JP2007515402A - 哺乳動物および鳥類の体脂肪および体重の減少方法 - Google Patents
哺乳動物および鳥類の体脂肪および体重の減少方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/20—Feeding-stuffs specially adapted for particular animals for horses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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- Feed For Specific Animals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52437603P | 2003-11-20 | 2003-11-20 | |
| PCT/US2004/037966 WO2005051092A2 (en) | 2003-11-20 | 2004-11-12 | Method of decreasing fat deposits and body weight in mammals and birds |
| US10/987,665 US20050113456A1 (en) | 2003-11-20 | 2004-11-12 | Method of decreasing fat deposits and body weight in mammals and birds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007515402A true JP2007515402A (ja) | 2007-06-14 |
| JP2007515402A5 JP2007515402A5 (https=) | 2007-07-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006541282A Pending JP2007515402A (ja) | 2003-11-20 | 2004-11-12 | 哺乳動物および鳥類の体脂肪および体重の減少方法 |
Country Status (8)
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| US (2) | US20050113456A1 (https=) |
| EP (1) | EP1684593A4 (https=) |
| JP (1) | JP2007515402A (https=) |
| AU (1) | AU2004292416B2 (https=) |
| CA (1) | CA2545559A1 (https=) |
| NZ (1) | NZ547178A (https=) |
| WO (1) | WO2005051092A2 (https=) |
| ZA (1) | ZA200604077B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2615173C (en) | 2005-07-14 | 2012-01-03 | Lipothera, Inc. | Sustained release enhanced lipolytic formulation for regional adipose tissue treatment |
| US20070264313A1 (en) * | 2006-05-12 | 2007-11-15 | Musser Robert E | Methods and compositions relating to animal dietary acids |
| JP2010506941A (ja) * | 2006-10-17 | 2010-03-04 | リセラ,インク. | 甲状腺眼症の治療のための方法、組成物及び製剤 |
| WO2009073051A1 (en) * | 2007-12-03 | 2009-06-11 | Bridge Pharma, Inc. | Use of rr/sr-ractopamine |
| WO2010027259A1 (en) | 2008-09-02 | 2010-03-11 | N.V. Nutricia | Nutritional compositions with coated lipid globules |
| WO2010068086A1 (en) | 2008-12-11 | 2010-06-17 | N.V. Nutricia | Nutritional compositions with large lipid globule size |
| US9132084B2 (en) * | 2009-05-27 | 2015-09-15 | Neothetics, Inc. | Methods for administration and formulations for the treatment of regional adipose tissue |
| GB2487868B (en) * | 2010-01-15 | 2014-12-10 | Neothetics Inc | Lyophilized cake formulations |
| WO2011115476A1 (en) | 2010-03-17 | 2011-09-22 | N.V. Nutricia | Infant nutrition for improving fatty acid composition of brain membranes later in life |
| UA111822C2 (uk) * | 2010-11-24 | 2016-06-24 | Общєство С Огранічєнной Отвєтствєнностью "Новамедіка" | Монотерапевтичий препарат селективного ліпофільного бета-агоніста тривалої дії і спосіб косметичного лікування ожиріння і контурного випинання |
| ES2693519T3 (es) | 2013-11-01 | 2018-12-12 | N.V. Nutricia | Composición lipídica para mejorar la composición corporal durante el crecimiento de recuperación |
| KR102273533B1 (ko) * | 2015-06-15 | 2021-07-06 | 삼성전자 주식회사 | 무선 통신 시스템에서 서비스 제공 방법 및 장치 |
| WO2017064304A1 (en) | 2015-10-15 | 2017-04-20 | N.V. Nutricia | Infant formula with special lipid architecture for promoting healthy growth |
| ES2987545T3 (es) | 2016-12-09 | 2024-11-15 | Nutricia Nv | Composición nutricional para su uso en la mejora del rendimiento cognitivo y/o la prevención del deterioro cognitivo |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04507091A (ja) * | 1989-07-07 | 1992-12-10 | ニコメッド ダーク エイ/エス | 体重減量医薬組成物 |
| US5399765A (en) * | 1994-05-23 | 1995-03-21 | Sepracor, Inc. | Enantioselective preparation of optically pure albuterol |
| US5545745A (en) * | 1994-05-23 | 1996-08-13 | Sepracor, Inc. | Enantioselective preparation of optically pure albuterol |
| WO1998048810A1 (en) * | 1997-04-30 | 1998-11-05 | Bridge Pharma, Inc. | Composition and methods using an eutomer |
| WO2002048090A1 (en) * | 2000-12-11 | 2002-06-20 | Cipla Limited | Process for preparing isomers of salbutamol |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0085514A3 (en) * | 1982-01-28 | 1984-02-29 | Beecham Group Plc | Compositions comprising a beta-antagonist and a beta-agonist, their preparation, and their use in treating obese humans and animals |
| GB8604134D0 (en) * | 1986-02-19 | 1986-03-26 | Glaxo Group Ltd | Veterinary preparations |
| IE60964B1 (en) * | 1986-12-11 | 1994-09-07 | Roussel Uclaf | Zootechnical compositions containing a beta-adrenergic |
| US5147869A (en) * | 1986-12-11 | 1992-09-15 | Roussel Uclaf | Zootechnical compositions |
| US5541188A (en) * | 1987-09-15 | 1996-07-30 | The Rowett Research Institute | Therapeutic applications of beta-adrenergic agonists |
| US5530029A (en) * | 1987-09-15 | 1996-06-25 | The Rowett Research Institute | Therapeutic applications of clenbuterol |
| FR2642075B1 (fr) * | 1989-01-25 | 1991-04-26 | Pasteur Institut | Polypeptides ayant une activite de recepteur (beta)-adrenergique chez l'homme, impliques dans la reponse lipolytique, acides nucleiques codant pour ces polypeptides et utilisation de ces polypeptides pour le criblage de substance active sur ces polypeptides |
| JP3085705B2 (ja) * | 1990-01-05 | 2000-09-11 | セプラカー・インコーポレーテツド | 喘息の治療のための光学的純粋r(−)アルブテロール |
| US5362755A (en) * | 1990-01-05 | 1994-11-08 | Sepracor, Inc. | Method for treating asthma using optically pure (R)-albuterol |
| JP3358631B2 (ja) * | 1993-05-17 | 2002-12-24 | 三菱瓦斯化学株式会社 | メタノ−ルの脱水素方法 |
| US5698199A (en) * | 1995-03-10 | 1997-12-16 | Kao Corporation | Lipolysis acceleration method |
| US5708036A (en) * | 1996-01-29 | 1998-01-13 | Pesterfield, Jr.; E. Charles | Method of treating premature uterine contractions using the optically active R(-)-isomer of albuterol |
| US7767708B2 (en) * | 1998-11-04 | 2010-08-03 | Schering-Plough Animal Health Corp. | Growth stimulant compositions |
| US6683115B2 (en) * | 1999-06-02 | 2004-01-27 | Theravance, Inc. | β2-adrenergic receptor agonists |
-
2004
- 2004-11-12 NZ NZ547178A patent/NZ547178A/en not_active IP Right Cessation
- 2004-11-12 WO PCT/US2004/037966 patent/WO2005051092A2/en not_active Ceased
- 2004-11-12 US US10/987,665 patent/US20050113456A1/en not_active Abandoned
- 2004-11-12 JP JP2006541282A patent/JP2007515402A/ja active Pending
- 2004-11-12 CA CA002545559A patent/CA2545559A1/en not_active Abandoned
- 2004-11-12 EP EP04810943A patent/EP1684593A4/en not_active Withdrawn
- 2004-11-12 AU AU2004292416A patent/AU2004292416B2/en not_active Ceased
-
2006
- 2006-05-19 ZA ZA2006/04077A patent/ZA200604077B/en unknown
-
2007
- 2007-08-06 US US11/834,580 patent/US20080020019A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04507091A (ja) * | 1989-07-07 | 1992-12-10 | ニコメッド ダーク エイ/エス | 体重減量医薬組成物 |
| US5399765A (en) * | 1994-05-23 | 1995-03-21 | Sepracor, Inc. | Enantioselective preparation of optically pure albuterol |
| US5545745A (en) * | 1994-05-23 | 1996-08-13 | Sepracor, Inc. | Enantioselective preparation of optically pure albuterol |
| WO1998048810A1 (en) * | 1997-04-30 | 1998-11-05 | Bridge Pharma, Inc. | Composition and methods using an eutomer |
| WO2002048090A1 (en) * | 2000-12-11 | 2002-06-20 | Cipla Limited | Process for preparing isomers of salbutamol |
Non-Patent Citations (5)
| Title |
|---|
| JPN6010013711, Warriss PD et al., "The effects of the beta−adrenergic agonist salbutamol on meat quality in pigs", Journal of Animal Science, 1990, 68巻1号, pp.128−136 * |
| JPN6010013715, Sota E et al., "Organ weights, muscle composition and fatty acid profiles in lambs fed salbutamol: Effect of a 5−day", Meat Science, 1995, 41巻1号, pp.29−35 * |
| JPN6010013722, Zhang XY et al., "Effects of enantiomers of beta 2−agonists on ACh release and smooth muscle contraction in the trache", Am J Physiol Lung Cell Mol Physiol, 1998, 274巻, pp.L32−L38 * |
| JPN6010013726, Boulton DW and Fawcett JP, "The pharmacokinetics of levosalbutamol : What are the clinical implications?", Clinical pharmacokinetics, 2001, 40巻1号, pp.23−40 * |
| JPN7010000771, Mirkin G, "Albuterol for weight control", Dr. Mirkin’s free weekly Fitness and Health e−Zine, 199407, page 1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20050113456A1 (en) | 2005-05-26 |
| ZA200604077B (en) | 2009-11-29 |
| EP1684593A4 (en) | 2010-02-10 |
| EP1684593A2 (en) | 2006-08-02 |
| WO2005051092A3 (en) | 2006-04-06 |
| CA2545559A1 (en) | 2005-06-09 |
| WO2005051092A2 (en) | 2005-06-09 |
| AU2004292416A1 (en) | 2005-06-09 |
| NZ547178A (en) | 2008-06-30 |
| AU2004292416B2 (en) | 2010-01-28 |
| US20080020019A1 (en) | 2008-01-24 |
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