JP2007504242A - マトリックスメタロプロテイナーゼ基質含有化合物およびそれらの使用法 - Google Patents
マトリックスメタロプロテイナーゼ基質含有化合物およびそれらの使用法 Download PDFInfo
- Publication number
- JP2007504242A JP2007504242A JP2006525453A JP2006525453A JP2007504242A JP 2007504242 A JP2007504242 A JP 2007504242A JP 2006525453 A JP2006525453 A JP 2006525453A JP 2006525453 A JP2006525453 A JP 2006525453A JP 2007504242 A JP2007504242 A JP 2007504242A
- Authority
- JP
- Japan
- Prior art keywords
- mmol
- diagnostic
- patient
- compound
- dimethylformamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RUSFFHVOSIXFTG-ZZEZOPTASA-N CCCC/C(/CCCCCCC(OCC)=O)=N/CC[Si](C)(C)C Chemical compound CCCC/C(/CCCCCCC(OCC)=O)=N/CC[Si](C)(C)C RUSFFHVOSIXFTG-ZZEZOPTASA-N 0.000 description 1
- RTWMNWVTWOAIFK-UHFFFAOYSA-N CCCCc(cc1)cc(C(CCCCCCC(OCC)=O)=O)c1O Chemical compound CCCCc(cc1)cc(C(CCCCCCC(OCC)=O)=O)c1O RTWMNWVTWOAIFK-UHFFFAOYSA-N 0.000 description 1
- XTRUIBKWGRFJPE-LZYBPNLTSA-N NC(c1ccc(N/N=C/c(cccc2)c2S(O)(=O)=O)nc1)=O Chemical compound NC(c1ccc(N/N=C/c(cccc2)c2S(O)(=O)=O)nc1)=O XTRUIBKWGRFJPE-LZYBPNLTSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0495—Pretargeting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49996603P | 2003-09-03 | 2003-09-03 | |
| US49996003P | 2003-09-03 | 2003-09-03 | |
| PCT/US2004/028660 WO2005023314A1 (en) | 2003-09-03 | 2004-09-02 | Compounds containing matrix metalloproteinase substrates and methods of their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007504242A true JP2007504242A (ja) | 2007-03-01 |
| JP2007504242A5 JP2007504242A5 (https=) | 2007-04-12 |
Family
ID=34278690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006525453A Pending JP2007504242A (ja) | 2003-09-03 | 2004-09-02 | マトリックスメタロプロテイナーゼ基質含有化合物およびそれらの使用法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050106100A1 (https=) |
| EP (1) | EP1691845A4 (https=) |
| JP (1) | JP2007504242A (https=) |
| AU (1) | AU2004270200A1 (https=) |
| CA (1) | CA2537771A1 (https=) |
| WO (1) | WO2005023314A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022523327A (ja) * | 2019-02-01 | 2022-04-22 | グリンプス バイオ, インコーポレイテッド | 細胞、細胞外マトリックスおよび組織微小環境における構造的再構築の検出 |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1522857A1 (en) * | 2003-10-09 | 2005-04-13 | Universiteit Maastricht | Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2 |
| EP1940841B9 (fr) | 2005-10-07 | 2017-04-19 | Guerbet | Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| CA2644694C (en) * | 2006-03-10 | 2014-05-13 | Sangeeta N. Bhatia | Triggered self-assembly conjugates and nanosystems |
| US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| CA2648385C (en) | 2006-04-04 | 2020-09-01 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| GB0707034D0 (en) | 2007-04-12 | 2007-05-23 | St Andrews The | Compounds |
| WO2009007846A2 (en) * | 2007-06-15 | 2009-01-15 | Universitetet If Oslo | Methods for modifying, isolating, detecting, visualizing, and quantifying citrullinated and/or homocitrullinated peptides, polypeptides and proteins |
| CA2697032C (en) * | 2007-08-22 | 2021-09-14 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| WO2009029936A1 (en) * | 2007-08-31 | 2009-03-05 | Case Western Reserve University | In vivo imaging of myelin |
| US8361438B2 (en) | 2008-01-08 | 2013-01-29 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| GB0819287D0 (en) | 2008-10-22 | 2008-11-26 | Univ Bradford | Compounds |
| CN104198712A (zh) * | 2008-10-29 | 2014-12-10 | Bg医药股份有限公司 | 半乳凝素-3免疫测定法 |
| US20100189651A1 (en) * | 2009-01-12 | 2010-07-29 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| JP5861223B2 (ja) * | 2009-02-23 | 2016-02-16 | サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. | プロタンパク質およびその使用方法 |
| JP5678045B2 (ja) | 2009-06-08 | 2015-02-25 | シンギュレックス・インコーポレイテッド | 高感度バイオマーカーパネル |
| CA2803520C (en) | 2009-07-08 | 2019-10-22 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| BR112012008063A2 (pt) * | 2009-08-25 | 2016-11-22 | Bg Medicine Inc | galectina-3 e terapia de ressincronização cardíaca. |
| US20150023873A1 (en) | 2011-11-11 | 2015-01-22 | Lantheus Medical Imaging, Inc. | Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging |
| GB2516882A (en) | 2013-08-02 | 2015-02-11 | Univ Bradford | Tumour-targeted theranostic |
| RU2607041C2 (ru) * | 2015-05-29 | 2017-01-10 | Общество с ограниченной ответственностью "Научно-производственная фирма ДНК-Технология" | Способ определения степени гноетечения на пародонте по уровню мРНК гена интерлейкина-8 (IL-8) человека |
| WO2018148596A1 (en) * | 2017-02-10 | 2018-08-16 | Boston Scientific Scimed, Inc. | Vascular ulcer treatment |
| EP3774838B9 (en) | 2018-04-10 | 2025-12-10 | Sanofi-Aventis Deutschland GmbH | Lixisenatide synthesis with capping |
| IN202021002695A (https=) * | 2020-01-21 | 2021-07-23 | ||
| JP2023550412A (ja) * | 2020-11-19 | 2023-12-01 | ノバルティス アーゲー | 前立腺特異的膜抗原(psma)リガンドの合成 |
| WO2025085511A1 (en) * | 2023-10-18 | 2025-04-24 | University Of Washington | Systems and methods for polymer-mediated activation of engineered cells |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4859777A (en) * | 1981-07-01 | 1989-08-22 | Eastman Kodak Company | Terpyridine chelating agents |
| US4452774A (en) * | 1982-04-30 | 1984-06-05 | President And Fellows Of Harvard College | Isonitrile radionuclide complexes for labelling and imaging agents |
| EP0247156B1 (en) * | 1985-11-18 | 1993-06-23 | Access Pharmaceuticals Inc. | Polychelating agents for image and spectral enhancement (and spectral shift) |
| CA1305160C (en) * | 1985-12-23 | 1992-07-14 | Paul Louis Bergstein | Ether isonitriles and radiolabeled complexes thereof |
| US4913891A (en) * | 1986-04-17 | 1990-04-03 | The United States Of America As Represented By The United States Department Of Energy | Positron emitter labeled enzyme inhibitors |
| US5567411A (en) * | 1986-11-10 | 1996-10-22 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group |
| US5252317A (en) * | 1986-11-10 | 1993-10-12 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Amplifier molecules for diagnosis and therapy derived from 3,5-bis[1-(3-amino-2,2-bis (aminomethyl)-propyl) oxymethyl] benzoic acid |
| US5064956A (en) * | 1987-06-24 | 1991-11-12 | The Dow Chemical Company | Process for preparing mono-n-alkylated polyazamacrocycles |
| US5087440A (en) * | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
| GB8923843D0 (en) * | 1989-10-23 | 1989-12-13 | Salutar Inc | Compounds |
| GB9006977D0 (en) * | 1990-03-28 | 1990-05-23 | Nycomed As | Compositions |
| EP0577675B1 (en) * | 1991-03-27 | 1999-12-08 | Nycomed Salutar Inc. | Contrast media |
| GB9209641D0 (en) * | 1992-05-02 | 1992-06-17 | Johnson Matthey Plc | Improvements in radiolabelling |
| US5760191A (en) * | 1993-02-05 | 1998-06-02 | Nycomed Imaging As | Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods |
| US5750088A (en) * | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
| US5744120A (en) * | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
| EP0692978A4 (en) * | 1993-03-31 | 1998-05-06 | Mallinckrodt Medical Inc | RADIOPHARMACEUTICAL PREPARATIONS THAT DO NOT CONTAIN TIN REDUCER |
| US5417959A (en) * | 1993-10-04 | 1995-05-23 | Mallinckrodt Medical, Inc. | Functionalized aza-crytand ligands for diagnostic imaging applications |
| US5520904A (en) * | 1995-01-27 | 1996-05-28 | Mallinckrodt Medical, Inc. | Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging |
| SE515621C2 (sv) * | 1995-05-08 | 2001-09-10 | Ericsson Telefon Ab L M | Förfarande vid lägesbestämning |
| US5801228A (en) * | 1995-06-07 | 1998-09-01 | Nycomed Imaging As | Polymeric contrast agents for medical imaging |
| IT1275571B (it) * | 1995-07-19 | 1997-08-07 | Consiglio Nazionale Ricerche | Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori |
| AU726914B2 (en) * | 1996-04-01 | 2000-11-23 | Epix Pharmaceuticals, Inc. | Bioactivated diagnostic imaging contrast agents |
| US5804161A (en) * | 1996-05-14 | 1998-09-08 | Nycomed Salutar Inc. | Contrast agents |
| DE19717904A1 (de) * | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| US6083486A (en) * | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| US5980863A (en) * | 1998-11-02 | 1999-11-09 | Eagle Vision Pharmaceutical Corporation | Manganese compositions and methods for MRI |
| US6254852B1 (en) * | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
| US6656448B1 (en) * | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
| WO2002072014A2 (en) * | 2001-03-08 | 2002-09-19 | Volcano Therapeutics, Inc. | Medical devices, compositions and methods for treating vulnerable plaque |
-
2004
- 2004-09-01 US US10/931,627 patent/US20050106100A1/en not_active Abandoned
- 2004-09-02 WO PCT/US2004/028660 patent/WO2005023314A1/en not_active Ceased
- 2004-09-02 AU AU2004270200A patent/AU2004270200A1/en not_active Abandoned
- 2004-09-02 EP EP04783037A patent/EP1691845A4/en not_active Withdrawn
- 2004-09-02 CA CA002537771A patent/CA2537771A1/en not_active Abandoned
- 2004-09-02 JP JP2006525453A patent/JP2007504242A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022523327A (ja) * | 2019-02-01 | 2022-04-22 | グリンプス バイオ, インコーポレイテッド | 細胞、細胞外マトリックスおよび組織微小環境における構造的再構築の検出 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004270200A1 (en) | 2005-03-17 |
| EP1691845A1 (en) | 2006-08-23 |
| WO2005023314A1 (en) | 2005-03-17 |
| US20050106100A1 (en) | 2005-05-19 |
| CA2537771A1 (en) | 2005-03-17 |
| EP1691845A4 (en) | 2009-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070226 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090623 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20091117 |