JP2007503851A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007503851A5 JP2007503851A5 JP2006523960A JP2006523960A JP2007503851A5 JP 2007503851 A5 JP2007503851 A5 JP 2007503851A5 JP 2006523960 A JP2006523960 A JP 2006523960A JP 2006523960 A JP2006523960 A JP 2006523960A JP 2007503851 A5 JP2007503851 A5 JP 2007503851A5
- Authority
- JP
- Japan
- Prior art keywords
- fiber
- optical fiber
- fluorescence
- diameter
- multimode optical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000835 fiber Substances 0.000 description 52
- 239000013307 optical fiber Substances 0.000 description 40
- 238000000034 method Methods 0.000 description 29
- 241001465754 Metazoa Species 0.000 description 16
- 230000005284 excitation Effects 0.000 description 15
- 238000005286 illumination Methods 0.000 description 11
- 230000004913 activation Effects 0.000 description 10
- 230000001678 irradiating effect Effects 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 7
- 230000008878 coupling Effects 0.000 description 7
- 238000010168 coupling process Methods 0.000 description 7
- 238000005859 coupling reaction Methods 0.000 description 7
- 239000006185 dispersion Substances 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 5
- 230000003213 activating effect Effects 0.000 description 5
- 230000005855 radiation Effects 0.000 description 5
- 238000005253 cladding Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229950006238 nadide Drugs 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- -1 aromatic amino acids Chemical class 0.000 description 1
- 230000006690 co-activation Effects 0.000 description 1
- 239000000512 collagen gel Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000012203 high throughput assay Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49624103P | 2003-08-19 | 2003-08-19 | |
| US60/496,241 | 2003-08-19 | ||
| PCT/US2004/026521 WO2005057244A2 (en) | 2003-08-19 | 2004-08-16 | Optical fiber delivery and collection system for biological applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007503851A JP2007503851A (ja) | 2007-03-01 |
| JP2007503851A5 true JP2007503851A5 (https=) | 2011-06-16 |
| JP4823906B2 JP4823906B2 (ja) | 2011-11-24 |
Family
ID=34676560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006523960A Expired - Fee Related JP4823906B2 (ja) | 2003-08-19 | 2004-08-16 | 多光子顕微鏡観察、分光法、および内視鏡観察などの生物学的用途のための光ファイバー送集光システム |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7702381B2 (https=) |
| EP (1) | EP1664854B1 (https=) |
| JP (1) | JP4823906B2 (https=) |
| AU (1) | AU2004297876A1 (https=) |
| CA (1) | CA2535843A1 (https=) |
| WO (1) | WO2005057244A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060233554A1 (en) * | 2005-04-14 | 2006-10-19 | Siddharth Ramachandran | Optical fiber systems for delivering short high power pulses |
| DE102005021205B4 (de) * | 2005-05-07 | 2007-08-16 | Mfd Diagnostics Gmbh | Verfahren und Anordnung zur lokalen Erfassung der Vitalität von lebenden Zellen in Zellkulturen oder im Gewebe |
| US20070073160A1 (en) * | 2005-09-13 | 2007-03-29 | Children's Medical Center Corporation | Light-guided transluminal catheter |
| US8954134B2 (en) | 2005-09-13 | 2015-02-10 | Children's Medical Center Corporation | Light-guided transluminal catheter |
| WO2008052153A2 (en) * | 2006-10-26 | 2008-05-02 | Cornell Research Foundation, Inc. | Production of optical pulses at a desired wavelength using soliton self-frequency shift |
| CN101553162A (zh) * | 2006-12-06 | 2009-10-07 | 皇家飞利浦电子股份有限公司 | 获取光学组织特性 |
| US8385997B2 (en) * | 2007-12-11 | 2013-02-26 | Tokitae Llc | Spectroscopic detection of malaria via the eye |
| US8840536B2 (en) * | 2007-12-11 | 2014-09-23 | Tokitae, LLC | Systems, devices, and methods including paramagnetic oscillation, rotation and translation of hemozoin asymmetric nanoparticles in response to multi-harmonic optical detection of the presence of hemozoin |
| DK2291640T3 (en) | 2008-05-20 | 2019-03-11 | Univ Health Network | Device and method for fluorescence-based imaging and monitoring |
| US9107694B2 (en) * | 2009-01-30 | 2015-08-18 | Koninklijke Philips N.V. | Examination apparatus |
| DE102009028994B3 (de) * | 2009-08-28 | 2011-02-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung und Verfahren zum spektroskopischen Nachweis von Molekülen |
| US9044141B2 (en) | 2010-02-10 | 2015-06-02 | Tokitae Llc | Systems, devices, and methods including a dark-field reflected-illumination apparatus |
| US8781184B2 (en) * | 2010-02-10 | 2014-07-15 | Tokitae Llc | Systems, devices, and methods for detection of malaria |
| EP2671105A4 (en) | 2011-02-04 | 2018-01-10 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Lightguides to simplify total emission detection for multiphoton microscopy |
| CN104219988A (zh) * | 2012-05-25 | 2014-12-17 | 奥林巴斯医疗株式会社 | 测量探头 |
| US9550072B2 (en) * | 2012-08-03 | 2017-01-24 | Cerca Solutions, LLC | Diagnostic device, therapeutic device, and uses thereof |
| US9155474B2 (en) * | 2013-08-14 | 2015-10-13 | Omega Optical, Inc. | System for multispectral imaging of fluorescence |
| CN103705201B (zh) * | 2014-01-16 | 2015-11-04 | 福建师范大学 | 一种适用于消化道病变检测的多模光谱分析系统 |
| JP2017513664A (ja) * | 2014-04-05 | 2017-06-01 | サージセンス コーポレイション | 組織酸素化のマッピングのための装置、システム、および方法 |
| KR101585011B1 (ko) * | 2014-04-11 | 2016-01-15 | 한국과학기술원 | 광섬유 래스터 스캐닝 방식의 멀티 모드 내시현미경 시스템 |
| JP2015227778A (ja) * | 2014-05-30 | 2015-12-17 | ソニー株式会社 | 画像取得装置及び画像取得方法 |
| EP3957232B1 (en) | 2014-07-24 | 2025-12-31 | University Health Network | DATA COLLECTION AND ANALYSIS FOR DIAGNOSTIC PURPOSES |
| WO2016174011A1 (en) | 2015-04-28 | 2016-11-03 | Cutech Srl | Compositions comprising valerian extracts |
| EP3426135B1 (en) | 2016-03-08 | 2024-01-03 | Enspectra Health, Inc. | Non-invasive detection of skin disease |
| GB201701355D0 (en) | 2017-01-27 | 2017-03-15 | Renishaw Plc | Direct laser writing and chemical etching |
| WO2018201082A1 (en) | 2017-04-28 | 2018-11-01 | Zebra Medical Technologies, Inc. | Systems and methods for imaging and measurement of sarcomeres |
| CN108937824A (zh) * | 2018-08-02 | 2018-12-07 | 深圳大学 | 一种内窥成像装置和荧光寿命分布图像的获取方法 |
| US11035794B2 (en) | 2018-09-28 | 2021-06-15 | Uchicago Argonne, Llc | Scalable, large-area optical sensing platform with compact light delivery and imaging system |
| CN113473900B (zh) | 2018-11-13 | 2024-09-24 | 恩斯派克特拉健康公司 | 用于生成深度剖面的方法和系统 |
| CN109656014B (zh) * | 2019-01-31 | 2024-03-19 | 北京超维景生物科技有限公司 | 多路荧光收集装置及三维非线性激光扫描腔体内窥镜 |
| CN109758098B (zh) * | 2019-01-31 | 2024-03-19 | 北京超维景生物科技有限公司 | 可变焦式腔体内窥镜探测装置及激光扫描腔体内窥镜 |
| AU2022234898A1 (en) | 2021-03-12 | 2023-09-28 | Stryker European Operations Limited | Neurosurgical methods and systems for detecting and removing tumorous tissue |
| CN113854949A (zh) * | 2021-11-10 | 2021-12-31 | 福建师范大学 | 基于宫腔镜的光声成像系统及其工作方法 |
| CN117582163B (zh) * | 2024-01-12 | 2024-04-19 | 武汉迅微光电技术有限公司 | 一种内窥式照明装置 |
| CN120918554B (zh) * | 2025-10-13 | 2026-02-06 | 深圳大学 | 一种基于空心螺旋扫描的多光子光纤阵列内窥成像装置及方法 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4576173A (en) | 1982-06-28 | 1986-03-18 | The Johns Hopkins University | Electro-optical device and method for monitoring instanteous singlet oxygen concentration produced during photoradiation using a CW excitation source |
| US4592361A (en) | 1982-06-28 | 1986-06-03 | The Johns Hopkins University | Electro-optical device and method for monitoring instantaneous singlet oxygen concentration produced during photoradiation using pulsed excitation and time domain signal processing |
| US4895156A (en) | 1986-07-02 | 1990-01-23 | Schulze John E | Sensor system using fluorometric decay measurements |
| US5119815A (en) | 1988-12-21 | 1992-06-09 | Nim, Incorporated | Apparatus for determining the concentration of a tissue pigment of known absorbance, in vivo, using the decay characteristics of scintered electromagnetic radiation |
| US5419323A (en) | 1988-12-21 | 1995-05-30 | Massachusetts Institute Of Technology | Method for laser induced fluorescence of tissue |
| SE8900612D0 (sv) | 1989-02-22 | 1989-02-22 | Jonas Johansson | Vaevnadskarakterisering utnyttjande ett blodfritt fluorescenskriterium |
| US5421337A (en) | 1989-04-14 | 1995-06-06 | Massachusetts Institute Of Technology | Spectral diagnosis of diseased tissue |
| US5034613A (en) | 1989-11-14 | 1991-07-23 | Cornell Research Foundation, Inc. | Two-photon laser microscopy |
| US5127405A (en) | 1990-02-16 | 1992-07-07 | The Boc Group, Inc. | Biomedical fiber optic probe with frequency domain signal processing |
| US5197470A (en) | 1990-07-16 | 1993-03-30 | Eastman Kodak Company | Near infrared diagnostic method and instrument |
| EP0573535B1 (en) * | 1991-02-26 | 2000-12-27 | Massachusetts Institute Of Technology | Systems and methods of molecular spectroscopy to provide for the diagnosis of tissue |
| CA2042075C (en) | 1991-05-08 | 2001-01-23 | Branko Palcic | Endoscopic imaging system |
| US5323775A (en) | 1991-09-13 | 1994-06-28 | Allergan, Inc. | Diagnostic method for determining precorneal retention time of ophthalmic formulations |
| US5353790A (en) | 1992-01-17 | 1994-10-11 | Board Of Regents, The University Of Texas System | Method and apparatus for optical measurement of bilirubin in tissue |
| US5311013A (en) | 1992-10-15 | 1994-05-10 | Abbott Laboratories | Optical fiber distribution system for an optical fiber sensor in a luminescent sensor system |
| US5333044A (en) | 1992-11-24 | 1994-07-26 | The United States Of America As Represented By The Department Of Energy | Fluorescent image tracking velocimeter |
| US5341805A (en) | 1993-04-06 | 1994-08-30 | Cedars-Sinai Medical Center | Glucose fluorescence monitor and method |
| US5590660A (en) | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
| US5579773A (en) | 1994-09-30 | 1996-12-03 | Martin Marietta Energy Systems, Inc. | Laser-induced differential normalized fluorescence method for cancer diagnosis |
| US5697373A (en) | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
| US5699795A (en) | 1995-03-31 | 1997-12-23 | Board Of Regents, The University Of Texas System | Optical probe for the detection of cervical neoplasia using fluorescence spectroscopy and apparatus incorporating same |
| IL113333A (en) * | 1995-04-11 | 2001-01-28 | Yoav Paltieli | Fiber-optic endoscope |
| US5628310A (en) | 1995-05-19 | 1997-05-13 | Joseph R. Lakowicz | Method and apparatus to perform trans-cutaneous analyte monitoring |
| US5812729A (en) * | 1995-07-21 | 1998-09-22 | Lockheed Martin Energy Systems, Inc. | Very high numerical aperture light transmitting device |
| DE29620732U1 (de) | 1995-09-26 | 1997-04-24 | Karl Storz Gmbh & Co, 78532 Tuttlingen | Vorrichtung zur photodynamischen Diagnose |
| JP3796635B2 (ja) | 1996-03-06 | 2006-07-12 | 富士写真フイルム株式会社 | 蛍光検出装置 |
| DE19622359B4 (de) | 1996-06-04 | 2007-11-22 | Carl Zeiss Jena Gmbh | Vorrichtung zur Einkopplung der Strahlung von Kurzpulslasern in einem mikroskopischen Strahlengang |
| US5862287A (en) | 1996-12-13 | 1999-01-19 | Imra America, Inc. | Apparatus and method for delivery of dispersion compensated ultrashort optical pulses with high peak power |
| US6249630B1 (en) * | 1996-12-13 | 2001-06-19 | Imra America, Inc. | Apparatus and method for delivery of dispersion-compensated ultrashort optical pulses with high peak power |
| CA2283949A1 (en) | 1997-03-13 | 1998-09-17 | Haishan Zeng | Methods and apparatus for detecting the rejection of transplanted tissue |
| US5995281A (en) | 1997-04-09 | 1999-11-30 | Carl Zeiss Jena Gmbh | Device for coupling the radiation of short-pulse lasers in an optical beam path of a microscope |
| US5986271A (en) | 1997-07-03 | 1999-11-16 | Lazarev; Victor | Fluorescence imaging system |
| US6238348B1 (en) | 1997-07-22 | 2001-05-29 | Scimed Life Systems, Inc. | Miniature spectrometer system and method |
| US6356088B1 (en) | 1997-08-01 | 2002-03-12 | Carl Zeiss Jena Gmbh | Highly compact laser scanning microscope with integrated short-pulse laser |
| US6320191B1 (en) * | 1998-03-27 | 2001-11-20 | Picometrix, Inc. | Dispersive precompensator for use in an electromagnetic radiation generation and detection system |
| DE19833025C2 (de) | 1998-07-23 | 2001-07-05 | Leica Microsystems | Optische Anordnung zur Übertragung kurzer Laserpulse in Lichtleitfasern |
| US6236779B1 (en) | 1999-05-24 | 2001-05-22 | Spectra Physics Lasers, Inc. | Photonic crystal fiber system for sub-picosecond pulses |
| CA2398029A1 (en) | 2000-02-08 | 2001-08-16 | Cornell Research Foundation, Inc. | Multiphoton excitation through optical fibers for fluorescence spectroscopy |
| GB0010950D0 (en) * | 2000-05-05 | 2000-06-28 | Univ Bath | A nonlinear optical device |
| US6898367B2 (en) * | 2000-06-17 | 2005-05-24 | Leica Microsystems Heidelberg Gmbh | Method and instrument for microscopy |
| DE20122791U1 (de) | 2000-06-17 | 2007-11-29 | Leica Microsystems Cms Gmbh | Scanmikroskop |
| DE10044636A1 (de) | 2000-09-08 | 2002-03-21 | Leica Microsystems | Optische Anordnung zur Beleuchtung von Objekten für konfokale Rastermikroskope |
| US6961599B2 (en) * | 2001-01-09 | 2005-11-01 | Childrens Hospital Los Angeles | Identifying or measuring selected substances or toxins in a subject using resonant raman signals |
| US7336988B2 (en) * | 2001-08-08 | 2008-02-26 | Lucent Technologies Inc. | Multi-photon endoscopy |
| US6986739B2 (en) * | 2001-08-23 | 2006-01-17 | Sciperio, Inc. | Architecture tool and methods of use |
| EP1442323A1 (en) * | 2001-10-09 | 2004-08-04 | Crystal Fibre A/S | Hermetically sealed optical fibre with voids or holes, method of its production, and its use |
| US7116887B2 (en) * | 2002-03-19 | 2006-10-03 | Nufern | Optical fiber |
| US20050024716A1 (en) * | 2003-07-15 | 2005-02-03 | Johan Nilsson | Optical device with immediate gain for brightness enhancement of optical pulses |
-
2004
- 2004-08-16 US US10/918,950 patent/US7702381B2/en not_active Expired - Fee Related
- 2004-08-16 WO PCT/US2004/026521 patent/WO2005057244A2/en not_active Ceased
- 2004-08-16 EP EP04817749.7A patent/EP1664854B1/en not_active Expired - Lifetime
- 2004-08-16 CA CA002535843A patent/CA2535843A1/en not_active Abandoned
- 2004-08-16 JP JP2006523960A patent/JP4823906B2/ja not_active Expired - Fee Related
- 2004-08-16 AU AU2004297876A patent/AU2004297876A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007503851A5 (https=) | ||
| JP4823906B2 (ja) | 多光子顕微鏡観察、分光法、および内視鏡観察などの生物学的用途のための光ファイバー送集光システム | |
| US20070213618A1 (en) | Scanning fiber-optic nonlinear optical imaging and spectroscopy endoscope | |
| JP5102622B2 (ja) | 検体のファイバ式マルチフォトン式顕微鏡イメージング装置および方法 | |
| US7019309B2 (en) | Tripartite fiber-coupled fluorescence instrument | |
| US8553337B2 (en) | Multi-path, multi-magnification, non-confocal fluorescence emission endoscopy apparatus and methods | |
| US8705184B2 (en) | Multi-path, multi-magnification, non-confocal fluorescence emission endoscopy apparatus and methods | |
| US20130324858A1 (en) | Multi-path, multi-magnification, non-confocal fluorescence emission endoscopy apparatus and methods | |
| Sparks et al. | A flexible wide‐field FLIM endoscope utilising blue excitation light for label‐free contrast of tissue | |
| Rivera et al. | Use of a lensed fiber for a large-field-of-view, high-resolution, fiber-scanning microendoscope | |
| CN202069570U (zh) | 一种荧光内窥成像系统 | |
| Trägårdh et al. | CARS microscopy through a multimode fiber probe with reduced four-wave mixing background | |
| Zhang et al. | Video-rate two-photon microendoscopy using second harmonic resonance fiber scanning | |
| Brown et al. | Epifluorescence light collection for multiphoton microscopic endoscopy | |
| AU2003204717B2 (en) | Apparatus | |
| Septier et al. | Miniaturized nonlinear micro-endoscopes | |
| Mytskaniuk | Endoscopie non-linéaire: instrumentation et applications | |
| Septier et al. | Label-free three photon micro-endoscope | |
| Liu et al. | Fiber laser and handheld probe based multiphoton microscope | |
| Zhao et al. | Two-photon microscopy based on fiber delivery of ultrashort laser pulses and supercontinumm generation in a photonic crystal fiber | |
| Liu et al. | Fiber-based multiphoton system | |
| Murugkar et al. | Development of a micromirror-scanned multimodal CARS miniaturized microscope for the in vivo study of spinal cord disorders | |
| Chu | Fiber Optic Devices and Systems | |
| Wu et al. | Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue | |
| Xiao et al. | In vivo mucosal tissue imaging using fiber-based two-photon approach |