JP2007508527A5 - - Google Patents
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- Publication number
- JP2007508527A5 JP2007508527A5 JP2006530040A JP2006530040A JP2007508527A5 JP 2007508527 A5 JP2007508527 A5 JP 2007508527A5 JP 2006530040 A JP2006530040 A JP 2006530040A JP 2006530040 A JP2006530040 A JP 2006530040A JP 2007508527 A5 JP2007508527 A5 JP 2007508527A5
- Authority
- JP
- Japan
- Prior art keywords
- organ damage
- end organ
- marker
- level
- risk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010020772 Hypertension Diseases 0.000 claims 6
- 230000001631 hypertensive effect Effects 0.000 claims 6
- 230000008816 organ damage Effects 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 5
- 102000000802 Galectin 3 Human genes 0.000 claims 3
- 108010001517 Galectin 3 Proteins 0.000 claims 3
- 102100029529 Thrombospondin-2 Human genes 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 210000000107 myocyte Anatomy 0.000 claims 3
- 108010060887 thrombospondin 2 Proteins 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03078161A EP1522857A1 (en) | 2003-10-09 | 2003-10-09 | Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2 |
| EP03078161.1 | 2003-10-09 | ||
| PCT/EP2004/010879 WO2005040817A1 (en) | 2003-10-09 | 2004-09-27 | Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010167334A Division JP2010279378A (ja) | 2003-10-09 | 2010-07-26 | ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法 |
| JP2011088342A Division JP5580774B2 (ja) | 2003-10-09 | 2011-04-12 | ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007508527A JP2007508527A (ja) | 2007-04-05 |
| JP2007508527A5 true JP2007508527A5 (OSRAM) | 2007-08-02 |
| JP4840744B2 JP4840744B2 (ja) | 2011-12-21 |
Family
ID=34306912
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006530040A Expired - Fee Related JP4840744B2 (ja) | 2003-10-09 | 2004-09-27 | ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法 |
| JP2010167334A Withdrawn JP2010279378A (ja) | 2003-10-09 | 2010-07-26 | ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法 |
| JP2011088342A Expired - Lifetime JP5580774B2 (ja) | 2003-10-09 | 2011-04-12 | ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法 |
| JP2014021394A Expired - Lifetime JP5789009B2 (ja) | 2003-10-09 | 2014-02-06 | ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法 |
| JP2015081540A Pending JP2015171365A (ja) | 2003-10-09 | 2015-04-13 | ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010167334A Withdrawn JP2010279378A (ja) | 2003-10-09 | 2010-07-26 | ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法 |
| JP2011088342A Expired - Lifetime JP5580774B2 (ja) | 2003-10-09 | 2011-04-12 | ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法 |
| JP2014021394A Expired - Lifetime JP5789009B2 (ja) | 2003-10-09 | 2014-02-06 | ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法 |
| JP2015081540A Pending JP2015171365A (ja) | 2003-10-09 | 2015-04-13 | ガレクチン−3またはトロンボスポンジン−2のレベルを定量することによって心不全を発症する危険性がある対象を同定する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US7888137B2 (OSRAM) |
| EP (4) | EP1522857A1 (OSRAM) |
| JP (5) | JP4840744B2 (OSRAM) |
| CN (2) | CN1879022B (OSRAM) |
| AT (1) | ATE532073T1 (OSRAM) |
| AU (2) | AU2004284496C1 (OSRAM) |
| CA (2) | CA2542033C (OSRAM) |
| CY (2) | CY1112359T1 (OSRAM) |
| DK (2) | DK2317324T3 (OSRAM) |
| ES (2) | ES2377012T3 (OSRAM) |
| PL (2) | PL1682907T3 (OSRAM) |
| PT (2) | PT1682907E (OSRAM) |
| SI (2) | SI2317324T1 (OSRAM) |
| WO (1) | WO2005040817A1 (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1522857A1 (en) * | 2003-10-09 | 2005-04-13 | Universiteit Maastricht | Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2 |
| US8153376B2 (en) | 2006-09-25 | 2012-04-10 | Universiteit Maastricht | Means and methods for diagnosing and/or treating a subject at risk of developing heart failure |
| WO2008091948A2 (en) * | 2007-01-23 | 2008-07-31 | University Of Virginia Patent Foundation | Galectin-3-binding, protein as a biomarker of cardiovascular disease |
| ATE534912T1 (de) * | 2007-09-17 | 2011-12-15 | Bg Medicine Inc | Beurteilung des risikos von kongestiver herzinsuffizienz bei patienten, die mit einem peroxisom-proliferator-aktivator-rezeptor-gamma agonisten oder einem thiazolidindion behandelt werden oder möglicherweise damit behandelt werden sollen |
| AU2009340423B2 (en) * | 2008-10-29 | 2014-07-24 | Bg Medicine, Inc. | Galectin-3 immunoassay |
| KR20120104167A (ko) | 2009-08-25 | 2012-09-20 | 비쥐 메디신, 인코포레이티드 | 갈렉틴―3 및 심장 재동기화 요법 |
| US20120029003A1 (en) * | 2010-07-02 | 2012-02-02 | Bg Medicine, Inc. | Galectin-3 and statin therapy |
| EP2631656B1 (en) * | 2010-10-18 | 2016-07-27 | Hideaki Hara | Marker for amyotrophic lateral sclerosis, and use thereof |
| EP2460890A1 (en) * | 2010-12-01 | 2012-06-06 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Gpnmb/Osteoactivin as a drug target and biomarker in cardiac diseases |
| CA2825954A1 (en) * | 2011-01-31 | 2012-08-09 | Bg Medicine, Inc. | Use of galectin-3 for detecting and prognosing heart failure after acute coronary syndrome |
| JP6215713B2 (ja) | 2011-03-17 | 2017-10-18 | クリティカル ケア ダイアグノスティクス インコーポレイテッド | 有害臨床転帰のリスクを予測する方法 |
| AR086543A1 (es) | 2011-05-25 | 2014-01-08 | Bg Medicine Inc | Inhibidores de galectina-3 y metodos de uso de los mismos, composicion farmaceutica |
| BR112014012823A2 (pt) * | 2011-12-08 | 2015-09-29 | Isaac Eliaz | redução dos níveis de galectina-3 por meio de plasmaferese |
| WO2014052803A2 (en) * | 2012-09-27 | 2014-04-03 | Siemens Healthcare Diagnostics Inc. | Cystatin c and galectin-3 as biomarkers for pulmonary arterial hypertension |
| CN104955471A (zh) * | 2012-11-15 | 2015-09-30 | 塔夫斯大学 | 使用半乳糖凝集素蛋白抑制剂用于治疗、调节或预防受试者的眼部血管生成或者纤维化的方法、组合物以及试剂盒 |
| EP3245515A1 (en) | 2015-01-18 | 2017-11-22 | DiaSorin S.p.A. | Use of 1,25-dihydroxyvitamin d values in ratio with pth as a prognostic biomarker |
| CN107614168B (zh) * | 2015-05-28 | 2019-10-25 | 京瓷株式会社 | 切削工具 |
| CN112553335A (zh) * | 2020-12-17 | 2021-03-26 | 核工业总医院 | 肾细胞癌生物标志物及其应用 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4632901A (en) | 1984-05-11 | 1986-12-30 | Hybritech Incorporated | Method and apparatus for immunoassays |
| US4704692A (en) | 1986-09-02 | 1987-11-03 | Ladner Robert C | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| AU2684488A (en) | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| US20010051350A1 (en) | 1995-05-02 | 2001-12-13 | Albert Nazareth | Diagnostic detection device and method |
| BE1010935A7 (nl) * | 1997-02-19 | 1999-03-02 | Delanghe Joris Richard Siegfri | Fenotypering van humaan haptoglobine in serum of plasma door middel van quantitatieve agglutinatie met streptococcus antigenen. |
| EP0988552B1 (en) | 1997-06-10 | 2010-11-24 | Lpath, Inc. | Methods for early detection of heart disease |
| EP1018018B1 (en) * | 1997-09-05 | 2010-08-04 | Southern Medical Diagnostics Pty Ltd | A method of diagnosis |
| US20060166276A1 (en) * | 1997-09-05 | 2006-07-27 | Lung Health Diagnostics Pty Ltd | Method of diagnosis and agents useful for same |
| CN1149396C (zh) * | 1997-10-24 | 2004-05-12 | 盐野义制药株式会社 | 利尿钠肽分解抑制方法及其用该方法分析利尿钠肽的改良方法 |
| DE69939723D1 (de) * | 1998-04-02 | 2008-11-20 | Genentech Inc | Verwendung von Intereferon Gamma zur Behandlung von Herzhypertrophie |
| CN1327228C (zh) * | 1999-01-29 | 2007-07-18 | 罗赫诊断器材股份有限公司 | 鉴定样品中的n-末端前bnp的方法 |
| DE60031512T2 (de) * | 1999-02-19 | 2007-08-23 | University Of Iowa Research Foundation | Diagnostika und therapeutika für maculare degeneration |
| ATE422556T1 (de) * | 1999-08-20 | 2009-02-15 | Univ Texas | Hdac4- und hdac5-abhängige regulation der genexpression im herzen |
| AU3087801A (en) | 2000-02-04 | 2001-08-14 | Molecular Dynamics Inc | Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells |
| JP2004532602A (ja) | 2000-04-05 | 2004-10-28 | インサイト・ゲノミックス・インコーポレイテッド | 泡沫細胞分化において発現される遺伝子 |
| KR100395254B1 (ko) | 2000-10-30 | 2003-08-21 | (주)자리타 바이오텍 | 종양 발생 예측 키트 |
| US20030166017A1 (en) * | 2000-11-09 | 2003-09-04 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the identification, assessment, prevention and therapy of cardiovascular disease |
| WO2002038794A2 (en) * | 2000-11-09 | 2002-05-16 | The Brigham And Women's Hospital, Inc. | Cardiovascular disease diagnostic and therapeutic targets |
| DE60144493D1 (de) * | 2000-12-08 | 2011-06-01 | Curagen Corp | Verfahren zur bestimmung und behandlung von tuberöse-sklerose komplex assoziierten erkrankungen |
| JP4035562B2 (ja) * | 2001-01-31 | 2008-01-23 | 国立大学法人富山大学 | ガレクチン−3誘導能を利用した物質のスクリーニング方法、肝の状態の診断方法およびこれらの方法を利用したキット |
| CA2441086A1 (en) | 2001-03-19 | 2002-09-26 | Wisconsin Alumni Research Foundation | Identification of gene expression alterations underlying the aging process in mammals |
| US20060019235A1 (en) | 2001-07-02 | 2006-01-26 | The Board Of Trustees Of The Leland Stanford Junior University | Molecular and functional profiling using a cellular microarray |
| US7447594B2 (en) | 2001-07-10 | 2008-11-04 | Ocimum Biosolutions, Inc. | Molecular cardiotoxicology modeling |
| US20030099958A1 (en) * | 2001-09-05 | 2003-05-29 | Vitivity, Inc. | Diagnosis and treatment of vascular disease |
| GB0124145D0 (en) | 2001-10-08 | 2001-11-28 | Bayer Ag | Genes and proteins for prevention,prediction,prognosis and therapy of cardiovascular disease |
| US20060141493A1 (en) | 2001-11-09 | 2006-06-29 | Duke University Office Of Science And Technology | Atherosclerotic phenotype determinative genes and methods for using the same |
| AU2003233147B2 (en) * | 2002-05-13 | 2008-03-06 | Arexis Ab | Autoimmune conditions and NADPH oxidase defects |
| WO2004038376A2 (en) | 2002-10-24 | 2004-05-06 | Duke University | Binary prediction tree modeling with many predictors and its uses in clinical and genomic applications |
| CA2505416A1 (en) | 2002-11-21 | 2004-06-10 | Wyeth | Methods for diagnosing rcc and other solid tumors |
| EP1431399A1 (en) * | 2002-12-20 | 2004-06-23 | Clinigenetics | Methods and composition for identifying therapeutic agents of atherosclerotic plaque lesions |
| US6889083B2 (en) | 2003-04-21 | 2005-05-03 | Medtronic, Inc. | Atrial tracking recovery to restore cardiac resynchronization therapy in dual chamber tracking modes |
| WO2005020784A2 (en) | 2003-05-23 | 2005-03-10 | Mount Sinai School Of Medicine Of New York University | Surrogate cell gene expression signatures for evaluating the physical state of a subject |
| WO2004111654A2 (en) | 2003-06-06 | 2004-12-23 | Ciphergen Biosystems, Inc. | Serum biomarkers in ischaemic heart disease |
| US20050106100A1 (en) | 2003-09-03 | 2005-05-19 | Harris Thomas D. | Compounds containing matrix metalloproteinase substrates and methods of their use |
| EP1560025A3 (en) * | 2003-10-03 | 2011-09-07 | F. Hoffmann-La Roche AG | Specific markers for diabetes |
| EP1522857A1 (en) * | 2003-10-09 | 2005-04-13 | Universiteit Maastricht | Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2 |
| DE10347436B4 (de) | 2003-10-13 | 2007-08-02 | Johann Wolfgang Goethe-Universität Frankfurt am Main | In vitro Verfahren zur Diagnose der kardiovaskulären Funktionalität von Blut-abgeleiteter zirkulierender Vorläuferzellen (BDP) |
| EP1720562A4 (en) | 2004-01-15 | 2009-10-28 | Scios Inc | METHOD FOR TREATING CARDIAL REMODELING AFTER MYOCARDIAL DAMAGE |
| WO2006026074A2 (en) | 2004-08-04 | 2006-03-09 | Duke University | Atherosclerotic phenotype determinative genes and methods for using the same |
| US20090258002A1 (en) | 2005-02-01 | 2009-10-15 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Biomarkers for Tissue Status |
| WO2006102497A2 (en) | 2005-03-22 | 2006-09-28 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease |
| US7632634B2 (en) | 2005-04-15 | 2009-12-15 | University Of Maryland Biotechnology Institute | Method and assay for early diagnosis of prostate cancer |
| US9592970B2 (en) | 2008-07-17 | 2017-03-14 | Toby D. Henderson | Robotic gantry with end effector for product lifting |
| AU2009340423B2 (en) | 2008-10-29 | 2014-07-24 | Bg Medicine, Inc. | Galectin-3 immunoassay |
| KR20120104167A (ko) | 2009-08-25 | 2012-09-20 | 비쥐 메디신, 인코포레이티드 | 갈렉틴―3 및 심장 재동기화 요법 |
-
2003
- 2003-10-09 EP EP03078161A patent/EP1522857A1/en not_active Withdrawn
-
2004
- 2004-09-27 DK DK10186331.4T patent/DK2317324T3/en active
- 2004-09-27 PT PT04765681T patent/PT1682907E/pt unknown
- 2004-09-27 ES ES04765681T patent/ES2377012T3/es not_active Expired - Lifetime
- 2004-09-27 EP EP14192739.2A patent/EP2919012A1/en not_active Withdrawn
- 2004-09-27 PL PL04765681T patent/PL1682907T3/pl unknown
- 2004-09-27 PL PL10186331T patent/PL2317324T3/pl unknown
- 2004-09-27 CN CN2004800332637A patent/CN1879022B/zh not_active Expired - Fee Related
- 2004-09-27 PT PT101863314T patent/PT2317324E/pt unknown
- 2004-09-27 AU AU2004284496A patent/AU2004284496C1/en not_active Ceased
- 2004-09-27 CA CA2542033A patent/CA2542033C/en not_active Expired - Lifetime
- 2004-09-27 ES ES10186331T patent/ES2530567T3/es not_active Expired - Lifetime
- 2004-09-27 CN CN201210321227.7A patent/CN102998458B/zh not_active Expired - Fee Related
- 2004-09-27 EP EP04765681A patent/EP1682907B1/en not_active Expired - Lifetime
- 2004-09-27 US US10/575,745 patent/US7888137B2/en active Active
- 2004-09-27 SI SI200432221T patent/SI2317324T1/sl unknown
- 2004-09-27 AT AT04765681T patent/ATE532073T1/de active
- 2004-09-27 WO PCT/EP2004/010879 patent/WO2005040817A1/en not_active Ceased
- 2004-09-27 SI SI200431813T patent/SI1682907T1/sl unknown
- 2004-09-27 DK DK04765681.4T patent/DK1682907T3/da active
- 2004-09-27 EP EP10186331.4A patent/EP2317324B1/en not_active Expired - Lifetime
- 2004-09-27 CA CA2842308A patent/CA2842308A1/en not_active Abandoned
- 2004-09-27 JP JP2006530040A patent/JP4840744B2/ja not_active Expired - Fee Related
-
2009
- 2009-10-19 AU AU2009227844A patent/AU2009227844B2/en not_active Ceased
-
2010
- 2010-07-26 JP JP2010167334A patent/JP2010279378A/ja not_active Withdrawn
- 2010-10-28 US US12/914,329 patent/US8084276B2/en not_active Expired - Fee Related
-
2011
- 2011-04-12 JP JP2011088342A patent/JP5580774B2/ja not_active Expired - Lifetime
- 2011-11-23 US US13/304,145 patent/US20120220532A1/en not_active Abandoned
-
2012
- 2012-02-01 CY CY20121100108T patent/CY1112359T1/el unknown
-
2013
- 2013-03-08 US US13/791,350 patent/US20130189716A1/en not_active Abandoned
-
2014
- 2014-02-06 JP JP2014021394A patent/JP5789009B2/ja not_active Expired - Lifetime
- 2014-05-05 US US14/269,707 patent/US20150037353A1/en not_active Abandoned
-
2015
- 2015-02-12 CY CY20151100136T patent/CY1116147T1/el unknown
- 2015-04-13 JP JP2015081540A patent/JP2015171365A/ja active Pending
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