JP2007511494A5 - - Google Patents
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- Publication number
- JP2007511494A5 JP2007511494A5 JP2006538954A JP2006538954A JP2007511494A5 JP 2007511494 A5 JP2007511494 A5 JP 2007511494A5 JP 2006538954 A JP2006538954 A JP 2006538954A JP 2006538954 A JP2006538954 A JP 2006538954A JP 2007511494 A5 JP2007511494 A5 JP 2007511494A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- contrast agent
- radioactive
- alkyl
- agent according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002285 radioactive effect Effects 0.000 claims 11
- 239000002872 contrast media Substances 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 claims 5
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 claims 5
- 229910021645 metal ion Inorganic materials 0.000 claims 5
- 101710170181 Metalloproteinase inhibitor Proteins 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 239000003475 metalloproteinase inhibitor Substances 0.000 claims 4
- 229940126170 metalloproteinase inhibitor Drugs 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 239000012217 radiopharmaceutical Substances 0.000 claims 4
- 229940121896 radiopharmaceutical Drugs 0.000 claims 4
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000002993 cycloalkylene group Chemical group 0.000 claims 3
- 125000005549 heteroarylene group Chemical group 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 150000004696 coordination complex Chemical class 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 2
- 150000002337 glycosamines Chemical class 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004474 heteroalkylene group Chemical group 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 229910052755 nonmetal Inorganic materials 0.000 claims 2
- 230000005298 paramagnetic effect Effects 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000006585 (C6-C10) arylene group Chemical group 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000005251 gamma ray Effects 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 238000012634 optical imaging Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0326546.9A GB0326546D0 (en) | 2003-11-14 | 2003-11-14 | Inhibitor imaging agents |
| GB0326546.9 | 2003-11-14 | ||
| PCT/GB2004/004792 WO2005049005A1 (en) | 2003-11-14 | 2004-11-12 | Inhibitor imaging agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007511494A JP2007511494A (ja) | 2007-05-10 |
| JP2007511494A5 true JP2007511494A5 (enExample) | 2007-10-25 |
| JP5043438B2 JP5043438B2 (ja) | 2012-10-10 |
Family
ID=29726529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538954A Expired - Fee Related JP5043438B2 (ja) | 2003-11-14 | 2004-11-12 | 阻害剤造影剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20070104644A1 (enExample) |
| EP (1) | EP1682113B1 (enExample) |
| JP (1) | JP5043438B2 (enExample) |
| KR (1) | KR20060118479A (enExample) |
| CN (1) | CN1901894A (enExample) |
| AT (1) | ATE384519T1 (enExample) |
| AU (1) | AU2004290950A1 (enExample) |
| BR (1) | BRPI0416528A (enExample) |
| CA (1) | CA2545267A1 (enExample) |
| DE (1) | DE602004011553T2 (enExample) |
| ES (1) | ES2299884T3 (enExample) |
| GB (1) | GB0326546D0 (enExample) |
| MX (1) | MXPA06005355A (enExample) |
| NO (1) | NO20062118L (enExample) |
| RU (1) | RU2006117298A (enExample) |
| WO (1) | WO2005049005A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200630337A (en) * | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| WO2007030012A2 (en) * | 2005-09-05 | 2007-03-15 | Stichting Voor De Technische Wetenscahappen | Extracellular matrix imaging |
| FR2891830B1 (fr) | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| GB0520527D0 (en) * | 2005-10-10 | 2005-11-16 | Ge Healthcare Ltd | Automated method |
| EP1989179B1 (en) | 2006-02-15 | 2011-01-26 | Ge Healthcare As | Contrast agents |
| WO2007110449A1 (en) * | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
| RU2008142598A (ru) * | 2006-03-29 | 2010-05-10 | Новартис АГ (CH) | Селективные гидроксаматные ингибиторы ммп |
| WO2007118853A1 (en) * | 2006-04-13 | 2007-10-25 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use as blockers of calcium channels |
| TW200812963A (en) * | 2006-04-13 | 2008-03-16 | Euro Celtique Sa | Benzenesulfonamide compounds and the use thereof |
| GB0610395D0 (en) * | 2006-05-25 | 2006-07-05 | Ge Healthcare Ltd | Novel imaging agents |
| JP2010513476A (ja) * | 2006-12-20 | 2010-04-30 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
| WO2008124118A1 (en) * | 2007-04-09 | 2008-10-16 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use therof |
| WO2009040659A2 (en) * | 2007-09-28 | 2009-04-02 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| EP2119690A1 (en) * | 2008-05-14 | 2009-11-18 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Radiolabelled MMP selective compounds |
| JP5322527B2 (ja) * | 2008-07-17 | 2013-10-23 | 浜松ホトニクス株式会社 | アポトーシスの検出に適した化合物 |
| EP2147684A1 (en) * | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
| WO2010138720A2 (en) * | 2009-05-27 | 2010-12-02 | The Scripps Research Institute | Compounds and methods for chelating metals in aqueous solutions |
| ES2576853T3 (es) | 2009-07-03 | 2016-07-11 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Compuestos dirigidos al receptor del manosa 6-fosfato independiente de cationes |
| US9023318B2 (en) * | 2011-06-08 | 2015-05-05 | Siemens Medical Solutions Usa, Inc. | Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof |
| US8871189B2 (en) * | 2011-11-30 | 2014-10-28 | Mallinckrodt Llc | MMP-targeted therapeutic and/or diagnostic nanocarriers |
| CN103980277B (zh) * | 2014-05-27 | 2016-06-15 | 青岛大学 | 一种叶酸巯基化衍生物的制备方法 |
| GB202012671D0 (en) * | 2020-08-13 | 2020-09-30 | Nrf Ithemba Labs | Theranostic Compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714465A (en) * | 1989-05-19 | 1998-02-03 | Amgen Inc. | Method of inhibiting tumor cell dissemination with a metalloproteinase inhibitor |
| US5863949A (en) * | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| PT1003720E (pt) * | 1997-08-08 | 2004-07-30 | Pfizer Prod Inc | Derivados de acido ariloxiarilsulfonilamino hidroxamico |
| ATE217863T1 (de) * | 1997-08-08 | 2002-06-15 | Pfizer Prod Inc | Arylsulfonylaminohydroxamsäurederivate |
| IL127496A0 (en) * | 1997-12-19 | 1999-10-28 | Pfizer Prod Inc | The use of MMP inhibitors for the treatment of ocular angiogenesis |
| ES2220004T3 (es) * | 1998-04-10 | 2004-12-01 | Pfizer Products Inc. | Derivados del acido ciclobutil-ariloxiarilsulfonilaminohidroxamico. |
| ATE260251T1 (de) * | 1999-08-18 | 2004-03-15 | Warner Lambert Co | Hydroxamsäurederivate als matrix- metalloproteinase-inhibitoren |
| IL138686A0 (en) * | 1999-10-01 | 2001-10-31 | Pfizer Prod Inc | α- SULFONYLAMINO HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVOUS SYSTEM DISORDERS |
| US6656448B1 (en) * | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
| AU2001265182A1 (en) * | 2000-05-30 | 2001-12-11 | Rafael Fridman | Inhibitors of matrix metalloproteinases |
| US8231858B2 (en) * | 2003-02-10 | 2012-07-31 | Ge Healthcare Limited | Diagnostic imaging agents with MMP inhibitory activity |
-
2003
- 2003-11-14 GB GBGB0326546.9A patent/GB0326546D0/en not_active Ceased
-
2004
- 2004-11-12 DE DE602004011553T patent/DE602004011553T2/de not_active Expired - Lifetime
- 2004-11-12 CN CNA2004800403628A patent/CN1901894A/zh active Pending
- 2004-11-12 KR KR1020067009293A patent/KR20060118479A/ko not_active Withdrawn
- 2004-11-12 US US10/560,371 patent/US20070104644A1/en not_active Abandoned
- 2004-11-12 BR BRPI0416528-4A patent/BRPI0416528A/pt not_active IP Right Cessation
- 2004-11-12 CA CA002545267A patent/CA2545267A1/en not_active Abandoned
- 2004-11-12 EP EP04798512A patent/EP1682113B1/en not_active Expired - Lifetime
- 2004-11-12 ES ES04798512T patent/ES2299884T3/es not_active Expired - Lifetime
- 2004-11-12 MX MXPA06005355A patent/MXPA06005355A/es unknown
- 2004-11-12 RU RU2006117298/15A patent/RU2006117298A/ru not_active Application Discontinuation
- 2004-11-12 WO PCT/GB2004/004792 patent/WO2005049005A1/en not_active Ceased
- 2004-11-12 AU AU2004290950A patent/AU2004290950A1/en not_active Abandoned
- 2004-11-12 JP JP2006538954A patent/JP5043438B2/ja not_active Expired - Fee Related
- 2004-11-12 AT AT04798512T patent/ATE384519T1/de not_active IP Right Cessation
-
2006
- 2006-05-11 NO NO20062118A patent/NO20062118L/no not_active Application Discontinuation
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