JP2007501616A5 - - Google Patents
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- Publication number
- JP2007501616A5 JP2007501616A5 JP2006522760A JP2006522760A JP2007501616A5 JP 2007501616 A5 JP2007501616 A5 JP 2007501616A5 JP 2006522760 A JP2006522760 A JP 2006522760A JP 2006522760 A JP2006522760 A JP 2006522760A JP 2007501616 A5 JP2007501616 A5 JP 2007501616A5
- Authority
- JP
- Japan
- Prior art keywords
- tff3
- seq
- antibody
- neutralizing agent
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000014456 Trefoil Factor-3 Human genes 0.000 claims 71
- 108010078184 Trefoil Factor-3 Proteins 0.000 claims 71
- 239000003795 chemical substances by application Substances 0.000 claims 40
- 230000003472 neutralizing effect Effects 0.000 claims 40
- 206010028980 Neoplasm Diseases 0.000 claims 31
- 238000000034 method Methods 0.000 claims 28
- 201000011510 cancer Diseases 0.000 claims 27
- 210000004027 cell Anatomy 0.000 claims 24
- 239000003814 drug Substances 0.000 claims 17
- 238000002360 preparation method Methods 0.000 claims 15
- 239000000523 sample Substances 0.000 claims 12
- 238000011282 treatment Methods 0.000 claims 11
- 230000000692 anti-sense effect Effects 0.000 claims 9
- 108091030071 RNAI Proteins 0.000 claims 8
- 230000009368 gene silencing by RNA Effects 0.000 claims 8
- 239000012472 biological sample Substances 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 230000006907 apoptotic process Effects 0.000 claims 4
- 239000005556 hormone Substances 0.000 claims 4
- 229940088597 hormone Drugs 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000001766 physiological effect Effects 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000004614 tumor growth Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 238000010317 ablation therapy Methods 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003098 androgen Substances 0.000 claims 2
- -1 antisense molecule Proteins 0.000 claims 2
- 210000000481 breast Anatomy 0.000 claims 2
- 230000021164 cell adhesion Effects 0.000 claims 2
- 230000012292 cell migration Effects 0.000 claims 2
- 230000009087 cell motility Effects 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 230000002611 ovarian Effects 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000009400 cancer invasion Effects 0.000 claims 1
- 230000004709 cell invasion Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 238000004091 panning Methods 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000005267 prostate cell Anatomy 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 230000003827 upregulation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49317303P | 2003-08-07 | 2003-08-07 | |
| US49843803P | 2003-08-28 | 2003-08-28 | |
| PCT/US2004/025508 WO2005013802A2 (en) | 2003-08-07 | 2004-08-05 | Trefoil factor 3 (tff3) as a target for anti-cancer therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007501616A JP2007501616A (ja) | 2007-02-01 |
| JP2007501616A5 true JP2007501616A5 (https=) | 2007-07-26 |
Family
ID=34138741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006522760A Withdrawn JP2007501616A (ja) | 2003-08-07 | 2004-08-05 | 抗癌治療のための標的としてのトレホイル因子3(tff3) |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20080233046A1 (https=) |
| EP (1) | EP1660136A4 (https=) |
| JP (1) | JP2007501616A (https=) |
| KR (1) | KR20060073589A (https=) |
| AU (1) | AU2004263140A1 (https=) |
| CA (1) | CA2534658A1 (https=) |
| IL (1) | IL173333A0 (https=) |
| MX (1) | MXPA06001327A (https=) |
| WO (1) | WO2005013802A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1833991A4 (en) * | 2004-12-22 | 2011-11-16 | Auckland Uniservices Ltd | TREFOIL FACTORS AND METHOD FOR THE TREATMENT OF PROLIFERATIVE DISEASES THEREWITH |
| US7601540B2 (en) * | 2006-07-18 | 2009-10-13 | Bristol-Myers Squibb Company | Gamma secretase notch biomarkers |
| US20080199455A1 (en) * | 2006-10-03 | 2008-08-21 | Lobie Peter E | Conformation specific antibodies that bind trefoil factors and methods of treating cancers and proliferation disorders using same |
| ES2332167B1 (es) * | 2007-12-04 | 2010-10-25 | Universidad Autonoma De Madrid | Empleo de trefoil factor-family 3 (tff3) en el pronostico de sujetos diagnosticados con cancer colorectal. |
| WO2011060040A1 (en) * | 2009-11-10 | 2011-05-19 | Abraxis Bioscience, Llc | Diagnostic and therapeutic applications of the u6 snrna |
| GB0920014D0 (en) | 2009-11-13 | 2009-12-30 | Medical Res Council | Cell sampling device |
| EP2661620A4 (en) * | 2011-01-08 | 2014-07-16 | Astute Medical Inc | METHOD AND COMPOSITIONS FOR DIAGNOSING AND PROGNOSING RENAL INJURY AND RENAL INSUFFICIENCY |
| WO2025166063A1 (en) | 2024-01-31 | 2025-08-07 | Bluerock Therapeutics Lp | Igfbp2 in cell culture |
| CN120209138B (zh) * | 2025-05-29 | 2025-10-03 | 杭州广科安德生物科技有限公司 | Tff3、osm蛋白的抗体及其组合和在结直肠癌诊断中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063755A (en) * | 1991-02-14 | 2000-05-16 | The General Hospital Corporation | Intestinal trefoil proteins |
| US5733748A (en) * | 1995-06-06 | 1998-03-31 | Human Genome Sciences, Inc. | Colon specific genes and proteins |
| US6337195B1 (en) * | 1995-06-06 | 2002-01-08 | Human Genome Sciences, Inc. | Colon specific genes and proteins |
| DE19701873C1 (de) * | 1997-01-21 | 1998-06-04 | Daimler Benz Ag | Halterung einer Abgasrückführleitung am Motorgehäuse einer Brennkraftmaschine |
| US6261562B1 (en) * | 1997-02-25 | 2001-07-17 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US6465611B1 (en) * | 1997-02-25 | 2002-10-15 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US6476207B1 (en) * | 1998-06-11 | 2002-11-05 | Chiron Corporation | Genes and gene expression products that are differentially regulated in prostate cancer |
| US5998148A (en) * | 1999-04-08 | 1999-12-07 | Isis Pharmaceuticals Inc. | Antisense modulation of microtubule-associated protein 4 expression |
| FR2810297B1 (fr) * | 2000-06-16 | 2002-08-02 | Cogema | Distributeur automatique de couvercles sur des boites |
| US6991901B2 (en) * | 2001-01-11 | 2006-01-31 | Curagen Corporation | Proteins and nucleic acids encoding same |
| JP2005512510A (ja) * | 2001-05-16 | 2005-05-12 | ノバルティス アクチエンゲゼルシャフト | 予後および治療標的として乳癌で発現される遺伝子 |
| WO2003004989A2 (en) * | 2001-06-21 | 2003-01-16 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| DE10215320A1 (de) * | 2002-04-02 | 2003-10-23 | Metagen Pharmaceuticals Gmbh | Verwendungen von TFF3 bindenden Substanzen zur Diagnose und Behandlung von Krebserkrankungen |
| AU2002349786A1 (en) * | 2002-06-19 | 2004-01-06 | Japan As Represented By The President Of The University Of Tokyo | Method for diagnosis of colorectal tumors |
| CA2519630A1 (en) * | 2003-03-20 | 2004-10-07 | Dana-Farber Cancer Institute, Inc. | Gene expression in breast cancer |
-
2004
- 2004-08-05 KR KR1020067002654A patent/KR20060073589A/ko not_active Abandoned
- 2004-08-05 CA CA002534658A patent/CA2534658A1/en not_active Abandoned
- 2004-08-05 AU AU2004263140A patent/AU2004263140A1/en not_active Abandoned
- 2004-08-05 MX MXPA06001327A patent/MXPA06001327A/es unknown
- 2004-08-05 US US10/567,330 patent/US20080233046A1/en not_active Abandoned
- 2004-08-05 JP JP2006522760A patent/JP2007501616A/ja not_active Withdrawn
- 2004-08-05 EP EP04780358A patent/EP1660136A4/en not_active Withdrawn
- 2004-08-05 WO PCT/US2004/025508 patent/WO2005013802A2/en not_active Ceased
- 2004-08-05 US US10/913,685 patent/US20050186212A1/en not_active Abandoned
-
2006
- 2006-01-24 IL IL173333A patent/IL173333A0/en unknown
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