JP2007519703A5 - - Google Patents
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- Publication number
- JP2007519703A5 JP2007519703A5 JP2006550330A JP2006550330A JP2007519703A5 JP 2007519703 A5 JP2007519703 A5 JP 2007519703A5 JP 2006550330 A JP2006550330 A JP 2006550330A JP 2006550330 A JP2006550330 A JP 2006550330A JP 2007519703 A5 JP2007519703 A5 JP 2007519703A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclodextrin
- composition according
- pharmaceutical composition
- preservative
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 229920000858 Cyclodextrin Polymers 0.000 claims 6
- 230000002335 preservative Effects 0.000 claims 6
- 239000003755 preservative agent Substances 0.000 claims 5
- 239000008186 active pharmaceutical agent Substances 0.000 claims 3
- 239000001116 FEMA 4028 Substances 0.000 claims 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 2
- 229960004853 betadex Drugs 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- 239000002462 tachykinin receptor antagonist Substances 0.000 claims 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N β-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 2
- LMWMTSCFTPQVCJ-UHFFFAOYSA-N 2-methylphenol;phenol Chemical compound OC1=CC=CC=C1.CC1=CC=CC=C1O LMWMTSCFTPQVCJ-UHFFFAOYSA-N 0.000 claims 1
- RLSSMJSEOOYNOY-UHFFFAOYSA-N M-Cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 claims 1
- 229960004063 Propylene glycol Drugs 0.000 claims 1
- 229940033663 Thimerosal Drugs 0.000 claims 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L Thiomersal Chemical group [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims 1
- 230000000845 anti-microbial Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940100630 metacresol Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Claims (9)
- 治療有効量の活性医薬成分、β-シクロデキストリン、医薬として許容される防腐剤、医薬として許容されるビヒクル、及び任意の医薬として許容される賦形剤を含む改善された注射部位寛容性を有する医薬組成物であって、当該防腐剤が、医薬として許容される抗菌性防腐効果を有し、そして当該活性医薬成分が以下の式Ｉ：
- 前記β-シクロデキストリンが、２-ヒドロキシプロピル-β-シクロデキストリン又はスルホブチル・エーテル-β-シクロデキストリンである、請求項１に記載の医薬組成物。
- 前記防腐剤が、チメロサール、プロピレン・グリコール、フェノール、又はメタ-クレゾールから選ばれるか、又はその組合せから選ばれる、請求項１又は２に記載の医薬組成物。
- 前記防腐剤が、前記活性医薬生物のシクロデキストリンへの結合値より小さいシクロデキストリンへの結合値を有する、請求項１〜３のいずれか一項に記載の医薬組成物。
- 約１ｍｇ/ｍｌ〜５ｍｇ/ｍｌの防腐剤が、シクロデキストリン中に隔離されていない、請求項１〜４のいずれか一項に記載の医薬組成物。
- 前記活性医薬成分のシクロデキストリンへの結合値が、５００Ｍ-1〜１０，０００Ｍ-1である、請求項１〜５のいずれか一項に記載の医薬組成物。
- 医薬として使用するための、請求項１〜６のいずれか一項に記載の医薬組成物。
- ニューロキニン受容体アンタゴニストを適応する疾患の治療用医薬の製造における、請求項２〜６のいずれか一項に記載の組成物の使用。
- ニューロキニン受容体アンタゴニストを適応する疾患の治療のための請求項１〜６のいずれか一項に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54089704P | 2004-01-30 | 2004-01-30 | |
| US60/540,897 | 2004-01-30 | ||
| PCT/IB2005/000100 WO2005082416A2 (en) | 2004-01-30 | 2005-01-17 | Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007519703A JP2007519703A (ja) | 2007-07-19 |
| JP2007519703A5 true JP2007519703A5 (ja) | 2007-11-29 |
| JP5021318B2 JP5021318B2 (ja) | 2012-09-05 |
Family
ID=34910697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006550330A Active JP5021318B2 (ja) | 2004-01-30 | 2005-01-17 | β−シクロデキストリンを液体投薬形態に用いて多用量製剤を達成するための抗菌性防腐剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8183230B2 (ja) |
| EP (1) | EP1713504B1 (ja) |
| JP (1) | JP5021318B2 (ja) |
| KR (1) | KR100834232B1 (ja) |
| CN (1) | CN101090735A (ja) |
| AR (2) | AR047469A1 (ja) |
| AU (1) | AU2005216709B2 (ja) |
| BR (1) | BRPI0506496B8 (ja) |
| CA (1) | CA2554346C (ja) |
| CO (1) | CO5700794A2 (ja) |
| CY (1) | CY1119188T1 (ja) |
| DK (1) | DK1713504T3 (ja) |
| ES (1) | ES2638113T3 (ja) |
| HU (1) | HUE034099T2 (ja) |
| IL (1) | IL176676A0 (ja) |
| LT (1) | LT1713504T (ja) |
| NO (1) | NO20063858L (ja) |
| NZ (1) | NZ548236A (ja) |
| PL (1) | PL1713504T3 (ja) |
| PT (1) | PT1713504T (ja) |
| RU (1) | RU2332997C2 (ja) |
| SI (1) | SI1713504T1 (ja) |
| TW (1) | TW200524632A (ja) |
| WO (1) | WO2005082416A2 (ja) |
| ZA (1) | ZA200605148B (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013273764B2 (en) * | 2011-11-29 | 2016-05-05 | Zoetis Services Llc | Pharmaceutical compositions |
| AU2012268889B2 (en) | 2011-11-29 | 2013-12-19 | Zoetis Services Llc | Pharmaceutical compositions |
| ES2860526T3 (es) * | 2013-07-19 | 2021-10-05 | Boehringer Ingelheim Vetmedica Gmbh | Derivados de ciclodextrina eterificada conservados que contienen una composición farmacéutica acuosa líquida |
| NL2015865B1 (en) | 2015-11-27 | 2017-06-13 | Le Vet B V | Maropitant Formulation. |
| CA3059418A1 (en) | 2017-04-10 | 2018-10-18 | Chase Therapeutics Corporation | Nk1-antagonist combination and method for treating synucleinopathies |
| US11266633B2 (en) | 2017-06-30 | 2022-03-08 | Chase Therapeutics Corporation | NK-1 antagonist compositions and methods for use in treating depression |
| WO2020167476A1 (en) | 2019-02-15 | 2020-08-20 | Saol International Limited | Injectable phenol formulations and methods of their use |
| EP3725298A1 (en) | 2019-04-16 | 2020-10-21 | Faes Farma, S.A. | Stable and preserved pharmaceutical compositions of bilastine |
| CN112370451A (zh) * | 2020-12-08 | 2021-02-19 | 河北科技大学 | 一种枸橼酸马罗匹坦包合物、注射液及制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5910510A (ja) * | 1982-07-08 | 1984-01-20 | Nippon Zenyaku Kogyo Kk | 低刺激性チアムリン注射剤 |
| JPS59152320A (ja) * | 1983-02-17 | 1984-08-31 | Takeda Chem Ind Ltd | 水性製剤 |
| JPS6419737A (en) * | 1987-07-15 | 1989-01-23 | Hitachi Ltd | Multilayer interconnection tape carrier |
| JPH039848A (ja) * | 1989-06-06 | 1991-01-17 | Canon Inc | 液体噴射記録装置 |
| UA27776C2 (uk) | 1991-05-31 | 2000-10-16 | Пфайзер Інк. | Похідні хінуклідину та їх фармацевтично прийнятні солі, що є антагоністами речовини р у ссавців, фармацевтична композиція, що має антагоністичну дію на речовину р у ссавців |
| US5602112A (en) * | 1992-06-19 | 1997-02-11 | Supergen, Inc. | Pharmaceutical formulation |
| CA2149242C (en) | 1992-11-12 | 1998-08-04 | Fumitaka Ito | Quinuclidine derivative for treatment of inflammatory and gastrointestinal disorders |
| US5393762A (en) | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
| EP1109581A1 (en) | 1998-09-02 | 2001-06-27 | Allergan Sales, Inc. | Preserved cyclodextrin-containing compositions |
| US6255320B1 (en) | 1999-06-01 | 2001-07-03 | Pfizer Inc. | Polymorphs of a crystalline azo-bicyclo (2,2,2) octan-3-amine citrate and their pharmaceutical compositions |
| WO2001001955A1 (en) * | 1999-07-02 | 2001-01-11 | Janssen Pharmaceutica N.V. | Nasal formulation of an antifungal |
| US7163681B2 (en) * | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
| US20030055023A1 (en) * | 2001-03-20 | 2003-03-20 | Rajewski Roger A. | Formulations containing etomidate and a sulfoalkyl ether cyclodextrin |
| US7034013B2 (en) * | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| HUP0401154A2 (hu) * | 2001-07-20 | 2004-10-28 | Pfizer Products Inc. | NK-1 receptor antagonisták használata kutyák, macskák és lovak nemkívánatos viselkedésének módosítására |
| AR038576A1 (es) * | 2002-02-22 | 2005-01-19 | Pharmacia Corp | Formulaciones de drogas antibioticas oftalmicas que contienen un compuesto de ciclodextrina y cloruro de cetil piridinio |
| US6869939B2 (en) | 2002-05-04 | 2005-03-22 | Cydex, Inc. | Formulations containing amiodarone and sulfoalkyl ether cyclodextrin |
| DE10228049A1 (de) | 2002-06-24 | 2004-01-15 | Merck Patent Gmbh | Flüssige Zubereitung enthaltend Oligopeptide |
| US6861526B2 (en) | 2002-10-16 | 2005-03-01 | Pfizer Inc. | Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine |
| MXPA06008648A (es) | 2004-01-30 | 2006-09-04 | Pfizer Prod Inc | Composiciones farmaceuticas de antagonistas del receptor de neuroquinina y ciclodextrina y metodos para una tolerancia mejorada en el sitio de inyeccion. |
| CN1913893A (zh) | 2004-01-30 | 2007-02-14 | 辉瑞产品有限公司 | 改善麻醉恢复的nk－1受体拮抗剂 |
| RU2320659C9 (ru) | 2004-02-02 | 2008-07-20 | Пфайзер Продактс Инк. | Способы получения 1-(2s, 3s)-2-бензгидрил-n-(5-трет-бутил-2-метоксибензил)хинуклидин-3-амина в виде камфорсульфатной соли, цитратной соли и свободного основания и промежуточное соединение |
-
2005
- 2005-01-17 PT PT57022634T patent/PT1713504T/pt unknown
- 2005-01-17 US US10/588,070 patent/US8183230B2/en active Active
- 2005-01-17 WO PCT/IB2005/000100 patent/WO2005082416A2/en active Application Filing
- 2005-01-17 RU RU2006127422/15A patent/RU2332997C2/ru not_active IP Right Cessation
- 2005-01-17 DK DK05702263.4T patent/DK1713504T3/en active
- 2005-01-17 JP JP2006550330A patent/JP5021318B2/ja active Active
- 2005-01-17 NZ NZ548236A patent/NZ548236A/en unknown
- 2005-01-17 BR BRPI0506496A patent/BRPI0506496B8/pt active IP Right Grant
- 2005-01-17 AU AU2005216709A patent/AU2005216709B2/en active Active
- 2005-01-17 LT LTEP05702263.4T patent/LT1713504T/lt unknown
- 2005-01-17 EP EP05702263.4A patent/EP1713504B1/en active Active
- 2005-01-17 HU HUE05702263A patent/HUE034099T2/en unknown
- 2005-01-17 SI SI200532166T patent/SI1713504T1/sl unknown
- 2005-01-17 PL PL05702263T patent/PL1713504T3/pl unknown
- 2005-01-17 CA CA002554346A patent/CA2554346C/en active Active
- 2005-01-17 CN CNA2005800032849A patent/CN101090735A/zh active Pending
- 2005-01-17 ES ES05702263.4T patent/ES2638113T3/es active Active
- 2005-01-17 KR KR1020067015283A patent/KR100834232B1/ko active IP Right Grant
- 2005-01-27 AR ARP050100283A patent/AR047469A1/es not_active Application Discontinuation
- 2005-01-28 TW TW094102680A patent/TW200524632A/zh unknown
-
2006
- 2006-06-22 ZA ZA200605148A patent/ZA200605148B/en unknown
- 2006-07-03 IL IL176676A patent/IL176676A0/en unknown
- 2006-07-26 CO CO06073023A patent/CO5700794A2/es not_active Application Discontinuation
- 2006-08-29 NO NO20063858A patent/NO20063858L/no not_active Application Discontinuation
-
2017
- 2017-08-04 CY CY20171100843T patent/CY1119188T1/el unknown
- 2017-08-16 AR ARP170102291A patent/AR109357A2/es not_active Application Discontinuation
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