JP2007500707A - ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法 - Google Patents

ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法 Download PDF

Info

Publication number
JP2007500707A
JP2007500707A JP2006522027A JP2006522027A JP2007500707A JP 2007500707 A JP2007500707 A JP 2007500707A JP 2006522027 A JP2006522027 A JP 2006522027A JP 2006522027 A JP2006522027 A JP 2006522027A JP 2007500707 A JP2007500707 A JP 2007500707A
Authority
JP
Japan
Prior art keywords
alkyl
formula
compound according
group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006522027A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007500707A5 (https=
Inventor
アデグボイェガ・ケイ・オイェレレ
ジョエル・エイ・ゴールドバーグ
アリア・オービン
ジョゼフ・エム・サルビーノ
ジャチェン・チョウ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melinta Subsidiary Corp
Original Assignee
Rib X Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rib X Pharmaceuticals Inc filed Critical Rib X Pharmaceuticals Inc
Publication of JP2007500707A publication Critical patent/JP2007500707A/ja
Publication of JP2007500707A5 publication Critical patent/JP2007500707A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2006522027A 2003-07-29 2004-07-28 ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法 Pending JP2007500707A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49085503P 2003-07-29 2003-07-29
PCT/US2004/024334 WO2005012270A2 (en) 2003-07-29 2004-07-28 Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same

Publications (2)

Publication Number Publication Date
JP2007500707A true JP2007500707A (ja) 2007-01-18
JP2007500707A5 JP2007500707A5 (https=) 2007-09-06

Family

ID=34115440

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006522027A Pending JP2007500707A (ja) 2003-07-29 2004-07-28 ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法

Country Status (4)

Country Link
US (1) US20070197541A1 (https=)
EP (1) EP1664001A2 (https=)
JP (1) JP2007500707A (https=)
WO (1) WO2005012270A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007500708A (ja) * 2003-07-29 2007-01-18 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールオキサゾリジノンの合成方法
JP2007520472A (ja) * 2003-12-22 2007-07-26 メルク　エンド　カムパニー　インコーポレーテッド ブラジキニン拮抗物質又は逆作用物質としてのアルファ−ヒドロキシアミド
WO2011034078A1 (ja) * 2009-09-16 2011-03-24 アステラス製薬株式会社 グリシン化合物

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012271A2 (en) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
EP1656370B1 (en) * 2003-06-03 2012-08-15 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic compounds and methods of making and using the same
AR046782A1 (es) 2003-12-17 2005-12-21 Rib X Pharmaceuticals Inc Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos.
JP5534497B2 (ja) * 2005-06-08 2014-07-02 メリンタ セラピューティクス，インコーポレイテッド トリアゾール類の合成方法
WO2008021849A2 (en) * 2006-08-09 2008-02-21 Smithkline Beecham Corporation Novel compounds as antagonists or inverse agonists at opioid receptors
JP5466759B2 (ja) 2009-05-28 2014-04-09 ノバルティス アーゲー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
SG176009A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
TR201808541T4 (tr) 2013-02-14 2018-07-23 Novartis Ag Nep (nötr endopeptidaz) inhibitörleri olarak ikame edilmiş bisfenil butanoik fosfonik asit türevleri.
JP6301371B2 (ja) 2013-02-14 2018-04-11 ノバルティス アーゲー インビボ効力が改善されたｎｅｐ阻害剤としての置換ビスフェニルブタン酸誘導体
KR102237887B1 (ko) 2013-03-15 2021-04-07 멜린타 서브시디어리 코프. 항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법
EP3604271A1 (en) 2013-06-28 2020-02-05 Auckland Uniservices Limited Peptides for amino acid and peptide conjugates and conjugation process
WO2016061772A1 (en) 2014-10-22 2016-04-28 Merck Sharp & Dohme Corp. Nargenicin compounds and uses thereof as antibacterial agents
CN107205989A (zh) 2014-11-14 2017-09-26 梅琳塔治疗公司 治疗、预防或降低皮肤感染风险的方法
CN107250103A (zh) 2014-12-23 2017-10-13 玛格丽特·安妮·布林布尔 氨基酸缀合物和肽缀合物以及其用途
CN107709314A (zh) 2015-06-11 2018-02-16 巴斯利尔药物国际股份公司 外排泵抑制剂及其治疗性用途
TW201735952A (zh) 2016-02-26 2017-10-16 瑪格蕾特 安 布萊博 胺基酸及肽共軛物以及共軛過程
US10202334B2 (en) 2016-12-09 2019-02-12 Celtaxsys, Inc. Pendant amines and derivatives as inhibitors of leukotriene A4 hydrolase
KR20240136380A (ko) 2022-01-14 2024-09-13 엔코 켐 인코포레이티드 프로토포르피리노겐 산화효소 억제제
CN120794967A (zh) * 2024-04-10 2025-10-17 沈阳药科大学 联芳基噁唑烷酮类化合物及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02124877A (ja) * 1988-07-29 1990-05-14 E I Du Pont De Nemours & Co アミノメチルオキソオキサゾリジニルアリールベンゼン誘導体
JPH0841056A (ja) * 1994-07-20 1996-02-13 Bayer Ag ６員の窒素含有ヘテロアリール−オキサゾリジノン類
WO2000010566A1 (en) * 1998-08-24 2000-03-02 Bristol-Myers Squibb Company Novel isoxazolinone antibacterial agents
WO2001081350A1 (en) * 2000-04-25 2001-11-01 Astrazeneca Ab Oxazolidinone derivatives with antibiotic activity
WO2001094342A1 (en) * 2000-06-05 2001-12-13 Dong A Pharm. Co., Ltd. Novel oxazolidinone derivatives and a process for the preparation thereof
JP2007500708A (ja) * 2003-07-29 2007-01-18 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールオキサゾリジノンの合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012271A2 (en) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
EP1656370B1 (en) * 2003-06-03 2012-08-15 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic compounds and methods of making and using the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02124877A (ja) * 1988-07-29 1990-05-14 E I Du Pont De Nemours & Co アミノメチルオキソオキサゾリジニルアリールベンゼン誘導体
JPH0841056A (ja) * 1994-07-20 1996-02-13 Bayer Ag ６員の窒素含有ヘテロアリール−オキサゾリジノン類
WO2000010566A1 (en) * 1998-08-24 2000-03-02 Bristol-Myers Squibb Company Novel isoxazolinone antibacterial agents
WO2001081350A1 (en) * 2000-04-25 2001-11-01 Astrazeneca Ab Oxazolidinone derivatives with antibiotic activity
WO2001094342A1 (en) * 2000-06-05 2001-12-13 Dong A Pharm. Co., Ltd. Novel oxazolidinone derivatives and a process for the preparation thereof
JP2007500708A (ja) * 2003-07-29 2007-01-18 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールオキサゾリジノンの合成方法

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007500708A (ja) * 2003-07-29 2007-01-18 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールオキサゾリジノンの合成方法
JP4777246B2 (ja) * 2003-07-29 2011-09-21 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールオキサゾリジノンの合成方法
JP2007520472A (ja) * 2003-12-22 2007-07-26 メルク　エンド　カムパニー　インコーポレーテッド ブラジキニン拮抗物質又は逆作用物質としてのアルファ−ヒドロキシアミド
WO2011034078A1 (ja) * 2009-09-16 2011-03-24 アステラス製薬株式会社 グリシン化合物
CN102498091A (zh) * 2009-09-16 2012-06-13 安斯泰来制药株式会社 甘氨酸化合物
JPWO2011034078A1 (ja) * 2009-09-16 2013-02-14 アステラス製薬株式会社 グリシン化合物
CN102498091B (zh) * 2009-09-16 2014-03-05 安斯泰来制药株式会社 甘氨酸化合物
US8802679B2 (en) 2009-09-16 2014-08-12 Astellas Pharma Inc. Glycine compound

Also Published As

Publication number Publication date
WO2005012270A2 (en) 2005-02-10
US20070197541A1 (en) 2007-08-23
EP1664001A2 (en) 2006-06-07
WO2005012270A3 (en) 2006-01-12

Similar Documents

Publication Publication Date Title
JP2007500707A (ja) ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法
EP1656370B1 (en) Biaryl heterocyclic compounds and methods of making and using the same
US7129259B2 (en) Halogenated biaryl heterocyclic compounds and methods of making and using the same
US20060270680A1 (en) Sulfonamide compounds and methods of making and using the same
AU2012229127A1 (en) Antimicrobial agents
US20150158827A1 (en) Process for the Synthesis of Triazoles
KR20120099435A (ko) 항미생물성 화합물 및 이의 제조 방법 및 사용 방법
JP2006523229A (ja) 二官能性複素環式化合物ならびにその製造および使用方法
JP2007509980A (ja) 二官能性マクロライド複素環式化合物およびそれらの化合物を調製および使用する方法
JP2008508271A (ja) ビアリール複素環式化合物ならびにその化合物を製造および使用する方法
JP2007512256A (ja) 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
TW202423920A (zh) 用於治療哺乳動物感染之新穎化合物
HK1090646B (en) Biaryl heterocyclic compounds and methods of making and using the same
HK1174627A (en) Biaryl heterocyclic compounds and methods of making and using the same

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070723

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070723

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20090917

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100727

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110315