JP2007502808A - 哺乳類における依存症の予防と治療のための薬剤組成物 - Google Patents
哺乳類における依存症の予防と治療のための薬剤組成物 Download PDFInfo
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- JP2007502808A JP2007502808A JP2006523697A JP2006523697A JP2007502808A JP 2007502808 A JP2007502808 A JP 2007502808A JP 2006523697 A JP2006523697 A JP 2006523697A JP 2006523697 A JP2006523697 A JP 2006523697A JP 2007502808 A JP2007502808 A JP 2007502808A
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- Prior art keywords
- chlorophenyl
- phenyl
- aza
- hydroxy
- bicyclo
- Prior art date
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- 206010012335 Dependence Diseases 0.000 title claims abstract description 36
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 23
- 241000124008 Mammalia Species 0.000 title claims description 7
- 238000011282 treatment Methods 0.000 title description 9
- 230000002265 prevention Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 69
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- 229940123158 Cannabinoid CB1 receptor antagonist Drugs 0.000 claims abstract description 27
- 239000003555 cannabinoid 1 receptor antagonist Substances 0.000 claims abstract description 27
- 229940123257 Opioid receptor antagonist Drugs 0.000 claims abstract description 23
- 208000011117 substance-related disease Diseases 0.000 claims abstract description 22
- 208000007848 Alcoholism Diseases 0.000 claims abstract description 21
- 239000003401 opiate antagonist Substances 0.000 claims abstract description 21
- 206010013654 Drug abuse Diseases 0.000 claims abstract description 15
- 208000022497 Cocaine-Related disease Diseases 0.000 claims abstract description 12
- 230000003542 behavioural effect Effects 0.000 claims abstract description 12
- 206010013663 drug dependence Diseases 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 12
- 208000029650 alcohol withdrawal Diseases 0.000 claims abstract description 11
- 201000006145 cocaine dependence Diseases 0.000 claims abstract description 11
- 208000001613 Gambling Diseases 0.000 claims abstract description 9
- 208000024891 symptom Diseases 0.000 claims abstract description 8
- 241000208125 Nicotiana Species 0.000 claims abstract description 7
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims abstract description 7
- 239000003937 drug carrier Substances 0.000 claims abstract description 7
- -1 1-methyl-1-phenyl-ethyl Chemical group 0.000 claims description 74
- 150000003839 salts Chemical class 0.000 claims description 44
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 38
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 37
- KBPHGUKTJKPERJ-UHFFFAOYSA-N 2-methoxyethanesulfonic acid Chemical compound COCCS(O)(=O)=O KBPHGUKTJKPERJ-UHFFFAOYSA-N 0.000 claims description 32
- 150000001408 amides Chemical class 0.000 claims description 32
- 150000004677 hydrates Chemical class 0.000 claims description 16
- 239000012453 solvate Substances 0.000 claims description 16
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- 239000000203 mixture Substances 0.000 claims description 13
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 9
- NOVIRJZSSSHOFF-UHFFFAOYSA-N 3-[1-(2,3-dihydro-1h-inden-2-ylmethyl)-3,4-dimethylpiperidin-4-yl]benzamide Chemical compound CC1CN(CC2CC3=CC=CC=C3C2)CCC1(C)C1=CC=CC(C(N)=O)=C1 NOVIRJZSSSHOFF-UHFFFAOYSA-N 0.000 claims description 8
- CMXNJCYHOYIGPE-UHFFFAOYSA-N 3-[1-[(1-hydroxy-3-phenylcyclobutyl)methyl]-3,4-dimethylpiperidin-4-yl]benzamide Chemical compound C1CC(C=2C=C(C=CC=2)C(N)=O)(C)C(C)CN1CC(C1)(O)CC1C1=CC=CC=C1 CMXNJCYHOYIGPE-UHFFFAOYSA-N 0.000 claims description 8
- VLJHXPKDNBNFPN-UHFFFAOYSA-N 3-[1-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-3,4-dimethylpiperidin-4-yl]benzamide Chemical compound CC1CN(CC2(O)CC3=CC=CC=C3C2)CCC1(C)C1=CC=CC(C(N)=O)=C1 VLJHXPKDNBNFPN-UHFFFAOYSA-N 0.000 claims description 8
- LTENPJFSBSGWFV-UHFFFAOYSA-N 3-[1-[3-(1-hydroxycyclohexyl)propyl]-3,4-dimethylpiperidin-4-yl]benzamide Chemical compound C1CC(C=2C=C(C=CC=2)C(N)=O)(C)C(C)CN1CCCC1(O)CCCCC1 LTENPJFSBSGWFV-UHFFFAOYSA-N 0.000 claims description 8
- YZMRJTFTIRSULG-UHFFFAOYSA-N 3-[2-[(1-hydroxy-3-phenylcyclobutyl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]benzamide Chemical compound NC(=O)C1=CC=CC(C23CC(CCC2)N(CC2(O)CC(C2)C=2C=CC=CC=2)CC3)=C1 YZMRJTFTIRSULG-UHFFFAOYSA-N 0.000 claims description 8
- ZCDWSEYWBPLIPE-UHFFFAOYSA-N 3-[2-[(2-hydroxy-3,4-dihydro-1h-naphthalen-2-yl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]benzamide Chemical compound NC(=O)C1=CC=CC(C23CC(CCC2)N(CC2(O)CC4=CC=CC=C4CC2)CC3)=C1 ZCDWSEYWBPLIPE-UHFFFAOYSA-N 0.000 claims description 8
- KDAMUYVTYZYYMY-UHFFFAOYSA-N 3-[2-[3-(1-hydroxycyclohexyl)propyl]-2-azabicyclo[3.3.1]nonan-5-yl]benzamide Chemical compound NC(=O)C1=CC=CC(C23CC(CCC2)N(CCCC2(O)CCCCC2)CC3)=C1 KDAMUYVTYZYYMY-UHFFFAOYSA-N 0.000 claims description 8
- NQDNSVFGDWTZRD-UHFFFAOYSA-N 3-[3-(2,3-dihydro-1h-inden-2-ylmethyl)-6-ethyl-3-azabicyclo[3.1.0]hexan-6-yl]benzamide Chemical compound C12CN(CC3CC4=CC=CC=C4C3)CC2C1(CC)C1=CC=CC(C(N)=O)=C1 NQDNSVFGDWTZRD-UHFFFAOYSA-N 0.000 claims description 8
- PNUIAAYEYHRGJI-UHFFFAOYSA-N 3-[3-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-8-methoxy-3-azabicyclo[3.2.1]octan-8-yl]benzamide Chemical compound C1N(CC2(O)CC3=CC=CC=C3C2)CC2CCC1C2(OC)C1=CC=CC(C(N)=O)=C1 PNUIAAYEYHRGJI-UHFFFAOYSA-N 0.000 claims description 8
- PCUUSYJXGVLVTO-UHFFFAOYSA-N 3-[3-[3-(1-hydroxycyclohexyl)propyl]-8-methoxy-3-azabicyclo[3.2.1]octan-8-yl]benzamide Chemical compound C=1C=CC(C(N)=O)=CC=1C1(OC)C(C2)CCC1CN2CCCC1(O)CCCCC1 PCUUSYJXGVLVTO-UHFFFAOYSA-N 0.000 claims description 8
- KJJLEOOLZLWLSS-UHFFFAOYSA-N 3-[6-ethyl-3-[(1-hydroxy-3-phenylcyclobutyl)methyl]-3-azabicyclo[3.1.0]hexan-6-yl]benzamide Chemical compound C1C2C(CC)(C=3C=C(C=CC=3)C(N)=O)C2CN1CC(C1)(O)CC1C1=CC=CC=C1 KJJLEOOLZLWLSS-UHFFFAOYSA-N 0.000 claims description 8
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- ZFMTXYPTAWEVCX-UHFFFAOYSA-N 3-[6-ethyl-3-[(2-hydroxy-3,4-dihydro-1h-naphthalen-2-yl)methyl]-3-azabicyclo[3.1.0]hexan-6-yl]benzamide Chemical compound C12CN(CC3(O)CC4=CC=CC=C4CC3)CC2C1(CC)C1=CC=CC(C(N)=O)=C1 ZFMTXYPTAWEVCX-UHFFFAOYSA-N 0.000 claims description 8
- IIMDLDQJDZKMRU-UHFFFAOYSA-N 3-[6-ethyl-3-[3-(1-hydroxycyclohexyl)propyl]-3-azabicyclo[3.1.0]hexan-6-yl]benzamide Chemical compound C1C2C(CC)(C=3C=C(C=CC=3)C(N)=O)C2CN1CCCC1(O)CCCCC1 IIMDLDQJDZKMRU-UHFFFAOYSA-N 0.000 claims description 8
- DQASZCKCSVFDCH-UHFFFAOYSA-N n-[3-[2-[(1-hydroxy-3-phenylcyclobutyl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]phenyl]-2-methoxyethanesulfonamide Chemical compound COCCS(=O)(=O)NC1=CC=CC(C23CC(CCC2)N(CC2(O)CC(C2)C=2C=CC=CC=2)CC3)=C1 DQASZCKCSVFDCH-UHFFFAOYSA-N 0.000 claims description 8
- RQZJNXFHIROAPH-UHFFFAOYSA-N n-[3-[2-[(1-hydroxy-3-phenylcyclobutyl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]phenyl]methanesulfonamide Chemical compound CS(=O)(=O)NC1=CC=CC(C23CC(CCC2)N(CC2(O)CC(C2)C=2C=CC=CC=2)CC3)=C1 RQZJNXFHIROAPH-UHFFFAOYSA-N 0.000 claims description 8
- PARWEPAVIFDMQQ-UHFFFAOYSA-N n-[3-[2-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]phenyl]-2-methoxyethanesulfonamide Chemical compound COCCS(=O)(=O)NC1=CC=CC(C23CC(CCC2)N(CC2(O)CC4=CC=CC=C4C2)CC3)=C1 PARWEPAVIFDMQQ-UHFFFAOYSA-N 0.000 claims description 8
- MWQBBRUNZRMVLU-UHFFFAOYSA-N n-[3-[2-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]phenyl]methanesulfonamide Chemical compound CS(=O)(=O)NC1=CC=CC(C23CC(CCC2)N(CC2(O)CC4=CC=CC=C4C2)CC3)=C1 MWQBBRUNZRMVLU-UHFFFAOYSA-N 0.000 claims description 8
- HFTKEKZOAHFQKB-UHFFFAOYSA-N n-[3-[2-[(2-hydroxy-3,4-dihydro-1h-naphthalen-2-yl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]phenyl]methanesulfonamide Chemical compound CS(=O)(=O)NC1=CC=CC(C23CC(CCC2)N(CC2(O)CC4=CC=CC=C4CC2)CC3)=C1 HFTKEKZOAHFQKB-UHFFFAOYSA-N 0.000 claims description 8
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- VWCPRVNVISOSDS-UHFFFAOYSA-N n-[3-[2-[3-(1-hydroxycyclohexyl)propyl]-2-azabicyclo[3.3.1]nonan-5-yl]phenyl]methanesulfonamide Chemical compound CS(=O)(=O)NC1=CC=CC(C23CC(CCC2)N(CCCC2(O)CCCCC2)CC3)=C1 VWCPRVNVISOSDS-UHFFFAOYSA-N 0.000 claims description 8
- UWTVBOIAYXZBRE-UHFFFAOYSA-N n-[3-[3-(2,3-dihydro-1h-inden-2-ylmethyl)-6-ethyl-3-azabicyclo[3.1.0]hexan-6-yl]phenyl]-2-methoxyethanesulfonamide Chemical compound C12CN(CC3CC4=CC=CC=C4C3)CC2C1(CC)C1=CC=CC(NS(=O)(=O)CCOC)=C1 UWTVBOIAYXZBRE-UHFFFAOYSA-N 0.000 claims description 8
- GDHQBJVFNKIBKI-UHFFFAOYSA-N n-[3-[3-(2,3-dihydro-1h-inden-2-ylmethyl)-6-ethyl-3-azabicyclo[3.1.0]hexan-6-yl]phenyl]methanesulfonamide Chemical compound C12CN(CC3CC4=CC=CC=C4C3)CC2C1(CC)C1=CC=CC(NS(C)(=O)=O)=C1 GDHQBJVFNKIBKI-UHFFFAOYSA-N 0.000 claims description 8
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- ZBVPUFSKFGYNLC-UHFFFAOYSA-N n-[3-[6-ethyl-3-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-3-azabicyclo[3.1.0]hexan-6-yl]phenyl]methanesulfonamide Chemical compound C12CN(CC3(O)CC4=CC=CC=C4C3)CC2C1(CC)C1=CC=CC(NS(C)(=O)=O)=C1 ZBVPUFSKFGYNLC-UHFFFAOYSA-N 0.000 claims description 8
- LWWRWOHYBARKAQ-UHFFFAOYSA-N n-[3-[6-ethyl-3-[3-(1-hydroxycyclohexyl)propyl]-3-azabicyclo[3.1.0]hexan-6-yl]phenyl]-2-methoxyethanesulfonamide Chemical compound C1C2C(CC)(C=3C=C(NS(=O)(=O)CCOC)C=CC=3)C2CN1CCCC1(O)CCCCC1 LWWRWOHYBARKAQ-UHFFFAOYSA-N 0.000 claims description 8
- XWJBBHRGYQANKK-UHFFFAOYSA-N 3-[2-[(2-hydroxy-1,3-dihydroinden-2-yl)methyl]-2-azabicyclo[3.3.1]nonan-5-yl]benzamide Chemical compound NC(=O)C1=CC=CC(C23CC(CCC2)N(CC2(O)CC4=CC=CC=C4C2)CC3)=C1 XWJBBHRGYQANKK-UHFFFAOYSA-N 0.000 claims description 7
- CQMGDWUBLFGSDQ-UHFFFAOYSA-N 3-[3-[(1-hydroxy-3-phenylcyclobutyl)methyl]-8-methoxy-3-azabicyclo[3.2.1]octan-8-yl]benzamide Chemical compound C=1C=CC(C(N)=O)=CC=1C1(OC)C(C2)CCC1CN2CC(C1)(O)CC1C1=CC=CC=C1 CQMGDWUBLFGSDQ-UHFFFAOYSA-N 0.000 claims description 7
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- YBQGLTGAHBCMME-UHFFFAOYSA-N 4-amino-1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)purin-6-yl]piperidine-4-carboxamide Chemical compound C1CC(C(=O)N)(N)CCN1C1=NC=NC2=C1N=C(C=1C(=CC=CC=1)Cl)N2C1=CC=C(Cl)C=C1 YBQGLTGAHBCMME-UHFFFAOYSA-N 0.000 claims description 5
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- UNAZAADNBYXMIV-UHFFFAOYSA-N otenabant Chemical compound C1CC(NCC)(C(N)=O)CCN1C1=NC=NC2=C1N=C(C=1C(=CC=CC=1)Cl)N2C1=CC=C(Cl)C=C1 UNAZAADNBYXMIV-UHFFFAOYSA-N 0.000 claims description 5
- CZLBJIOKKYHVOG-UHFFFAOYSA-N 1-[2-(2-chlorophenyl)-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]-3-(ethylamino)azetidine-3-carboxamide Chemical compound C1C(NCC)(C(N)=O)CN1C1=CC=NC2=C(C=3C=CC(Cl)=CC=3)C(C=3C(=CC=CC=3)Cl)=NN12 CZLBJIOKKYHVOG-UHFFFAOYSA-N 0.000 claims description 4
- ZNNPDKATJWCFJB-UHFFFAOYSA-N 1-[2-(2-chlorophenyl)-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]-4-(ethylamino)piperidine-4-carboxamide Chemical compound C1CC(NCC)(C(N)=O)CCN1C1=CC=NC2=C(C=3C=CC(Cl)=CC=3)C(C=3C(=CC=CC=3)Cl)=NN12 ZNNPDKATJWCFJB-UHFFFAOYSA-N 0.000 claims description 4
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- HYBPYDGGQPVUBJ-UHFFFAOYSA-N 1-[7-(2-chlorophenyl)-8-(4-chlorophenyl)-2-methylpyrazolo[1,5-a][1,3,5]triazin-4-yl]-3-(propan-2-ylamino)azetidine-3-carboxamide Chemical compound C1C(NC(C)C)(C(N)=O)CN1C1=NC(C)=NC2=C(C=3C=CC(Cl)=CC=3)C(C=3C(=CC=CC=3)Cl)=NN12 HYBPYDGGQPVUBJ-UHFFFAOYSA-N 0.000 claims description 4
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- BMVXCPBXGZKUPN-UHFFFAOYSA-N 1-hexanamine Chemical compound CCCCCCN BMVXCPBXGZKUPN-UHFFFAOYSA-N 0.000 claims description 4
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| PCT/IB2004/002596 WO2005018645A1 (en) | 2003-08-21 | 2004-08-09 | A pharmaceutical composition for the prevention and treatment of addiction in a mammal |
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| JP2007502808A true JP2007502808A (ja) | 2007-02-15 |
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| EP (1) | EP1658082A1 (enExample) |
| JP (1) | JP2007502808A (enExample) |
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| MX (1) | MXPA06002035A (enExample) |
| WO (1) | WO2005018645A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010013591A1 (ja) | 2008-07-30 | 2010-02-04 | Hirai Koji | 擬似嗜好物品 |
| JP2012512873A (ja) * | 2008-12-18 | 2012-06-07 | イーライ リリー アンド カンパニー | プリン化合物 |
| WO2018159716A1 (ja) * | 2017-03-02 | 2018-09-07 | 株式会社 三和化学研究所 | アルコール使用障害の治療薬 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60226161T2 (de) * | 2001-10-22 | 2009-07-02 | Pfizer Products Inc., Groton | 3-azabicyclo[3.1.0]hexan derivative als antagonisten der opioid rezeptoren |
| CA2499994C (en) * | 2002-09-23 | 2012-07-10 | Verion, Inc. | Abuse-resistant pharmaceutical compositions |
| US7129239B2 (en) * | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| CN102558155A (zh) | 2003-01-14 | 2012-07-11 | 阿伦纳药品公司 | 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗 |
| TWI335328B (en) * | 2003-07-14 | 2011-01-01 | Arena Pharm Inc | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related hereto |
| KR101071438B1 (ko) | 2005-10-21 | 2011-10-10 | 미쓰비시 타나베 파마 코퍼레이션 | 카나비노이드 수용체 길항제로서의피라졸로[1,5-ａ]피리미딘 화합물 |
| AR061793A1 (es) | 2006-07-05 | 2008-09-24 | Mitsubishi Tanabe Pharma Corp | Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica |
| WO2008039023A1 (en) * | 2006-09-29 | 2008-04-03 | Green Cross Corporation | Heteroaryl-pyrazole derivatives as cannabinoid cb1 receptor antagonists |
| WO2008044111A1 (en) * | 2006-10-13 | 2008-04-17 | Pfizer Products Inc. | Pharmaceutical formulation tablet |
| US8252791B2 (en) * | 2008-08-13 | 2012-08-28 | Jenrin Discovery, Inc. | Purine compounds as cannabinoid receptor blockers |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| MX2013003184A (es) | 2010-09-22 | 2013-06-07 | Arena Pharm Inc | Moduladores del receptor gpr119 y el tratamiento de transtornos relacionados con el mismo. |
| BR112013011737A2 (pt) | 2010-11-15 | 2016-08-09 | Univ Leuven Kath | composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv |
| CA2927527C (en) | 2013-11-20 | 2021-06-01 | Sanwa Kagaku Kenkyusho Co., Ltd. | Novel 3-azabicyclo[3.1.0]hexane derivative and use thereof as u-opioid receptor antagonist |
| AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| HK1246778A1 (zh) | 2015-05-20 | 2018-09-14 | 株式会社三和化学研究所 | 一种新型的3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用 |
| US10696677B2 (en) * | 2016-12-21 | 2020-06-30 | Research Triangle Institute | Diaryl purine derivatives with improved bioavailability |
| BR112020015712A2 (pt) * | 2018-02-05 | 2020-12-08 | Alkermes, Inc. | Compostos para tratamento de dor |
| WO2023064228A1 (en) * | 2021-10-11 | 2023-04-20 | Anebulo Pharmaceuticals, Inc. | Method of treating addiction |
| AU2022362107A1 (en) | 2021-10-11 | 2024-05-02 | Anebulo Pharmaceuticals, Inc. | Crystalline forms of a cannabinoid receptor type 1 (cb1) modulator and methods of use and preparation thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003035622A1 (en) * | 2001-10-22 | 2003-05-01 | Pfizer Products Inc. | 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003267728A1 (en) * | 2002-10-18 | 2004-05-04 | Pfizer Products Inc. | Cannabinoid receptor ligands and uses thereof |
| US7129239B2 (en) * | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| US7247628B2 (en) * | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
| US7329658B2 (en) * | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7176210B2 (en) * | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
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2004
- 2004-06-17 US US10/870,209 patent/US20050043327A1/en not_active Abandoned
- 2004-08-09 EP EP04744231A patent/EP1658082A1/en not_active Withdrawn
- 2004-08-09 JP JP2006523697A patent/JP2007502808A/ja active Pending
- 2004-08-09 CA CA002536280A patent/CA2536280A1/en not_active Abandoned
- 2004-08-09 BR BRPI0413693-4A patent/BRPI0413693A/pt not_active IP Right Cessation
- 2004-08-09 MX MXPA06002035A patent/MXPA06002035A/es not_active Application Discontinuation
- 2004-08-09 WO PCT/IB2004/002596 patent/WO2005018645A1/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003035622A1 (en) * | 2001-10-22 | 2003-05-01 | Pfizer Products Inc. | 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010013591A1 (ja) | 2008-07-30 | 2010-02-04 | Hirai Koji | 擬似嗜好物品 |
| JP2012512873A (ja) * | 2008-12-18 | 2012-06-07 | イーライ リリー アンド カンパニー | プリン化合物 |
| WO2018159716A1 (ja) * | 2017-03-02 | 2018-09-07 | 株式会社 三和化学研究所 | アルコール使用障害の治療薬 |
| JPWO2018159716A1 (ja) * | 2017-03-02 | 2019-12-26 | 株式会社三和化学研究所 | アルコール使用障害の治療薬 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2536280A1 (en) | 2005-03-03 |
| US20050043327A1 (en) | 2005-02-24 |
| BRPI0413693A (pt) | 2006-10-24 |
| WO2005018645A1 (en) | 2005-03-03 |
| EP1658082A1 (en) | 2006-05-24 |
| MXPA06002035A (es) | 2006-05-17 |
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