JP2007516696A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007516696A5 JP2007516696A5 JP2006533791A JP2006533791A JP2007516696A5 JP 2007516696 A5 JP2007516696 A5 JP 2007516696A5 JP 2006533791 A JP2006533791 A JP 2006533791A JP 2006533791 A JP2006533791 A JP 2006533791A JP 2007516696 A5 JP2007516696 A5 JP 2007516696A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- ige
- protein
- acid molecule
- signal peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 22
- 102000004169 proteins and genes Human genes 0.000 claims 22
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 12
- 108020001507 fusion proteins Proteins 0.000 claims 11
- 102000037865 fusion proteins Human genes 0.000 claims 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 230000002519 immonomodulatory effect Effects 0.000 claims 6
- 244000052769 pathogen Species 0.000 claims 6
- 230000001717 pathogenic effect Effects 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 238000012606 in vitro cell culture Methods 0.000 claims 2
- 108010029697 CD40 Ligand Proteins 0.000 claims 1
- 102100032937 CD40 ligand Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108010008038 Synthetic Vaccines Proteins 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229940124551 recombinant vaccine Drugs 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47820503P | 2003-06-13 | 2003-06-13 | |
| US47821003P | 2003-06-13 | 2003-06-13 | |
| PCT/US2004/018962 WO2005000235A2 (en) | 2003-06-13 | 2004-06-14 | NUCLEIC ACID SEQUENCES ENCODING AND COMPOSITIONS COMPRISING IgE SIGNAL PEPTIDE AND/OR IL-15 AND METHODS FOR USING THE SAME |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012029973A Division JP5623444B2 (ja) | 2003-06-13 | 2012-02-14 | ＩｇＥシグナルペプチドおよび／またはＩＬ−１５をコードする核酸配列およびそれらを含む組成物およびその使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007516696A JP2007516696A (ja) | 2007-06-28 |
| JP2007516696A5 true JP2007516696A5 (https=) | 2012-04-05 |
Family
ID=33555491
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533791A Pending JP2007516696A (ja) | 2003-06-13 | 2004-06-14 | ＩｇＥシグナルペプチドおよび／またはＩＬ−１５をコードする核酸配列およびそれらを含んでなる組成物およびその使用法 |
| JP2012029973A Expired - Fee Related JP5623444B2 (ja) | 2003-06-13 | 2012-02-14 | ＩｇＥシグナルペプチドおよび／またはＩＬ−１５をコードする核酸配列およびそれらを含む組成物およびその使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012029973A Expired - Fee Related JP5623444B2 (ja) | 2003-06-13 | 2012-02-14 | ＩｇＥシグナルペプチドおよび／またはＩＬ−１５をコードする核酸配列およびそれらを含む組成物およびその使用法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8173786B2 (https=) |
| EP (2) | EP1638987B1 (https=) |
| JP (2) | JP2007516696A (https=) |
| KR (2) | KR101225473B1 (https=) |
| CN (1) | CN1832956B (https=) |
| AU (2) | AU2004251070B2 (https=) |
| BR (1) | BRPI0411363A (https=) |
| CA (1) | CA2529145C (https=) |
| IL (1) | IL172496A (https=) |
| MX (1) | MXPA05013526A (https=) |
| NZ (2) | NZ570709A (https=) |
| WO (1) | WO2005000235A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| KR101421745B1 (ko) * | 2006-01-13 | 2014-07-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 코돈 최적화된 ｉｌ―15를 사용하는 백신 및 면역치료제, 및 그의 사용 방법 |
| AU2007278831B2 (en) | 2006-07-28 | 2013-03-21 | The Trustees Of The University Of Pennsylvania | Improved vaccines and methods for using the same |
| US10426827B1 (en) * | 2006-11-06 | 2019-10-01 | Microvax, Llc | Dengue hemorrhagic fever virus vaccine |
| ES2685435T3 (es) * | 2008-01-11 | 2018-10-09 | Inovio Pharmaceuticals, Inc. | Nuevas vacunas frente a múltiples subtipos del virus del dengue |
| US10071154B2 (en) * | 2008-04-04 | 2018-09-11 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same |
| KR101589511B1 (ko) * | 2008-04-04 | 2016-02-01 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 치쿤구니야 바이러스 단백질의 공통 서열, 이를 인코딩하는 핵산 분자, 조성물 및 이를 이용하는 방법 |
| CN102821790A (zh) | 2009-09-14 | 2012-12-12 | 宾夕法尼亚大学托管会 | 包含IL-15受体α和/或编码IL-15受体α的核酸分子的疫苗和免疫治疗剂,以及其使用方法 |
| CA2788902C (en) * | 2010-02-08 | 2019-09-03 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same |
| CN103442732B (zh) | 2011-02-11 | 2017-04-12 | 宾夕法尼亚大学托管会 | 编码乙型肝炎病毒核心蛋白的核酸分子和包含其的疫苗 |
| US9238679B2 (en) | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
| KR20140116095A (ko) | 2011-12-12 | 2014-10-01 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Mrsa pbp2a 및 이의 단편들을 포함하는 단백질, 이를 인코딩한 핵산, 및 mrsa 감염을 예방 및 치료하기 위한 조성물 및 그의 용도 |
| CA2870182A1 (en) | 2012-04-10 | 2013-10-17 | The Trustees Of The University Of Pennsylvania | Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same |
| CA3194125A1 (en) * | 2012-04-12 | 2013-10-17 | The Trustees Of The University Of Pennsylvania | Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same |
| EP3783098A1 (en) * | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| EP3656864A1 (en) | 2014-02-14 | 2020-05-27 | Board of Regents, The University of Texas System | Chimeric antigen receptors and methods of making |
| AU2015323944B2 (en) * | 2014-10-01 | 2018-11-29 | Inovio Pharmaceuticals, Inc. | Vaccines having an antigen and interleukin-21 as an adjuvant |
| MX2018004917A (es) * | 2015-10-22 | 2019-04-01 | Modernatx Inc | Vacuna de virus sincitial respiratorio. |
| EA201892124A1 (ru) | 2016-12-02 | 2019-04-30 | Дэвид Б. Уэйнер | Днк-конструкции антител и способы их применения |
| CU24546B1 (es) * | 2016-12-30 | 2021-09-07 | Ct Ingenieria Genetica Biotecnologia | Composición vacunal que comprende un mutante de la interleucina-15 humana |
| KR20190102259A (ko) | 2017-01-10 | 2019-09-03 | 인트렉손 코포레이션 | 신규의 유전자 스위치 발현 시스템을 통한 폴리펩티드의 발현 조절 |
| EP3973973A1 (en) | 2017-10-31 | 2022-03-30 | KaliVir Immunotherapeutics, Inc. | Platform oncolytic vector for systemic delivery |
| WO2019118760A1 (en) | 2017-12-13 | 2019-06-20 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting mesothelin and uses thereof |
| AU2018383663B2 (en) | 2017-12-13 | 2023-12-21 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting BORIS and uses thereof |
| AU2018383662C1 (en) | 2017-12-13 | 2023-02-09 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting MUC16 and uses thereof |
| CA3150224A1 (en) | 2019-09-10 | 2021-03-18 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| CN115135340A (zh) * | 2019-12-19 | 2022-09-30 | 威斯塔解剖学和生物学研究所 | 针对非洲猪瘟病毒的疫苗及其使用方法 |
| US12064481B2 (en) * | 2020-11-02 | 2024-08-20 | Drexel University | Compositions and methods employing adenosine deaminase-1 (ADA-1) as an adjuvant |
| CA3197371A1 (en) | 2020-11-19 | 2022-05-27 | Kalivir Immunotherapeutics, Inc. | Oncolytic immunotherapy by tumor micro-environment remodeling |
| EP4329786A4 (en) | 2021-04-30 | 2024-12-11 | KaliVir Immunotherapeutics, Inc. | Oncolytic viruses for modified mhc expression |
| US12605349B2 (en) | 2024-09-05 | 2026-04-21 | Orbus Therapeutics, Inc. | Methods of treating grade 3 astrocytoma |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2157994A (en) | 1937-11-08 | 1939-05-09 | Kelsey Hayes Wheel Co | Brake mechanism |
| US5077044A (en) | 1980-05-19 | 1991-12-31 | The Board Of Trustees Of The Leland Stanford Jr. University | Novel non-reverting shigella live vaccines |
| US5174993A (en) * | 1981-12-24 | 1992-12-29 | Health Research Inc. | Recombinant avipox virus and immunological use thereof |
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US5338683A (en) | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| US5110587A (en) | 1981-12-24 | 1992-05-05 | Health Research, Incorporated | Immunogenic composition comprising synthetically modified vaccinia virus |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| US5223424A (en) | 1985-09-06 | 1993-06-29 | Prutech Research And Development | Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence |
| US5310668A (en) * | 1986-06-20 | 1994-05-10 | Merck & Co., Inc. | Varicella-zoster virus as a live recombinant vaccine |
| US5242829A (en) | 1986-09-23 | 1993-09-07 | Therion Biologics Corporation | Recombinant pseudorabies virus |
| US5294441A (en) | 1987-06-04 | 1994-03-15 | Washington University | Avirulent microbes and uses therefor: salmonella typhi |
| IL86583A0 (en) | 1987-06-04 | 1988-11-15 | Molecular Eng Ass | Vaccine containing a derivative of a microbe and method for the production thereof |
| US5387744A (en) | 1987-06-04 | 1995-02-07 | Washington University | Avirulent microbes and uses therefor: Salmonella typhi |
| US5112749A (en) | 1987-10-02 | 1992-05-12 | Praxis Biologics, Inc. | Vaccines for the malaria circumsporozoite protein |
| JP3044062B2 (ja) | 1989-03-08 | 2000-05-22 | ヘルス・リサーチ・インク | 組換えポックスウイルス宿主選択系 |
| US5225336A (en) | 1989-03-08 | 1993-07-06 | Health Research Incorporated | Recombinant poxvirus host range selection system |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| EP0465560B1 (en) | 1989-03-31 | 1996-06-05 | Washington University | VACCINES CONTAINING AVIRULENT phoP-TYPE MICROORGANISMS |
| EP0431668B1 (en) * | 1989-12-04 | 1995-02-15 | Akzo Nobel N.V. | Recombinant herpesvirus of turkeys and live vector vaccines derived thereof |
| US5294548A (en) | 1990-04-02 | 1994-03-15 | American Biogenetic Sciences, Inc | Recombianant Hepatitis a virus |
| US5462734A (en) | 1990-11-02 | 1995-10-31 | Wisconsin Alumni Research Foundation | Bovine herpesvirus vaccine and method of using same |
| US5240703A (en) | 1991-03-01 | 1993-08-31 | Syntro Corporation | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| AU675702B2 (en) | 1993-01-26 | 1997-02-13 | Leslie R. Coney | Compositions and methods for delivery of genetic material |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| NL9401820A (nl) | 1994-11-02 | 1996-06-03 | Meyn Maschf | Inrichting voor het bewerken van aan zijn poten opgehangen gevogelte. |
| US5962428A (en) | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5840530A (en) | 1995-08-01 | 1998-11-24 | Hoffmann-La Roche Inc. | DNA encoding receptors for the beta-2 chain of human IL-12 |
| KR100780158B1 (ko) * | 1996-10-23 | 2007-11-27 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 면역 치료법 및 개량 백신 |
| AU9588398A (en) * | 1997-09-29 | 1999-04-23 | Beth Israel Deaconess Medical Center | Vaccine compositions and methods of enhancing vaccine efficacy |
| CA2313805A1 (en) * | 1997-12-19 | 1999-07-01 | Immunex Corporation | Method for reducing susceptibility to hiv infection |
| MXPA00007893A (es) * | 1998-02-11 | 2002-10-23 | Maxygen Inc | Direccion de vectores de vacunas geneticas. |
| US7560105B1 (en) * | 1999-10-04 | 2009-07-14 | Leids Universitair Medisch Centrum | Dendritic cells activated in the presence of glucocorticoid hormones are capable of suppressing antigen-specific T cell responses |
| AU2001259744A1 (en) * | 2000-05-11 | 2001-11-20 | Baylor Research Institute | Compositions and methods for producing antigen-presenting cells |
| AU1152402A (en) * | 2000-10-04 | 2002-04-15 | Univ Pennsylvania | Highly expressible genes |
| IL160358A0 (en) | 2001-08-23 | 2004-07-25 | Genmab As | Human antibodies specific for interleukin 15 (il-15) |
| WO2004000217A2 (en) * | 2002-06-20 | 2003-12-31 | The Trustees Of The University Of Pennsylvania | Vaccines for suppressing ige-mediated allergic disease and methods for using the same |
| NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| KR20140137679A (ko) | 2013-05-23 | 2014-12-03 | 삼성전자주식회사 | 카드 소켓 장치 |
-
2004
- 2004-06-13 NZ NZ570709A patent/NZ570709A/en not_active IP Right Cessation
- 2004-06-14 CN CN2004800228915A patent/CN1832956B/zh not_active Expired - Fee Related
- 2004-06-14 KR KR1020117023822A patent/KR101225473B1/ko not_active Expired - Fee Related
- 2004-06-14 EP EP04776577.1A patent/EP1638987B1/en not_active Expired - Lifetime
- 2004-06-14 AU AU2004251070A patent/AU2004251070B2/en not_active Ceased
- 2004-06-14 US US10/560,650 patent/US8173786B2/en not_active Expired - Fee Related
- 2004-06-14 BR BRPI0411363-2A patent/BRPI0411363A/pt not_active Application Discontinuation
- 2004-06-14 WO PCT/US2004/018962 patent/WO2005000235A2/en not_active Ceased
- 2004-06-14 CA CA2529145A patent/CA2529145C/en not_active Expired - Fee Related
- 2004-06-14 MX MXPA05013526A patent/MXPA05013526A/es active IP Right Grant
- 2004-06-14 EP EP10191165A patent/EP2292634A3/en not_active Withdrawn
- 2004-06-14 JP JP2006533791A patent/JP2007516696A/ja active Pending
- 2004-06-14 NZ NZ544077A patent/NZ544077A/en not_active IP Right Cessation
- 2004-06-14 KR KR1020057023994A patent/KR101269548B1/ko not_active Expired - Fee Related
-
2005
- 2005-12-11 IL IL172496A patent/IL172496A/en active IP Right Grant
-
2012
- 2012-02-14 JP JP2012029973A patent/JP5623444B2/ja not_active Expired - Fee Related
- 2012-05-07 US US13/466,015 patent/US20120276142A1/en not_active Abandoned
- 2012-05-16 AU AU2012202867A patent/AU2012202867B2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007516696A5 (https=) | ||
| HRP20191594T1 (hr) | Poticanje imunosnog odgovora | |
| Yelverton et al. | Rabies virus glycoprotein analogs: biosynthesis in Escherichia coli | |
| JP2009523422A5 (https=) | ||
| JP2009540801A5 (https=) | ||
| WO2002012281A3 (en) | Molecular vaccine linking an endoplasmic reticulum chaperone polypeptide to an antigen | |
| MXPA02006888A (es) | Flavivirus recombinantes y metodos para utilizar los mismos. | |
| DK1829551T3 (da) | Modificeret varmchokprotein-antigenpeptid-kompleks | |
| UA98620C2 (uk) | Атенуйований вірус класичної лихоманки свиней, що містить модифікований глікопротеїн е2 | |
| NO20015587L (no) | Ekspresjon og eksport av interferon-<alfa> proteiner som Fc fusjonsproteiner | |
| CA2623329A1 (en) | Chimeric antigen containing hepatitis c virus polypeptide and fc fragment for eliciting an immune response | |
| WO2008005880A3 (en) | Antibodies for norovirus | |
| CA2505942A1 (en) | West nile virus vaccine | |
| RU2017127024A (ru) | Герпесвирус с измененным спектром мишеней, содержащий гибридный гликопротеин н | |
| WO2004108937A1 (en) | Cell surface expression vector of sars virus antigen and microorganisms transformed thereby | |
| WO2021171297A1 (en) | Compositions comprising ltb and pathogenic antigens, and use thereof | |
| JP2004506018A5 (https=) | ||
| DK0644894T3 (da) | Peptid til stimulering af Hepatitis C virus-specifikke cytotoksiske T-lymfocytter | |
| DE602007011616D1 (de) | Verfahren zur herstellung von oligopeptiden | |
| CN102178950B (zh) | 一种亚单位疫苗免疫佐剂及应用 | |
| ZA200806551B (en) | Hepatitis C virus non structural fusion protein | |
| WO2008136470A1 (ja) | Ｈｃｖ遺伝子 | |
| KR101635673B1 (ko) | Ａ형 간염 바이러스 백신 소재 단백질 ｖｐ1-3ｎ 및 백신 조성물 | |
| ATE435660T1 (de) | Immunogenes polypeptid bestehend aus optimierten kryptischen peptiden aus tumorantigenen und seine verwendungen | |
| KR101987775B1 (ko) | 구제역 바이러스의 가용성 다가 항원단백질 및 이의 용도 |