JP2007510714A5 - - Google Patents
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- Publication number
- JP2007510714A5 JP2007510714A5 JP2006538993A JP2006538993A JP2007510714A5 JP 2007510714 A5 JP2007510714 A5 JP 2007510714A5 JP 2006538993 A JP2006538993 A JP 2006538993A JP 2006538993 A JP2006538993 A JP 2006538993A JP 2007510714 A5 JP2007510714 A5 JP 2007510714A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- statin
- hours
- transporting
- rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 21
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 16
- 230000002378 acidificating effect Effects 0.000 claims 4
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 3
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 3
- 238000010521 absorption reaction Methods 0.000 claims 3
- 229960005370 atorvastatin Drugs 0.000 claims 3
- 229960000672 rosuvastatin Drugs 0.000 claims 3
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 210000000936 intestine Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51677003P | 2003-11-04 | 2003-11-04 | |
| US10/967,167 US8987322B2 (en) | 2003-11-04 | 2004-10-19 | Pharmaceutical formulations for carrier-mediated transport statins and uses thereof |
| PCT/IB2004/003849 WO2005041939A1 (en) | 2003-11-04 | 2004-10-29 | Pharmaceutical formulations for carrier-mediated transport statins and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007510714A JP2007510714A (ja) | 2007-04-26 |
| JP2007510714A5 true JP2007510714A5 (enExample) | 2007-11-29 |
Family
ID=34556205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538993A Pending JP2007510714A (ja) | 2003-11-04 | 2004-10-29 | 担体輸送スタチンの医薬製剤およびそれらの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8987322B2 (enExample) |
| EP (2) | EP2319501B1 (enExample) |
| JP (1) | JP2007510714A (enExample) |
| AU (1) | AU2004284884A1 (enExample) |
| CA (1) | CA2543716C (enExample) |
| ES (2) | ES2500924T3 (enExample) |
| IL (1) | IL175134A0 (enExample) |
| NO (1) | NO20062432L (enExample) |
| WO (1) | WO2005041939A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| CA2628666A1 (en) * | 2005-11-21 | 2007-05-24 | Teva Pharmaceutical Industries Ltd. | Atorvastatin formulation |
| US20090093499A1 (en) * | 2005-12-20 | 2009-04-09 | Lek Pharmaceuticals D.D. | Pharmaceutical composition |
| MX2008011418A (es) * | 2006-03-06 | 2008-09-22 | Teva Pharma | Composiciones de ezetimibe. |
| CA2648594C (en) * | 2006-04-07 | 2012-10-16 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| ES2300188B1 (es) * | 2006-05-24 | 2009-05-01 | Ferrer Internacional, S.A. | Comprimido bicapa para la prevencion de los accidentes cardiovasculares. |
| JP2010529142A (ja) * | 2007-06-08 | 2010-08-26 | アドレネクス・ファーマシューティカルズ，インコーポレイテッド | アドレナリン調節異常症を治療する徐放性の製剤および方法 |
| US20090082315A1 (en) * | 2007-09-05 | 2009-03-26 | Raif Tawakol | Compositions and Methods for Controlling Cholesterol Levels |
| TR200800269A2 (tr) * | 2008-01-15 | 2009-08-21 | Bi̇li̇m İlaç Sanayi̇ Ti̇caret A.Ş. | Stabil farmasötik formülasyon ve hazırlama yöntemleri |
| TWI391150B (zh) * | 2008-01-22 | 2013-04-01 | Taiwan Biotech Co Ltd | 腸溶性長效塗覆芯與藥物劑型及其製造方法 |
| EP2285353A1 (en) * | 2008-01-30 | 2011-02-23 | Lupin Limited | Modified release formulations of hmg coa reductase inhibitors |
| JP2011519928A (ja) | 2008-05-07 | 2011-07-14 | メリオン・リサーチ・Ｉｉｉ・リミテッド | ペプチドの組成物及びその調製方法 |
| AR075613A1 (es) * | 2009-02-25 | 2011-04-20 | Merrion Res Iii Ltd | Composicion y suministro de drogas de bifosfonato. metodo de tratamiento |
| US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
| US9089484B2 (en) * | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
| JP2014501784A (ja) | 2011-01-07 | 2014-01-23 | メリオン・リサーチ・Ｉｉｉ・リミテッド | 経口投与用の鉄の医薬組成物 |
| JP7211704B2 (ja) | 2015-01-29 | 2023-01-24 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１アゴニスト及び腸溶コーティングを含む錠剤 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| GB1478759A (en) | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| US4088884A (en) * | 1976-01-26 | 1978-05-09 | The United States Of America As Represented By The Secretary Of The Navy | Wide aperture optical communications detector |
| US4200098A (en) | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
| US4557925A (en) | 1982-07-08 | 1985-12-10 | Ab Ferrosan | Membrane-coated sustained-release tablets and method |
| SE8601624D0 (sv) * | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
| US4904474A (en) * | 1988-01-25 | 1990-02-27 | Alza Corporation | Delivery of drug to colon by oral disage form |
| EP0465096A1 (en) | 1990-06-26 | 1992-01-08 | Merck & Co. Inc. | Plasma cholesterol level lowering composition |
| US6764697B1 (en) * | 1991-06-27 | 2004-07-20 | Alza Corporation | System for delaying drug delivery up to seven hours |
| US5573776A (en) | 1992-12-02 | 1996-11-12 | Alza Corporation | Oral osmotic device with hydrogel driving member |
| US5916595A (en) * | 1997-12-12 | 1999-06-29 | Andrx Pharmaceutials, Inc. | HMG co-reductase inhibitor |
| CO5140079A1 (es) | 1998-10-14 | 2002-03-22 | Novartis Ag | Composicion farmaceutica de liberacion sostenida y metodo para liberar un agente farmaceuticamente activo de liberacion sostenida y metodo para liberar un agente far- maceuticamente activo |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| WO2000053173A1 (en) * | 1999-03-08 | 2000-09-14 | Merck & Co., Inc. | Dihydroxy open-acid and salts of hmg-co-a reductase inhibitors |
| US6569461B1 (en) * | 1999-03-08 | 2003-05-27 | Merck & Co., Inc. | Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors |
| SI20425A (sl) * | 1999-12-10 | 2001-06-30 | LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. | Priprava amorfnega atorvastatina |
| JP2003530383A (ja) * | 2000-04-11 | 2003-10-14 | アセロジエニクス・インコーポレイテツド | 血漿ｈｄｌコレステロールレベルを上昇させ、ｈｄｌ機能性を向上させる化合物および方法 |
| US20020147232A1 (en) * | 2000-05-26 | 2002-10-10 | Claus Sundgreen | Pharmaceutical compositions comprising desglymidodrine as an active drug substance |
| IL156552A0 (en) * | 2000-12-21 | 2004-01-04 | Aventis Pharma Gmbh | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
| FR2834212B1 (fr) * | 2001-12-27 | 2004-07-09 | Besins Int Belgique | Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques |
| WO2003057195A1 (en) | 2002-01-11 | 2003-07-17 | Athpharma Limited | Pravastatin pharmaceutical formulations and methods of their use |
| EP2033631A3 (en) | 2002-09-03 | 2009-06-03 | Circ Pharma Research and Development Limited | Pravastatin pharmaceutical formulations and methods of their use |
| EP1545503A4 (en) | 2002-09-03 | 2007-12-12 | Circ Pharma Res And Dev Ltd | PHARMACEUTICAL FORMULATIONS AND METHODS FOR MODIFIED RELEASE OF STATINES |
-
2004
- 2004-10-19 US US10/967,167 patent/US8987322B2/en not_active Expired - Fee Related
- 2004-10-29 WO PCT/IB2004/003849 patent/WO2005041939A1/en not_active Ceased
- 2004-10-29 EP EP10185149.1A patent/EP2319501B1/en not_active Expired - Lifetime
- 2004-10-29 CA CA2543716A patent/CA2543716C/en not_active Expired - Fee Related
- 2004-10-29 JP JP2006538993A patent/JP2007510714A/ja active Pending
- 2004-10-29 ES ES10185149.1T patent/ES2500924T3/es not_active Expired - Lifetime
- 2004-10-29 EP EP04791793.5A patent/EP1682095B1/en not_active Expired - Lifetime
- 2004-10-29 ES ES04791793.5T patent/ES2509869T3/es not_active Expired - Lifetime
- 2004-10-29 AU AU2004284884A patent/AU2004284884A1/en not_active Abandoned
-
2006
- 2006-04-24 IL IL175134A patent/IL175134A0/en unknown
- 2006-05-29 NO NO20062432A patent/NO20062432L/no not_active Application Discontinuation
-
2015
- 2015-02-23 US US14/629,232 patent/US20150164893A1/en not_active Abandoned
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