JP2007277257A5 - - Google Patents
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- Publication number
- JP2007277257A5 JP2007277257A5 JP2007158916A JP2007158916A JP2007277257A5 JP 2007277257 A5 JP2007277257 A5 JP 2007277257A5 JP 2007158916 A JP2007158916 A JP 2007158916A JP 2007158916 A JP2007158916 A JP 2007158916A JP 2007277257 A5 JP2007277257 A5 JP 2007277257A5
- Authority
- JP
- Japan
- Prior art keywords
- piperidinyl
- dihydro
- benzamidazol
- oxo
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 phenyloxy Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 17
- DEDZSLCZHWTGOR-UHFFFAOYSA-N propylcyclohexane Chemical compound CCCC1CCCCC1 DEDZSLCZHWTGOR-UHFFFAOYSA-N 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- MVLOWDRGPHBNNF-UHFFFAOYSA-N 3-ethyl-2-methylhexane Chemical compound CCCC(CC)C(C)C MVLOWDRGPHBNNF-UHFFFAOYSA-N 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- BKIMMITUMNQMOS-UHFFFAOYSA-N normal nonane Natural products CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- PFSHCAFPPIIXMS-UHFFFAOYSA-N 1,3-dihydroindene Chemical compound C1=CC=C2C[CH]CC2=C1 PFSHCAFPPIIXMS-UHFFFAOYSA-N 0.000 claims 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000006623 cyclooctylmethyl group Chemical group 0.000 claims 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 2
- UFUASNAHBMBJIX-UHFFFAOYSA-N propan-1-one Chemical group CC[C]=O UFUASNAHBMBJIX-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000001207 fluorophenyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 102000051367 mu Opioid Receptors Human genes 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 108010020615 nociceptin receptor Proteins 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 108020001612 μ-opioid receptors Proteins 0.000 claims 1
- 0 **N(CC1)CCC1N(c1c(*)ccc(*)c1N1*)C1=O Chemical compound **N(CC1)CCC1N(c1c(*)ccc(*)c1N1*)C1=O 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16939499P | 1999-12-06 | 1999-12-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541507A Division JP2003524634A (ja) | 1999-12-06 | 2000-12-06 | ノシセプチン受容体親和性を有するベンズイミダゾール化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007277257A JP2007277257A (ja) | 2007-10-25 |
| JP2007277257A5 true JP2007277257A5 (cg-RX-API-DMAC7.html) | 2007-12-20 |
Family
ID=22615490
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541507A Pending JP2003524634A (ja) | 1999-12-06 | 2000-12-06 | ノシセプチン受容体親和性を有するベンズイミダゾール化合物 |
| JP2007158916A Pending JP2007277257A (ja) | 1999-12-06 | 2007-06-15 | ノシセプチン受容体親和性を有するベンズイミダゾール化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541507A Pending JP2003524634A (ja) | 1999-12-06 | 2000-12-06 | ノシセプチン受容体親和性を有するベンズイミダゾール化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7456198B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1242085B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2003524634A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE302770T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU1816901A (cg-RX-API-DMAC7.html) |
| DE (1) | DE60022226D1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1049284B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2001039775A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1816901A (en) * | 1999-12-06 | 2001-06-12 | Euro-Celtique S.A. | Benzimidazole compounds having nociceptin receptor affinity |
| IL158484A0 (en) * | 2001-04-18 | 2004-05-12 | Euro Celtique Sa | Nociceptin analogs |
| CA2465328C (en) * | 2001-11-01 | 2011-06-14 | Michael Francis Gross | Piperidines |
| JP4056977B2 (ja) | 2002-03-29 | 2008-03-05 | 田辺三菱製薬株式会社 | 睡眠障害治療薬 |
| JP2005289816A (ja) * | 2002-05-14 | 2005-10-20 | Banyu Pharmaceut Co Ltd | ベンズイミダゾール誘導体 |
| DE10252666A1 (de) * | 2002-11-11 | 2004-08-05 | Grünenthal GmbH | N-Piperidyl-cyclohexan-Derivate |
| US7202259B2 (en) * | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| AR045939A1 (es) | 2003-09-25 | 2005-11-16 | Solvay Pharm Bv | Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos |
| AR045843A1 (es) | 2003-10-03 | 2005-11-16 | Solvay Pharm Bv | Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos |
| KR100886002B1 (ko) | 2004-01-30 | 2009-03-03 | 유로-셀띠끄 소시에떼 아노님 | 4-테트라졸릴-4-페닐피페리딘 화합물의 제조방법 |
| UA83919C2 (en) * | 2004-04-20 | 2008-08-26 | Санофи Авентис | Polymorphic forms of methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, clopidrogel hydrobromide |
| US7300947B2 (en) * | 2005-07-13 | 2007-11-27 | Banyu Pharmaceutical Co., Ltd. | N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives |
| AR054816A1 (es) * | 2005-07-13 | 2007-07-18 | Banyu Pharma Co Ltd | Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos |
| WO2007037513A1 (ja) * | 2005-09-30 | 2007-04-05 | Banyu Pharmaceutical Co., Ltd. | アリール置換含窒素複素環化合物 |
| US20080015214A1 (en) * | 2005-10-24 | 2008-01-17 | Bignan Gilles C | 3-piperidin-4-yl-indole orl-1 receptor modulators |
| JP2009525269A (ja) * | 2006-01-30 | 2009-07-09 | ユーロ−セルティーク エス．エイ． | カルシウムチャネルブロッカーとしての環状尿素化合物 |
| GB0605784D0 (en) * | 2006-03-22 | 2006-05-03 | Glaxo Group Ltd | Compounds |
| GB0605786D0 (en) * | 2006-03-22 | 2006-05-03 | Glaxo Group Ltd | Compounds |
| US8775704B2 (en) * | 2006-04-05 | 2014-07-08 | Nvidia Corporation | Method and system for communication between a secondary processor and an auxiliary display subsystem of a notebook |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| EP2397477B1 (en) * | 2007-01-16 | 2014-03-05 | Purdue Pharma LP | Heterocyclic-substituted piperidine compounds and the uses thereof |
| BRPI0808025A2 (pt) * | 2007-03-01 | 2014-06-24 | Mitsubishi Tanabe Pharma Corp | Composto de benzimidazol e uso farmacêutico do mesmo |
| RU2451017C2 (ru) * | 2007-03-01 | 2012-05-20 | Мицубиси Танабе Фарма Корпорейшн | Бензимидазольное соединение и его фармацевтическое применение |
| MY150602A (en) | 2007-08-31 | 2014-01-30 | Purdue Pharma Lp | Subtituted-quinoxaline-type piperidine compounds and the uses thereof |
| WO2009124883A1 (en) * | 2008-04-09 | 2009-10-15 | H. Lundbeck A/S | Novel 1,3-dihydro-benzoimidazol-2-ones as m1 agonists |
| KR101333660B1 (ko) | 2008-07-21 | 2013-11-27 | 시오노기세이야쿠가부시키가이샤 | 치환-퀴녹살린-형 가교-피페리딘 화합물 및 그의 용도 |
| US8736617B2 (en) * | 2008-08-04 | 2014-05-27 | Nvidia Corporation | Hybrid graphic display |
| TW201016675A (en) | 2008-09-16 | 2010-05-01 | Mitsubishi Tanabe Pharma Corp | Crystalline benzoimidazole compound and salt thereof |
| US9075559B2 (en) * | 2009-02-27 | 2015-07-07 | Nvidia Corporation | Multiple graphics processing unit system and method |
| US9135675B2 (en) * | 2009-06-15 | 2015-09-15 | Nvidia Corporation | Multiple graphics processing unit display synchronization system and method |
| US8766989B2 (en) * | 2009-07-29 | 2014-07-01 | Nvidia Corporation | Method and system for dynamically adding and removing display modes coordinated across multiple graphics processing units |
| US8780122B2 (en) * | 2009-09-16 | 2014-07-15 | Nvidia Corporation | Techniques for transferring graphics data from system memory to a discrete GPU |
| US9111325B2 (en) * | 2009-12-31 | 2015-08-18 | Nvidia Corporation | Shared buffer techniques for heterogeneous hybrid graphics |
| US9951038B2 (en) | 2012-12-27 | 2018-04-24 | Purdue Pharma L.P. | Quinazolin-4(3H)-one-type piperidine compounds and uses thereof |
| US10118927B2 (en) | 2012-12-27 | 2018-11-06 | Purdue Pharma L.P. | Substituted piperidin-4-amino-type compounds and uses thereof |
| WO2014102594A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
| WO2014102588A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
| US9818379B2 (en) | 2013-08-08 | 2017-11-14 | Nvidia Corporation | Pixel data transmission over multiple pixel interfaces |
| US20240287019A1 (en) * | 2021-06-07 | 2024-08-29 | Kinki University | T-type calcium channel blocker |
| CN121843930A (zh) * | 2024-01-05 | 2026-04-10 | 宜昌人福药业有限责任公司 | 一种环己基取代哌啶衍生物、包含其的药物组合物及其用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE633495A (cg-RX-API-DMAC7.html) * | 1962-06-13 | |||
| US3161645A (en) | 1962-12-18 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds |
| US3318900A (en) | 1964-05-06 | 1967-05-09 | Janssen Pharmaceutica Nv | Derivatives of benzimidazolinyl piperidine |
| GR69650B (cg-RX-API-DMAC7.html) * | 1978-07-20 | 1982-07-07 | Science Union & Cie | |
| US4329353A (en) * | 1980-10-22 | 1982-05-11 | Janssen Pharmaceutica, N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof |
| JPS58180481A (ja) | 1982-04-15 | 1983-10-21 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
| EP0974583B1 (en) | 1995-09-13 | 2002-05-29 | Kyowa Hakko Kogyo Co., Ltd. | Phenylpiperidine derivatives |
| US6180649B1 (en) * | 1996-04-19 | 2001-01-30 | Nerosearch A/S | 1-(4-piperidyl)-benzimidazoles having neurotrophic activity |
| ES2226129T3 (es) | 1997-05-30 | 2005-03-16 | Banyu Pharmaceutical Co., Ltd. | Derivados de 2-0x0imidazol. |
| SI0921125T1 (en) | 1997-12-05 | 2002-04-30 | F. Hoffmann-La Roche Ag | 1,3,8-Triazaspiro(4,5)decan-4-on derivatives |
| US6166209A (en) | 1997-12-11 | 2000-12-26 | Hoffmann-La Roche Inc. | Piperidine derivatives |
| US6626939B1 (en) | 1997-12-18 | 2003-09-30 | Boston Scientific Scimed, Inc. | Stent-graft with bioabsorbable structural support |
| AU1679099A (en) * | 1998-01-19 | 1999-08-02 | Pfizer Inc. | 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists |
| NZ507760A (en) | 1998-03-26 | 2002-10-25 | Japan Tobacco Inc | Amide derivatives and nociceptin antagonists |
| AU3809999A (en) | 1998-05-18 | 1999-12-06 | Novo Nordisk A/S | Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes |
| ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
| US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| AU1816901A (en) * | 1999-12-06 | 2001-06-12 | Euro-Celtique S.A. | Benzimidazole compounds having nociceptin receptor affinity |
-
2000
- 2000-12-06 AU AU18169/01A patent/AU1816901A/en not_active Abandoned
- 2000-12-06 JP JP2001541507A patent/JP2003524634A/ja active Pending
- 2000-12-06 US US09/730,934 patent/US7456198B2/en not_active Expired - Lifetime
- 2000-12-06 EP EP00980981A patent/EP1242085B1/en not_active Expired - Lifetime
- 2000-12-06 HK HK03101335.9A patent/HK1049284B/en not_active IP Right Cessation
- 2000-12-06 WO PCT/US2000/033019 patent/WO2001039775A1/en not_active Ceased
- 2000-12-06 AT AT00980981T patent/ATE302770T1/de not_active IP Right Cessation
- 2000-12-06 DE DE60022226T patent/DE60022226D1/de not_active Expired - Lifetime
-
2006
- 2006-07-28 US US11/494,826 patent/US7678809B2/en not_active Expired - Fee Related
-
2007
- 2007-06-15 JP JP2007158916A patent/JP2007277257A/ja active Pending