JP2007502864A - 有効性を高めたケモカインレセプタ結合複素環化合物 - Google Patents

有効性を高めたケモカインレセプタ結合複素環化合物 Download PDF

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JP2007502864A
JP2007502864A JP2006533279A JP2006533279A JP2007502864A JP 2007502864 A JP2007502864 A JP 2007502864A JP 2006533279 A JP2006533279 A JP 2006533279A JP 2006533279 A JP2006533279 A JP 2006533279A JP 2007502864 A JP2007502864 A JP 2007502864A
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alkyl
alkenyl
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JP2007502864A5 (https=
Inventor
ギャリー ジェイ． ブリジャー，
アル カラー，
カーティス ハーウィグ，
レナート スケルルジュ，
デービッド ボグッキ，
トレバー アール． ウィルソン，
ジェイソン クローフォード，
アーネスト ジェイ． マッカカーン，
べム アツマ，
シキアオ ナン，
ユアンシ チョウ，
ドミニク スカルズ，
クリストファー デニス スミス，
フルリ， マリア ロザリア ディ
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アノーメッド インコーポレイティド
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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JP2006533279A 2003-05-23 2004-05-21 有効性を高めたケモカインレセプタ結合複素環化合物 Pending JP2007502864A (ja)

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US44617003A 2003-05-23 2003-05-23
US10/457,034 US7354932B2 (en) 2001-12-21 2003-06-06 Chemokine receptor binding heterocyclic compounds with enhanced efficacy
PCT/US2004/015977 WO2004106493A2 (en) 2003-05-23 2004-05-21 Chemokine receptor binding heterocyclic compounds with enhanced efficacy

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JP2007502864A5 JP2007502864A5 (https=) 2007-07-19

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US (6) US7354932B2 (https=)
EP (1) EP1628533A4 (https=)
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WO (1) WO2004106493A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021506838A (ja) * 2017-12-19 2021-02-22 エックス４ ファーマシューティカルズ， インコーポレイテッド 非環式ｃｘｃｒ４阻害剤およびその使用
JP2021535146A (ja) * 2018-08-31 2021-12-16 エックス４ ファーマシューティカルズ， インコーポレイテッド Ｃｘｃｒ４阻害剤の組成物ならびに調製および使用の方法

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US20220409589A1 (en) * 2001-12-21 2022-12-29 Genzyme Corporation Chemokine receptor binding heterocyclic compounds with enhanced efficacy
US7354932B2 (en) * 2001-12-21 2008-04-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
WO2004092169A1 (ja) * 2003-04-18 2004-10-28 Ono Pharmaceutical Co., Ltd. スピロピペリジン化合物およびその医薬用途
EP1730113B1 (en) * 2004-03-15 2016-12-28 Genzyme Corporation Process for the synthesis of a cxcr4 antagonist
DE102004023506A1 (de) 2004-05-10 2005-12-01 Grünenthal GmbH Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate
EP1790639B1 (en) * 2004-08-27 2014-03-26 Ono Pharmaceutical Co., Ltd. Spirocyclic compounds and their use as cxcr4-antagonists
TW200619206A (en) * 2004-09-29 2006-06-16 Anormed Inc Chemokine-binding heterocyclic compound salts, and methods of use thereof
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