HK1049284B - Benzimidazole compounds having nociceptin receptor affinity - Google Patents

Benzimidazole compounds having nociceptin receptor affinity Download PDF

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Publication number
HK1049284B
HK1049284B HK03101335.9A HK03101335A HK1049284B HK 1049284 B HK1049284 B HK 1049284B HK 03101335 A HK03101335 A HK 03101335A HK 1049284 B HK1049284 B HK 1049284B
Authority
HK
Hong Kong
Prior art keywords
compound
alkyl
compounds
group
halogen
Prior art date
Application number
HK03101335.9A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1049284A1 (en
Inventor
Kyle Donald
R. Goehring Richard
Shao Bin
Original Assignee
Euro-Celtique, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro-Celtique, S.A. filed Critical Euro-Celtique, S.A.
Publication of HK1049284A1 publication Critical patent/HK1049284A1/en
Publication of HK1049284B publication Critical patent/HK1049284B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK03101335.9A 1999-12-06 2000-12-06 Benzimidazole compounds having nociceptin receptor affinity HK1049284B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16939499P 1999-12-06 1999-12-06
US60/169,394 1999-12-06
PCT/US2000/033019 WO2001039775A1 (en) 1999-12-06 2000-12-06 Benzimidazole compounds having nociceptin receptor affinity

Publications (2)

Publication Number Publication Date
HK1049284A1 HK1049284A1 (en) 2003-05-09
HK1049284B true HK1049284B (en) 2006-02-24

Family

ID=22615490

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03101335.9A HK1049284B (en) 1999-12-06 2000-12-06 Benzimidazole compounds having nociceptin receptor affinity

Country Status (8)

Country Link
US (2) US7456198B2 (cg-RX-API-DMAC7.html)
EP (1) EP1242085B1 (cg-RX-API-DMAC7.html)
JP (2) JP2003524634A (cg-RX-API-DMAC7.html)
AT (1) ATE302770T1 (cg-RX-API-DMAC7.html)
AU (1) AU1816901A (cg-RX-API-DMAC7.html)
DE (1) DE60022226D1 (cg-RX-API-DMAC7.html)
HK (1) HK1049284B (cg-RX-API-DMAC7.html)
WO (1) WO2001039775A1 (cg-RX-API-DMAC7.html)

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JP2005289816A (ja) * 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
DE10252666A1 (de) * 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
US7202259B2 (en) * 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
AR045939A1 (es) 2003-09-25 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos
AR045843A1 (es) 2003-10-03 2005-11-16 Solvay Pharm Bv Derivados de bencimidazolonas y quinazolinonas sustituidas con hidronopol como agonistas en receptores orl 1 humanos
KR100886002B1 (ko) 2004-01-30 2009-03-03 유로-셀띠끄 소시에떼 아노님 4-테트라졸릴-4-페닐피페리딘 화합물의 제조방법
UA83919C2 (en) * 2004-04-20 2008-08-26 Санофи Авентис Polymorphic forms of methyl(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, clopidrogel hydrobromide
US7300947B2 (en) * 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
AR054816A1 (es) * 2005-07-13 2007-07-18 Banyu Pharma Co Ltd Derivados de n-dihidroxialquil 2-oxo- imidazol sustituidos
WO2007037513A1 (ja) * 2005-09-30 2007-04-05 Banyu Pharmaceutical Co., Ltd. アリール置換含窒素複素環化合物
US20080015214A1 (en) * 2005-10-24 2008-01-17 Bignan Gilles C 3-piperidin-4-yl-indole orl-1 receptor modulators
JP2009525269A (ja) * 2006-01-30 2009-07-09 ユーロ−セルティーク エス．エイ． カルシウムチャネルブロッカーとしての環状尿素化合物
GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0605786D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
US8775704B2 (en) * 2006-04-05 2014-07-08 Nvidia Corporation Method and system for communication between a secondary processor and an auxiliary display subsystem of a notebook
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
EP2397477B1 (en) * 2007-01-16 2014-03-05 Purdue Pharma LP Heterocyclic-substituted piperidine compounds and the uses thereof
BRPI0808025A2 (pt) * 2007-03-01 2014-06-24 Mitsubishi Tanabe Pharma Corp Composto de benzimidazol e uso farmacêutico do mesmo
RU2451017C2 (ru) * 2007-03-01 2012-05-20 Мицубиси Танабе Фарма Корпорейшн Бензимидазольное соединение и его фармацевтическое применение
MY150602A (en) 2007-08-31 2014-01-30 Purdue Pharma Lp Subtituted-quinoxaline-type piperidine compounds and the uses thereof
WO2009124883A1 (en) * 2008-04-09 2009-10-15 H. Lundbeck A/S Novel 1,3-dihydro-benzoimidazol-2-ones as m1 agonists
KR101333660B1 (ko) 2008-07-21 2013-11-27 시오노기세이야쿠가부시키가이샤 치환-퀴녹살린-형 가교-피페리딘 화합물 및 그의 용도
US8736617B2 (en) * 2008-08-04 2014-05-27 Nvidia Corporation Hybrid graphic display
TW201016675A (en) 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
US9075559B2 (en) * 2009-02-27 2015-07-07 Nvidia Corporation Multiple graphics processing unit system and method
US9135675B2 (en) * 2009-06-15 2015-09-15 Nvidia Corporation Multiple graphics processing unit display synchronization system and method
US8766989B2 (en) * 2009-07-29 2014-07-01 Nvidia Corporation Method and system for dynamically adding and removing display modes coordinated across multiple graphics processing units
US8780122B2 (en) * 2009-09-16 2014-07-15 Nvidia Corporation Techniques for transferring graphics data from system memory to a discrete GPU
US9111325B2 (en) * 2009-12-31 2015-08-18 Nvidia Corporation Shared buffer techniques for heterogeneous hybrid graphics
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
US10118927B2 (en) 2012-12-27 2018-11-06 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
WO2014102594A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
WO2014102588A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
US9818379B2 (en) 2013-08-08 2017-11-14 Nvidia Corporation Pixel data transmission over multiple pixel interfaces
US20240287019A1 (en) * 2021-06-07 2024-08-29 Kinki University T-type calcium channel blocker
CN121843930A (zh) * 2024-01-05 2026-04-10 宜昌人福药业有限责任公司 一种环己基取代哌啶衍生物、包含其的药物组合物及其用途

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BE633495A (cg-RX-API-DMAC7.html) * 1962-06-13
US3161645A (en) 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
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US4329353A (en) * 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
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US6166209A (en) 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
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AU1679099A (en) * 1998-01-19 1999-08-02 Pfizer Inc. 4-(2-keto-1-benzimidazolinyl)piperidine compounds as orl1-receptor agonists
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AU3809999A (en) 1998-05-18 1999-12-06 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
ID29137A (id) * 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
AU1816901A (en) * 1999-12-06 2001-06-12 Euro-Celtique S.A. Benzimidazole compounds having nociceptin receptor affinity

Also Published As

Publication number Publication date
DE60022226D1 (de) 2005-09-29
EP1242085B1 (en) 2005-08-24
JP2007277257A (ja) 2007-10-25
ATE302770T1 (de) 2005-09-15
WO2001039775A1 (en) 2001-06-07
US7456198B2 (en) 2008-11-25
EP1242085A1 (en) 2002-09-25
US20060264638A1 (en) 2006-11-23
EP1242085A4 (en) 2003-02-12
HK1049284A1 (en) 2003-05-09
US20020128288A1 (en) 2002-09-12
AU1816901A (en) 2001-06-12
US7678809B2 (en) 2010-03-16
JP2003524634A (ja) 2003-08-19

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20101206