JP2007503406A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007503406A5 JP2007503406A5 JP2006524250A JP2006524250A JP2007503406A5 JP 2007503406 A5 JP2007503406 A5 JP 2007503406A5 JP 2006524250 A JP2006524250 A JP 2006524250A JP 2006524250 A JP2006524250 A JP 2006524250A JP 2007503406 A5 JP2007503406 A5 JP 2007503406A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- iii
- process according
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000000034 method Methods 0.000 claims 2
- RRGUKTPIGVIEKM-UHFFFAOYSA-N Cilostazol Chemical compound C=1C=C2NC(=O)CCC2=CC=1OCCCCC1=NN=NN1C1CCCCC1 RRGUKTPIGVIEKM-UHFFFAOYSA-N 0.000 claims 1
- 229960004588 cilostazol Drugs 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- HOSGXJWQVBHGLT-UHFFFAOYSA-N Oc(cc1)cc(CC2)c1NC2=O Chemical compound Oc(cc1)cc(CC2)c1NC2=O HOSGXJWQVBHGLT-UHFFFAOYSA-N 0.000 description 1
Description
式（ＩＩＩ）の５−（４−ハロブチル）−１−シクロヘキシル−１Ｈ−テトラゾール
Claims (1)
- 式（ＩＩ）の化合物
と反応させることを含むシロスタゾール（Ｉ）の調製方法であって、
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001670A ITMI20031670A1 (it) | 2003-08-26 | 2003-08-26 | Processo per la preparazione di cilostazolo e di suoi intermedi. |
| PCT/EP2004/008475 WO2005019204A1 (en) | 2003-08-26 | 2004-07-29 | A process for the preparation of cilostazol and of the intermediates thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007503406A JP2007503406A (ja) | 2007-02-22 |
| JP2007503406A5 true JP2007503406A5 (ja) | 2007-08-23 |
Family
ID=34204178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006524250A Pending JP2007503406A (ja) | 2003-08-26 | 2004-07-29 | シロスタゾールおよびその中間体の調製方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070027325A1 (ja) |
| EP (1) | EP1660480A1 (ja) |
| JP (1) | JP2007503406A (ja) |
| IL (1) | IL173887A0 (ja) |
| IT (1) | ITMI20031670A1 (ja) |
| WO (1) | WO2005019204A1 (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050101631A1 (en) | 2002-08-01 | 2005-05-12 | Otsuka Pharmaceuticals Company | Process for producing carbostyril derivatives |
| CN100462360C (zh) * | 2005-08-15 | 2009-02-18 | 上海立科药物化学有限公司 | N-环己基-5-(4-氯丁基)-1h-四氮唑的合成方法 |
| CN105601578B (zh) * | 2014-11-24 | 2018-06-08 | 中国科学院大连化学物理研究所 | 一种1,5-二取代四唑化合物的制备方法 |
| CN105111190B (zh) * | 2015-09-17 | 2017-11-07 | 浙江金立源药业有限公司 | 一种西洛他唑的合成方法 |
| CN111454227A (zh) * | 2020-05-21 | 2020-07-28 | 湖南复瑞生物医药技术有限责任公司 | 一种西洛他唑中间体的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2507337A (en) * | 1946-06-12 | 1950-05-09 | Bilhuber Inc E | 1, 5-dialkyl tetrazoles and preparation thereof |
| JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| US6515128B2 (en) * | 2000-03-20 | 2003-02-04 | Teva Pharmaceutical Industries Ltd. | Processes for preparing cilostazol |
-
2003
- 2003-08-26 IT IT001670A patent/ITMI20031670A1/it unknown
-
2004
- 2004-07-29 WO PCT/EP2004/008475 patent/WO2005019204A1/en active Application Filing
- 2004-07-29 EP EP04763582A patent/EP1660480A1/en not_active Withdrawn
- 2004-07-29 JP JP2006524250A patent/JP2007503406A/ja active Pending
- 2004-07-29 US US10/569,404 patent/US20070027325A1/en not_active Abandoned
-
2006
- 2006-02-22 IL IL173887A patent/IL173887A0/en unknown