JP2007504840A - Ｇｒｐ９４ベース組成物及びそれらの使用方法 - Google Patents

Ｇｒｐ９４ベース組成物及びそれらの使用方法 Download PDF

Info

Publication number
JP2007504840A
JP2007504840A JP2006533063A JP2006533063A JP2007504840A JP 2007504840 A JP2007504840 A JP 2007504840A JP 2006533063 A JP2006533063 A JP 2006533063A JP 2006533063 A JP2006533063 A JP 2006533063A JP 2007504840 A JP2007504840 A JP 2007504840A
Authority
JP
Japan
Prior art keywords
grp94
peptide
protein
cell
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006533063A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007504840A5 (enExample
Inventor
アーゴン、ヤー
ギデイルビッツ、タリ
ビスワス、チャハンダ
シーメン、バージット、ビンダラップ
ワンダーリング、シェリー
オストロブスキー、オルガ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Children's Hospital of Philadelphia
Original Assignee
Children's Hospital of Philadelphia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Children's Hospital of Philadelphia filed Critical Children's Hospital of Philadelphia
Publication of JP2007504840A publication Critical patent/JP2007504840A/ja
Publication of JP2007504840A5 publication Critical patent/JP2007504840A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4262—Heat shock proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6043—Heat shock proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2006533063A 2003-05-12 2004-05-12 Ｇｒｐ９４ベース組成物及びそれらの使用方法 Pending JP2007504840A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US46972303P 2003-05-12 2003-05-12
US47799003P 2003-06-12 2003-06-12
US47814903P 2003-06-12 2003-06-12
US56636204P 2004-04-28 2004-04-28
US56636304P 2004-04-28 2004-04-28
PCT/US2004/015120 WO2004101766A2 (en) 2003-05-12 2004-05-12 Grp94-based compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2007504840A true JP2007504840A (ja) 2007-03-08
JP2007504840A5 JP2007504840A5 (enExample) 2009-04-30

Family

ID=33459327

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006533063A Pending JP2007504840A (ja) 2003-05-12 2004-05-12 Ｇｒｐ９４ベース組成物及びそれらの使用方法

Country Status (6)

Country Link
US (1) US7589174B2 (enExample)
EP (1) EP1625141A4 (enExample)
JP (1) JP2007504840A (enExample)
AU (1) AU2004239338A1 (enExample)
CA (1) CA2525385A1 (enExample)
WO (1) WO2004101766A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022516445A (ja) * 2018-12-24 2022-02-28 ビステラ， インコーポレイテッド エピトープおよびパラトープを同定する方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060029610A1 (en) * 2003-05-12 2006-02-09 Yair Argon GRP94-based compositions and methods of use thereof
US20080199486A1 (en) * 2003-05-12 2008-08-21 Yair Argon Grp94-based compositions and methods of use thereof
US9488655B2 (en) * 2004-07-14 2016-11-08 The Regents Of The University Of California Biomarkers for detection of early- and late-stage endometrial cancer
WO2012047930A2 (en) 2010-10-04 2012-04-12 The Regents Of The University Of California Compositions and methods for treatment of gynecologic cancers
WO2006019906A1 (en) 2004-07-14 2006-02-23 The Regents Of The University Of California Biomarker for early detection of ovarian cancer
CN100419078C (zh) * 2005-11-18 2008-09-17 李川源 一种表达糖调节蛋白的方法及其应用
US8512708B2 (en) 2008-03-13 2013-08-20 Compugen Ltd. GP96 derived peptides
EP2751126B1 (en) 2011-08-29 2018-03-07 The Regents of The University of California Use of hdl-related molecules to treat and prevent proinflammatory conditions
US10345287B2 (en) * 2012-09-28 2019-07-09 The United States Of America, As Represented By The Secretary Of The Navy Calibrating single plasmonic nanostructures for quantitative biosening
US20210277052A1 (en) * 2020-03-03 2021-09-09 Hauptman-Woodward Medical Research Institute Recombinant grp94 chaperones and methods of using the same to modulate glycosylation in fusion proteins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5188964A (en) * 1990-04-12 1993-02-23 Board Of Regents, The University Of Texas System Method and kit for the prognostication of breast cancer patient via heat shock/stress protein determination
US6017540A (en) * 1997-02-07 2000-01-25 Fordham University Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes
US20020039583A1 (en) * 1999-09-30 2002-04-04 Subjeck John R. Stress protein compositions and methods for prevention and treatment of cancer and infectious disease
US7235649B2 (en) 2000-03-24 2007-06-26 Duke University Isolated GRP94 ligand binding domain polypeptide and nucleic acid encoding same, and screening methods employing same
WO2001072779A1 (en) 2000-03-24 2001-10-04 Duke University Characterization of grp94-ligand interactions and purification, screening, and therapeutic methods relating thereto
AU2001277961A1 (en) 2000-08-07 2002-02-18 Antigenics, Llc Compositions comprising heat shock proteins or alpha(2)macroglobulin, antigenic molecules and saponins, and methods of use thereof
WO2002036574A1 (en) 2000-11-06 2002-05-10 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Geldanamycin derivatives useful for the treatment of cancer
US20060029610A1 (en) * 2003-05-12 2006-02-09 Yair Argon GRP94-based compositions and methods of use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6010024874, Ｅｕｒ．Ｉ．Ｂｉｏｃｈｅｍ．， ｖｏｌ．２６８， ｐｐ．４２９−４３６ （２００１） *
JPN6010024876, Ｓｃｉｅｎｃｅ， ｖｏｌ．２７８， ｐｐ．１１７−１２０ （１９９７） *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022516445A (ja) * 2018-12-24 2022-02-28 ビステラ， インコーポレイテッド エピトープおよびパラトープを同定する方法
JP7511561B2 (ja) 2018-12-24 2024-07-05 ビステラ， インコーポレイテッド エピトープおよびパラトープを同定する方法

Also Published As

Publication number Publication date
US7589174B2 (en) 2009-09-15
WO2004101766A3 (en) 2005-03-24
WO2004101766A2 (en) 2004-11-25
AU2004239338A1 (en) 2004-11-25
CA2525385A1 (en) 2004-11-25
US20050063982A1 (en) 2005-03-24
EP1625141A4 (en) 2007-07-04
EP1625141A2 (en) 2006-02-15

Similar Documents

Publication Publication Date Title
CN100381570C (zh) 滑膜细胞蛋白质
US6723534B2 (en) Purified and isolated PIWI family genes and gene products and therapeutic and screening methods using same
JP2017500854A (ja) ポリペプチド、核酸およびその使用
US7589174B2 (en) GRP94-based compositions and methods of use thereof
US20120266262A1 (en) Methods and compositions relating to zpa polypeptides
Beer et al. Impaired immune responses and prolonged allograft survival in Sly1 mutant mice
JP2004081217A (ja) Ａ−３３関連抗原およびそれらの薬理学的使用
JP2002510490A (ja) Ｌｙｓｔタンパク質複合体およびｌｙｓｔ相互作用タンパク質
US7052889B2 (en) Mammalian SUV39H2 proteins and isolated DNA molecules encoding them
JP2007527712A (ja) 新規な遺伝子破壊、これに関する組成物と方法
JP2003055266A (ja) Ｍｅｋ５ならびに心臓肥大および拡張型心筋症に関連する方法および組成物
JP2002526099A (ja) Ｎｌｋ１−相互作用タンパク質
JP2009544324A (ja) 遺伝子破壊、それに関連する組成物および方法
JP2007504840A5 (enExample)
JP2004532042A (ja) Ｂｃｌ−２調節因子（ＢＭＦ）配列及びアポトーシスの調節におけるそれらの使用
US20080199486A1 (en) Grp94-based compositions and methods of use thereof
US20060029610A1 (en) GRP94-based compositions and methods of use thereof
JP2003535596A (ja) Ｓｕｖ３９ｈ２メチルトランスフェラーゼのモジュレーターのスクリーニング法
US20090162848A1 (en) Noxin, a novel stress-induced gene involved in cell cycle and apoptosis
US20060179497A1 (en) Methods to treat conditions associated with insulin signaling dysregulation
US20070298026A1 (en) Methods for Identifying Treatment and Inducing Infertility Using Smc1-Beta
US6740751B2 (en) Methods and compositions for stabilizing microtubules and intermediate filaments in striated muscle cells
WO2000010602A9 (en) Lats knock-out animal models and their uses
CA2494575A1 (en) Compositions and methods for the treatment of osteoporosis
JP2003144168A (ja) 核外移行機能又は核−細胞質間移行機能を有する細胞周期関連タンパク質

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070512

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070512

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090310

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100511

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20101109