JP2007509186A5 - - Google Patents

Info

Publication number

JP2007509186A5

JP2007509186A5 JP2006537550A JP2006537550A JP2007509186A5 JP 2007509186 A5 JP2007509186 A5 JP 2007509186A5 JP 2006537550 A JP2006537550 A JP 2006537550A JP 2006537550 A JP2006537550 A JP 2006537550A JP 2007509186 A5 JP2007509186 A5 JP 2007509186A5

Authority

JP

Japan

Prior art keywords

ache

inhibitor

use according

expression

seq

Prior art date

2004-10-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 102100033639 Acetylcholinesterase Human genes 0.000 claims 20
• 108010022752 Acetylcholinesterase Proteins 0.000 claims 20
• 239000003112 inhibitor Substances 0.000 claims 12
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 108091034117 Oligonucleotide Proteins 0.000 claims 5
• 239000000074 antisense oligonucleotide Substances 0.000 claims 5
• 238000012230 antisense oligonucleotides Methods 0.000 claims 5
• 108090000695 Cytokines Proteins 0.000 claims 4
• 102000004127 Cytokines Human genes 0.000 claims 4
• 239000000654 additive Substances 0.000 claims 4
• 230000000996 additive effect Effects 0.000 claims 4
• 239000003085 diluting agent Substances 0.000 claims 4
• 230000000770 proinflammatory effect Effects 0.000 claims 4
• 239000004480 active ingredient Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 101150060184 ACHE gene Proteins 0.000 claims 2
• 229940124596 AChE inhibitor Drugs 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 208000035143 Bacterial infection Diseases 0.000 claims 2
• 108090000994 Catalytic RNA Proteins 0.000 claims 2
• 102000053642 Catalytic RNA Human genes 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 2
• 208000022362 bacterial infectious disease Diseases 0.000 claims 2
• 230000001186 cumulative effect Effects 0.000 claims 2
• 230000001419 dependent effect Effects 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 230000009368 gene silencing by RNA Effects 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 108091092562 ribozyme Proteins 0.000 claims 2
• 230000035945 sensitivity Effects 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 1
• 108010065805 Interleukin-12 Proteins 0.000 claims 1
• 108090000171 Interleukin-18 Proteins 0.000 claims 1
• 108090001005 Interleukin-6 Proteins 0.000 claims 1
• 108090001007 Interleukin-8 Proteins 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 101710163270 Nuclease Proteins 0.000 claims 1
• 206010037660 Pyrexia Diseases 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 230000001754 anti-pyretic effect Effects 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 239000002221 antipyretic Substances 0.000 claims 1
• 230000036760 body temperature Effects 0.000 claims 1
• 210000003169 central nervous system Anatomy 0.000 claims 1
• 210000001174 endocardium Anatomy 0.000 claims 1
• 210000001508 eye Anatomy 0.000 claims 1
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 230000028709 inflammatory response Effects 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 210000003516 pericardium Anatomy 0.000 claims 1
• 210000003491 skin Anatomy 0.000 claims 1
• 230000001629 suppression Effects 0.000 claims 1
• 210000002229 urogenital system Anatomy 0.000 claims 1