520444 A JP 2007520444A
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- alkyl
- compound
- pyridin
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- -1 bicyclic quinazolin-4-ylamine derivatives Chemical class 0.000 title claims abstract description 155
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- 150000003839 salts Chemical class 0.000 claims description 108
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- 125000001424 substituent group Chemical group 0.000 claims description 95
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 81
- 210000004027 cell Anatomy 0.000 claims description 70
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims description 69
- 229910052739 hydrogen Inorganic materials 0.000 claims description 58
- 239000001257 hydrogen Substances 0.000 claims description 58
- 229910052736 halogen Inorganic materials 0.000 claims description 53
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- 150000002431 hydrogen Chemical class 0.000 claims description 29
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 28
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 27
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 25
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- 229910005965 SO 2 Inorganic materials 0.000 claims description 22
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 21
- 239000011575 calcium Substances 0.000 claims description 21
- 229910052791 calcium Inorganic materials 0.000 claims description 21
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 20
- 125000002252 acyl group Chemical group 0.000 claims description 19
- 125000003118 aryl group Chemical group 0.000 claims description 18
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- 125000002837 carbocyclic group Chemical group 0.000 claims description 17
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- 125000003545 alkoxy group Chemical group 0.000 claims description 16
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 16
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 16
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 15
- 150000005215 alkyl ethers Chemical class 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
- 125000004043 oxo group Chemical group O=* 0.000 claims description 13
- 229910052760 oxygen Inorganic materials 0.000 claims description 13
- 229910052717 sulfur Inorganic materials 0.000 claims description 12
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 11
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 11
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- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
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- 125000003386 piperidinyl group Chemical group 0.000 claims description 8
- 229940124530 sulfonamide Drugs 0.000 claims description 8
- 150000003456 sulfonamides Chemical class 0.000 claims description 8
- 229910052721 tungsten Inorganic materials 0.000 claims description 8
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims description 7
- 125000002947 alkylene group Chemical group 0.000 claims description 7
- 239000007789 gas Substances 0.000 claims description 7
- 125000004193 piperazinyl group Chemical group 0.000 claims description 7
- 239000007921 spray Substances 0.000 claims description 7
- 125000004423 acyloxy group Chemical group 0.000 claims description 6
- 125000004414 alkyl thio group Chemical group 0.000 claims description 6
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- IMACFCSSMIZSPP-UHFFFAOYSA-N phenacyl chloride Chemical compound ClCC(=O)C1=CC=CC=C1 IMACFCSSMIZSPP-UHFFFAOYSA-N 0.000 claims description 6
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- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 5
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- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 4
- 150000001412 amines Chemical class 0.000 claims description 4
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- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 4
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
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- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims description 3
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims description 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
- 206010006482 Bronchospasm Diseases 0.000 claims description 3
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- 201000001947 Reflex Sympathetic Dystrophy Diseases 0.000 claims description 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 3
- 230000007885 bronchoconstriction Effects 0.000 claims description 3
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- 230000027425 release of sequestered calcium ion into cytosol Effects 0.000 claims 3
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- FHTHLMOKHXEATE-UHFFFAOYSA-N 1-[3,3-dimethyl-6-[[2-(2-methylpropoxymethyl)-7-[3-(trifluoromethyl)pyridin-2-yl]pyrido[2,3-d]pyrimidin-4-yl]amino]-2h-indol-1-yl]ethanone Chemical compound N=1C2=NC(COCC(C)C)=NC(NC=3C=C4C(C(CN4C(C)=O)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1C(F)(F)F FHTHLMOKHXEATE-UHFFFAOYSA-N 0.000 claims 1
- KTTBKTIZTKLPCG-UHFFFAOYSA-N 1-[3,3-dimethyl-6-[[2-(2-methylpropoxymethyl)-7-pyridin-2-ylpyrido[2,3-d]pyrimidin-4-yl]amino]-2h-indol-1-yl]ethanone Chemical compound N=1C2=NC(COCC(C)C)=NC(NC=3C=C4C(C(CN4C(C)=O)(C)C)=CC=3)=C2C=CC=1C1=CC=CC=N1 KTTBKTIZTKLPCG-UHFFFAOYSA-N 0.000 claims 1
- FZODJOGHTDQWND-UHFFFAOYSA-N 1-[6-[[2-(methoxymethyl)-7-[3-(trifluoromethyl)pyridin-2-yl]pyrido[2,3-d]pyrimidin-4-yl]amino]-3,3-dimethyl-2h-indol-1-yl]ethanone Chemical compound N=1C2=NC(COC)=NC(NC=3C=C4C(C(CN4C(C)=O)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1C(F)(F)F FZODJOGHTDQWND-UHFFFAOYSA-N 0.000 claims 1
- DDHQDLDEVUBIAJ-UHFFFAOYSA-N 1-[6-[[7-(3-chloropyridin-2-yl)-2-(ethoxymethyl)pyrido[2,3-d]pyrimidin-4-yl]amino]-3,3-dimethyl-2h-indol-1-yl]ethanone Chemical compound N=1C2=NC(COCC)=NC(NC=3C=C4C(C(CN4C(C)=O)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1Cl DDHQDLDEVUBIAJ-UHFFFAOYSA-N 0.000 claims 1
- VZTYUPSGOWLVBU-UHFFFAOYSA-N 2-(2-methylpropoxymethyl)-7-[3-(trifluoromethyl)pyridin-2-yl]-n-(1,3,3-trimethyl-2h-indol-6-yl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC(C)C)=NC(NC=3C=C4C(C(CN4C)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1C(F)(F)F VZTYUPSGOWLVBU-UHFFFAOYSA-N 0.000 claims 1
- IOMOPRNICIERFL-UHFFFAOYSA-N 2-(2-methylpropoxymethyl)-7-pyridin-2-yl-n-(1,3,3-trimethyl-2h-indol-6-yl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC(C)C)=NC(NC=3C=C4C(C(CN4C)(C)C)=CC=3)=C2C=CC=1C1=CC=CC=N1 IOMOPRNICIERFL-UHFFFAOYSA-N 0.000 claims 1
- QPACYHJNEDJKGO-UHFFFAOYSA-N 2-(2-methylpropoxymethyl)-7-pyridin-2-yl-n-(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC(C)C)=NC(NC=3C=C4C(C(CN(C)C4)(C)C)=CC=3)=C2C=CC=1C1=CC=CC=N1 QPACYHJNEDJKGO-UHFFFAOYSA-N 0.000 claims 1
- QWUYTCGIPVPPBA-UHFFFAOYSA-N 2-(ethoxymethyl)-7-(3-methylpyridin-2-yl)-n-(1,3,3-trimethyl-2h-indol-6-yl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC)=NC(NC=3C=C4C(C(CN4C)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1C QWUYTCGIPVPPBA-UHFFFAOYSA-N 0.000 claims 1
- ULYHLTQGPSTNIH-UHFFFAOYSA-N 2-(ethoxymethyl)-7-(3-methylpyridin-2-yl)-n-(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC)=NC(NC=3C=C4C(C(CN(C)C4)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1C ULYHLTQGPSTNIH-UHFFFAOYSA-N 0.000 claims 1
- DBHKMBAQFSWZDT-UHFFFAOYSA-N 2-(methoxymethyl)-7-(3-methylpyridin-2-yl)-n-(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COC)=NC(NC=3C=C4C(C(CN(C)C4)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1C DBHKMBAQFSWZDT-UHFFFAOYSA-N 0.000 claims 1
- GPWJOEUJUVTTEP-UHFFFAOYSA-N 2-(methoxymethyl)-7-[3-(trifluoromethyl)pyridin-2-yl]-n-(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)-1,8-naphthyridin-4-amine Chemical compound N=1C2=NC(COC)=CC(NC=3C=C4C(C(CN(C)C4)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1C(F)(F)F GPWJOEUJUVTTEP-UHFFFAOYSA-N 0.000 claims 1
- FOUNQNSFZOTUHB-UHFFFAOYSA-N 2-(methoxymethyl)-7-[3-(trifluoromethyl)pyridin-2-yl]-n-(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COC)=NC(NC=3C=C4C(C(CN(C)C4)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1C(F)(F)F FOUNQNSFZOTUHB-UHFFFAOYSA-N 0.000 claims 1
- PMUFZJDTZFHGMK-UHFFFAOYSA-N 2-methyl-n-[2-(2-methylpropoxymethyl)-7-(3-methylpyridin-2-yl)pyrido[2,3-d]pyrimidin-4-yl]-1,3-benzoxazol-6-amine Chemical compound N=1C2=NC(COCC(C)C)=NC(NC=3C=C4OC(C)=NC4=CC=3)=C2C=CC=1C1=NC=CC=C1C PMUFZJDTZFHGMK-UHFFFAOYSA-N 0.000 claims 1
- BVHMUENOZZCADF-UHFFFAOYSA-N 4-methyl-n-[2-(2-methylpropoxymethyl)-7-[3-(trifluoromethyl)pyridin-2-yl]pyrido[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1,4-benzoxazin-6-amine Chemical compound N=1C2=NC(COCC(C)C)=NC(NC=3C=C4N(C)CCOC4=CC=3)=C2C=CC=1C1=NC=CC=C1C(F)(F)F BVHMUENOZZCADF-UHFFFAOYSA-N 0.000 claims 1
- LBYNRSNRKHMYOF-UHFFFAOYSA-N 4-methyl-n-[2-(2-methylpropoxymethyl)-7-pyridin-2-ylpyrido[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1,4-benzoxazin-6-amine Chemical compound N=1C2=NC(COCC(C)C)=NC(NC=3C=C4N(C)CCOC4=CC=3)=C2C=CC=1C1=CC=CC=N1 LBYNRSNRKHMYOF-UHFFFAOYSA-N 0.000 claims 1
- VETKDCUTSMTNIN-UHFFFAOYSA-N 7-(3-chloropyridin-2-yl)-2-(2-methylpropoxymethyl)-n-(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC(C)C)=NC(NC=3C=C4C(C(CN(C)C4)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1Cl VETKDCUTSMTNIN-UHFFFAOYSA-N 0.000 claims 1
- BAGYILOEONTUTO-UHFFFAOYSA-N 7-(3-chloropyridin-2-yl)-2-(ethoxymethyl)-n-(1,3,3-trimethyl-2h-indol-6-yl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC)=NC(NC=3C=C4C(C(CN4C)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1Cl BAGYILOEONTUTO-UHFFFAOYSA-N 0.000 claims 1
- DRNCPHGTYCPFCG-UHFFFAOYSA-N 7-(3-chloropyridin-2-yl)-2-(ethoxymethyl)-n-(2,4,4-trimethyl-1,3-dihydroisoquinolin-7-yl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC)=NC(NC=3C=C4C(C(CN(C)C4)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1Cl DRNCPHGTYCPFCG-UHFFFAOYSA-N 0.000 claims 1
- OZDKRWMSINJUKE-UHFFFAOYSA-N 7-(3-chloropyridin-2-yl)-n-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(2-methylpropoxymethyl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC(C)C)=NC(NC=3C=C4OCCOC4=CC=3)=C2C=CC=1C1=NC=CC=C1Cl OZDKRWMSINJUKE-UHFFFAOYSA-N 0.000 claims 1
- NVHCVLVCJQEYRS-UHFFFAOYSA-N 7-(3-chloropyridin-2-yl)-n-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(ethoxymethyl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC)=NC(NC=3C=C4OCCOC4=CC=3)=C2C=CC=1C1=NC=CC=C1Cl NVHCVLVCJQEYRS-UHFFFAOYSA-N 0.000 claims 1
- NNGGKNWKQGWMGH-UHFFFAOYSA-N 7-(3-chloropyridin-2-yl)-n-(4,4-dimethyl-2,3-dihydro-1h-quinolin-7-yl)-2-(2-methylpropoxymethyl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC(C)C)=NC(NC=3C=C4C(C(CCN4)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1Cl NNGGKNWKQGWMGH-UHFFFAOYSA-N 0.000 claims 1
- DDTLGKAUZLDJMH-UHFFFAOYSA-N 7-(3-chloropyridin-2-yl)-n-(4,4-dimethyl-2,3-dihydro-1h-quinolin-7-yl)-2-(ethoxymethyl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COCC)=NC(NC=3C=C4C(C(CCN4)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1Cl DDTLGKAUZLDJMH-UHFFFAOYSA-N 0.000 claims 1
- PUMFCZFRYZVZSV-UHFFFAOYSA-N 7-(3-chloropyridin-2-yl)-n-(4,4-dimethyl-2,3-dihydro-1h-quinolin-7-yl)-2-(methoxymethyl)pyrido[2,3-d]pyrimidin-4-amine Chemical compound N=1C2=NC(COC)=NC(NC=3C=C4C(C(CCN4)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1Cl PUMFCZFRYZVZSV-UHFFFAOYSA-N 0.000 claims 1
- MIZKXSZTQLZCEC-UHFFFAOYSA-N 7-[[2-(methoxymethyl)-7-[3-(trifluoromethyl)pyridin-2-yl]pyrido[2,3-d]pyrimidin-4-yl]amino]-2,4,4-trimethylisoquinoline-1,3-dione Chemical compound N=1C2=NC(COC)=NC(NC=3C=C4C(C(C(=O)N(C)C4=O)(C)C)=CC=3)=C2C=CC=1C1=NC=CC=C1C(F)(F)F MIZKXSZTQLZCEC-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
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- C07—ORGANIC CHEMISTRY
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50151503P | 2003-09-09 | 2003-09-09 | |
| US51598403P | 2003-10-31 | 2003-10-31 | |
| PCT/US2004/029583 WO2005023807A2 (en) | 2003-09-09 | 2004-09-09 | 4 - heterobicyclyamino - substituted quinazolines and analogues therof as capsaicin - antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007520444A true JP2007520444A (ja) | 2007-07-26 |
| JP2007520444A5 JP2007520444A5 (https=) | 2007-11-01 |
Family
ID=34278740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006526316A Withdrawn JP2007520444A (ja) | 2003-09-09 | 2004-09-09 | 置換二環式キナゾリン−４−イルアミン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070105865A1 (https=) |
| EP (1) | EP1678173A2 (https=) |
| JP (1) | JP2007520444A (https=) |
| AU (1) | AU2004270740A1 (https=) |
| CA (1) | CA2537883A1 (https=) |
| WO (1) | WO2005023807A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015501826A (ja) * | 2011-12-16 | 2015-01-19 | ロレアル | ７−アミノ−１，２，３，４−テトラヒドロキノリン構造を有するカプラー、それを含む染色組成物、方法及び使用 |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2509233A1 (en) * | 2002-12-13 | 2004-07-01 | Neurogen Corporation | 2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators |
| EP1720542A4 (en) * | 2004-03-04 | 2007-11-28 | Neurogen Corp | ARYL ALKYLAMINO-SUBSTITUTED CHINAZOLINE ANALOGUE |
| JP2007532570A (ja) * | 2004-04-08 | 2007-11-15 | ニューロジェン・コーポレーション | 置換シンノリン−４−イルアミン類 |
| KR101042490B1 (ko) | 2004-07-15 | 2011-06-16 | 니뽄 다바코 산교 가부시키가이샤 | 축합 벤즈아미드 화합물 및 바닐로이드 수용체 1형(ｖｒ1)활성 저해제 |
| TW200621251A (en) | 2004-10-12 | 2006-07-01 | Neurogen Corp | Substituted biaryl quinolin-4-ylamine analogues |
| US7429608B2 (en) | 2005-01-20 | 2008-09-30 | Amgen Inc. | Benzo[d]imidazol analogs as vanilloid receptor ligands and their use in treatments |
| AU2006208042A1 (en) * | 2005-01-25 | 2006-08-03 | Neurogen Corporation | Substituted pyridazinyl-and pyrimidinyl-quinolin-4-ylamine analogues |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| EP1979348B1 (en) * | 2005-12-21 | 2012-01-18 | Abbott Laboratories | Anti-viral compounds |
| US7915411B2 (en) | 2005-12-21 | 2011-03-29 | Abbott Laboratories | Anti-viral compounds |
| US7906508B2 (en) | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
| CA2632508A1 (en) * | 2005-12-28 | 2008-06-05 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compound and inhibitor of vanilloid receptor type 1 (vr1) activity |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| WO2008005303A2 (en) * | 2006-06-30 | 2008-01-10 | Janssen Pharmaceutica N.V. | Thiazolopyrimidine modulators of trpv1 |
| US8236950B2 (en) | 2006-12-20 | 2012-08-07 | Abbott Laboratories | Anti-viral compounds |
| WO2008129000A1 (en) * | 2007-04-20 | 2008-10-30 | Novartis Ag | Pyridopyrimidine derivatives and use thereof in the treatment of itch and itch related disorders |
| WO2009078999A1 (en) | 2007-12-17 | 2009-06-25 | Janssen Pharmaceutica N.V. | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1 |
| MX2013010163A (es) | 2011-03-09 | 2013-10-30 | Merck Patent Gmbh | Derivados de pirido[2,3-b] pirazina y sus usos terapeuticos. |
| US8716297B2 (en) | 2011-07-15 | 2014-05-06 | Abbvie Inc. | Chemical entities to be used for Wee1 inhibition for the treatment of cancer |
| WO2013012915A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| FR2984318B1 (fr) | 2011-12-16 | 2014-06-27 | Oreal | Coupleur de structure 7 amino-1,2,3,4-tetrahydroquinoleines cationiques, composition tinctoriale en comprenant, procedes et utilisations |
| FR3072286B1 (fr) | 2017-10-13 | 2022-08-12 | Oreal | 7-amino-1,2,3,4-tetrahydroquinoleines particuliers, procede et composition |
| FI4426434T3 (fi) | 2021-11-02 | 2025-11-24 | Flare Therapeutics Inc | Pparg:n käänteisagonisteja ja niiden käyttöjä |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395733B1 (en) * | 1995-06-07 | 2002-05-28 | Pfizer Inc | Heterocyclic ring-fused pyrimidine derivatives |
| GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| HRP970371A2 (en) * | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| ID19609A (id) * | 1996-07-13 | 1998-07-23 | Glaxo Group Ltd | Senyawa-senyawa heterosiklik |
| US6225318B1 (en) * | 1996-10-17 | 2001-05-01 | Pfizer Inc | 4-aminoquinazolone derivatives |
| US6413971B1 (en) * | 1996-11-27 | 2002-07-02 | Pfizer Inc | Fused bicyclic pyrimidine derivatives |
| JP2004525071A (ja) * | 2000-07-20 | 2004-08-19 | ニューロジェン コーポレイション | カプサイシン受容体リガンド |
| CN1627944A (zh) * | 2002-01-17 | 2005-06-15 | 神经能质公司 | 取代的喹唑啉－4－基胺类似物作为辣椒辣素调节剂 |
| CA2509233A1 (en) * | 2002-12-13 | 2004-07-01 | Neurogen Corporation | 2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators |
| TW200510373A (en) * | 2003-07-14 | 2005-03-16 | Neurogen Corp | Substituted quinolin-4-ylamine analogues |
| US7329664B2 (en) * | 2003-07-16 | 2008-02-12 | Neurogen Corporation | Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues |
-
2004
- 2004-09-09 JP JP2006526316A patent/JP2007520444A/ja not_active Withdrawn
- 2004-09-09 CA CA002537883A patent/CA2537883A1/en not_active Abandoned
- 2004-09-09 WO PCT/US2004/029583 patent/WO2005023807A2/en not_active Ceased
- 2004-09-09 US US10/571,203 patent/US20070105865A1/en not_active Abandoned
- 2004-09-09 AU AU2004270740A patent/AU2004270740A1/en not_active Abandoned
- 2004-09-09 EP EP04783712A patent/EP1678173A2/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015501826A (ja) * | 2011-12-16 | 2015-01-19 | ロレアル | ７−アミノ−１，２，３，４−テトラヒドロキノリン構造を有するカプラー、それを含む染色組成物、方法及び使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005023807A3 (en) | 2005-04-21 |
| WO2005023807A2 (en) | 2005-03-17 |
| EP1678173A2 (en) | 2006-07-12 |
| US20070105865A1 (en) | 2007-05-10 |
| CA2537883A1 (en) | 2005-03-17 |
| AU2004270740A1 (en) | 2005-03-17 |
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