JP2007516696A5 - - Google Patents
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- Publication number
- JP2007516696A5 JP2007516696A5 JP2006533791A JP2006533791A JP2007516696A5 JP 2007516696 A5 JP2007516696 A5 JP 2007516696A5 JP 2006533791 A JP2006533791 A JP 2006533791A JP 2006533791 A JP2006533791 A JP 2006533791A JP 2007516696 A5 JP2007516696 A5 JP 2007516696A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- ige
- protein
- acid molecule
- signal peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 22
- 102000004169 proteins and genes Human genes 0.000 claims 22
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 12
- 108020001507 fusion proteins Proteins 0.000 claims 11
- 102000037865 fusion proteins Human genes 0.000 claims 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 230000002519 immonomodulatory effect Effects 0.000 claims 6
- 244000052769 pathogen Species 0.000 claims 6
- 230000001717 pathogenic effect Effects 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000012606 in vitro cell culture Methods 0.000 claims 2
- 108010029697 CD40 Ligand Proteins 0.000 claims 1
- 102100032937 CD40 ligand Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108010008038 Synthetic Vaccines Proteins 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229940124551 recombinant vaccine Drugs 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47821003P | 2003-06-13 | 2003-06-13 | |
| US47820503P | 2003-06-13 | 2003-06-13 | |
| PCT/US2004/018962 WO2005000235A2 (en) | 2003-06-13 | 2004-06-14 | NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IgE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012029973A Division JP5623444B2 (ja) | 2003-06-13 | 2012-02-14 | ＩｇＥシグナルペプチドおよび／またはＩＬ−１５をコードする核酸配列およびそれらを含む組成物およびその使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007516696A JP2007516696A (ja) | 2007-06-28 |
| JP2007516696A5 true JP2007516696A5 (https=) | 2012-04-05 |
Family
ID=33555491
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533791A Pending JP2007516696A (ja) | 2003-06-13 | 2004-06-14 | ＩｇＥシグナルペプチドおよび／またはＩＬ−１５をコードする核酸配列およびそれらを含んでなる組成物およびその使用法 |
| JP2012029973A Expired - Fee Related JP5623444B2 (ja) | 2003-06-13 | 2012-02-14 | ＩｇＥシグナルペプチドおよび／またはＩＬ−１５をコードする核酸配列およびそれらを含む組成物およびその使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012029973A Expired - Fee Related JP5623444B2 (ja) | 2003-06-13 | 2012-02-14 | ＩｇＥシグナルペプチドおよび／またはＩＬ−１５をコードする核酸配列およびそれらを含む組成物およびその使用法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8173786B2 (https=) |
| EP (2) | EP1638987B1 (https=) |
| JP (2) | JP2007516696A (https=) |
| KR (2) | KR101269548B1 (https=) |
| CN (1) | CN1832956B (https=) |
| AU (2) | AU2004251070B2 (https=) |
| BR (1) | BRPI0411363A (https=) |
| CA (1) | CA2529145C (https=) |
| IL (1) | IL172496A (https=) |
| MX (1) | MXPA05013526A (https=) |
| NZ (2) | NZ570709A (https=) |
| WO (1) | WO2005000235A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| ES2374458T3 (es) | 2006-01-13 | 2012-02-16 | The Trustees Of The University Of Pennsylvania | Vacunas y agentes inmunoterapéuticos que utilizan il-15 optimizada en codones, y métodos para utilización de los mismos. |
| CA3057039C (en) | 2006-07-28 | 2023-02-28 | The Trustees Of The University Of Pennsylvania | Hiv consensus envelope sequences and methods for using same |
| US10426827B1 (en) * | 2006-11-06 | 2019-10-01 | Microvax, Llc | Dengue hemorrhagic fever virus vaccine |
| KR101686942B1 (ko) * | 2008-01-11 | 2016-12-28 | 이노비오 파마수티컬즈, 인크. | 뎅기 바이러스 다중 서브타입에 대항하는 신규한 백신 |
| CA2720166A1 (en) * | 2008-04-04 | 2009-10-08 | David B. Weiner | Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same |
| KR101652767B1 (ko) * | 2008-04-04 | 2016-08-31 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Ｉｌ-28을 이용한 백신 및 면역치료제, 및 그를 사용하는 방법 및 조성물 |
| WO2011032179A1 (en) | 2009-09-14 | 2011-03-17 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same |
| EP2539354B1 (en) * | 2010-02-08 | 2017-04-05 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same |
| US9238679B2 (en) | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
| EA032364B1 (ru) | 2011-02-11 | 2019-05-31 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Молекула нуклеиновой кислоты, кодирующая коровый белок вируса гепатита в, и вакцина, содержащая указанную молекулу |
| JP6407028B2 (ja) | 2011-12-12 | 2018-10-17 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | ＭＲＳＡのＰＢＰ２ａ及びその断片を含むタンパク質、それをコードする核酸、並びにＭＲＳＡ感染を予防する及び治療するための組成物及びそれらの使用 |
| HK1210479A1 (en) | 2012-04-10 | 2016-04-22 | The Trustees Of The University Of Pennsylvania | Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same |
| CA3194125A1 (en) * | 2012-04-12 | 2013-10-17 | The Trustees Of The University Of Pennsylvania | Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same |
| EP3783098A1 (en) * | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| KR102375998B1 (ko) | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| KR20230145241A (ko) * | 2014-10-01 | 2023-10-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신 |
| EA201891000A1 (ru) * | 2015-10-22 | 2018-12-28 | МОДЕРНАТиЭкс, ИНК. | Вакцина против респираторно-синцитиального вируса |
| EA201892124A1 (ru) | 2016-12-02 | 2019-04-30 | Дэвид Б. Уэйнер | Днк-конструкции антител и способы их применения |
| CU24546B1 (es) * | 2016-12-30 | 2021-09-07 | Ct Ingenieria Genetica Biotecnologia | Composición vacunal que comprende un mutante de la interleucina-15 humana |
| EP3568474A1 (en) | 2017-01-10 | 2019-11-20 | Intrexon Corporation | Modulating expression of polypeptides via new gene switch expression systems |
| EP3703723A4 (en) | 2017-10-31 | 2021-12-15 | KaliVir Immunotherapeutics, Inc. | ONCOLYTIC PLATFORM VECTOR FOR SYSTEMS ADMINISTRATION |
| WO2019118764A1 (en) | 2017-12-13 | 2019-06-20 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting muc16 and uses thereof |
| KR102668476B1 (ko) | 2017-12-13 | 2024-05-23 | 이노비오 파마수티컬즈, 인크. | Boris를 표적으로 하는 암 백신 및 이의 용도 |
| WO2019118760A1 (en) | 2017-12-13 | 2019-06-20 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting mesothelin and uses thereof |
| WO2021050789A1 (en) | 2019-09-10 | 2021-03-18 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| JP2023510112A (ja) * | 2019-12-19 | 2023-03-13 | ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー | アフリカ豚熱ウイルスに対するワクチン、およびそれを使用する方法 |
| US12064481B2 (en) * | 2020-11-02 | 2024-08-20 | Drexel University | Compositions and methods employing adenosine deaminase-1 (ADA-1) as an adjuvant |
| TW202227621A (zh) | 2020-11-19 | 2022-07-16 | 美商凱立凡爾免疫治療股份有限公司 | 重塑腫瘤微環境的溶瘤免疫療法 |
| BR112023022681A2 (pt) * | 2021-04-30 | 2024-01-23 | Kalivir Immunotherapeutics Inc | Vírus oncolíticos para expressão modificada de mhc |
| US12605349B2 (en) | 2024-09-05 | 2026-04-21 | Orbus Therapeutics, Inc. | Methods of treating grade 3 astrocytoma |
Family Cites Families (42)
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|---|---|---|---|---|
| US2157994A (en) | 1937-11-08 | 1939-05-09 | Kelsey Hayes Wheel Co | Brake mechanism |
| US5077044A (en) | 1980-05-19 | 1991-12-31 | The Board Of Trustees Of The Leland Stanford Jr. University | Novel non-reverting shigella live vaccines |
| US5110587A (en) * | 1981-12-24 | 1992-05-05 | Health Research, Incorporated | Immunogenic composition comprising synthetically modified vaccinia virus |
| US5338683A (en) | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| US5174993A (en) | 1981-12-24 | 1992-12-29 | Health Research Inc. | Recombinant avipox virus and immunological use thereof |
| US4722848A (en) * | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| US5223424A (en) * | 1985-09-06 | 1993-06-29 | Prutech Research And Development | Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence |
| US5310668A (en) * | 1986-06-20 | 1994-05-10 | Merck & Co., Inc. | Varicella-zoster virus as a live recombinant vaccine |
| US5242829A (en) * | 1986-09-23 | 1993-09-07 | Therion Biologics Corporation | Recombinant pseudorabies virus |
| US5294441A (en) * | 1987-06-04 | 1994-03-15 | Washington University | Avirulent microbes and uses therefor: salmonella typhi |
| US5387744A (en) | 1987-06-04 | 1995-02-07 | Washington University | Avirulent microbes and uses therefor: Salmonella typhi |
| IL86583A0 (en) | 1987-06-04 | 1988-11-15 | Molecular Eng Ass | Vaccine containing a derivative of a microbe and method for the production thereof |
| US5112749A (en) | 1987-10-02 | 1992-05-12 | Praxis Biologics, Inc. | Vaccines for the malaria circumsporozoite protein |
| US5225336A (en) * | 1989-03-08 | 1993-07-06 | Health Research Incorporated | Recombinant poxvirus host range selection system |
| WO1990010693A1 (en) | 1989-03-08 | 1990-09-20 | Health Research, Inc. | Recombinant poxvirus host selection system |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| ES2090129T3 (es) * | 1989-03-31 | 1996-10-16 | Univ Washington | Vacunas que contienen microorganismos tipo phop avirulentos. |
| EP0431668B1 (en) | 1989-12-04 | 1995-02-15 | Akzo Nobel N.V. | Recombinant herpesvirus of turkeys and live vector vaccines derived thereof |
| US5294548A (en) * | 1990-04-02 | 1994-03-15 | American Biogenetic Sciences, Inc | Recombianant Hepatitis a virus |
| US5462734A (en) | 1990-11-02 | 1995-10-31 | Wisconsin Alumni Research Foundation | Bovine herpesvirus vaccine and method of using same |
| US5240703A (en) * | 1991-03-01 | 1993-08-31 | Syntro Corporation | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
| HU219767B (hu) | 1993-01-26 | 2001-07-30 | Leslie R. Coney | Készítmények és eljárások genetikai anyag sejtbe történő beviteléhez |
| US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5739118A (en) * | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| NL9401820A (nl) * | 1994-11-02 | 1996-06-03 | Meyn Maschf | Inrichting voor het bewerken van aan zijn poten opgehangen gevogelte. |
| US5962428A (en) | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| EP0759466B1 (en) * | 1995-08-01 | 2005-12-28 | F. Hoffmann-La Roche Ag | Low binding affinity interleukin-12 beta receptors |
| AU729579B2 (en) * | 1996-10-23 | 2001-02-01 | Trustees Of The University Of Pennsylvania, The | Immunotherapy and improved vaccines |
| AU9588398A (en) * | 1997-09-29 | 1999-04-23 | Beth Israel Deaconess Medical Center | Vaccine compositions and methods of enhancing vaccine efficacy |
| IL136731A0 (en) * | 1997-12-19 | 2001-06-14 | Immunex Corp | Method for reducing susceptibility to hiv infection |
| AU3291099A (en) * | 1998-02-11 | 1999-08-30 | Maxygen, Inc. | Genetic vaccine vector engineering |
| US7560105B1 (en) | 1999-10-04 | 2009-07-14 | Leids Universitair Medisch Centrum | Dendritic cells activated in the presence of glucocorticoid hormones are capable of suppressing antigen-specific T cell responses |
| EP1280889B1 (en) | 2000-05-11 | 2007-08-29 | Baylor Research Institute | Compositions and methods for producing antigen-presenting cells |
| AU2002211490A1 (en) | 2000-10-04 | 2002-04-15 | The Trustees Of The University Of Pennsylvania | Compositions and methods of using capsid protein from flaviviruses and pestiviruses |
| RS51829B (sr) | 2001-08-23 | 2012-02-29 | Genmab A/S. | Ljudska antitela specifična za interleukin 15 (il-15) |
| WO2004000217A2 (en) * | 2002-06-20 | 2003-12-31 | The Trustees Of The University Of Pennsylvania | Vaccines for suppressing ige-mediated allergic disease and methods for using the same |
| NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| KR20140137679A (ko) | 2013-05-23 | 2014-12-03 | 삼성전자주식회사 | 카드 소켓 장치 |
-
2004
- 2004-06-13 NZ NZ570709A patent/NZ570709A/en not_active IP Right Cessation
- 2004-06-14 KR KR1020057023994A patent/KR101269548B1/ko not_active Expired - Fee Related
- 2004-06-14 EP EP04776577.1A patent/EP1638987B1/en not_active Expired - Lifetime
- 2004-06-14 NZ NZ544077A patent/NZ544077A/en not_active IP Right Cessation
- 2004-06-14 EP EP10191165A patent/EP2292634A3/en not_active Withdrawn
- 2004-06-14 BR BRPI0411363-2A patent/BRPI0411363A/pt not_active Application Discontinuation
- 2004-06-14 CN CN2004800228915A patent/CN1832956B/zh not_active Expired - Fee Related
- 2004-06-14 CA CA2529145A patent/CA2529145C/en not_active Expired - Fee Related
- 2004-06-14 MX MXPA05013526A patent/MXPA05013526A/es active IP Right Grant
- 2004-06-14 US US10/560,650 patent/US8173786B2/en not_active Expired - Fee Related
- 2004-06-14 WO PCT/US2004/018962 patent/WO2005000235A2/en not_active Ceased
- 2004-06-14 AU AU2004251070A patent/AU2004251070B2/en not_active Ceased
- 2004-06-14 JP JP2006533791A patent/JP2007516696A/ja active Pending
- 2004-06-14 KR KR1020117023822A patent/KR101225473B1/ko not_active Expired - Fee Related
-
2005
- 2005-12-11 IL IL172496A patent/IL172496A/en active IP Right Grant
-
2012
- 2012-02-14 JP JP2012029973A patent/JP5623444B2/ja not_active Expired - Fee Related
- 2012-05-07 US US13/466,015 patent/US20120276142A1/en not_active Abandoned
- 2012-05-16 AU AU2012202867A patent/AU2012202867B2/en not_active Ceased
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