JP2007516714A5 - 間葉系前駆細胞の骨芽細胞への分化を誘導する化合物の同定方法 - Google Patents

間葉系前駆細胞の骨芽細胞への分化を誘導する化合物の同定方法 Download PDF

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JP2007516714A5
JP2007516714A5 JP2006546129A JP2006546129A JP2007516714A5 JP 2007516714 A5 JP2007516714 A5 JP 2007516714A5 JP 2006546129 A JP2006546129 A JP 2006546129A JP 2006546129 A JP2006546129 A JP 2006546129A JP 2007516714 A5 JP2007516714 A5 JP 2007516714A5
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osteoblasts
progenitor cells
compound
mesenchymal progenitor
induce differentiation
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本発明は更に哺乳類の未分化細胞の骨芽細胞への分化を誘導する化合物を同定する方法に関連している。以下の（ａ）〜（ｄ）で構成される。
（ａ）表４にリストアップされ、表４にリストアップされた遺伝子の幾つかによってコードされたポリペプチド、及び／又は前記ポリペプチドの断片及び／又は誘導体を１又はそれ以上の化合物と接触させる工程；
（ｂ）ポリペプチドに対する化合物の結合親和性を決定する工程；
（ｃ）哺乳類の未分化細胞を少なくとも１０μモル濃度の結合親和性を示す化合物と接触させる工程；
（ｄ）哺乳類の未分化細胞の分化を誘導する化合物を同定する工程。

Claims (2)

  1. （ａ）１以上の化合物と、Ｇタンパク質結合レセプター２３遺伝子によってコードされたポリペプチド又は前記ポリペプチドの断片若しくは誘導体とを接触させる工程と、
    （ｂ）前記ポリペプチドに対する前記化合物の結合親和性を決定する工程と、
    （ｃ）少なくとも１０μモル濃度の結合親和性を示す前記化合物と、間葉系前駆細胞の個体群とを接触させる工程と、
    （ｄ）前記間葉系前駆細胞の骨芽細胞への分化を誘導する化合物を同定する工程と、
    で成ることを特徴とする間葉系前駆細胞の骨芽細胞への分化を誘導する化合物の同定方法。
  2. 前記化合物は低分子化合物、ペプチド、脂質、天然物及び生理活性物質のグループから選択される請求項１に記載の間葉系前駆細胞の骨芽細胞への分化を誘導する化合物の同定方法。
JP2006546129A 2003-12-29 2004-12-29 間葉系前駆細胞の骨芽細胞への分化を誘導する化合物の同定方法 Expired - Fee Related JP5667333B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP03/14994 2003-12-29
PCT/EP2003/014994 WO2005063983A1 (en) 2003-12-29 2003-12-29 Modulators of bone homeostasis identified in a high-throughput screen
PCT/EP2004/014885 WO2005063976A2 (en) 2003-12-29 2004-12-29 Methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts

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JP2007516714A JP2007516714A (ja) 2007-06-28
JP2007516714A5 true JP2007516714A5 (ja) 2014-11-13
JP5667333B2 JP5667333B2 (ja) 2015-02-12

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US (2) US7638288B2 (ja)
EP (4) EP2248898A3 (ja)
JP (1) JP5667333B2 (ja)
AU (1) AU2003300239A1 (ja)
CA (1) CA2551920A1 (ja)
WO (2) WO2005063983A1 (ja)

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