JP2007501798A - 免疫抑制された患者のためのワクチン免疫治療 - Google Patents

免疫抑制された患者のためのワクチン免疫治療 Download PDF

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JP2007501798A
JP2007501798A JP2006522764A JP2006522764A JP2007501798A JP 2007501798 A JP2007501798 A JP 2007501798A JP 2006522764 A JP2006522764 A JP 2006522764A JP 2006522764 A JP2006522764 A JP 2006522764A JP 2007501798 A JP2007501798 A JP 2007501798A
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ジョン ダブリュー. ヘデン,
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アイ アール エックス セーラピューティクス, インコーポレイテッド
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JP2006522764A 2003-08-08 2004-08-05 免疫抑制された患者のためのワクチン免疫治療 Pending JP2007501798A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/637,869 US7182942B2 (en) 2000-10-27 2003-08-08 Vaccine immunotherapy for immune suppressed patients
PCT/US2004/025518 WO2005025494A2 (en) 2003-08-08 2004-08-05 Vaccine immunotherapy for immune suppressed patients

Related Child Applications (1)

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JP2012105898A Division JP2012144579A (ja) 2003-08-08 2012-05-07 免疫抑制された患者のためのワクチン免疫治療

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JP2007501798A true JP2007501798A (ja) 2007-02-01
JP2007501798A5 JP2007501798A5 (enExample) 2007-09-20

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JP2006522764A Pending JP2007501798A (ja) 2003-08-08 2004-08-05 免疫抑制された患者のためのワクチン免疫治療
JP2012105898A Pending JP2012144579A (ja) 2003-08-08 2012-05-07 免疫抑制された患者のためのワクチン免疫治療

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US (2) US7182942B2 (enExample)
EP (2) EP2420249A1 (enExample)
JP (2) JP2007501798A (enExample)
AT (1) ATE526986T1 (enExample)
AU (1) AU2004271930A1 (enExample)
CA (1) CA2578375A1 (enExample)
DK (1) DK1653912T3 (enExample)
ES (1) ES2374920T3 (enExample)
PT (1) PT1653912E (enExample)
WO (1) WO2005025494A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010519222A (ja) * 2007-02-15 2010-06-03 アイ アール エックス セーラピューティクス, インコーポレイテッド 免疫抑制された患者のための免疫療法
JP2011504932A (ja) * 2007-11-28 2011-02-17 アイ アール エックス セーラピューティクス, インコーポレイテッド 免疫学的効果を増大させる方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7030219B2 (en) 2000-04-28 2006-04-18 Johns Hopkins University B7-DC, Dendritic cell co-stimulatory molecules
CA2950109C (en) 2000-10-27 2019-02-19 John W. Hadden Vaccine immunotherapy for immune suppressed patients
US7182942B2 (en) 2000-10-27 2007-02-27 Irx Therapeutics, Inc. Vaccine immunotherapy for immune suppressed patients
US20070025958A1 (en) 2000-10-27 2007-02-01 Hadden John W Vaccine immunotherapy
US20060194242A1 (en) * 2000-10-27 2006-08-31 Hadden John W Immunotherapy for immune suppressed patients
GB0525535D0 (en) * 2005-12-15 2006-01-25 Cgt Corp Tumour treatment
AU2007270686B2 (en) * 2006-07-07 2011-05-26 Tiltan Pharma Ltd. Anti-cancer therapy comprising an H2-blocker, at least one antiinflammatory agent and a cytotoxic agent
US9157760B2 (en) * 2007-01-12 2015-10-13 Aol Inc. Community mapping and direction indicating
EA201500417A1 (ru) * 2008-08-25 2015-11-30 Эмплиммьюн, Инк. Композиции антагонистов pd-1 и способы применения
WO2010098788A2 (en) * 2008-08-25 2010-09-02 Amplimmune, Inc. Pd-i antagonists and methods for treating infectious disease
AU2010248761B2 (en) 2009-05-15 2016-02-11 Irx Therapeutics, Inc. Vaccine immunotherapy
CN107050430B (zh) 2009-12-08 2021-10-15 伊尔克斯治疗有限公司 逆转朗格汉斯细胞免疫抑制的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034119A2 (en) * 2000-10-27 2002-05-02 Immuno-Rx, Inc. Vaccine immunotherapy for immune suppressed patients
WO2003035004A2 (en) * 2001-10-26 2003-05-01 Immuno-Rx, Inc. Immunotherapy for reversing immune suppression
WO2003061566A2 (en) * 2002-01-24 2003-07-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Anti-cancer combination and use thereof

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116951A (en) * 1977-04-22 1978-09-26 Hoffmann-La Roche Inc. [Asn2 ]-thymosin α1 and analogs thereof
DE2919592A1 (de) * 1979-05-15 1981-01-15 Max Planck Gesellschaft Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon
US4470926A (en) * 1980-01-18 1984-09-11 Max-Planck-Gesellschaft zur F/o/ rderung der Wissenschaften e.V. Medicaments containing thymosin alpha 1 fragments and having an immunostimulant action, and fragments of thymosin alpha 1
DE3100974A1 (de) * 1980-01-18 1982-01-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente enthaltende arzneimittel mit immunregulierender wirkung, und thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente
US4612365A (en) * 1980-03-25 1986-09-16 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften Medicaments containing alpha 1-thymosin and having an immuno regulatory action and alpha 1-thymosin fragments
US4390623A (en) * 1980-10-02 1983-06-28 Hooper Trading Company Serum-free and mitogen-free T-cell growth factor and process for making same
US4475196A (en) * 1981-03-06 1984-10-02 Zor Clair G Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4464355A (en) * 1981-03-26 1984-08-07 Hooper Trading Co. Serum-free and mitogen-free T-cell growth factor and process for making same
US4447233A (en) * 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) * 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) * 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4486194A (en) * 1983-06-08 1984-12-04 James Ferrara Therapeutic device for administering medicaments through the skin
US5503841A (en) * 1985-09-20 1996-04-02 Cetus Oncology Corporation Human IL-2 as a vaccine adjuvant
US5100664A (en) * 1985-09-20 1992-03-31 Cetus Corporation Human IL-2 as a vaccine adjuvant
US5643565A (en) * 1985-09-20 1997-07-01 Chiron Corporation Human IL-2 as a vaccine adjuvant
US4959217A (en) * 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US4925678A (en) * 1987-04-01 1990-05-15 Ranney David F Endothelial envelopment drug carriers
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5167616A (en) * 1989-12-14 1992-12-01 Alza Corporation Iontophoretic delivery method
US5225182A (en) * 1991-10-31 1993-07-06 Sharma Yash P Vectored drug delivery system using a cephaloplastin linking agent and a methed of using the system
DE69533941T2 (de) * 1994-11-17 2005-12-29 University Of South Florida, Tampa Verfahren zur herstellung eines arzneimittels zur behandlung des sekundärimmunmangels
US5632983A (en) * 1994-11-17 1997-05-27 University Of South Florida Method for treating secondary immunodeficiency
KR970030154A (ko) * 1995-11-24 1997-06-26 윤종용 칼라 음극선관용 전자총
EP0974357A1 (en) * 1998-07-16 2000-01-26 Schering-Plough Chemokines as adjuvants of immune response
US7182942B2 (en) 2000-10-27 2007-02-27 Irx Therapeutics, Inc. Vaccine immunotherapy for immune suppressed patients
DE10104969C2 (de) 2001-02-03 2002-11-21 Aeg Infrarot Module Gmbh Kaltteil eines Kyrokühlers mit verbesserter Wärmeübertragung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034119A2 (en) * 2000-10-27 2002-05-02 Immuno-Rx, Inc. Vaccine immunotherapy for immune suppressed patients
WO2003035004A2 (en) * 2001-10-26 2003-05-01 Immuno-Rx, Inc. Immunotherapy for reversing immune suppression
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JP2011504932A (ja) * 2007-11-28 2011-02-17 アイ アール エックス セーラピューティクス, インコーポレイテッド 免疫学的効果を増大させる方法

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US7182942B2 (en) 2007-02-27
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ATE526986T1 (de) 2011-10-15
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JP2012144579A (ja) 2012-08-02
US20040071658A1 (en) 2004-04-15
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