JP2007507544A - 哺乳動物ｔ１ｒ３甘味レセプター - Google Patents

哺乳動物ｔ１ｒ３甘味レセプター Download PDF

Info

Publication number
JP2007507544A
JP2007507544A JP2006534237A JP2006534237A JP2007507544A JP 2007507544 A JP2007507544 A JP 2007507544A JP 2006534237 A JP2006534237 A JP 2006534237A JP 2006534237 A JP2006534237 A JP 2006534237A JP 2007507544 A JP2007507544 A JP 2007507544A
Authority
JP
Japan
Prior art keywords
seq
receptor
taste
polypeptide
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006534237A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007507544A5 (enExample
Inventor
イゾルデ エルレンバッハ，
ニコラス ジェイ． ピー． ルイバ，
グレイス チャオ，
チャールズ エス． ズーカー，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
US Department of Health and Human Services
Original Assignee
University of California
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, US Department of Health and Human Services filed Critical University of California
Publication of JP2007507544A publication Critical patent/JP2007507544A/ja
Publication of JP2007507544A5 publication Critical patent/JP2007507544A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2006534237A 2003-10-02 2004-10-04 哺乳動物ｔ１ｒ３甘味レセプター Pending JP2007507544A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/679,102 US20050106571A1 (en) 2003-10-02 2003-10-02 Mammalian T1R3 sweet taste receptors
PCT/US2004/032678 WO2005033125A2 (en) 2003-10-02 2004-10-04 Mammalian t1r3 sweet taste receptors

Publications (2)

Publication Number Publication Date
JP2007507544A true JP2007507544A (ja) 2007-03-29
JP2007507544A5 JP2007507544A5 (enExample) 2008-05-15

Family

ID=34422153

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006534237A Pending JP2007507544A (ja) 2003-10-02 2004-10-04 哺乳動物ｔ１ｒ３甘味レセプター

Country Status (6)

Country Link
US (3) US20050106571A1 (enExample)
EP (1) EP1684789A4 (enExample)
JP (1) JP2007507544A (enExample)
AU (1) AU2004278425A1 (enExample)
CA (1) CA2540837A1 (enExample)
WO (1) WO2005033125A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201006846A (en) * 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
EP1301595A2 (en) * 2000-05-22 2003-04-16 Incyte Genomics, Inc. G-protein coupled receptors
TW201022287A (en) * 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US20080244761A1 (en) * 2001-03-07 2008-10-02 Senomyx, Inc. T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
US7763431B1 (en) 2001-03-07 2010-07-27 Senomyx, Inc. Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US7301009B2 (en) 2001-06-26 2007-11-27 Senomyx, Inc. Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli
US7309577B2 (en) * 2001-03-07 2007-12-18 Senomyx, Inc. Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste
DK2327985T3 (en) 2001-06-26 2016-09-05 Senomyx Inc H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds
US8796441B2 (en) 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
DE602006012460D1 (de) 2006-06-07 2010-04-08 Nutrinova Gmbh Verfahren zum Screening von Substanzen die die Aktivität von Gpcrs modulieren
WO2008014450A2 (en) * 2006-07-27 2008-01-31 The Coca-Cola Company Model taste cells and methods of use for identifying modulators of taste sensation
EP2066812A4 (en) * 2006-09-21 2010-04-28 Univ Rochester COMPOSITIONS AND METHODS RELATED TO PROTEIN SHIFT THERAPY FOR MYOTONE DYSTROPHY
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
CA2713885A1 (en) * 2008-02-01 2009-08-20 Chromocell Corporation Novel cell lines and methods
WO2010065568A2 (en) 2008-12-01 2010-06-10 Laboratory Corporation Of America Holdings METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95
SG172983A1 (en) 2009-01-15 2011-08-29 Lab Corp America Holdings Methods of determining patient response by measurement of her-3
EP2387717B1 (en) * 2009-01-15 2014-12-10 Laboratory Corporation of America Holdings Methods of determining patient response by measurement of her-2 expression
WO2013022948A1 (en) 2011-08-08 2013-02-14 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
US9804157B1 (en) 2013-03-15 2017-10-31 Senomyx, Inc. Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives
MX384586B (es) 2013-05-10 2025-03-14 Pepsico Inc Ensayo de internalización del receptor del gusto.
CN111973155B (zh) * 2020-08-23 2023-06-16 吾征智能技术(北京)有限公司 一种基于人体口味异常变化的疾病认知自学习系统

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160424A1 (en) * 2001-03-30 2002-10-31 Adler Jon Elliot T1R hetero-oligomeric taste receptors
WO2002086079A2 (en) * 2001-04-20 2002-10-31 Mount Sinai School Of Medicine T1r3 a novel taste receptor
JP2002355044A (ja) * 2001-05-01 2002-12-10 National Food Research Institute 新規遺伝子

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020061522A1 (en) 2000-02-29 2002-05-23 Glucksmann Maria Alexandra 1983, 52881, 2398, 45449, 50289, and 52872 novel G protein-coupled receptors and uses therefor
US7402400B2 (en) * 2001-07-03 2008-07-22 Regents Of The University Of California Mammalian sweet taste receptors
AU764180B2 (en) 1998-07-28 2003-08-14 Regents Of The University Of California, The Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
JP2003531614A (ja) 2000-04-28 2003-10-28 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 炭水化物化合物および他の甘味物質の感知に関連する遺伝子および配列変異
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
US20030143668A1 (en) 2001-06-18 2003-07-31 National Institute Of Advanced Industrial Guanosine triphosphate-binding protein coupled receptors
EP2327985B2 (en) 2001-06-26 2019-08-21 Senomyx, Inc. T1R Hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds
WO2003025137A2 (en) 2001-09-18 2003-03-27 Irm, Llc Sweet taste receptors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160424A1 (en) * 2001-03-30 2002-10-31 Adler Jon Elliot T1R hetero-oligomeric taste receptors
WO2002086079A2 (en) * 2001-04-20 2002-10-31 Mount Sinai School Of Medicine T1r3 a novel taste receptor
JP2002355044A (ja) * 2001-05-01 2002-12-10 National Food Research Institute 新規遺伝子

Also Published As

Publication number Publication date
US20070105159A1 (en) 2007-05-10
US20090155819A1 (en) 2009-06-18
CA2540837A1 (en) 2005-04-14
US7459277B2 (en) 2008-12-02
US20050106571A1 (en) 2005-05-19
US7939279B2 (en) 2011-05-10
EP1684789A4 (en) 2006-12-27
WO2005033125A2 (en) 2005-04-14
AU2004278425A1 (en) 2005-04-14
EP1684789A2 (en) 2006-08-02
WO2005033125A3 (en) 2006-03-23

Similar Documents

Publication Publication Date Title
US9347935B2 (en) Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1
US7939279B2 (en) Mammalian T1R3 sweet taste receptors
EP2381256B1 (en) Mammalian sweet and amino acid heterodimeric taste receptors
AU2002320294A1 (en) Mammalian sweet and amino acid heterodimeric taste receptors
JP4339542B2 (ja) Ｔ２ｒ、すなわち味覚受容体の新規ファミリー
JP4657450B2 (ja) 感覚伝達に関与するｇタンパク質共役レセプターをコードする核酸
TW200825181A (en) Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
JP2010189391A (ja) Ｔ１ｒヘテロオリゴマー味覚受容体及び前記受容体を発現する細胞系並びに味覚化合物の特定のためのその使用
JP5307404B2 (ja) Ｇタンパク質共役受容体ｒｃｃ３５６の天然リガンドおよびその使用
ES2587610T5 (es) Receptores gustativos heterooligómeros T1R y líneas celulares que expresan dichos receptores y uso de los mismos para la identificación de compuestos de sabor

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070918

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080331

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100721

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110131