JP2007501798A5 - - Google Patents

Info

Publication number

JP2007501798A5

JP2007501798A5 JP2006522764A JP2006522764A JP2007501798A5 JP 2007501798 A5 JP2007501798 A5 JP 2007501798A5 JP 2006522764 A JP2006522764 A JP 2006522764A JP 2006522764 A JP2006522764 A JP 2006522764A JP 2007501798 A5 JP2007501798 A5 JP 2007501798A5

Authority

JP

Japan

Prior art keywords

composition

effective amount

csf

ncm

cyclophosphamide

Prior art date

2004-08-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 67
• CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 44
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 24
• 229960004397 cyclophosphamide Drugs 0.000 claims 24
• 229960000905 indomethacin Drugs 0.000 claims 22
• 102000004127 Cytokines Human genes 0.000 claims 19
• 108090000695 Cytokines Proteins 0.000 claims 19
• 206010028980 Neoplasm Diseases 0.000 claims 19
• 239000000427 antigen Substances 0.000 claims 16
• 102000036639 antigens Human genes 0.000 claims 16
• 108091007433 antigens Proteins 0.000 claims 16
• 108010002352 Interleukin-1 Proteins 0.000 claims 11
• 108010002350 Interleukin-2 Proteins 0.000 claims 11
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 10
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 10
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 10
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 9
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 9
• 108010065805 Interleukin-12 Proteins 0.000 claims 9
• 108090001005 Interleukin-6 Proteins 0.000 claims 9
• 108090001007 Interleukin-8 Proteins 0.000 claims 9
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 8
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 8
• -1 IFN-δ Proteins 0.000 claims 7
• 238000011282 treatment Methods 0.000 claims 6
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 5
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 4
• RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 4
• 230000028993 immune response Effects 0.000 claims 4
• 238000009169 immunotherapy Methods 0.000 claims 4
• RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 claims 4
• 238000012360 testing method Methods 0.000 claims 4
• 210000004443 dendritic cell Anatomy 0.000 claims 3
• 210000001165 lymph node Anatomy 0.000 claims 3
• 230000007761 synergistic anti-cancer Effects 0.000 claims 3
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 2
• 101150021539 MT-CO2 gene Proteins 0.000 claims 2
• 206010027476 Metastases Diseases 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 230000002001 anti-metastasis Effects 0.000 claims 2
• 238000011394 anticancer treatment Methods 0.000 claims 2
• 229940047495 celebrex Drugs 0.000 claims 2
• 229960000590 celecoxib Drugs 0.000 claims 2
• 229960001680 ibuprofen Drugs 0.000 claims 2
• 230000036039 immunity Effects 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 230000009401 metastasis Effects 0.000 claims 2
• 238000001959 radiotherapy Methods 0.000 claims 2
• 229960000371 rofecoxib Drugs 0.000 claims 2
• 238000001356 surgical procedure Methods 0.000 claims 2
• 229940087652 vioxx Drugs 0.000 claims 2
• 206010063397 Rosai-Dorfman syndrome Diseases 0.000 claims 1
• 208000006489 Sinus Histiocytosis Diseases 0.000 claims 1
• 230000007547 defect Effects 0.000 claims 1
• 230000004069 differentiation Effects 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 230000001926 lymphatic effect Effects 0.000 claims 1
• 230000035800 maturation Effects 0.000 claims 1
• 210000001616 monocyte Anatomy 0.000 claims 1
• 230000004044 response Effects 0.000 claims 1
• 230000009885 systemic effect Effects 0.000 claims 1